{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:57:50Z","timestamp":1773925070729,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Genetics"],"published-print":{"date-parts":[[1999,6]]},"DOI":"10.1016\/s0168-9525(99)01719-9","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T01:14:54Z","timestamp":1027646094000},"page":"229-235","source":"Crossref","is-referenced-by-count":215,"title":["NF-\u03baB to the rescue: RELs, apoptosis and cellular transformation"],"prefix":"10.1016","volume":"15","author":[{"given":"Shi","family":"Yin Foo","sequence":"first","affiliation":[]},{"given":"Garry P.","family":"Nolan","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0168-9525(99)01719-9_BIB1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0169-328X(98)00066-7","article-title":"The NF-\u03baB\/Rel family of proteins mediates A\u03b2-induced neurotoxicity and glial activation","volume":"57","author":"Bales","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.274.5291.1383","article-title":"Neuroprotection by aspirin and sodium salicylate through blockade of NF-\u03baB activation","volume":"274","author":"Grilli","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-\u03baB and Rel proteins: evolutionarily conserved mediators of immune response","volume":"16","author":"Ghosh","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(00)81409-9","article-title":"Cotranslational biogenesis of NF-\u03baB p50 by the 26S proteosome","volume":"92","author":"Lin","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-\u03baB and I\u03baB proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0167-5699(97)01197-3","article-title":"Signal transduction through NF-\u03baB","volume":"19","author":"May","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/358597a0","article-title":"Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of NF-\u03baB","volume":"358","author":"Wulczyn","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/359339a0","article-title":"The candidate proto-oncogene bcl-3 is an antagonist of p50\/NF-\u03baB-mediated inhibition","volume":"359","author":"Franzoso","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB9","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1128\/MCB.13.6.3557","article-title":"The proto-oncogene bcl-3 encodes a nuclear I\u03baB-like molecule that preferentially interacts with NF-\u03baB p50 and p52 in a phosphorylation-dependent manner","volume":"13","author":"Nolan","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB10","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/MCB.15.5.2689","article-title":"Inducible nuclear expression of newly synthesized I\u03baB-\u03b1 negatively regulates DNA-binding and transcriptional activation of NF-\u03baB","volume":"15","author":"Arenzana-Seisdedos","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(95)90511-1","article-title":"I\u03baB-\u03b2 regulates the persistent response in a biphasic activation of NF-\u03baB","volume":"80","author":"Thompson","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB12","first-page":"2839","article-title":"Structural alterations of the NF-\u03baB transcription factor Lyt-10 in lymphoid malignancies","volume":"8","author":"Fracchiolla","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB13","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1172\/JCI119848","article-title":"Aberrant nuclear factor-\u03baB\/Rel expression and the pathogensis of breast cancer","volume":"100","author":"Sovak","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB14","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/sj.onc.1201015","article-title":"Constitutive expression of lymphoma-associated NFKB2\/Lyt-10 proteins is tumorigenic in murine fibroblasts","volume":"14","author":"Ciana","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1083\/jcb.134.1.13","article-title":"Bcl-2 down-regulates the activity of transcription factor NF-\u03baB induced upon apoptosis","volume":"134","author":"Grimm","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB16","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1126\/science.1299224","article-title":"Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-\u03baB","volume":"258","author":"Kitajima","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/376167a0","article-title":"Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-\u03baB","volume":"376","author":"Beg","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB18","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.274.5288.784","article-title":"TNF-\u03b1 and cancer therapy-induced apoptosis:potentiation by inhibition of NF-\u03baB","volume":"274","author":"Wang","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)81375-6","article-title":"Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-\u03baB activation prevents cell death","volume":"87","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB20","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.274.5288.787","article-title":"Suppression of TNF-\u03b1-induced apoptosis by NF-\u03baB","volume":"274","author":"Van Antwerp","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB21","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.16.9.5015","article-title":"Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells","volume":"16","author":"Wu","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB22","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1002\/j.1460-2075.1996.tb00845.x","article-title":"Inhibition of NF-\u03baB\/Rel induces apoptosis of murine B cells","volume":"15","author":"Wu","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.physiol.60.1.575","article-title":"The many roles of c-myc in apoptosis","volume":"60","author":"Thompson","year":"1998","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1074-7613(00)80307-6","article-title":"TGF-\u03b21 inhibits NF-\u03baB\/Rel activity inducing apoptosis in B cells","volume":"5","author":"Arsura","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB25","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.4049\/jimmunol.153.10.4357","article-title":"Cross-linking CD40 on B cells rapidly activates nuclear factor-\u03baB","volume":"153","author":"Berberich","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB26","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.181.3.1169","article-title":"Role of Rel-related factors in control of c-myc gene transcription in receptor-meditaed apoptosis of the murine B cell WEHI 231 line","volume":"181","author":"Lee","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB27","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1128\/MCB.17.8.4390","article-title":"Regulation of I\u03baB-\u03b2 in WEHI 231 mature B cells","volume":"17","author":"Phillips","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB28","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1073\/pnas.95.5.2307","article-title":"Alterations in NF-\u03baB function in transgenic epithelial demonstrate a growth inhibitory role for NF-\u03baB","volume":"95","author":"Seitz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB29","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1128\/MCB.16.4.1342","article-title":"Constitutive expression of Bcl-3 in thymocytes increases the DNA binding of NF-\u03baB1 (p50) homodimers in vivo","volume":"16","author":"Caamano","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0092-8674(90)90347-H","article-title":"The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control","volume":"60","author":"Ohno","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB31","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S1074-7613(00)80291-5","article-title":"Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture and germinal center formation","volume":"6","author":"Franzoso","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1101\/gad.11.2.187","article-title":"Immunological defects in mice with a targeted disruption in Bcl-3","volume":"11","author":"Schwarz","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB33","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1074\/jbc.274.2.987","article-title":"Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor-\u03baB","volume":"274","author":"Kasibhatla","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB34","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1126\/science.281.5379.998","article-title":"IEX-1L, an apoptosis inhibitor involved in NF-\u03baB-mediated cell survival","volume":"281","author":"Wu","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB35","doi-asserted-by":"crossref","first-page":"10057","DOI":"10.1073\/pnas.94.19.10057","article-title":"Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-\u03baB control","volume":"94","author":"Chu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB36","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1126\/science.281.5383.1680","article-title":"Anti-apoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress Caspase 8 activation","volume":"281","author":"Wang","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB37","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1128\/JVI.69.4.2168-2174.1995","article-title":"LMP-1 activates NF-\u03baB by targeting the inhibitory molecule I\u03baB-\u03b1","volume":"69","author":"Herrero","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB38","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.1074\/jbc.270.21.12343","article-title":"Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis","volume":"270","author":"Sarma","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB39","doi-asserted-by":"crossref","first-page":"20067","DOI":"10.1016\/S0021-9258(17)32128-2","article-title":"NF-\u03baB activation of p53. A potential mechanism for suppression of cell growth in response to stress","volume":"269","author":"Wu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB40","doi-asserted-by":"crossref","first-page":"6970","DOI":"10.1128\/MCB.17.12.6970","article-title":"Tumor necrosis factor alpha and interleukin-1\u03b2 regulate the murine manganese superoxide dismutase gene throuh a complex intronic enhancer involving C\/EBP-\u03b2 and NF-\u03baB","volume":"17","author":"Jones","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB41","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1128\/MCB.17.11.6526","article-title":"c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1\/S-phase transition","volume":"17","author":"Bash","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB42","doi-asserted-by":"crossref","first-page":"R144","DOI":"10.1016\/S0960-9822(97)70074-5","article-title":"Tumor suppressors: a developing role for p53?","volume":"7","author":"Hall","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB43","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0344-0338(96)80088-4","article-title":"The role of p53 in cell cycle regulation","volume":"192","author":"Shaw","year":"1996","journal-title":"Pathol. Res. Prac."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB44","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.onc.1201638","article-title":"Nuclear factor-\u03baB-dependent regulation of p53 expression is induced by daunorubicin genotoxic drug","volume":"16","author":"Hellin","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB45","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1074\/jbc.274.4.1879","article-title":"CREB-binding protein is a nuclear integrator of nuclear factor-\u03baB and p53 signaling","volume":"274","author":"Wadgaonkar","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1097-2765(00)80066-0","article-title":"Phosphorylation of NF-\u03baB by PKA stimulated transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP\/p300","volume":"1","author":"Zhong","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB47","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1126\/science.275.5299.523","article-title":"Regulation of NF-\u03baB by cyclin-dependent kinases associated with the p300 coactivator","volume":"275","author":"Perkins","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0168-9525(99)01719-9_BIB48","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1073\/pnas.94.7.2927","article-title":"CREB-binding protein\/p300 are transcriptional coactivators of p65","volume":"94","author":"Gerritsen","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB49","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/nar\/26.3.847","article-title":"Factors associated with the mammalian RNA polymerase II holoenzyme complex","volume":"26","author":"Neish","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0168-9525(99)01719-9_BIB50","doi-asserted-by":"crossref","first-page":"27544","DOI":"10.1074\/jbc.271.44.27544","article-title":"p202, an interferon-inducible modulator of trancription, inhibits transcriptional activation by the p53 tumor suppressor protein and a segment from the p53 protein that binds to p202 overcomes this inhibition","volume":"271","author":"Datta","year":"1996","journal-title":"J. Biol. Chem."}],"container-title":["Trends in Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952599017199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952599017199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T10:00:39Z","timestamp":1681639239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168952599017199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S0168952599017199"],"URL":"https:\/\/doi.org\/10.1016\/s0168-9525(99)01719-9","relation":{},"ISSN":["0168-9525"],"issn-type":[{"value":"0168-9525","type":"print"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}