{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:10:01Z","timestamp":1776773401251,"version":"3.51.2"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational Statistics &amp; Data Analysis"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/s0167-9473(02)00323-7","type":"journal-article","created":{"date-parts":[[2003,4,4]],"date-time":"2003-04-04T23:49:40Z","timestamp":1049500180000},"page":"197-214","source":"Crossref","is-referenced-by-count":45,"title":["Design efficiency in dose finding studies"],"prefix":"10.1016","volume":"45","author":[{"given":"Xavier","family":"Paoletti","sequence":"first","affiliation":[]},{"given":"John","family":"O'Quigley","sequence":"additional","affiliation":[]},{"given":"Jean","family":"Maccario","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/S0167-9473(02)00323-7_BIB1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/(SICI)1097-0258(19980530)17:10<1103::AID-SIM793>3.0.CO;2-9","article-title":"Cancer phase I clinical trials","volume":"17","author":"Babb","year":"1998","journal-title":"Statist. Med."},{"issue":"3","key":"10.1016\/S0167-9473(02)00323-7_BIB2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0197-2456(01)00205-7","article-title":"The bivariate continual reassessment method extending the CRM to phase I trials of two competing outcomes","volume":"23","author":"Braun","year":"2002","journal-title":"Control Clin. Trials"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB3","series-title":"Statistical Decision Theory and Related Topics V","first-page":"467","article-title":"Random walks for quantile estimation","author":"Durham","year":"1994"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/10543409408835079","article-title":"Practical modifications of the CRM for phase I cancer study","volume":"4","author":"Faries","year":"1994","journal-title":"J. Biopharm. Statist."},{"key":"10.1016\/S0167-9473(02)00323-7_BIB5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.0006-341X.2000.00609.x","article-title":"On curve-free method for phase I clinical trials","volume":"56","author":"Gasparini","year":"2000","journal-title":"Biometrics"},{"issue":"11","key":"10.1016\/S0167-9473(02)00323-7_BIB6","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/sim.4780141102","article-title":"Some practical improvements in the continual reassessment method for phase I studies","volume":"14","author":"Goodman","year":"1995","journal-title":"Statist. Med."},{"key":"10.1016\/S0167-9473(02)00323-7_BIB7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0197-2456(94)90003-5","article-title":"Simulation as a design tool for phase I\/II clinical trials","volume":"15","author":"Gooley","year":"1994","journal-title":"Controlled Clin. Trials"},{"issue":"6","key":"10.1016\/S0167-9473(02)00323-7_BIB8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0197-2456(00)00091-X","article-title":"Longitudinal design for phase I clinical trials using the continual reassessment method","volume":"21","author":"Legedza","year":"2000","journal-title":"Control Clin. Trials"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB9","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/sim.4780140909","article-title":"An extension of the CRM using a preliminary up and down design in a dose finding study in cancer patients, in order to investigate a greater range of doses","volume":"14","author":"M\u00f8ller","year":"1995","journal-title":"Statist. Med."},{"key":"10.1016\/S0167-9473(02)00323-7_BIB10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/biostatistics\/3.1.51","article-title":"Non-parametric optimal design in dose finding studies","volume":"3","author":"O'Quigley","year":"2002","journal-title":"Biostatistique"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2307\/2531628","article-title":"Continual reassessment method","volume":"46","author":"O'Quigley","year":"1990","journal-title":"Biometrics"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/biomet\/85.3.741","article-title":"A stopping rule for the continual reassessment method","volume":"85","author":"O'Quigley","year":"1998","journal-title":"Biometrika"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2307\/2532905","article-title":"Continual reassessment method","volume":"52","author":"O'Quigley","year":"1996","journal-title":"Biometrics"},{"issue":"1","key":"10.1016\/S0167-9473(02)00323-7_BIB14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1081\/BIP-100100998","article-title":"Two sample continual reassessment method","volume":"9","author":"O'Quigley","year":"1999","journal-title":"J. Biopharm. Statist."},{"key":"10.1016\/S0167-9473(02)00323-7_BIB15","unstructured":"Paoletti, X., 2001. Phase I clinical trials in oncology: optimality, efficiency and reliability in various situations. Ph.D. Dissertation, University Paris-V Ren\u00e9 Descartes."},{"key":"10.1016\/S0167-9473(02)00323-7_BIB16","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/(SICI)1097-0258(19960815)15:15<1605::AID-SIM325>3.0.CO;2-2","article-title":"Improved designs for dose escalation studies using pharmacokinetics measurements","volume":"15","author":"Piantadosi","year":"1996","journal-title":"Statist. Med."},{"key":"10.1016\/S0167-9473(02)00323-7_BIB17","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2307\/2531693","article-title":"Design and analysis of phase I clinical trials","volume":"45","author":"Storer","year":"1989","journal-title":"Biometrics"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2307\/2534012","article-title":"A strategy for dose-finding and safety monitoring based on efficacy and adverse outcomes in phase I\/II clinical trials","volume":"54","author":"Thall","year":"1998","journal-title":"Biometrics"},{"key":"10.1016\/S0167-9473(02)00323-7_BIB19","first-page":"201","article-title":"Bayesian decision procedures with application to dose-finding studies","volume":"11","author":"Whitehead","year":"1997","journal-title":"Internat. J. Pharm. Med."},{"issue":"2","key":"10.1016\/S0167-9473(02)00323-7_BIB20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1081\/BIP-100101181","article-title":"Multinomial phase II cancer trials incorporating response and early progression","volume":"9","author":"Zee","year":"1999","journal-title":"J. Biopharm. Statist."}],"container-title":["Computational Statistics &amp; Data Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167947302003237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167947302003237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T18:31:03Z","timestamp":1554402663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167947302003237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0167947302003237"],"URL":"https:\/\/doi.org\/10.1016\/s0167-9473(02)00323-7","relation":{},"ISSN":["0167-9473"],"issn-type":[{"value":"0167-9473","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}