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Parasitol."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB131","doi-asserted-by":"crossref","first-page":"C650","DOI":"10.1152\/ajpcell.1994.267.2.C650","article-title":"Selection for mdrl P-glycoprotein enhances swelling-activated K+ and Cl\u2212 currents in NIH\/3T3 cells","volume":"267","author":"Luckie","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB132","first-page":"A122","article-title":"Overexpression of mu-mdr-l protein inhibits Ca+-independent C\u2212HCO3 exchange in transfected Chinese-hamster ovary cells","volume":"66","author":"Luz","year":"1994","journal-title":"Biophys. 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Sci."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB172","first-page":"11588","article-title":"Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeastcells","volume":"90","author":"Ruetz","year":"1993"},{"key":"10.1016\/S0163-7258(97)00083-1_BIB173","first-page":"9942","article-title":"The pfmdr1 gene of Plasmodium falciparum confers cellular-resistance to antimalarial-drugs in yeast-cells","volume":"93","author":"Ruetz","year":"1996"},{"key":"10.1016\/S0163-7258(97)00083-1_BIB174","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1074\/jbc.272.5.2652","article-title":"Identification of a chloroquine importer in Plasmodium falciparum: differences in import kinetics are genetically linked with the chloroquine-resistant phenotype","volume":"272","author":"Sanchez","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB175","first-page":"P95","article-title":"Cell swelling inhibits drug efflux from cells expressing the multidrug-resistance phenotype","volume":"475","author":"Sardini","year":"1994","journal-title":"J. Physiol."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB176","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1242\/jcs.107.12.3281","article-title":"Drug efflux mediated by the human multidrug-resistance P-glycoprotein is inhibited by cell swelling","volume":"107","author":"Sardini","year":"1994","journal-title":"J. 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Ther."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB193","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/355167a0","article-title":"Inhibition by chloroquine of a novel heme polymerase enzyme-activity in malaria trophozoites","volume":"355","author":"Slater","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0163-7258(97)00083-1_BIB194","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1172\/JCI110702","article-title":"Verapamil restoration of daunorubicin responsiveness in daunorubicin-resistant Ehrlich ascites-carcinoma","volume":"70","author":"Slater","year":"1982","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB195","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0035-9203(92)90221-W","article-title":"The relationship between the response of Plasmodium falciparum malaria to mefloquine in African children and its sensitivity in vitro","volume":"86","author":"Sowunmi","year":"1992","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB196","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1432-1033.1992.tb17083.x","article-title":"Kinetics of daunorubicin transport by P-glycoprotein of intact cancer-cells","volume":"207","author":"Spoelstra","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0163-7258(97)00083-1_BIB197","first-page":"763","article-title":"Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates","volume":"45","author":"Stein","year":"1994","journal-title":"Mol. 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