{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:45:17Z","timestamp":1770752717730,"version":"3.50.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[1995,7]]},"DOI":"10.1016\/s0165-6147(00)89032-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:10:41Z","timestamp":1027606241000},"page":"232-238","source":"Crossref","is-referenced-by-count":566,"title":["Agonist-receptor efficacy II: agonist trafficking of receptor signals"],"prefix":"10.1016","volume":"16","author":[{"given":"T.","family":"Kenakin","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0165-6147(00)89032-X_BIB1","first-page":"818","volume":"44","author":"Bascands","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB2","first-page":"744","volume":"34","author":"Costa","year":"1988","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1096\/fasebj.8.12.8088459","volume":"8","author":"Neubig","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB4","first-page":"347","volume":"40","author":"Matesic","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0165-6147(00)89020-3","volume":"16","author":"Kenakin","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB6","first-page":"696","volume":"45","author":"Eason","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/365170a0","volume":"365","author":"Spengler","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0165-6147(00)89032-X_BIB8","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/j.1460-2075.1994.tb06385.x","volume":"13","author":"Robb","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB9","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0024-3205(88)90467-5","volume":"43","author":"Kenakin","year":"1988","journal-title":"Life Sci."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB10","first-page":"214","volume":"35","author":"Kenakin","year":"1989","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB11","first-page":"462","volume":"263","author":"Meller","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB12","first-page":"10208","volume":"88","author":"Garret","year":"1991"},{"key":"10.1016\/S0165-6147(00)89032-X_BIB13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0014-2999(93)90152-8","volume":"235","author":"Maggi","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB14","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1476-5381.1990.tb15851.x","volume":"100","author":"Maggi","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB15","first-page":"287","volume":"45","author":"Pradier","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB16","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1074\/jbc.270.4.1493","volume":"270","author":"Perlamn","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0165-6147(94)90086-8","volume":"15","author":"Kenakin","year":"1994","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/S0165-6147(00)89032-X_BIB18","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1021\/bi00180a024","volume":"33","author":"Gettys","year":"1994","journal-title":"Biochemistry"}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016561470089032X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016561470089032X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T01:09:36Z","timestamp":1578532176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016561470089032X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["S016561470089032X"],"URL":"https:\/\/doi.org\/10.1016\/s0165-6147(00)89032-x","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}