{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:03:04Z","timestamp":1765713784737},"reference-count":46,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1016\/s0264-410x(99)00393-x","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T01:18:44Z","timestamp":1027646324000},"page":"1218-1226","source":"Crossref","is-referenced-by-count":41,"title":["Salivary anti-capsular antibodies in infants and children immunised with Streptococcus pneumoniae capsular polysaccharides conjugated to diphtheria or tetanus toxoid"],"prefix":"10.1016","volume":"18","author":[{"given":"Maija","family":"Korkeila","sequence":"first","affiliation":[]},{"given":"Hannele","family":"Lehtonen","sequence":"additional","affiliation":[]},{"given":"Heidi","family":"\u00c5hman","sequence":"additional","affiliation":[]},{"given":"Odile","family":"Leroy","sequence":"additional","affiliation":[]},{"given":"Juhani","family":"Eskola","sequence":"additional","affiliation":[]},{"given":"Helena","family":"K\u00e4yhty","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0264-410X(99)00393-X_BIB1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/infdis\/172.5.1273","article-title":"Pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine is immunogenic in infants and children","volume":"172","author":"K\u00e4yhty","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0022-3476(96)80130-2","article-title":"Immunogenicity of heptavalent pneumococcal conjugate vaccine in infants","volume":"128","author":"Anderson","year":"1996","journal-title":"J. Pediatr."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00006454-199602000-00009","article-title":"Pentavalent pneumococcal oligosaccharide conjugate vaccine PncCRM is well-tolerated and able to induce an antibody response in infants","volume":"15","author":"\u00c5hman","year":"1996","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1086\/514063","article-title":"Infant immunization with pneumococcal CRM197 vaccine: effect of saccharide size on immunogenicity and interactions with simultaneously administered vaccines","volume":"176","author":"Daum","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB5","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/00006454-199712000-00007","article-title":"A glycoprotein pneumococcal conjugate vaccine primes for antibody responses to a pneumococcal polysaccharide vaccine in Gambian children","volume":"16","author":"Obaro","year":"1997","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB6","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00006454-199707000-00009","article-title":"Immune responses of infants vaccinated with serotype 6B pneumococcal polysaccharide conjugated with tetanus toxoid","volume":"16","author":"Sigurdardottir","year":"1997","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00006454-199803000-00008","article-title":"Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory","volume":"17","author":"\u00c5hman","year":"1998","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB8","doi-asserted-by":"crossref","unstructured":"\u00c5hman H, K\u00e4yhty H, Vuorela A, Leroy O, Eskola J, Dose dependency of antibody response in infants and children to pneumococcal polysaccharides conjugated to tetanus toxoid, Vaccine 1999;17:2726\u201332","DOI":"10.1016\/S0264-410X(99)00048-1"},{"key":"10.1016\/S0264-410X(99)00393-X_BIB9","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/infdis\/164.5.982","article-title":"Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine","volume":"164","author":"Takala","year":"1991","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00006454-199307000-00010","article-title":"Vaccination with Haemophilus influenzae type b meningococcal protein conjugate vaccine reduces oropharyngeal carriage of Haemophilus influenzae type b among American Indian children","volume":"12","author":"Takala","year":"1993","journal-title":"Pediatr Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0022-3476(05)83529-2","article-title":"Decreased Haemophilus colonization in children vaccinated with Haemophilus influenzae type b conjugate vaccine","volume":"122","author":"Murphy","year":"1993","journal-title":"J. Pediatr."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/00006454-199307000-00009","article-title":"Carriage of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines","volume":"12","author":"Mohle-Boetani","year":"1993","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00006454-199306000-00005","article-title":"Haemophilus influenzae type b carriage and immunity four years after receiving the Haemophilus influenzae oligosaccharide-CRM197 (HbOC) conjugate vaccine","volume":"12","author":"Barbour","year":"1993","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/infdis\/171.1.93","article-title":"The impact of conjugate vaccine on carriage of Haemophilus influenzae type b","volume":"171","author":"Barbour","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00006454-199504000-00008","article-title":"Anti-capsular polysaccharide antibody concentrations in saliva after immunization with Haemophilus influenzae type b conjugate vaccines","volume":"14","author":"Kauppi","year":"1995","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1365-2249.1998.00501.x","article-title":"Subclass distribution of saliva and serum IgA after immunization with Haemophilus influenzae type b conjugate vaccines","volume":"111","author":"Kauppi-Korkeila","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/infdis\/167.2.365","article-title":"Anti-capsular polysaccharide antibodies reduce nasopharyngeal colonization by Haemophilus influenzae type b in infant rats","volume":"167","author":"Kauppi","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB18","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1093\/infdis\/174.6.1337","article-title":"Mechanism of antibody mediated reduction of nasopharyngeal colonization by Haemophilus influenzae type b studied in an infant rat model","volume":"174","author":"Kauppi-Korkeila","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0140-6736(05)65585-7","article-title":"Carriage of pneumococci after pneumococcal vaccination (letter)","volume":"348","author":"Obaro","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/S0264-410X(99)00393-X_BIB20","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/infdis\/174.6.1271","article-title":"Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine","volume":"174","author":"Dagan","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB21","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/00006454-199711000-00011","article-title":"Reduction of pneumococcal nasopharyngeal carriage in early infancy after immunization with tetravalent pneumococcal vaccines conjugated to either tetanus toxoid or diphtheria toxoid","volume":"16","author":"Dagan","year":"1997","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB22","series-title":"Programs and Abstracts of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Toronto)","first-page":"13","article-title":"Immunogenicity and impact on carriage of 9-valent pneumococcal conjugate vaccine given to infants in Soweto, South Africa","author":"Mbelle","year":"1997"},{"key":"10.1016\/S0264-410X(99)00393-X_BIB23","series-title":"Programs and Abstracts of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Toronto)","first-page":"193","article-title":"Effect of vaccination with octavalent conjugated pneumococcal vaccines on pneumococcal carriage in infants","author":"Kristinsson","year":"1997"},{"key":"10.1016\/S0264-410X(99)00393-X_BIB24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0022-3476(05)80865-0","article-title":"Bacterial polysaccharide immune globulin for prophylaxis of acute otitis media in high-risk children","volume":"123","author":"Shurin","year":"1993","journal-title":"J. Pediatr."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF01958979","article-title":"Successful intravenous immunoglobulin therapy for recurrent pneumococcal otitis media in young children","volume":"153","author":"Ishizaka","year":"1994","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/infdis\/173.1.119","article-title":"Immunogenicity and efficacy of Streptococcus pneumoniae polysaccharide-protein conjugate vaccines against homologous and heterologous serotypes in the chinchilla otitis media model","volume":"173","author":"Giebink","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/infdis\/172.4.1115","article-title":"Nasopharyngeal antibodies to pneumococcal capsular polysaccharides in children with acute otitis media","volume":"172","author":"Virolainen","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB28","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1128\/IAI.9.6.1028-1032.1974","article-title":"Immune response to acute otitis media in children. I. Serotypes isolated and serum and middle ear fluid antibody in pneumococcal otitis media","volume":"9","author":"Sloyer","year":"1974","journal-title":"Infect. Immun."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00006454-198607000-00011","article-title":"Antibody response of young children to parenteral vaccination with pneumococcal capsular polysaccharides: a comparison between antibody levels in serum and middle ear effusion","volume":"5","author":"Koskela","year":"1986","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB30","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3109\/00016489509139404","article-title":"Antibodies to pneumolysin and pneumococcal capsular polysaccharides in middle ear fluid of children with acute otitis media","volume":"115","author":"Virolainen","year":"1995","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/clinids\/3.2.342","article-title":"The pathogenesis of pneumococcal otitis media in chinchillas and the efficacy of vaccination in prophylaxis","volume":"3","author":"Giebink","year":"1981","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/jcm.4.3.306-308.1976","article-title":"Immune response to acute otitis media: association between middle ear fluid antibody and the clearing of clinical infection","volume":"4","author":"Sloyer","year":"1976","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0264-410X(97)00235-1","article-title":"Pneumococcal conjugate vaccination in adults: circulating antibody secreting cell response and humoral antibody responses in saliva and in serum","volume":"16","author":"Nieminen","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/S0264-410X(99)00393-X_BIB34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00006454-198706000-00006","article-title":"Serum antibodies to pneumococcal C polysaccharide in children: response to acute pneuococcal otitis media or to vaccination","volume":"6","author":"Koskela","year":"1987","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB35","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1128\/CDLI.2.5.590-597.1995","article-title":"Assignment of weight-based antibody units to a human antipneumococcal standard reference serum, Lot 89-S","volume":"2","author":"Quataert","year":"1995","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB36","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev.mi.37.100183.003131","article-title":"The IgA1 proteases of pathogenic bacteria","volume":"37","author":"Plaut","year":"1983","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB37","first-page":"296","article-title":"Defence mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases","volume":"52","author":"Kilian","year":"1988","journal-title":"Mircobiol. Rev."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB38","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1128\/IAI.66.5.2093-2098.1998","article-title":"Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants","volume":"66","author":"Dagan","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00006454-198601000-00008","article-title":"Antibody response to 14-valent pneumococcal capsular polysaccharide vaccine in preschool age children","volume":"5","author":"Leinonen","year":"1986","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB40","first-page":"34","article-title":"Possibilities of preventing otitis media by vaccination","volume":"39","author":"M\u00e4kel\u00e4","year":"1983","journal-title":"Scand. J. Infect. Dis. Suppl."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB41","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-3083.1992.tb03126.x","article-title":"Effect of mucosal and systemic immunization with pneumococcal polysaccharide type 3, 4 and 14 in the rat","volume":"36","author":"Van den Dobbelsteen","year":"1992","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/iai.30.2.427-430.1980","article-title":"Different secretory immunoglobulin A antibody responses to cholera vaccination in Swedish and Pakistani Women","volume":"30","author":"Svennerholm","year":"1980","journal-title":"Infect. Immun."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00915547","article-title":"The common mucosal immune system and current strategies for induction of immune responses in external secretion","volume":"7","author":"Mestecky","year":"1987","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB44","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1172\/JCI110830","article-title":"Activation of human B lymphocytes after immunization with pneumococcal polysaccharides","volume":"71","author":"Kehrl","year":"1983","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB45","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.4049\/jimmunol.140.11.3793","article-title":"Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies","volume":"140","author":"Lue","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/S0264-410X(99)00393-X_BIB46","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.4049\/jimmunol.144.10.3770","article-title":"Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses","volume":"144","author":"Tarkowski","year":"1990","journal-title":"J. Immunol."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X9900393X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X9900393X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T10:37:43Z","timestamp":1681641463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X9900393X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":46,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0264410X9900393X"],"URL":"https:\/\/doi.org\/10.1016\/s0264-410x(99)00393-x","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}