{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:06:52Z","timestamp":1772759212344,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Brain Research"],"published-print":{"date-parts":[[1997,8]]},"DOI":"10.1016\/s0169-328x(97)00120-4","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T22:50:49Z","timestamp":1027637449000},"page":"140-144","source":"Crossref","is-referenced-by-count":59,"title":["Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system"],"prefix":"10.1016","volume":"48","author":[{"given":"Zippel","family":"Renata","sequence":"first","affiliation":[]},{"given":"Gnesutta","family":"Nerina","sequence":"additional","affiliation":[]},{"given":"Matus-Leibovitch","family":"Noa","sequence":"additional","affiliation":[]},{"given":"Mancinelli","family":"Enzo","sequence":"additional","affiliation":[]},{"given":"Saya","family":"Daniella","sequence":"additional","affiliation":[]},{"given":"Vogel","family":"Zvi","sequence":"additional","affiliation":[]},{"given":"Sturani","family":"Emmapaola","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0169-328X(97)00120-4_BIB1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0006-8993(77)90594-7","article-title":"Rat hippocampal neurons in dispersed cell culture","volume":"126","author":"Banker","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1146\/annurev.bi.56.070187.004023","article-title":"Ras genes","volume":"56","author":"Barbacid","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB3","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1073\/pnas.89.14.6511","article-title":"Identification of murine homologues of the Drosophila Son of Sevenless gene: potential activators of Ras","volume":"89","author":"Bowtell","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB4","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1128\/MCB.16.9.4888","article-title":"The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium","volume":"16","author":"Buchsbaum","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB5","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1002\/j.1460-2075.1992.tb05494.x","article-title":"Isolation of multiple mouse cDNAs with coding homology to Saccharomices cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24","volume":"11","author":"Cen","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB6","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.8493579","article-title":"Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2","volume":"260","author":"Chardin","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/376524a0","article-title":"Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF","volume":"376","author":"Farnsworth","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/excr.1994.1048","article-title":"Expression of two different products of CDC25Mm, a mammalian Ras activator, during developement of mouse brain","volume":"210","author":"Ferrari","year":"1994","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0896-6273(00)80040-9","article-title":"Ca2+ dependent routes to Ras: mechanisms for neuronal survival, differentiation and plasticity","volume":"16","author":"Finkbeiner","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB10","first-page":"47","article-title":"Expression of Ras protooncogene proteins in normal tissues","volume":"1","author":"Furth","year":"1987","journal-title":"Oncogene"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB11","first-page":"1097","article-title":"Expression of alternative forms of Ras exchange facttors GRF and SOS1 in different human tissues and cell lines","volume":"12","author":"Guerrero","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1146\/annurev.bi.62.070193.004223","article-title":"Function and regulation of Ras","volume":"62","author":"Lowy","year":"1993","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB13","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1002\/j.1460-2075.1992.tb05274.x","article-title":"Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae Ras activator","volume":"11","author":"Martegani","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/382268a0","article-title":"Phosphorylation-dependent activation of the Ras-GRF\/CDC25Mm exchange factor by muscarinic receptors and G-protein \u03b2 \u03b3 subunits","volume":"382","author":"Mattingly","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0169-328X(95)00166-P","article-title":"Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following morphine treatment","volume":"34","author":"Matus-Leibovitch","year":"1995","journal-title":"Mol. Brain Res."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0022-2836(89)90388-4","article-title":"Structural organization of multiple rat calmodulin genes","volume":"208","author":"Nojima","year":"1989","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/358351a0","article-title":"Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21","volume":"358","author":"Shou","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB18","first-page":"1687","article-title":"Differential response of the Rass exchange factor, Ras-GRF to tyrosinee kinase and G protein mediated signals","volume":"10","author":"Shou","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB19","doi-asserted-by":"crossref","unstructured":"E. Sturani, A. Abbondio, P. Branduardi, C. Ferrari, R. Zippel, E. Martegani, M. Vanoni, S. Denis-Donini, The Ras guanine nucleotide exchange factor CDC25Mm is present at synaptic junctions, Exp. Cell Res. (1997) in press.","DOI":"10.1006\/excr.1997.3660"},{"key":"10.1016\/S0169-328X(97)00120-4_BIB20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00231605","article-title":"Organ specific expression of Ras gene products in the normal rat","volume":"75","author":"Tanaka","year":"1987","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0169-328X(93)90136-D","article-title":"Localization of the cellular expression pattern of cdc25NEF and Ras in the juvenile rat brain","volume":"19","author":"Wei","year":"1993","journal-title":"Mol. Brain Res."},{"key":"10.1016\/S0169-328X(97)00120-4_BIB22","first-page":"2697","article-title":"The brain specific Ras exchange factor CDC25Mm: modulation of its activity through Gi-protein-mediated signals","volume":"12","author":"Zippel","year":"1996","journal-title":"Oncogene"}],"container-title":["Molecular Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169328X97001204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169328X97001204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T23:55:00Z","timestamp":1580255700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169328X97001204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["S0169328X97001204"],"URL":"https:\/\/doi.org\/10.1016\/s0169-328x(97)00120-4","relation":{},"ISSN":["0169-328X"],"issn-type":[{"value":"0169-328X","type":"print"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}