{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:00:15Z","timestamp":1762160415517},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1987,1,1]],"date-time":"1987-01-01T00:00:00Z","timestamp":536457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[1987,1]]},"DOI":"10.1016\/s0168-8278(87)80021-1","type":"journal-article","created":{"date-parts":[[2005,6,17]],"date-time":"2005-06-17T15:43:40Z","timestamp":1119023020000},"page":"140-147","source":"Crossref","is-referenced-by-count":150,"title":["Cirrhosis and the aetiology of hepatocellular carcinoma"],"prefix":"10.1016","volume":"4","author":[{"given":"Philip J.","family":"Johnson","sequence":"first","affiliation":[]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0168-8278(87)80021-1_bib1","first-page":"295","article-title":"On a case of hypertrophic cirrhosis with remarks on the pathology of cirrhosis","volume":"xiii","author":"Price","year":"1883","journal-title":"Guy's Hosp Rep"},{"key":"10.1016\/S0168-8278(87)80021-1_bib2","first-page":"21s","article-title":"Hepatitis B virus as the etiologic agent in hepatocellular carcinoma \u2014 Epidemiologic considerations","volume":"2","author":"Beasley","year":"1982","journal-title":"Hepatology"},{"key":"10.1016\/S0168-8278(87)80021-1_bib3","first-page":"40","article-title":"Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association","volume":"24","author":"Szmuness","year":"1978","journal-title":"Progr Med Virol"},{"key":"10.1016\/S0168-8278(87)80021-1_bib4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0300-5089(21)00709-4","article-title":"Hepatocellular carcinoma and type B hepatitis","volume":"9","author":"Hadziyannis","year":"1980","journal-title":"Clin Gastroenterol"},{"key":"10.1016\/S0168-8278(87)80021-1_bib5","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1056\/NEJM198103263041312","article-title":"Hepatitis B virus and the prevention of primary hepatocellular carcinoma","volume":"304","author":"Blumberg","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/S0168-8278(87)80021-1_bib6","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","article-title":"Hepatocellular carcinoma and hepatitis B virus \u2014 A prospective study of 22 707 men in Taiwan","volume":"ii","author":"Beasley","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/S0168-8278(87)80021-1_bib7","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1056\/NEJM198110293051807","article-title":"Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma","volume":"305","author":"Shafritz","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/S0168-8278(87)80021-1_bib8","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1056\/NEJM198206103062302","article-title":"Evidence that the hepatitis B virus has a role in liver-cell carcinoma in alcoholic liver disease","volume":"306","author":"Brechot","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/S0168-8278(87)80021-1_bib9","first-page":"6077","article-title":"Hepatitis, alcohol consumption, cigarette smoking and hepatocellular carcinoma in Los Angeles","volume":"43","author":"Yu","year":"1983","journal-title":"Cancer Res"},{"key":"10.1016\/S0168-8278(87)80021-1_bib10","series-title":"Quadrennial Review, The World Congresses in Stockholm","first-page":"75","article-title":"Non-A Non-B hepatitis","author":"Trepo","year":"1982"},{"key":"10.1016\/S0168-8278(87)80021-1_bib11","doi-asserted-by":"crossref","first-page":"794","DOI":"10.7326\/0003-4819-101-6-794","article-title":"Primary hepatocellular carcinoma after chronic non-A, non-B post transfusion hepatitis","volume":"101","author":"Gilliam","year":"1984","journal-title":"Ann Int Med"},{"key":"10.1016\/S0168-8278(87)80021-1_bib12","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0140-6736(70)91737-X","article-title":"Chronic liver disease and primary liver-cell cancer with hepatitis associated (Australia) antigen in serum","volume":"i","author":"Sherlock","year":"1970","journal-title":"Lancet"},{"key":"10.1016\/S0168-8278(87)80021-1_bib13","first-page":"4533","article-title":"A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks","volume":"75","author":"Summers","year":"1978"},{"key":"10.1016\/S0168-8278(87)80021-1_bib14","series-title":"Viral Hepatitis (1981 International Symposium)","first-page":"57","article-title":"The hepadna virus group: hepatitis B and related viruses","author":"Robinson","year":"1982"},{"key":"10.1016\/S0168-8278(87)80021-1_bib15","first-page":"267","article-title":"Long term effects of aflatoxin Bl and viral hepatitis on marmoset liver. A preliminary report","volume":"30","author":"Lin","year":"1974","journal-title":"Lab Invest"},{"key":"10.1016\/S0168-8278(87)80021-1_bib16","series-title":"The German Thorotrast Study","year":"1984"},{"key":"10.1016\/S0168-8278(87)80021-1_bib17","first-page":"585","article-title":"Endothelial-cell sarcoma of the liver following thorotrast injection","volume":"23","author":"MacMahon","year":"1974","journal-title":"Amer J Path"},{"key":"10.1016\/S0168-8278(87)80021-1_bib18","first-page":"287","article-title":"\u00dcber schwere Thorotrastsch\u00e4digung der Leber","volume":"78","author":"Albertini","year":"1948","journal-title":"Schweiz Med Wschr"},{"key":"10.1016\/S0168-8278(87)80021-1_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/archinte.1951.03810070052007","article-title":"Late effects of thorium dioxide in man","volume":"88","author":"Cassel","year":"1951","journal-title":"Arch Int Med"},{"key":"10.1016\/S0168-8278(87)80021-1_bib20","series-title":"Radiation Carcinogenesis: Epidemiology and Biological Significance","article-title":"Results of The German Thorotrast Study","author":"Van Kaick","year":"1984"},{"key":"10.1016\/S0168-8278(87)80021-1_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(80)90776-X","article-title":"Oral-contraceptive-associated liver tumour's occurrence of malignancy and difficulties in diagnosis","volume":"i","author":"Neuberger","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/S0168-8278(87)80021-1_bib22","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0140-6736(72)92649-9","article-title":"Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma","volume":"ii","author":"Johnson","year":"1972","journal-title":"Lancet"},{"key":"10.1016\/S0168-8278(87)80021-1_bib23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/hep.1840020408","article-title":"Hepatocellular carcinoma in women: probable lack of aetiological association with oral contraceptive steroids","volume":"2","author":"Goddman","year":"1982","journal-title":"Hepatology"},{"key":"10.1016\/S0168-8278(87)80021-1_bib24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/bjc.1983.199","article-title":"Trends in mortality from carcinoma of the liver and the use of oral contraceptives","volume":"48","author":"Forman","year":"1983","journal-title":"Brit J Cancer"},{"key":"10.1016\/S0168-8278(87)80021-1_bib25","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1136\/gut.19.11.1022","article-title":"Hepatocellular carcinoma in Great Britain: Influence of age, sex, HBsAg status and aetiology of underlying cirrhosis","volume":"19","author":"Johnson","year":"1978","journal-title":"Gut"},{"key":"10.1016\/S0168-8278(87)80021-1_bib26","first-page":"391","article-title":"Hepatocellular carcinoma in the non-cirrhotic liver: a comparison with that complicating cirrhosis","volume":"211","author":"Melia","year":"1984","journal-title":"Quart J Med, New Series LIII"},{"key":"10.1016\/S0168-8278(87)80021-1_bib27","series-title":"Hepatocellular Carcinoma","article-title":"Pathology of hepatocellular carcinoma","author":"Peters","year":"1976"},{"key":"10.1016\/S0168-8278(87)80021-1_bib28","first-page":"145","article-title":"The incidence of primary hepatic carcinoma in cirrhosis","volume":"50","author":"Parker","year":"1956"},{"key":"10.1016\/S0168-8278(87)80021-1_bib29","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(85)91785-4","article-title":"Risk factors for the development of hepatocellular carcinoma in cirrhosis. A prospective study of 613 patients","volume":"ii","author":"Zaman","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/S0168-8278(87)80021-1_bib30","first-page":"581","article-title":"Studies on the occurrence of spontaneous hepatomas in mice of strains C3H and CBA","volume":"11","author":"Andervont","year":"1952","journal-title":"J Nat Cancer Inst"},{"key":"10.1016\/S0168-8278(87)80021-1_bib31","first-page":"445","article-title":"Influence of hormones on N-Z-fluorenyldiacetamid-induced hyperplastic hepatic nodules in rats","volume":"43","author":"Reuber","year":"1969","journal-title":"J Nat Cancer Inst"},{"key":"10.1016\/S0168-8278(87)80021-1_bib32","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/bjc.1983.268","article-title":"Sex steroid receptor proteins in foetal, adult and malignant human liver tissue","volume":"48","author":"Iqbal","year":"1983","journal-title":"Brit J Cancer"},{"key":"10.1016\/S0168-8278(87)80021-1_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ijc.2910040407","article-title":"Aflatoxin carcinogenesis \u2014 Inhibition of liver cancer induction in hypophysectomized rats","volume":"4","author":"Goodall","year":"1969","journal-title":"Intern J Cancer"},{"key":"10.1016\/S0168-8278(87)80021-1_bib34","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0006-291X(83)90854-9","article-title":"Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicity","volume":"114","author":"O'Brien","year":"1983","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/S0168-8278(87)80021-1_bib35","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/jcp.26.12.936","article-title":"Hepatic cirrhosis: A clinicopathological review of 520 cases","volume":"26","author":"MacSween","year":"1973","journal-title":"J Clin Path"},{"key":"10.1016\/S0168-8278(87)80021-1_bib36","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1056\/NEJM198511143132004","article-title":"Survival and causes of death in cirrhotic and in non-cirrhotic patients with primary haemochromatosis","volume":"313","author":"Niederau","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/S0168-8278(87)80021-1_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/gut.7.1.77","article-title":"Cirrhosis and hepatoma in alcoholics","volume":"7","author":"Lee","year":"1966","journal-title":"Gut"},{"key":"10.1016\/S0168-8278(87)80021-1_bib38","series-title":"Hepatocellular Carcinoma","first-page":"60","article-title":"Hepatitis B virus and hepatocellular carcinoma","year":"1982"},{"key":"10.1016\/S0168-8278(87)80021-1_bib39","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(01)07375-5","article-title":"Precancerous lesions of the alimentary tract","volume":"ii","author":"Stwart","year":"1931","journal-title":"Lancet"},{"key":"10.1016\/S0168-8278(87)80021-1_bib40","first-page":"4217","article-title":"The multistep nature of cancer development","volume":"44","author":"Farber","year":"1984","journal-title":"Cancer Res"},{"key":"10.1016\/S0168-8278(87)80021-1_bib41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/275060a0","article-title":"Initiation of chemical carcinogenesis requires cell proliferation","volume":"275","author":"Cayama","year":"1978","journal-title":"Nature"},{"key":"10.1016\/S0168-8278(87)80021-1_bib42","first-page":"832","article-title":"The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosoethylamine or N-2-fluoroenylacetamide","volume":"71","author":"Ito","year":"1980","journal-title":"Gann"},{"key":"10.1016\/S0168-8278(87)80021-1_bib43","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0016-5085(19)32658-7","article-title":"Clinical observations during a relatively early stage of hepatocellular carcinoma, with special reference to serum fetoprotein levels","volume":"69","author":"Okuda","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1016\/S0168-8278(87)80021-1_bib44","series-title":"Viral Hepatitis and Liver Disease","first-page":"245","article-title":"Hepatitis B virus and hepatocellular carcinoma","author":"Robinson","year":"1984"},{"key":"10.1016\/S0168-8278(87)80021-1_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-8278(86)80002-2","article-title":"Hepatitis B virus DNA in the hepatocyte. A series of 160 biopsies","volume":"2","author":"Harrison","year":"1986","journal-title":"J Hepatol"},{"key":"10.1016\/S0168-8278(87)80021-1_bib46","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0168-8278(86)80080-0","article-title":"Integration of HBV-DNA may not be a prerequisite for the maintenance of the state of malignant transformation \u2014 An analysis of 110 liver biopsies","volume":"2","author":"Fowler","year":"1986","journal-title":"J Hepatol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827887800211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827887800211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T23:59:07Z","timestamp":1626047947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827887800211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["S0168827887800211"],"URL":"https:\/\/doi.org\/10.1016\/s0168-8278(87)80021-1","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}