{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:11:37Z","timestamp":1783077097159,"version":"3.54.6"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Biotechnology"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1016\/s0167-7799(01)01910-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T11:36:50Z","timestamp":1027597010000},"page":"160-166","source":"Crossref","is-referenced-by-count":442,"title":["Protein microarray technology"],"prefix":"10.1016","volume":"20","author":[{"given":"Markus F","family":"Templin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Schrenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra C","family":"Traub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F","family":"V\u00f6hringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O","family":"Joos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0167-7799(01)01910-2_BIB1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0731-7085(89)80079-2","article-title":"Multi-analyte immunoassay","volume":"7","author":"Ekins","year":"1989","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB2","first-page":"655","article-title":"Multispot, multianalyte, immunoassay","volume":"48","author":"Ekins","year":"1990","journal-title":"Ann. Biol. Clin. (Paris)"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB3","first-page":"337","article-title":"Multianalyte microspot immunoassay. The microanalytical \u2018compact disk\u2019 of the future","volume":"50","author":"Ekins","year":"1992","journal-title":"Ann. Biol. Clin. (Paris)"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB4","first-page":"155","article-title":"Microspot \u2013 an ultrasensitive microarray-based ligand assay system. A practical application of ambient analyte assay theory","volume":"3","author":"Finckh","year":"1998","journal-title":"Proc. UK NEQAS Meeting"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB5","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB6","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1126\/science.1058040","article-title":"The sequence of the human genome","volume":"291","author":"Venter","year":"2001","journal-title":"Science"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0008-6363(95)00236-7","article-title":"Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts","volume":"31","author":"Linck","year":"1996","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB8","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/elps.1150191103","article-title":"Proteome and proteomics: new technologies, new concepts, and new words","volume":"19","author":"Anderson","year":"1998","journal-title":"Electrophoresis"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB9","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between protein and mRNA abundance in yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB10","first-page":"680","article-title":"Array-based proteomics: high-throughput expression and purification of IMAGE consortium cDNA clones","volume":"1","author":"Albala","year":"1999","journal-title":"Curr. Opin. Mol. Ther."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB11","doi-asserted-by":"crossref","unstructured":"Cahill, D.J. (2000) Protein arrays: a high-throughput solution for proteomics research? Proteomics: A Trends Guide, 47\u201351","DOI":"10.1016\/S0167-7799(00)00006-8"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/74442","article-title":"Large-scale functional analysis using peptide or protein arrays","volume":"18","author":"Emili","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/364555a0","article-title":"Multiplexed biochemical assays with biological chips","volume":"364","author":"Fodor","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB14","doi-asserted-by":"crossref","unstructured":"Phimister, B. (1999) The chipping forecast. Nat. Genet. 21 supplement","DOI":"10.1038\/4423"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB15","doi-asserted-by":"crossref","unstructured":"Haab, B.B. et al. (2001) Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions. Genome Biol. 2, Research 0004.0001\u20130004.0013","DOI":"10.1186\/gb-2001-2-2-research0004"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/bp088059d","article-title":"Recent progress in biomolecular engineering","volume":"16","author":"Ryu","year":"2000","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB17","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1073\/pnas.071058398","article-title":"Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease","volume":"98","author":"Lecerf","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB18","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1073\/pnas.96.11.6025","article-title":"Making artificial antibodies: a format for phage display of combinatorial heterodimeric arrays","volume":"96","author":"Gao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/jmbi.1999.3444","article-title":"Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides","volume":"296","author":"Knappik","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB20","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2741\/Soomets","article-title":"Antisense properties of peptide nucleic acids","volume":"4","author":"Soomets","year":"1999","journal-title":"Front. Biosci."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-5521(00)00058-2","article-title":"Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA","volume":"8","author":"Braasch","year":"2001","journal-title":"Chem. Biol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB22","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.2144\/01305dd02","article-title":"Aptamers as reagents for high-throughput screening","volume":"30","author":"Green","year":"2001","journal-title":"Biotechniques"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB23","first-page":"5","article-title":"Aptamers as therapeutic and diagnostic agents","volume":"74","author":"Brody","year":"2000","journal-title":"J. Biotechnol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB24","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1073\/pnas.061028198","article-title":"The use of mRNA display to select high-affinity protein-binding peptides","volume":"98","author":"Wilson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S1369-5274(00)00093-X","article-title":"Protein arrays for gene expression and molecular interaction screening","volume":"3","author":"Walter","year":"2000","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB26","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1093\/nar\/26.21.5007","article-title":"A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library","volume":"26","author":"Bussow","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/abio.1999.4063","article-title":"Protein microarrays for gene expression and antibody screening","volume":"270","author":"Lueking","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/79494","article-title":"Antibody arrays for high-throughput screening of antibody\u2013antigen interactions","volume":"18","author":"de Wildt","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB29","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1517\/14622416.1.4.395","article-title":"Recent trends in protein biochip technology","volume":"1","author":"Weinberger","year":"2000","journal-title":"Pharmacogenomics"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB30","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2144\/00295rr02","article-title":"Tissue-specific microdissection coupled with ProteinChip array technologies: applications in cancer research","volume":"29","author":"von Eggeling","year":"2000","journal-title":"Biotechniques"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB31","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1002\/1522-2683(20000701)21:13<2641::AID-ELPS2641>3.0.CO;2-5","article-title":"A microarray enzyme-linked immunosorbent assay for autoimmune diagnostics","volume":"21","author":"Joos","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/9878","article-title":"Quantifying DNA\u2013protein interactions by double-stranded DNA arrays","volume":"17","author":"Bulyk","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/abio.1999.4363","article-title":"Protein microchips: use for immunoassay and enzymatic reactions","volume":"278","author":"Arenkov","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/81576","article-title":"Analysis of yeast protein kinases using protein chips","volume":"26","author":"Zhu","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB35","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1093\/nar\/28.2.e3","article-title":"UPA, a universal protein array system for quantitative detection of protein\u2013protein, protein\u2013DNA, protein\u2013RNA and protein\u2013ligand interactions","volume":"28","author":"Ge","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB36","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1021\/ja991083q","article-title":"Printing small molecules as microarrays and detecting protein\u2013ligand interactions en masse","volume":"121","author":"MacBeath","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB37","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.289.5485.1760","article-title":"Printing proteins as microarrays for high-throughput function determination","volume":"289","author":"MacBeath","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB38","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1126\/science.1062191","article-title":"Global analysis of protein activities using proteome chips","volume":"293","author":"Zhu","year":"2001","journal-title":"Science"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB39","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.1073\/pnas.170237197","article-title":"Inaugural article: immunoassays with rolling circle DNA amplification: a versatile platform for ultrasensitive antigen detection","volume":"97","author":"Schweitzer","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB40","doi-asserted-by":"crossref","first-page":"778","DOI":"10.2144\/99274rr01","article-title":"High-throughput microarray-based enzyme-linked immunosorbent assay (ELISA)","volume":"27","author":"Mendoza","year":"1999","journal-title":"Biotechniques"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/CCLM.2001.032","article-title":"Simultaneous detection of multiple proteins with an array-based enzyme-linked immunosorbent assay (ELISA) and enhanced chemiluminescence (ECL)","volume":"39","author":"Huang","year":"2001","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB42","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0968-0004(00)01725-4","article-title":"Antibodies: indispensable tools for biomedical research","volume":"25","author":"Goldman","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB43","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2144\/99262rr04","article-title":"Organelle isolation by magnetic immunoabsorption","volume":"26","author":"Kausch","year":"1999","journal-title":"Biotechniques"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-1759(01)00398-2","article-title":"High-throughput generation and engineering of recombinant human antibodies","volume":"254","author":"Krebs","year":"2001","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/PL00006684","article-title":"Anti-self antibodies selected from a human IgD heavy chain repertoire: a novel approach to generate therapeutic human antibodies against tumor-associated differentiation antigens","volume":"50","author":"Raum","year":"2001","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB46","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1182\/blood.V97.4.966","article-title":"Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII","volume":"97","author":"van den Brink","year":"2001","journal-title":"Blood"},{"key":"10.1016\/S0167-7799(01)01910-2_BIB47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s002620100182","article-title":"Tumor cell killing by in vitro affinity-matured recombinant human monoclonal antibodies","volume":"50","author":"Huls","year":"2001","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB48","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/(SICI)1098-1128(200005)20:3<212::AID-MED5>3.0.CO;2-F","article-title":"PROfusion: genetically tagged proteins for functional proteomics and beyond","volume":"20","author":"Kreider","year":"2000","journal-title":"Med. Res. Rev."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB49","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/protein\/12.10.873","article-title":"Affinity maturation of a Taq DNA polymerase specific affibody by helix shuffling","volume":"12","author":"Gunneriusson","year":"1999","journal-title":"Protein Eng."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB50","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1128\/AEM.65.9.4134-4140.1999","article-title":"Staphylococcal surface display of immunoglobulin A (IgA)- and IgE-specific in vitro-selected binding proteins (affibodies) based on Staphylococcus aureus protein A","volume":"65","author":"Gunneriusson","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s001090000140","article-title":"Peptide aptamers: powerful new tools for molecular medicine","volume":"78","author":"Hoppe-Seyler","year":"2000","journal-title":"J. Mol. Med."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB52","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/clinchem\/45.9.1628","article-title":"Aptamers: an emerging class of molecules that rival antibodies in diagnostics","volume":"45","author":"Jayasena","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB53","first-page":"198","article-title":"In vitro protein display in drug discovery","volume":"4","author":"Lohse","year":"2001","journal-title":"Curr. Opin. Drug. Discov. Dev."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB54","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/abio.2000.4595","article-title":"A fiber-optic microarray biosensor using aptamers as receptors","volume":"282","author":"Lee","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0167-7799(01)01910-2_BIB55","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0928-0987(00)00201-3","article-title":"Development of novel biomedicine based on genome science","volume":"13","author":"Baba","year":"2001","journal-title":"Eur. J. Pharmacol. Sci."}],"container-title":["Trends in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779901019102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779901019102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T18:45:47Z","timestamp":1733251547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167779901019102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0167779901019102"],"URL":"https:\/\/doi.org\/10.1016\/s0167-7799(01)01910-2","relation":{},"ISSN":["0167-7799"],"issn-type":[{"value":"0167-7799","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}