{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:31:35Z","timestamp":1760851895259},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Virological Methods"],"published-print":{"date-parts":[[1999,6]]},"DOI":"10.1016\/s0166-0934(99)00034-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T22:26:53Z","timestamp":1027636013000},"page":"77-84","source":"Crossref","is-referenced-by-count":25,"title":["A high throughput assay of the hepatitis C virus nonstructural protein 3 serine proteinase"],"prefix":"10.1016","volume":"80","author":[{"given":"Nobuko","family":"Kakiuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunitada","family":"Shimotohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0166-0934(99)00034-8_BIB1","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/JVI.67.7.3835-3844.1993","article-title":"Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3\/4 and NS4\/5 junctions","volume":"67","author":"Bartenschlager","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB2","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1128\/AAC.41.5.992","article-title":"Glycosylated flavones as selective inhibitors of topoisomerase IV","volume":"41","author":"Bernard","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/abio.1996.0235","article-title":"Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease","volume":"237","author":"Bianchi","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB4","first-page":"4856","article-title":"Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells","volume":"56","author":"Bible","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB5","first-page":"2973","article-title":"Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in humanbreast carcinoma cells","volume":"56","author":"Carlson","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB6","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1073\/pnas.88.6.2451","article-title":"Genetic organization and diversity of the hepatitis C virus","volume":"88","author":"Choo","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB7","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1073\/pnas.94.12.6110","article-title":"Casein kinase II is a selective target of HIV-1 transcriptional inhibitors","volume":"94","author":"Critchfield","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/bbrc.1993.1429","article-title":"The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor","volume":"192","author":"Eckart","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB9","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1128\/JVI.68.6.3753-3760.1994","article-title":"Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins","volume":"68","author":"Failla","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB10","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1128\/JVI.67.5.2832-2843.1993","article-title":"Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites","volume":"67","author":"Grakoui","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB11","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1128\/JVI.67.8.4665-4675.1993","article-title":"Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus","volume":"67","author":"Hijikata","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB12","doi-asserted-by":"crossref","first-page":"19773","DOI":"10.1073\/pnas.90.22.10773","article-title":"Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus","volume":"90","author":"Hijikata","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/hep.1840140227","article-title":"Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease","volume":"14","author":"Houghton","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1006\/bbrc.1995.1764","article-title":"Bacterial expression and analysis of cleavage activity of HCV serine proteinase using recombinant and synthetic substrate","volume":"210","author":"Kakiuchi","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/oxfordjournals.jbchem.a021819","article-title":"Cleavage activity of hepatitis C virus serine proteinase","volume":"122","author":"Kakiuchi","year":"1997","journal-title":"J. Biochem."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-5793(97)01566-4","article-title":"Non-peptide inhibitors of HCV serine proteinase","volume":"421","author":"Kakiuchi","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB17","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1073\/pnas.87.24.9524","article-title":"Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis","volume":"87","author":"Kato","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0092-8674(00)81351-3","article-title":"Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide","volume":"87","author":"Kim","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0378-1119(94)90009-4","article-title":"Processing of hepatitis C viral polyprotein in Escherichia coli","volume":"145","author":"Komoda","year":"1994","journal-title":"Gene"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB20","doi-asserted-by":"crossref","first-page":"7351","DOI":"10.1128\/JVI.68.11.7351-7357.1994","article-title":"Substrate requirements of hepatitis C virus serine proteinase for intermolecular polypeptide cleavage in Escherichia coli","volume":"68","author":"Komoda","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB21","doi-asserted-by":"crossref","first-page":"8147","DOI":"10.1128\/JVI.68.12.8147-8157.1994","article-title":"Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics","volume":"68","author":"Lin","year":"1994","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/S0166-0934(99)00034-8_BIB22","first-page":"634","article-title":"Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3","volume":"19","author":"Manabe","year":"1994","journal-title":"Virology"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB23","doi-asserted-by":"crossref","first-page":"20952","DOI":"10.1016\/S0021-9258(17)31914-2","article-title":"Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3)","volume":"269","author":"Nagase","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB24","doi-asserted-by":"crossref","first-page":"6694","DOI":"10.1128\/JVI.70.10.6694-6700.1996","article-title":"Activity of purified hepatitis C virus protease NS3 on peptide substrates","volume":"70","author":"Steinkuhler","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB25","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1128\/JVI.65.3.1105-1113.1991","article-title":"Structure and organization of the hepatitis C virus genome isolated from human carriers","volume":"65","author":"Takamizawa","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/abio.1997.2063","article-title":"An enzyme-linked immunosorbent assay for detecting proteolytic activity of hepatitis C virus proteinase","volume":"247","author":"Takeshita","year":"1997","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/abio.1996.0331","article-title":"A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates","volume":"240","author":"Taliani","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0378-1119(94)90008-6","article-title":"Identification of the domain required for trans-cleavage activity of hepatitis C viral serine proteinase","volume":"145","author":"Tanji","year":"1994","journal-title":"Gene"},{"key":"10.1016\/S0166-0934(99)00034-8_BIB29","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1128\/JVI.69.3.1575-1581.1995","article-title":"Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing","volume":"69","author":"Tanji","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB30","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1128\/JVI.67.7.4017-4026.1993","article-title":"NS3 is a serine protease required for processing of hepatitis C virus polyprotein","volume":"67","author":"Tomei","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/S0166-0934(99)00034-8_BIB31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-5793(96)01532-3","article-title":"Expression of highly active recombinant NS3 protease domain of hepatitis C virus in E. coli","volume":"402","author":"Vishnuvardhan","year":"1997","journal-title":"FEBS Lett."}],"container-title":["Journal of Virological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093499000348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093499000348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T15:46:13Z","timestamp":1620834373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166093499000348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S0166093499000348"],"URL":"https:\/\/doi.org\/10.1016\/s0166-0934(99)00034-8","relation":{},"ISSN":["0166-0934"],"issn-type":[{"value":"0166-0934","type":"print"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}