{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:40:47Z","timestamp":1767980447700,"version":"3.49.0"},"reference-count":174,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":5281,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[1999,2]]},"DOI":"10.1016\/s0167-4889(98)00178-5","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:31:18Z","timestamp":1027657878000},"page":"1-24","source":"Crossref","is-referenced-by-count":166,"title":["Signal perception and transduction: the role of protein kinases"],"prefix":"10.1016","volume":"1449","author":[{"given":"Paul W","family":"Schenk","sequence":"first","affiliation":[]},{"given":"B.Ewa","family":"Snaar-Jagalska","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0167-4889(98)00178-5_BIB1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.bi.63.070194.002315","article-title":"Molecular mechanisms of action of steroid\/thyroid receptor superfamily members","volume":"63","author":"Tsai","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.ph.56.030194.001205","article-title":"Modulation of ion channels by protein phosphorylation and dephosphorylation","volume":"56","author":"Levitan","year":"1994","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/373573a0","article-title":"Protein modules and signalling networks","volume":"373","author":"Pawson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0968-0004(96)10033-5","article-title":"Not all Shc\u2019s roads lead to Ras","volume":"21","author":"Bonfini","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0898-6568(94)90041-8","article-title":"The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus","volume":"6","author":"Guan","year":"1994","journal-title":"Cell. Signal."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(06)00122-9","article-title":"Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B\u03b1","volume":"7","author":"Alessi","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0959-437X(98)80062-2","article-title":"Mechanism of activation and function of protein kinase B","volume":"8","author":"Alessi","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB8","doi-asserted-by":"crossref","first-page":"15934","DOI":"10.1074\/jbc.271.27.15934","article-title":"Specificity of LIM domain interactions with receptor tyrosine kinases","volume":"271","author":"Wu","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB9","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1128\/MCB.18.4.2298","article-title":"Shc and Enigma are both required for mitogenic signaling by Ret\/ptc2","volume":"18","author":"Durick","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1126\/science.1650499","article-title":"Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes","volume":"253","author":"Fischer","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0300-9084(97)82739-3","article-title":"Receptor protein tyrosine phosphatases: involvement in cell\u2013cell interaction and signaling","volume":"79","author":"Zondag","year":"1997","journal-title":"Biochimie"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.iy.12.040194.000505","article-title":"CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development","volume":"12","author":"Trowbridge","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1083\/jcb.141.1.287","article-title":"Dynamic interaction of PTP\u03bc with multiple cadherins in vivo","volume":"141","author":"Brady-Kalnay","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB14","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/j.1460-2075.1996.tb00665.x","article-title":"Tight association of GRB2 with receptor protein-tyrosine phosphatase \u03b1 is mediated by the SH2 and C-terminal SH3 domains","volume":"15","author":"den Hertog","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/0968-0004(94)90059-0","article-title":"TGF-\u03b2-receptor-mediated signaling","volume":"19","author":"Derynck","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB16","first-page":"F105","article-title":"TGF-\u03b2 receptor signaling","volume":"1333","author":"Derynck","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/383168a0","article-title":"Receptor-associated Mad homologues synergize as effectors of the TGF-\u03b2 response","volume":"383","author":"Zhang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB18","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1101\/gad.12.11.1587","article-title":"Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases","volume":"12","author":"de Caestecker","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB19","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0092-8674(00)80158-0","article-title":"Signal transduction via the multi-step phosphorelay: not necessarily a road less traveled","volume":"86","author":"Appleby","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0968-0004(94)90135-X","article-title":"Histidine and aspartate phosphorylation: two-component systems and the limits of homology","volume":"19","author":"Swanson","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB21","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1126\/science.7624781","article-title":"Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor","volume":"269","author":"Maeda","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0092-8674(00)80162-2","article-title":"Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 \u2018two-component\u2019 osmosensor","volume":"86","author":"Posas","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB23","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/emboj\/17.5.1385","article-title":"Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator","volume":"17","author":"Posas","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB24","doi-asserted-by":"crossref","first-page":"30741","DOI":"10.1016\/S0021-9258(18)47339-5","article-title":"Guanylyl cyclase receptors","volume":"269","author":"Garbers","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0014-5793(97)00358-X","article-title":"New insights on the functions of the guanylyl cyclase receptors","volume":"410","author":"Wedel","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB26","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1074\/jbc.271.1.544","article-title":"Atrial natriuretic peptide induces the expression of MKP-1, a mitogen-activated protein kinase phosphatase, in glomerular mesangial cells","volume":"271","author":"Sugimoto","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0968-0004(97)01086-4","article-title":"Distinct and specific functions of cGMP-dependent protein kinases","volume":"22","author":"Lohmann","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/377591a0","article-title":"Cytokine receptor signalling","volume":"377","author":"Ihle","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB29","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1096\/fasebj.10.14.9002549","article-title":"Regulation of STAT-dependent pathways by growth factors and cytokines","volume":"10","author":"Leaman","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB30","doi-asserted-by":"crossref","first-page":"24684","DOI":"10.1074\/jbc.272.39.24684","article-title":"Role of Janus kinase\/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation","volume":"272","author":"Marrero","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0168-9525(97)01006-8","article-title":"The JAK-STAT pathway in Drosophila","volume":"13","author":"Hou","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB32","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1093\/emboj\/17.14.4018","article-title":"Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor","volume":"17","author":"Araki","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(92)90115-S","article-title":"Integrins: versatility, modulation, and signaling in cell adhesion","volume":"69","author":"Hynes","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.7716514","article-title":"Integrins and signal transduction pathways: the road taken","volume":"268","author":"Clark","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/bies.950190208","article-title":"Signaling through focal adhesion kinase","volume":"19","author":"Hanks","year":"1997","journal-title":"BioEssays"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB36","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1083\/jcb.136.6.1385","article-title":"Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts","volume":"136","author":"Lin","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB37","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1128\/MCB.18.5.2571","article-title":"Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2\/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events","volume":"18","author":"Schlaepfer","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1991.tb15778.x","article-title":"Structure\/function relationship of proteins belonging to the family of receptors coupled to GTP-binding proteins","volume":"196","author":"Strosberg","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB39","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/366575a0","article-title":"Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid","volume":"366","author":"Brown","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB40","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1074\/jbc.273.3.1506","article-title":"Edg-2\/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid","volume":"273","author":"Erickson","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB41","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1073\/pnas.95.11.6151","article-title":"A single receptor encoded by vzg-1\/lpA1\/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid","volume":"95","author":"Fukushima","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB42","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1074\/jbc.273.2.685","article-title":"Essential role for G-protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase","volume":"273","author":"Daaka","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB43","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1074\/jbc.273.2.669","article-title":"The many faces of G protein signaling","volume":"273","author":"Hamm","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(00)80117-8","article-title":"GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein \u03b1 subunits","volume":"86","author":"Berman","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB45","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1074\/jbc.273.3.1269","article-title":"Mammalian RGS proteins: barbarians at the gate","volume":"273","author":"Berman","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB46","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.275.5296.42","article-title":"There are GAPs and there are GAPs","volume":"275","author":"Iyengar","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB47","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1128\/MCB.13.8.4852","article-title":"Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A","volume":"13","author":"Hagiwara","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1040-7952(98)80003-7","article-title":"Mammalian adenylyl cyclases","volume":"32","author":"Smit","year":"1998","journal-title":"Adv. Second Messenger Phosphoprotein Res."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB49","doi-asserted-by":"crossref","first-page":"15045","DOI":"10.1074\/jbc.272.24.15045","article-title":"Regulation of phosphoinositide-specific phospholipase C isozymes","volume":"272","author":"Rhee","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/382083a0","article-title":"Regulation by cAMP-dependent protein kinease of a G-protein-mediated-phospholipase C","volume":"382","author":"Liu","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB51","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/361315a0","article-title":"Inositol trisphosphate and calcium signalling","volume":"361","author":"Berridge","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB52","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.ph.57.030195.002221","article-title":"The multifunctional calcium\/calmodulin-dependent protein kinase: from form to function","volume":"57","author":"Braun","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB53","unstructured":"N.R. Murray, L.J. Thompson, A.P. Fields, The role of protein kinase C in cellular proliferation and cell cycle control, in: P.J. Parker, L.V. Dekker (Eds.), Protein Kinase C, R.G. Landes, USA, 1997, pp. 97\u2013120."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB54","doi-asserted-by":"crossref","first-page":"24631","DOI":"10.1074\/jbc.270.42.24631","article-title":"G\u03b112 and G\u03b113 stimulate Rho-dependent stress fiber formation and focal adhesion assembly","volume":"270","author":"Buhl","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB55","doi-asserted-by":"crossref","first-page":"12949","DOI":"10.1074\/jbc.270.22.12949","article-title":"Lysophosphatidic acid, a multifunctional phospholipid messenger","volume":"270","author":"Moolenaar","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB56","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0955-0674(97)80059-2","article-title":"Lysophosphatidic acid: G-protein signalling and cellular responses","volume":"9","author":"Moolenaar","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB57","doi-asserted-by":"crossref","first-page":"12706","DOI":"10.1073\/pnas.91.26.12706","article-title":"Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G\u03b2\u03b3 activation of p21ras","volume":"91","author":"Koch","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB58","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1074\/jbc.272.7.4637","article-title":"G\u03b2\u03b3 subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor","volume":"272","author":"Luttrell","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB59","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1093\/emboj\/16.11.3097","article-title":"Gi-mediated activation of the Ras\/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc","volume":"16","author":"Kranenburg","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB60","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1126\/science.275.5298.394","article-title":"Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase \u03b3","volume":"275","author":"Lopez-Ilasaca","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB61","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1128\/MCB.15.2.1102","article-title":"DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases","volume":"15","author":"Roche","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB62","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.273.5272.245","article-title":"Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)","volume":"273","author":"Kimura","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB63","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.bi.61.070192.002035","article-title":"Protein isoprenylation and methylation at carboxy-terminal cysteine residues","volume":"61","author":"Clarke","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB64","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(94)90104-X","article-title":"Myristylation and palmitylation of Src family members: the fats of the matter","volume":"76","author":"Resh","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB65","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0898-6568(96)00088-5","article-title":"Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins","volume":"8","author":"Resh","year":"1996","journal-title":"Cell. Signal."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB66","first-page":"F51","article-title":"Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?","volume":"1333","author":"Cox","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0968-0004(98)01185-2","article-title":"Protein methylation: a signal event in post-translational modification","volume":"23","author":"Aletta","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0092-8674(88)90015-3","article-title":"O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation","volume":"55","author":"Jackson","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB69","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0074-7696(08)60416-7","article-title":"Nuclear and cytoplasmic glycosylation","volume":"181","author":"Snow","year":"1998","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB70","first-page":"261","article-title":"Regulation of Jun\/AP-1 oncoproteins by protein phosphorylation","volume":"28","author":"Woodgett","year":"1993","journal-title":"Adv. Second Messenger Phosphoprotein Res."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB71","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","article-title":"The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification","volume":"9","author":"Hanks","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB72","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0968-0004(96)10068-2","article-title":"The protein kinases of budding yeast: six score and more","volume":"22","author":"Hunter","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(98)00606-1","article-title":"The structural basis for substrate recognition and control by protein kinases","volume":"430","author":"Johnson","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB74","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1096\/fasebj.9.13.7557015","article-title":"How do protein kinases discriminate between serine\/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase","volume":"9","author":"Taylor","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB75","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1242\/jcs.110.10.1141","article-title":"Histidine kinases in signal transduction pathways of eukaryotes","volume":"110","author":"Loomis","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB76","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/dbio.1998.8854","article-title":"The hybrid histidine kinase dhkB regulates spore germination in Dictyostelium discoideum","volume":"196","author":"Zinda","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB77","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1040-7952(97)80012-2","article-title":"Mitochondrial \u03b1-ketoacid dehydrogenase kinases","volume":"31","author":"Popov","year":"1997","journal-title":"Adv. Second Messenger Phosphoprotein Res."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB78","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0092-8674(00)80351-7","article-title":"Activation mechanism of the MAP kinase ERK2 by dual phosphorylation","volume":"90","author":"Canagarajah","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB79","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0968-0004(00)88978-1","article-title":"Parallel signal processing among mammalian MAPKs","volume":"20","author":"Cano","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB80","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0167-4889(96)00083-3","article-title":"How do protein kinases recognize their substrates?","volume":"1314","author":"Pinna","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB81","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0968-0004(97)01131-6","article-title":"The protein kinase resource","volume":"22","author":"Smith","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB82","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0167-4889(93)90201-Y","article-title":"The genetic subtypes of cAMP-dependent protein kinase \u2013 functionally different or redundant?","volume":"1178","author":"D\u00f8skeland","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB83","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0960-9822(98)70037-5","article-title":"3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro","volume":"8","author":"Alessi","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB84","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.279.5351.707","article-title":"Phosphorylation and activation of p70s6k by PDK1","volume":"279","author":"Pullen","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB85","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.279.5351.673","article-title":"Lipid-regulated kinases: some common themes at last","volume":"279","author":"Downward","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB86","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1074\/jbc.273.26.16621","article-title":"Regulation of the p70 S6 kinase by phosphorylation in vivo","volume":"273","author":"Weng","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB87","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev.bb.23.060194.002353","article-title":"Evolution of the EF-hand family of proteins","volume":"23","author":"Nakayama","year":"1994","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB88","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1104\/pp.108.2.451","article-title":"Plant protein kinase families and signal transduction","volume":"108","author":"Stone","year":"1995","journal-title":"Plant Physiol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB89","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0165-6147(96)10033-X","article-title":"Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin","volume":"17","author":"Kohama","year":"1996","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB90","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1432-1033.1997.00259.x","article-title":"The AMP-activated protein kinase: Fuel gauge of the mammalian cell?","volume":"246","author":"Hardie","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB91","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/374131a0","article-title":"Principles of CDK regulation","volume":"374","author":"Morgan","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB92","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/bies.950170603","article-title":"Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle","volume":"17","author":"Nigg","year":"1995","journal-title":"BioEssays"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB93","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/j.1460-2075.1993.tb05715.x","article-title":"Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation","volume":"12","author":"Hughes","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB94","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0092-8674(95)90458-1","article-title":"Glycogen synthase kinase 3 regulates cell fate in Dictyostelium","volume":"80","author":"Harwood","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB95","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1021\/bi00180a030","article-title":"Casein kinase 2 down-regulation and activation by polybasic peptides are mediated by acidic residues in the 55-64 region of the \u03b2-subunit. A study with calmodulin as phosphorylatable substrate","volume":"33","author":"Meggio","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB96","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-4615-5371-7_7","article-title":"Protein kinase CK2 (\u2018casein kinase-2\u2019) and its implication in cell division and proliferation","volume":"3","author":"Pinna","year":"1997","journal-title":"Prog. Cell Cycle Res."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB97","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1357-2725(96)00142-2","article-title":"Protein kinase CK2","volume":"29","author":"Pinna","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB98","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-5793(98)00538-9","article-title":"Biochemical characterization of HIV-1 Rev as a potent activator of casein kinase II in vitro","volume":"428","author":"Ohtsuki","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB99","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1040-7952(97)80007-9","article-title":"Specificity in protein-tyrosine kinase signaling","volume":"31","author":"Cantley","year":"1997","journal-title":"Adv. Second Messenger Phosphoprotein Res."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2443.1996.d01-234.x","article-title":"Vertebrate non-receptor protein-tyrosine kinase families","volume":"1","author":"Neet","year":"1996","journal-title":"Genes Cells"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB101","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/j.1460-2075.1994.tb06361.x","article-title":"Activation of MEK family kinases requires phosphorylation of two conserved Ser\/Thr residues","volume":"13","author":"Zheng","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB102","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1096\/fasebj.9.9.7601337","article-title":"The MAPK signaling cascade","volume":"9","author":"Seger","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB103","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1093\/emboj\/16.16.4961","article-title":"MEK kinases are regulated by EGF and selectively interact with Rac\/Cdc42","volume":"16","author":"Fanger","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB104","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0092-8674(95)90023-3","article-title":"Rho family members: activators of MAP kinase cascades","volume":"82","author":"Vojtek","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB105","doi-asserted-by":"crossref","first-page":"24313","DOI":"10.1074\/jbc.271.40.24313","article-title":"Sounding the alarm: protein kinase cascades activated by stress and inflammation","volume":"271","author":"Kyriakis","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB106","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0968-0004(94)90133-3","article-title":"The ins and outs of Raf kinases","volume":"19","author":"Daum","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB107","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0968-0004(00)88944-6","article-title":"Regulation of Ras-mediated signalling: more than one way to skin a cat","volume":"20","author":"Burgering","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB108","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/27938","article-title":"A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity","volume":"394","author":"Tzivion","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB109","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1365-313X.1997.12010083.x","article-title":"Interaction of the maize and Arabidopsis kinase interaction domains with a subset of receptor-like protein kinases: implications for transmembrane signaling in plants","volume":"12","author":"Braun","year":"1997","journal-title":"Plant J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB110","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/j.1460-2075.1995.tb07082.x","article-title":"Crystal structure of casein kinase-1, a phosphate-directed protein kinase","volume":"14","author":"Xu","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB111","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1073\/pnas.89.7.2878","article-title":"A protein kinase associated with paired helical filaments in Alzheimer disease","volume":"89","author":"Vincent","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB112","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1021\/bi971763a","article-title":"Proteolytic fragments of the Alzheimer\u2019s disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms","volume":"37","author":"Walter","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB113","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1128\/MCB.16.10.5375","article-title":"Prenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase","volume":"16","author":"Wang","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB114","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1073\/pnas.94.2.581","article-title":"Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae","volume":"94","author":"Ho","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB115","doi-asserted-by":"crossref","first-page":"31321","DOI":"10.1074\/jbc.270.52.31321","article-title":"Identification and characterization of a novel family of serine\/threonine kinases containing two N-terminal LIM motifs","volume":"270","author":"Okano","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB116","doi-asserted-by":"crossref","first-page":"31331","DOI":"10.1074\/jbc.270.52.31331","article-title":"Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells","volume":"270","author":"Toshima","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB117","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0168-9525(94)90034-5","article-title":"The LIM domain: a new structural motif found in zinc-finger-like proteins","volume":"10","author":"S\u00e1nchez-Garc\u0131\u0301a","year":"1994","journal-title":"Trends Genet."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB118","first-page":"295","article-title":"LIM domain proteins","volume":"318","author":"Dawid","year":"1995","journal-title":"C.R. Acad. Sci. Paris"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB119","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0168-9525(98)01424-3","article-title":"LIM domains: multiple roles as adapters and functional modifiers in protein interactions","volume":"14","author":"Dawid","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB120","doi-asserted-by":"crossref","first-page":"31029","DOI":"10.1074\/jbc.271.49.31029","article-title":"Protein-protein interaction of zinc finger LIM domains with protein kinase C","volume":"271","author":"Kuroda","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB121","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-5793(96)01303-8","article-title":"Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain","volume":"399","author":"Hiraoka","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB122","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/31729","article-title":"Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase","volume":"393","author":"Arber","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB123","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/31735","article-title":"Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization","volume":"393","author":"Yang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB124","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.1411571","article-title":"Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C","volume":"258","author":"Nishizuka","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB125","doi-asserted-by":"crossref","first-page":"28495","DOI":"10.1074\/jbc.270.48.28495","article-title":"Protein kinase C: structure, function, and regulation","volume":"270","author":"Newton","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB126","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0092-8674(95)90011-X","article-title":"Crystal structure of the cys2 activator-binding domain of protein kinase C\u03b4 in complex with phorbol ester","volume":"81","author":"Zhang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB127","unstructured":"N. Srinivasan, T.L. Blundell, Insights into the structures of functional modules in the protein kinase C family, in: P.J. Parker, L.V. Dekker (Eds.), Protein Kinase C, R.G. Landes, USA, 1997, pp. 11\u201324."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB128","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0006-291X(92)91363-U","article-title":"Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme","volume":"188","author":"Smith","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB129","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1073\/pnas.92.2.492","article-title":"An autoregulatory region in protein kinase C: the pseudoanchoring site","volume":"92","author":"Ron","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1096\/fasebj.12.1.35","article-title":"Anchoring proteins for protein kinase C: a means for isozyme selectivity","volume":"12","author":"Mochly-Rosen","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB131","unstructured":"S. Ohno, The distinct biological potential of PKC isotypes, in: P.J. Parker, L.V. Dekker (Eds.), Protein Kinase C, R.G. Landes, USA, 1997, pp. 75\u201395."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB132","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1096\/fasebj.9.7.7737456","article-title":"Protein kinase C and lipid signaling for sustained cellular responses","volume":"9","author":"Nishizuka","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB133","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1016\/S0021-9258(18)50638-4","article-title":"Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids","volume":"254","author":"Takai","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB134","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/364249a0","article-title":"Protein kinase C\u03b1 activates RAF-1 by direct phosphorylation","volume":"364","author":"Kolch","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB135","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1126\/science.280.5360.109","article-title":"Requirement of Ras-GTP\u2013Raf complexes for activation of Raf-1 by protein kinase C","volume":"280","author":"Marais","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB136","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1016\/S0021-9258(18)41866-2","article-title":"Differential regulation of glycogen synthase kinase-3\u03b2 by protein kinase C isotypes","volume":"267","author":"Goode","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB137","doi-asserted-by":"crossref","first-page":"23512","DOI":"10.1074\/jbc.271.38.23512","article-title":"Protein kinase C \u03b4 activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf","volume":"271","author":"Ueda","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB138","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1128\/MCB.17.2.732","article-title":"Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase","volume":"17","author":"Cai","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB139","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1093\/emboj\/17.11.3101","article-title":"Calcineurin preferentially synergizes with PKC-\u03b8 to activate JNK and IL-2 promoter in T lymphocytes","volume":"17","author":"Werlen","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1432-1033.1995.tb20389.x","article-title":"Characterization of activators and inhibitors of protein kinase C\u03bc","volume":"227","author":"Johannes","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB141","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0021-9258(18)54107-7","article-title":"Activation of the \u03b6 isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate","volume":"268","author":"Nakanishi","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB142","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/j.1460-2075.1996.tb00414.x","article-title":"EGF or PDGF receptors activate atypical PKC\u03bb through phosphatidylinositol 3-kinase","volume":"15","author":"Akimoto","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB143","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1074\/jbc.272.10.6146","article-title":"Protein kinase C-\u03b6 mediates angiotensin II activation of ERK1\/2 in vascular smooth muscle cells","volume":"272","author":"Liao","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB144","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1016\/S0021-9258(18)52986-0","article-title":"Functional divergence of protein kinase C (PKC) family members","volume":"268","author":"Hata","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0955-0674(96)80067-6","article-title":"Regulation of transcription by MAP kinase cascades","volume":"8","author":"Treisman","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB146","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0955-0674(97)80061-0","article-title":"Mitogen-activated protein kinase pathways","volume":"9","author":"Robinson","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB147","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1074\/jbc.273.7.3854","article-title":"Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases","volume":"273","author":"English","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB148","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0168-9525(98)01425-5","article-title":"The riddle of MAP kinase signaling specificity","volume":"14","author":"Madhani","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB149","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1128\/MMBR.62.2.249-274.1998","article-title":"Signalling in the yeasts: an informational cascade with links to the filamentous fungi","volume":"62","author":"Banuett","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0960-9822(98)70108-3","article-title":"Functional binding between G\u03b2 and the LIM domain of Ste5 is required to activate the MEKK Ste11","volume":"8","author":"Feng","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB151","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0968-0004(00)88992-6","article-title":"G\u03b2\u03b3 interactions with PH domains and Ras-MAPK signaling pathways","volume":"20","author":"Inglese","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB152","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1093\/emboj\/17.9.2574","article-title":"Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway","volume":"17","author":"Li","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB153","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0960-9822(98)70020-X","article-title":"Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK","volume":"8","author":"Yu","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB154","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0092-8674(00)81189-7","article-title":"Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation","volume":"93","author":"Khokhlatchev","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB155","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1074\/jbc.271.15.8951","article-title":"ERK3 is a constitutively nuclear protein kinase","volume":"271","author":"Cheng","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB156","doi-asserted-by":"crossref","first-page":"20608","DOI":"10.1074\/jbc.271.34.20608","article-title":"Cyclin D1 expression is regulated positively by the p42\/44MAPK and negatively by the p38\/HOGMAPK pathway","volume":"271","author":"Lavoie","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB157","doi-asserted-by":"crossref","first-page":"8881","DOI":"10.1073\/pnas.92.19.8881","article-title":"Association of mitogen-activated protein kinase with the microtubule cytoskeleton","volume":"92","author":"Reszka","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB158","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1128\/MCB.18.6.3257","article-title":"Basal extracellular signal-regulated kinase activity modulates cell\u2013cell and cell\u2013matrix interactions","volume":"18","author":"Lu","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB159","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0955-0674(98)80143-9","article-title":"Signal transduction by the c-Jun N-terminal kinase (JNK) \u2013 from inflammation to development","volume":"10","author":"Ip","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB160","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB161","doi-asserted-by":"crossref","first-page":"30823","DOI":"10.1074\/jbc.270.51.30823","article-title":"Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells","volume":"270","author":"Sakata","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB162","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1126\/science.270.5244.2008","article-title":"Identification of a member of the MAPKKK family as a potential mediator of TGF-\u03b2 signal transduction","volume":"270","author":"Yamaguchi","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB163","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1093\/emboj\/16.16.4973","article-title":"A human homolog of the yeast Ssk2\/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways","volume":"16","author":"Takekawa","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB164","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1126\/science.280.5363.599","article-title":"Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest","volume":"280","author":"Takenaka","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB165","doi-asserted-by":"crossref","first-page":"8232","DOI":"10.1074\/jbc.273.14.8232","article-title":"MKK6 activates myocardial cell NF-\u03baB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner","volume":"273","author":"Zechner","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB166","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1074\/jbc.273.17.10792","article-title":"The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase\/Akt pathway","volume":"273","author":"Berra","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB167","doi-asserted-by":"crossref","first-page":"27205","DOI":"10.1074\/jbc.271.44.27205","article-title":"The dual specificity phosphatases M3\/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases","volume":"271","author":"Muda","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB168","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1074\/jbc.273.15.9323","article-title":"The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity","volume":"273","author":"Muda","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB169","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.280.5367.1262","article-title":"Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase","volume":"280","author":"Camps","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB170","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/340245a0","article-title":"A novel genetic system to detect protein\u2013protein interactions","volume":"340","author":"Fields","year":"1989","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB171","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/40805","article-title":"A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade","volume":"388","author":"Tsunoda","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB172","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0968-0004(98)01195-5","article-title":"Multi-ligand interactions with receptor-like protein tyrosine phosphatase \u03b2: implications for intercellular signaling","volume":"23","author":"Peles","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-4889(98)00178-5_BIB173","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/30018","article-title":"Receptor clustering as a cellular mechanism to control sensitivity","volume":"393","author":"Bray","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0167-4889(98)00178-5_BIB174","doi-asserted-by":"crossref","first-page":"10755","DOI":"10.1074\/jbc.273.17.10755","article-title":"Visualization of dynamic trafficking of a protein kinase C \u03b2II\/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization","volume":"273","author":"Feng","year":"1998","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488998001785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488998001785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T03:37:27Z","timestamp":1621049847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488998001785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":174,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["S0167488998001785"],"URL":"https:\/\/doi.org\/10.1016\/s0167-4889(98)00178-5","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}