{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:31:57Z","timestamp":1648701117446},"reference-count":66,"publisher":"Elsevier","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000]]},"DOI":"10.1016\/s0169-7161(00)18032-0","type":"book-chapter","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T19:58:53Z","timestamp":1113854333000},"page":"895-911","source":"Crossref","is-referenced-by-count":0,"title":["30 Carcinogenic potency: Statistical perspectives"],"prefix":"10.1016","author":[{"given":"Anup","family":"Dewanji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0169-7161(00)18032-0_bib1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/01621459.1983.10477936","article-title":"Experimental design for binary data","volume":"78","author":"Abdelbasit","year":"1983","journal-title":"J. Amer. Statist. Assoc."},{"key":"10.1016\/S0169-7161(00)18032-0_bib2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2307\/2532937","article-title":"Interval estimation of inverse dose-response","volume":"51","author":"Alho","year":"1995","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1539-6924.1988.tb01193.x","article-title":"Correlation between carcinogenic potencies of chemicals in animals and humans","volume":"8","author":"Allen","year":"1988","journal-title":"Risk Anal."},{"key":"10.1016\/S0169-7161(00)18032-0_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/science.3563506","article-title":"Ranking possible carcinogenic hazards","volume":"236","author":"Ames","year":"1987","journal-title":"Science"},{"key":"10.1016\/S0169-7161(00)18032-0_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1954.1","article-title":"The age distribution of cancer and a multistage theory of carcinogenesis","volume":"8","author":"Armitage","year":"1954","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/S0169-7161(00)18032-0_bib6","first-page":"19","article-title":"Stochastic models for carcinogenesis","author":"Armitage","year":"1961"},{"key":"10.1016\/S0169-7161(00)18032-0_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2307\/2531856","article-title":"Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples","volume":"44","author":"Bailer","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2307\/2532549","article-title":"An index of tumorigenic potency","volume":"49","author":"Bailer","year":"1993","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0273-2300(85)90008-X","article-title":"The calculation and use of carcinogenic potency: A review","volume":"5","author":"Barr","year":"1985","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/S0169-7161(00)18032-0_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0272-0590(85)90051-X","article-title":"Some tautologous aspects of the comparison of carcinogenic potency in rats and mice","volume":"5","author":"Bernstein","year":"1985","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/S0169-7161(00)18032-0_bib11","first-page":"503","article-title":"Quantitative analysis of dose-response data obtained with three carcinogenic hydrocarbons in strain C3H mice","volume":"3","author":"Bryan","year":"1943","journal-title":"J. Nat. Cancer Inst."},{"key":"10.1016\/S0169-7161(00)18032-0_bib12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2307\/2530913","article-title":"A growth-curve model approach to multivariate quantal bioassay","volume":"40","author":"Carter","year":"1984","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2307\/3315707","article-title":"Estimation of mutagenic potency and determination of sources of variability for Ames bioassay data","volume":"21","author":"Darlington","year":"1993","journal-title":"Canad. J. Statist."},{"key":"10.1016\/S0169-7161(00)18032-0_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2307\/2531053","article-title":"Nonparametric methods for survival\/sacrifice experiments","volume":"42","author":"Dewanji","year":"1986","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2307\/2532550","article-title":"A Weibull model for the estimation of tumorigenic potency","volume":"49","author":"Dewanji","year":"1993","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2307\/2347946","article-title":"Regression analysis of tumor prevalence data","volume":"32","author":"Dinse","year":"1983","journal-title":"Appl. Statist."},{"key":"10.1016\/S0169-7161(00)18032-0_bib17","series-title":"Potential Carcinogenic Hazards from Drugs","first-page":"60","article-title":"Quantitative aspects in chemical carcinogenesis","author":"Druckrey","year":"1967"},{"key":"10.1016\/S0169-7161(00)18032-0_bib18","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2307\/3315708","article-title":"Semi-nonparametric estimates of dose-response mutagenic potency of environmental chemicals and an assessment of inter- and intra-laboratory variation using a short-term bioassay","volume":"21","author":"Eastwood","year":"1993","journal-title":"Canad. J. Statist."},{"key":"10.1016\/S0169-7161(00)18032-0_bib19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2307\/2532154","article-title":"Modeling the effect of dose on the lifetime tumor rate from an animal carcinogenicity experiment","volume":"47","author":"Finkelstein","year":"1991","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2307\/2347543","article-title":"Estimating carcinogenic potency from a rodent tumorigenicity experiment","volume":"36","author":"Finkelstein","year":"1987","journal-title":"Appl. Statist."},{"key":"10.1016\/S0169-7161(00)18032-0_bib21","series-title":"Statistical Methods in Biological Assay","author":"Finney","year":"1964"},{"key":"10.1016\/S0169-7161(00)18032-0_bib22","series-title":"Statistical Methods in Biological Assay","author":"Finney","year":"1978"},{"key":"10.1016\/S0169-7161(00)18032-0_bib23","first-page":"957","article-title":"Statistical issues in interpretation of chronic bioassay tests for carcinogenicity","volume":"62","author":"Gart","year":"1979","journal-title":"J. Nat. Cancer Inst."},{"key":"10.1016\/S0169-7161(00)18032-0_bib24","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1539-6924.1996.tb00816.x","article-title":"Comparison of contact site cancer potency across dose routes: case study with epichlorohydrin","volume":"16","author":"Ginsberg","year":"1996","journal-title":"Risk Anal."},{"key":"10.1016\/S0169-7161(00)18032-0_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1289\/ehp.84589","article-title":"A carcinogenic potency data base of the standardized results of animal bioassays","volume":"58","author":"Gold","year":"1984","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/S0169-7161(00)18032-0_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0272-0590(86)90239-3","article-title":"An empirical comparison of methods used to estimate carcinogenic potency in long-term animal bioassays: Lifetable vs summary incidence data","volume":"6","author":"Gold","year":"1986","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/S0169-7161(00)18032-0_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1289\/ehp.8667161","article-title":"Chronological supplement to the carcinogenic potency database: Standardized results of animal bioassays published through December 1982","volume":"67","author":"Gold","year":"1986","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/S0169-7161(00)18032-0_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1289\/ehp.8776211","article-title":"Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents","volume":"76","author":"Gold","year":"1987","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/S0169-7161(00)18032-0_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1289\/ehp.8774237","article-title":"Second chronological supplement to the carcinogenic potency standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986","volume":"74","author":"Gold","year":"1987","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/S0169-7161(00)18032-0_bib30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1289\/ehp.8979259","article-title":"Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database","volume":"79","author":"Gold","year":"1989","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/S0169-7161(00)18032-0_bib31","first-page":"475","article-title":"Statistical Analysis of survival experiments","volume":"53","author":"Hoel","year":"1972","journal-title":"J. Nat. Cancer Inst."},{"key":"10.1016\/S0169-7161(00)18032-0_bib32","first-page":"188","article-title":"The relative potency of carcinogenic compounds","volume":"35","author":"Iball","year":"1939","journal-title":"Amer. J. Cancer"},{"key":"10.1016\/S0169-7161(00)18032-0_bib33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1017\/S0022172400019197","article-title":"The statistical treatment of measurements of the carcinogenic properties of tars (Part I) and mineral oils (Part II)","volume":"44","author":"Irwin","year":"1946","journal-title":"J. Hygiene"},{"key":"10.1016\/S0169-7161(00)18032-0_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2307\/2532092","article-title":"Efficient design for estimation of median lethal dose and quantal dose-response curves","volume":"46","author":"Kalish","year":"1990","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2307\/2529978","article-title":"An illness-death model for the study of the carcinogenic process using survival\/sacrifice data","volume":"36","author":"Kodell","year":"1980","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2307\/2530700","article-title":"Standardized tumor rates for chronic bioassays","volume":"42","author":"Kodell","year":"1986","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15287399109531461","article-title":"Carcinogenic potency correlations: Real or artifactual?","volume":"32","author":"Kodell","year":"1991","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/S0169-7161(00)18032-0_bib38","series-title":"Modern Statistical Methods in Chronic Disease Epidemiology","first-page":"259","article-title":"Statistical modelling and extrapolation of carcinogenesis data","author":"Krewski","year":"1986"},{"key":"10.1016\/S0169-7161(00)18032-0_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0273-2300(05)80043-1","article-title":"Quantitative factors in chemical carcinogenesis: variation in carcinogenic potency","volume":"12","author":"Krewski","year":"1990","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/S0169-7161(00)18032-0_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2307\/2531245","article-title":"The impact of litter effects on dose-response modelling in teratology","volume":"42","author":"Kupper","year":"1986","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib41","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2307\/3315709","article-title":"Components of variation in mutagenic potency values based on Ames Salmonella test","volume":"21","author":"Leroux","year":"1993","journal-title":"Canad. J. Statist."},{"key":"10.1016\/S0169-7161(00)18032-0_bib42","series-title":"Essentials of Toxicology","author":"Loomis","year":"1978"},{"key":"10.1016\/S0169-7161(00)18032-0_bib43","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/sim.4780140812","article-title":"An alternative approach to the optimal design of an LD50 bioassay","volume":"14","author":"Markus","year":"1995","journal-title":"Statist. Med."},{"key":"10.1016\/S0169-7161(00)18032-0_bib44","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/01621459.1984.10478091","article-title":"Tests for differences in tumor incidence based on animal carcinogenesis experiments","volume":"79","author":"McKnight","year":"1984","journal-title":"J. Amer. Statist. Assoc."},{"key":"10.1016\/S0169-7161(00)18032-0_bib45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2307\/2531634","article-title":"Sequential designs in bioassay","volume":"46","author":"McLeish","year":"1990","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib46","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2307\/2532213","article-title":"A measure of tumorigenic potency incorporating dose-response shape","volume":"49","author":"Meier","year":"1993","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib47","series-title":"Origins of Human Cancer","first-page":"1473","article-title":"Comparisons of carcinogenic and mutagenic potency","author":"Meselson","year":"1977"},{"key":"10.1016\/S0169-7161(00)18032-0_bib48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1539-6924.1990.tb01053.x","article-title":"Two-event models for carcinogenesis: Biological, mathematical and statistical considerations","volume":"10","author":"Moolgavkar","year":"1990","journal-title":"Risk Anal."},{"key":"10.1016\/S0169-7161(00)18032-0_bib49","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/carcin\/11.8.1271","article-title":"Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments I. Single agent regimen","volume":"11","author":"Moolgavkar","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1016\/S0169-7161(00)18032-0_bib50","series-title":"Analysis of Quantal Response Data","author":"Morgan","year":"1992"},{"key":"10.1016\/S0169-7161(00)18032-0_bib51","first-page":"427","article-title":"Quantitative risk assessment: State-of-the-art for carcinogenesis","volume":"37","author":"Park","year":"1983","journal-title":"Amer. Statist."},{"key":"10.1016\/S0169-7161(00)18032-0_bib52","series-title":"Long-Term and Short-Term Screening Assays for Carcinogenesis: A Critical Appraisal","first-page":"311","article-title":"Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments","author":"Peto","year":"1980"},{"key":"10.1016\/S0169-7161(00)18032-0_bib53","first-page":"1","article-title":"The TD50: A proposed general convention for the numerical description of the carcinogenic patterns of chemicals in chronic-exposed animal experiments","volume":"58","author":"Peto","year":"1984","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/S0169-7161(00)18032-0_bib54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1539-6924.1992.tb01314.x","article-title":"Concordance of carcinogenic response between rodent species: Potency dependence and potential underestimation","volume":"12","author":"Piegorsch","year":"1992","journal-title":"Risk Anal."},{"key":"10.1016\/S0169-7161(00)18032-0_bib55","first-page":"4372","article-title":"Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program's carcinogenicity experiments","volume":"46","author":"Portier","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/S0169-7161(00)18032-0_bib56","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1539-6924.1987.tb00481.x","article-title":"Issues concerning the estimation of the TD50","volume":"7","author":"Portier","year":"1987","journal-title":"Risk Analysis"},{"key":"10.1016\/S0169-7161(00)18032-0_bib57","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1539-6924.1991.tb00639.x","article-title":"A multistage model of carcinogenesis incorporating DNA damage and repair","volume":"11","author":"Portier","year":"1991","journal-title":"Risk Anal."},{"key":"10.1016\/S0169-7161(00)18032-0_bib58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2307\/2530741","article-title":"Calculation of carcinogenic potency from long-term animal carcinogenesis experiments","volume":"40","author":"Sawyer","year":"1984","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2307\/2530532","article-title":"Estimation of the median lethal dose when responses within a littler are correlated","volume":"37","author":"Segreti","year":"1981","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib60","series-title":"Optimal Design","author":"Silvey","year":"1980"},{"key":"10.1016\/S0169-7161(00)18032-0_bib61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2307\/2530742","article-title":"Nonparametric estimation of distributions of time to onset and time to death for specific diseases in survival\/sacrifice experiments","volume":"40","author":"Turnbull","year":"1984","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib62","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1017\/S0022172400010111","article-title":"The relative potency of carcinogenic tars and oils","volume":"29","author":"Twort","year":"1930","journal-title":"J. Hygiene"},{"key":"10.1016\/S0169-7161(00)18032-0_bib63","first-page":"293","article-title":"Suggested methods for the standardization of the carcinogenic activity of different agents for the skin of mice","volume":"17","author":"Twort","year":"1933","journal-title":"Amer. J. Cancer"},{"key":"10.1016\/S0169-7161(00)18032-0_bib64","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2307\/2531952","article-title":"A dose-response model incorporating nonlinear kinetics","volume":"43","author":"Van Ryzin","year":"1987","journal-title":"Biometrics"},{"key":"10.1016\/S0169-7161(00)18032-0_bib65","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1539-6924.1990.tb00546.x","article-title":"The fallacy of ranking possible carcinogen hazards using the TD50 (with discussion)","volume":"10","author":"Wartenberg","year":"1990","journal-title":"Risk Anal."},{"key":"10.1016\/S0169-7161(00)18032-0_bib66","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2307\/2531213","article-title":"Interval estimation of the median lethal dose","volume":"42","author":"Williams","year":"1986","journal-title":"Biometrics"}],"container-title":["Handbook of Statistics","Bioenvironmental and Public Health Statistics"],"original-title":[],"deposited":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T02:57:06Z","timestamp":1548557826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169716100180320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":66,"URL":"https:\/\/doi.org\/10.1016\/s0169-7161(00)18032-0","relation":{},"ISSN":["0169-7161"],"issn-type":[{"value":"0169-7161","type":"print"}],"subject":[],"published":{"date-parts":[[2000]]}}}