{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:57:03Z","timestamp":1773838623591,"version":"3.50.1"},"reference-count":236,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neurobiology"],"published-print":{"date-parts":[[1997,1]]},"DOI":"10.1016\/s0301-0082(96)00046-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T20:11:38Z","timestamp":1027627898000},"page":"19-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":171,"title":["The neurotrophic action and signalling of epidermal growth factor"],"prefix":"10.1016","volume":"51","author":[{"given":"Masashi","family":"Yamada","sequence":"first","affiliation":[]},{"given":"Toshihiko","family":"Ikeuchi","sequence":"additional","affiliation":[]},{"given":"Hiroshi","family":"Hatanaka","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0301-0082(96)00046-9_BIB1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(91)90589-N","article-title":"Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices","volume":"547","author":"Abe","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0006-8993(92)91433-F","article-title":"Epidermal growth factor selectively enhances NMDA receptor-mediated increase of intracellular Ca2+ concentration in rat hippocampal neurons","volume":"587","author":"Abe","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0092-8674(00)81077-6","article-title":"Mammalian SH2-containing protein tyrosine phosphatases","volume":"85","author":"Adachi","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0012-1606(84)90007-1","article-title":"The ontogeny of epidermal growth factor receptors during mouse development","volume":"103","author":"Adamson","year":"1984","journal-title":"Dev. Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0165-3806(85)90214-7","article-title":"Epidermal growth factor and bovine growth hormone stimulate differentiation and myelination of brain cell aggregates in culture","volume":"353","author":"Almazan","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/978-3-642-68560-6_2","article-title":"Morphological development of the rat cerebellum and some of its mechanisms","volume":"6","author":"Altman","year":"1982","journal-title":"Exp. Brain Res. [Suppl.]"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB7","doi-asserted-by":"crossref","first-page":"15277","DOI":"10.1016\/S0021-9258(18)98613-8","article-title":"Pro-Leu-Ser\/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase","volume":"266","author":"Alvarez","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB8","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0896-6273(91)90233-P","article-title":"EGF and TGF-\u03b1 stimulate retinal neuroepithelial cell proliferation in vitro","volume":"6","author":"Anchan","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.2173144","article-title":"Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors","volume":"250","author":"Anderson","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB10","first-page":"6264","article-title":"Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors","volume":"80","author":"Anzano","year":"1983"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/348693a0","article-title":"The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily","volume":"348","author":"Aroian","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(89)90182-7","article-title":"PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells","volume":"57","author":"Auger","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB13","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1002\/j.1460-2075.1992.tb05426.x","article-title":"Phosphatidylinositol 3\u2032-kinase is activated by association with IRS-1 during insulin stimulation","volume":"11","author":"Backer","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0026-895X(25)08725-5","article-title":"Epidermal growth factor-mediated inhibition of neurotransmitter glutamate release from rat forebrain synaptosomes","volume":"49","author":"Barrie","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB15","first-page":"5192","article-title":"Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor","volume":"14","author":"Batzer","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB16","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1128\/MCB.15.12.6496","article-title":"Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2","volume":"15","author":"Beerli","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB17","first-page":"2774","article-title":"Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors","volume":"82","author":"Beguinot","year":"1985"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/312315a0","article-title":"Inositol trisphosphate, a novel second messenger in cellular signal transduction","volume":"312","author":"Berridge","year":"1984","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB19","first-page":"653","article-title":"The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-roch domain and a leucine zipper-like motif","volume":"6","author":"Blake","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB20","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1002\/j.1460-2075.1993.tb05851.x","article-title":"The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation","volume":"12","author":"Blake","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/366643a0","article-title":"Proteins regulating Ras and its relatives","volume":"366","author":"Boguski","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB22","doi-asserted-by":"crossref","first-page":"16564","DOI":"10.1016\/S0021-9258(17)46260-0","article-title":"The epidermal growth factor precursor isolated from murine kidney membranes. Chemical characterization and biological properties","volume":"265","author":"Breyer","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0092-8674(93)90146-H","article-title":"Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor","volume":"73","author":"Buday","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB24","doi-asserted-by":"crossref","first-page":"9478","DOI":"10.1016\/S0021-9258(18)98375-4","article-title":"Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit","volume":"268","author":"Carpenter","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB25","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.bi.56.070187.004313","article-title":"Receptors for epidermal growth factor and other polypeptide mitogens","volume":"56","author":"Carpenter","year":"1987","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.bi.48.070179.001205","article-title":"Epidermal growth factor","volume":"48","author":"Carpenter","year":"1979","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB27","doi-asserted-by":"crossref","first-page":"14303","DOI":"10.1016\/S0021-9258(17)36789-3","article-title":"The erbB3 gene product is a receptor for heregulin","volume":"269","author":"Carraway","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0092-8674(94)90564-9","article-title":"A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling","volume":"78","author":"Carraway","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jnr.490300213","article-title":"EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture","volume":"30","author":"Casper","year":"1991","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB30","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1046\/j.1471-4159.1994.62062166.x","article-title":"Epidermal growth factor and basic fibroblast growth factor have independent actions on mesencephalic dopamine neurons in culture","volume":"62","author":"Casper","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB31","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1046\/j.1471-4159.1995.65031016.x","article-title":"Epidermal growth factor and basic fibroblast growth factor protect dopaminergic neurons from glutamate toxicity in culture","volume":"65","author":"Casper","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB32","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0092-8674(92)90068-N","article-title":"Growth factor signaling: where is the specificity?","volume":"68","author":"Chao","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cb.08.110192.002335","article-title":"1002 protein phosphateses?","volume":"8","author":"Charbonneau","year":"1992","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB34","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/S0021-9258(17)43389-8","article-title":"C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity","volume":"259","author":"Cochet","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0021-9258(18)52482-0","article-title":"Interaction between the epidermal growth factor receptor and phosphoinositide kinases","volume":"266","author":"Cochet","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2880001","article-title":"Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors","volume":"288","author":"Cockcroft","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0092-8674(95)90406-9","article-title":"Modular binding domains in signal transduction proteins","volume":"80","author":"Cohen","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB38","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S0021-9258(19)83739-0","article-title":"Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal","volume":"237","author":"Cohen","year":"1962","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB39","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0012-1606(65)90005-9","article-title":"The stimulation of epidermal proliferation by a specific protein (EGF)","volume":"12","author":"Cohen","year":"1965","journal-title":"Dev. Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jid.1963.1","article-title":"The stimulation of epideral keratinization by a protein isolated from the submaxillary gland of the mouse","volume":"40","author":"Cohen","year":"1963","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB41","first-page":"1737","article-title":"In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase","volume":"13","author":"Cooper","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0896-6273(95)90244-9","article-title":"Differential expression of ARIA isoforms in the rat brain","volume":"14","author":"Corfas","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB43","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","article-title":"Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cell","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0092-8674(93)90411-I","article-title":"Extracellular signals and reversible protein phosphorylation: what to Mek of it all","volume":"74","author":"Crews","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB45","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/379557a0","article-title":"Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors","volume":"379","author":"Daub","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB47","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(88)80001-1","article-title":"Transforming growth factor","volume":"54","author":"Derynck","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB48","doi-asserted-by":"crossref","first-page":"15125","DOI":"10.1074\/jbc.270.25.15125","article-title":"Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain","volume":"270","author":"Dikic","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB49","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/307521a0","article-title":"Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences","volume":"307","author":"Downward","year":"1984","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00694752","article-title":"Heterodimerization and functional interaction between EGF receptor family members: A new signaling paradigm with implication for breast cancer research","volume":"35","author":"Earp","year":"1995","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/363045a0","article-title":"Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation","volume":"363","author":"Egan","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/343377a0","article-title":"Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases","volume":"343","author":"Ellis","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB53","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1146\/annurev.cb.07.110191.003311","article-title":"Mechanisms and functions of cell death","volume":"7","author":"Ellis","year":"1991","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0006-8993(90)90004-U","article-title":"High oxygen atmosphere for neuronal cell culture with nerve growth factor. II. Survival and growth of clonal rat pheochromocytoma PC12h cells","volume":"536","author":"Enokido","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0092-8674(91)90409-R","article-title":"cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of P13-kinase to the PDGF \u03b2-receptor","volume":"65","author":"Escobedo","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB56","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.6144184","article-title":"Epidermal growth factor immunoreactive material in the central nervous system: location and development","volume":"224","author":"Fallon","year":"1984","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB57","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(93)90407-H","article-title":"ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family","volume":"72","author":"Falls","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB58","doi-asserted-by":"crossref","first-page":"20363","DOI":"10.1016\/S0021-9258(19)88710-0","article-title":"Epidermal growth factor receptor in synaptic fractions of the rat central nervous system","volume":"267","author":"Faundez","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB59","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1126\/science.8096088","article-title":"SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases","volume":"259","author":"Feng","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB60","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0168-9525(94)90149-X","article-title":"Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction","volume":"10","author":"Feng","year":"1994","journal-title":"Trends. Genet."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB61","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jnr.490300306","article-title":"Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GABAergic CNS neurons comparison with basic fibroblast growth factor","volume":"30","author":"Ferrari","year":"1991","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.ph.51.030189.000435","article-title":"Epidermal growth factor and the kidney","volume":"51","author":"Fisher","year":"1989","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1471-4159.1992.tb09273.x","article-title":"Inositol lipids and signal transduction in the nervous system: an update","volume":"58","author":"Fisher","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB64","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/jnr.490410614","article-title":"Distribution of erb-B2, erb-B3, and erb-B4 in the developing avian nervous system","volume":"41","author":"Francoeur","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB65","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0092-8674(95)90534-0","article-title":"The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase","volume":"81","author":"Franke","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB66","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0092-8674(93)90734-8","article-title":"Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter","volume":"74","author":"Fu","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB67","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/363088a0","article-title":"Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras","volume":"363","author":"Gale","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB68","doi-asserted-by":"crossref","first-page":"20242","DOI":"10.1074\/jbc.270.35.20242","article-title":"Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation","volume":"270","author":"Galisteo","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB69","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0006-8993(88)91369-8","article-title":"Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization","volume":"438","author":"G\u00f3mez-Pinilla","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB70","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1432-1033.1990.tb19384.x","article-title":"Microtubule-associated protein et al. Microtubule-associated protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells","volume":"193","author":"Gotoh","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB71","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1128\/MCB.15.3.1182","article-title":"Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling","volume":"15","author":"Graus-Porta","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB72","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/303722a0","article-title":"Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor","volume":"303","author":"Gray","year":"1983","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB73","first-page":"2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Greene","year":"1976"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB74","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/257325a0","article-title":"Isolation and structure of urogastrone and its relationship to epidermal growth factor","volume":"257","author":"Gregory","year":"1975","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB75","doi-asserted-by":"crossref","first-page":"13050","DOI":"10.1016\/S0021-9258(19)38617-X","article-title":"Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase","volume":"268","author":"Griswold-Prenner","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB76","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/08977199409010997","article-title":"Structure-function r","volume":"11","author":"Groenen","year":"1994","journal-title":"Growth Factors"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB77","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-3806(83)90223-7","article-title":"Epidermal growth factor (EGF) stimulation of cultured brain cells. II. Incrased production of extracellular soluble proteins","volume":"313","author":"Guentert-Lauber","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB78","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000112297","article-title":"Responsiveness of astrocytes in serum-free aggregate cultures to epidermal growth factor: dependence on the cell cycle and the epidermal growth factor concentration","volume":"7","author":"Guentert-Lauber","year":"1985","journal-title":"Dev. Neurosci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB79","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0006-291X(88)90754-1","article-title":"Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras ocogene","volume":"150","author":"Guerrero","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB80","first-page":"119","article-title":"Dissecting the mode of action of a neuronal growth factor","volume":"165","author":"Halegoua","year":"1991","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB81","first-page":"302","article-title":"Cell transformation by the epidermal growth factor receptor and v-erbB","volume":"3","author":"Hayman","year":"1991","journal-title":"Cancer Cells"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB82","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0896-6273(92)90241-5","article-title":"Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation","volume":"9","author":"Hempstead","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB83","first-page":"7691","article-title":"Epidermal growth factor stimulates substrate-selective protein-tyrosine-phosphatase activity","volume":"90","author":"Hern\u00e1ndez-Sotomayor","year":"1993"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB84","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1840698","article-title":"A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF","volume":"251","author":"Higashiyama","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB85","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0092-8674(92)90166-A","article-title":"Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit","volume":"70","author":"Hiles","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB86","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF01960230","article-title":"Influence of age on epidermal growth factor receptor level in the rat brain","volume":"44","author":"Hiramatsu","year":"1988","journal-title":"Experientia"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB87","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/379560a0","article-title":"A Grb2-associated docking protein in EGF- and insulin-receptor signalling","volume":"379","author":"Holgado-Madruga","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB88","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.256.5060.1205","article-title":"Identification of heregulin, a specific activator of p185erbB2","volume":"256","author":"Holmes","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB89","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0165-3806(83)90222-5","article-title":"Epidermal growth factor (EGF) stimulation of cultured brain cells. I. Enhancement of the developmental increase in glial enzymatic activity","volume":"313","author":"Honegger","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB90","first-page":"981","article-title":"Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors","volume":"12","author":"Hu","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB91","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1471-4159.1996.66010124.x","article-title":"Nerve growth factor, epidermal growth factor, and insulin differentially potentiate ATP-induced [Ca2+]i rise and dopamine secretion in PC12 cells","volume":"66","author":"Huang","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB92","first-page":"2420","article-title":"Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function","volume":"13","author":"Huang","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB93","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.88.1.189","article-title":"Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor","volume":"88","author":"Huff","year":"1981","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB94","first-page":"165","article-title":"The biology of erbB-2\/neu\/HER-2 and its role in cancer","volume":"1198","author":"Hynes","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB95","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0968-0004(94)90026-4","article-title":"Signaling by the cytokine receptor superfamily: JAKs and STATs","volume":"19","author":"Ihle","year":"1994","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB96","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/cne.901940302","article-title":"Temporal and spatial patterns of Purkinje cell formation in the mouse cerebellum","volume":"194","author":"Inouye","year":"1980","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB97","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0168-0102(91)90071-6","article-title":"Epidermal growth factor and basic fibroblast growth factor promote the generation of long-term potentiation in the dentate gyrus of anaesthetized rats","volume":"12","author":"Ishiyama","year":"1991","journal-title":"Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB98","first-page":"227","article-title":"Schwann cell lineage-specific neu (erbB-2) gene expression in the developing rat nervous system","volume":"4","author":"Jin","year":"1993","journal-title":"Cell Growth Differ."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB99","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000181108","article-title":"Human urinary epidermal growth factor: effects of age, sex and pregnancy","volume":"31","author":"Kasai","year":"1989","journal-title":"Horm. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB100","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0169-328X(92)90241-3","article-title":"Comparison between epidermal growth factor, transforming growth factor-\u03b1 and EGF receptor levels in regions of adult rat brain","volume":"16","author":"Kaser","year":"1992","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB101","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0306-4522(92)90383-D","article-title":"Epidermal growth factor affects both glia and cholinergic neurons in septal cell cultures","volume":"50","author":"Kenigsberg","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB102","first-page":"734","article-title":"Identification of glial cell types in involved in mediating epidermal growth factor's effects on septal cholinergic neurons","volume":"41","author":"Kenigsberg","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB103","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0092-8674(91)90461-7","article-title":"PDGF stimulation of inositol phospholipid hydrolysis requires PLC-\u03b3 1 phosphorylation on tyrosine residues 783 and 1254","volume":"65","author":"Kim","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB104","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/j.1460-2075.1988.tb02991.x","article-title":"Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3","volume":"7","author":"King","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB105","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1016\/S0021-9258(18)67492-7","article-title":"Effects of protein kinase C activation after epidermal growth factor binding on epidermal growth factor receptor phosphorylation","volume":"261","author":"King","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB106","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/jnr.490250308","article-title":"Modification of anoxic neuronal injury by human recombinant epidermal growth factor and its possible mechanism","volume":"25","author":"Kinoshita","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB107","first-page":"1451","article-title":"The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor","volume":"12","author":"Klippel","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB108","first-page":"8498","article-title":"Stage- and tissue-specific expression of the neu oncogene in rat development","volume":"84","author":"Kokai","year":"1987"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB109","first-page":"223","article-title":"Is breast-milk epidermal growth factor biologically active in the suckling?","volume":"5","author":"Koldovsky","year":"1989","journal-title":"Nutrition"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB110","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-8993(90)91608-J","article-title":"Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro","volume":"535","author":"Kornblum","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB111","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0306-4522(95)00392-V","article-title":"A subpopulation of striatal GABAergic neurons expresses the epidermal growth factor receptor","volume":"69","author":"Kornblum","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB112","first-page":"9193","article-title":"Isolation and characterization of ERBB3, a third member of the ERBB\/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors","volume":"86","author":"Kraus","year":"1989"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB113","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1016\/S0021-9258(19)84934-7","article-title":"Transforming growth factor-\u03b1 in the mammalian brain. Immunohistochemical detection in neurons and characterization of its mRNA","volume":"264","author":"Kudlow","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB114","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.272.5264.1008","article-title":"Enhanced degradation of EGF receptors by a sorting nexin, SNX1","volume":"272","author":"Kurten","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB115","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0006-8993(90)90003-T","article-title":"High oxygen atmosphere for neuronal cell culture with nerve growth factor. I. Primary culture of basal forebrain cholinergic neurons from fetal and postnatal rats","volume":"536","author":"Kushima","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB116","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1471-4159.1986.tb00621.x","article-title":"Epidermal growth factor in synaptosomal fractions of mouse cerebral cortex","volume":"46","author":"Lakshmanan","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB117","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1083\/jcb.129.1.47","article-title":"Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase","volume":"129","author":"Lamaze","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB118","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1523\/JNEUROSCI.12-05-01688.1992","article-title":"Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-\u03b1 mRNA in mouse brain by quantitative nuclease protection assay","volume":"12","author":"Lazar","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB119","doi-asserted-by":"crossref","first-page":"21478","DOI":"10.1016\/S0021-9258(20)80562-6","article-title":"Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor","volume":"268","author":"Lechleider","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB120","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/nar\/18.4.1048","article-title":"Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3","volume":"18","author":"Lehmann","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB121","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0968-0004(94)90130-9","article-title":"Regulation of signal transduction and signal diversity by receptor oligomerization","volume":"19","author":"Lemmon","year":"1994","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB122","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00210517","article-title":"Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar cultures","volume":"220","author":"Leutz","year":"1981","journal-title":"Cell Tissue Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB123","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-3940(82)90293-2","article-title":"Cell type-specificity of epidermal growth factor (EGF) binding in primary cultures of early postnatal mouse cerebellum","volume":"30","author":"Leutz","year":"1982","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB124","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/363085a0","article-title":"Guanine-nucleotide-releasing factor hSOs 1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling","volume":"363","author":"Li","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB125","first-page":"5824","article-title":"The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors","volume":"12","author":"Li","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB126","first-page":"753","article-title":"Expression of epidermal growth factor receptors in human brain tumors","volume":"44","author":"Libermann","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB127","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0092-8674(86)90006-1","article-title":"Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms","volume":"44","author":"Lin","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB128","first-page":"2511","article-title":"The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains","volume":"11","author":"Liu","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB129","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0092-8674(85)90208-9","article-title":"The Drosophila EGF receptor gene homolog: conservation of both hormone binding and kinase domains","volume":"40","author":"Livneh","year":"1985","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB130","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0092-8674(92)90167-B","article-title":"The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling","volume":"70","author":"Lowenstein","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB131","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0896-6273(93)90319-M","article-title":"Peptide growth factor control of olfactory neurogenesis and neuron survival in vitro: roles of EGF and TGF-\u03b2 s","volume":"10","author":"Mahanthappa","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB132","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1523\/JNEUROSCI.13-07-03034.1993","article-title":"Peptide growth factors protect against ischemia in culture by preventing nitric oxide toxicity","volume":"13","author":"Maiese","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB133","first-page":"287","article-title":"C-erbB and the epidermal growth-factor receptor: a molecule with dual identity","volume":"948","author":"Maihle","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB134","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/362312a0","article-title":"Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system","volume":"362","author":"Marchionni","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB135","first-page":"435","article-title":"Tyrosine kinase activity is essential for the association of phospholipase C-\u03b3 with the epidermal growth factor receptor","volume":"10","author":"Margolis","year":"1990","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB136","first-page":"4684","article-title":"Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor","volume":"80","author":"Marquardt","year":"1983"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB137","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.6320373","article-title":"Rat transforming growth factor type 1: structure and relation to epidermal growth factor","volume":"223","author":"Marquardt","year":"1984","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB138","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB139","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/hep.1840090122","article-title":"Biological effects of epidermal growth factor, with emphasis on the gastrointestinal tract and liver: an update","volume":"9","author":"Marti","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB140","first-page":"9015","article-title":"Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries","volume":"89","author":"Matuoka","year":"1992"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB141","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0006-8993(94)91372-2","article-title":"Localization and characterization of epidermal growth-factor receptors in the developing rat medial septal area in culture","volume":"656","author":"Mazzoni","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB142","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-8993(95)01225-7","article-title":"Transforming growth factor differentially affects GABAergic and cholinergic neurons in rat medial septal cell cultures","volume":"707","author":"Mazzoni","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB143","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/0092-8674(89)90048-2","article-title":"Phospholipase C-\u03b3 is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro","volume":"57","author":"Meisenhelder","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB144","doi-asserted-by":"crossref","first-page":"21239","DOI":"10.1016\/S0021-9258(17)31954-3","article-title":"Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin","volume":"269","author":"Milarski","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB145","first-page":"8622","article-title":"Src homology region 2 domains direct protein-protein interactions in signal transduction","volume":"87","author":"Moran","year":"1990"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB146","series-title":"Epidermal growth factor: structure, expression, and function in the central nervous system. Neurotrophic factors","first-page":"339","author":"Morrison","year":"1993"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB147","first-page":"7537","article-title":"Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture","volume":"83","author":"Morrison","year":"1986"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB148","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.3498986","article-title":"Trophic stimulation of cultured neurons from neonatal rat brain by epidermal growth factor","volume":"238","author":"Morrison","year":"1987","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB149","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jnr.490210111","article-title":"Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons","volume":"21","author":"Morrison","year":"1988","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB150","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/312716a0","article-title":"Induction of c-fos gene and protein by growth factors precedes activation of c-myc","volume":"312","author":"M\u00fcller","year":"1984","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB151","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0304-3940(92)90136-U","article-title":"Epidermal growth factor-induced survival and proliferation of neuronal precursor cells from embryonic rat mesencephalon","volume":"135","author":"Mytilineou","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB152","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0014-5793(93)81169-Z","article-title":"Epidermal growth factor and transforming growth factor- can induce neuronal differentiation of rat pheochromocytoma C12 cells under particular culture conditions","volume":"315","author":"Nakafuku","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB153","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0021-9258(18)54107-7","article-title":"Activation of the \u03b6 isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate","volume":"268","author":"Nakanishi","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB154","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1074\/jbc.270.11.6320","article-title":"Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism","volume":"270","author":"Nesterov","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB155","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0304-3940(88)90693-3","article-title":"Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury","volume":"91","author":"Nieto-Sampedro","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB156","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0968-0004(93)90019-J","article-title":"The MAP kinase cascade is essential for diverse signal transduction pathways","volume":"18","author":"Nishida","year":"1993","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB157","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.1411571","article-title":"Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C","volume":"258","author":"Nishizuka","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB158","doi-asserted-by":"crossref","first-page":"22963","DOI":"10.1016\/S0021-9258(19)49410-6","article-title":"Identification of Trk binding sites for SHC and phosphatidylinositol 3\u2032-kinase and formation of a multimeric signaling complex","volume":"268","author":"Obermeier","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB159","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1074\/jbc.270.9.4325","article-title":"Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain","volume":"270","author":"Opresko","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0092-8674(91)90411-Q","article-title":"Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T\/pp60c-src complexes, and P13-kinase","volume":"65","author":"Otsu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB161","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(92)90855-4","article-title":"Protection from 1-methyl-4-phenylpyridinium (MPP +) toxicity and stimulation of regrowth of MPP(+)-damaged dopaminergic fibers by treatment of mesencephalic cultures with EGF and basic FGF","volume":"599","author":"Park","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB162","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/373573a0","article-title":"Protein modules and signalling networks","volume":"373","author":"Pawson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB163","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0092-8674(92)90131-U","article-title":"Isolation of the neu\/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells","volume":"69","author":"Peles","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB164","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/j.1460-2075.1993.tb05737.x","article-title":"Cell-type specific interaction of Neu differentiation factor (NDF\/heregulin) with Neu\/HER-2 suggests complex ligand-receptor relationships","volume":"12","author":"Peles","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(92)90536-L","article-title":"A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction","volume":"70","author":"Pelicci","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB166","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/mds.870060403","article-title":"Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats","volume":"6","author":"Pezzoli","year":"1991","journal-title":"Mov. Disord."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB167","first-page":"9387","article-title":"Brain neurons and glial cells express Neu differentiation factor\/heregulin: a survival factor for astrocytes","volume":"91","author":"Pinkas-Kramarski","year":"1994"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB168","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0196-9781(91)90115-6","article-title":"Epidermal growth factor and the nervous system","volume":"12","author":"Plata-Salam\u00e1n","year":"1991","journal-title":"Peptides"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB169","first-page":"1969","article-title":"The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity","volume":"10","author":"Plowman","year":"1990","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB170","first-page":"4905","article-title":"Molecular cloning and expression of an additional epidermal growth factor receptor-related gene","volume":"87","author":"Plowman","year":"1990"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB171","first-page":"1746","article-title":"Ligand-specific activation of HER4\/p180erbB4, a fourth member of the epidermal growth factor receptor family","volume":"90","author":"Plowman","year":"1993"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB172","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/366473a0","article-title":"Heregulin induces tyrosine phosphorylation of HER4\/p180erbB4","volume":"366","author":"Plowman","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB173","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0896-6273(92)90033-A","article-title":"PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity","volume":"9","author":"Qui","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB174","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/syn.890020307","article-title":"Visualization of growth factor receptor sites in rat forebrain","volume":"2","author":"Quirion","year":"1988","journal-title":"Synapse"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB175","first-page":"2203","article-title":"SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells","volume":"13","author":"Rabin","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB176","first-page":"9121","article-title":"Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells","volume":"89","author":"Raffioni","year":"1992"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB177","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/313228a0","article-title":"Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues","volume":"313","author":"Rall","year":"1985","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB178","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1523\/JNEUROSCI.12-11-04565.1992","article-title":"A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes","volume":"12","author":"Reynolds","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB179","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.2541501","article-title":"Studies of inositol phospholipid-specific phospholipase C","volume":"244","author":"Rhee","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB180","first-page":"1113","article-title":"Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels","volume":"93","author":"Rosen","year":"1996"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB181","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/363083a0","article-title":"The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1","volume":"363","author":"Rozakis-Adcock","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB182","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.8378774","article-title":"Induction by EGF and interferon-of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei","volume":"261","author":"Ruff-Jamison","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB183","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj2900609","article-title":"Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex","volume":"290","author":"Ruiz-Larrea","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB184","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.8397445","article-title":"A common nuclear signal transduction pathway activated by growth factor and cytokine receptors","volume":"261","author":"Sadowski","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB185","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jnr.490420204","article-title":"Epidermal growth factor (EGF), transforming growth factor-\u03b1 (TGF-\u03b1), and basic fibroblast growth factor (bFGF) differentially influence neural precursor cells of mouse embryonic mesencephalon","volume":"42","author":"Santa-Olalla","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB186","doi-asserted-by":"crossref","first-page":"7612","DOI":"10.1016\/S0021-9258(19)44569-9","article-title":"The primary structure of epidermal growth factor","volume":"247","author":"Savage","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB187","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1016\/S0021-9258(19)43242-0","article-title":"Epidermal growth factor. Location of disulfide bonds","volume":"248","author":"Savage","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB188","doi-asserted-by":"crossref","first-page":"10447","DOI":"10.1016\/S0021-9258(18)81641-6","article-title":"Epidermal growth factor immunoreactive material in the rat brain. Localization and identification of multiple species","volume":"264","author":"Schaudies","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB189","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0968-0004(93)90031-H","article-title":"How receptor tyrosine kinases activate Ras","volume":"18","author":"Schlessinger","year":"1993","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB190","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0959-437X(94)90087-6","article-title":"SH2\/SH3 signaling proteins","volume":"4","author":"Schlessinger","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB191","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0896-6273(92)90177-F","article-title":"Growth factor signaling by receptor tyrosine kinases","volume":"9","author":"Schlessinger","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB192","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1126\/science.6602382","article-title":"Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins","volume":"221","author":"Scott","year":"1983","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB193","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1111\/j.1471-4159.1993.tb13403.x","article-title":"Cellular localization of transforming growth factor-alpha mRNA in rat forebrain","volume":"60","author":"Seroogy","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB194","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(94)01300-7","article-title":"Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA","volume":"670","author":"Seroogy","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB195","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1126\/science.8456283","article-title":"Betacellulin: a mitogen from pancreatic \u03b2 cell tumors","volume":"259","author":"Shing","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB196","first-page":"6528","article-title":"Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7","volume":"85","author":"Shoyab","year":"1988"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB197","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.2466334","article-title":"Structure and function of human amphiregulin: a member of the epidermal growth factor family","volume":"243","author":"Shoyab","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB198","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/366580a0","article-title":"Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins","volume":"366","author":"Shuai","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB199","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jnr.490080233","article-title":"Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system","volume":"8","author":"Simpson","year":"1982","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB200","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(91)90410-Z","article-title":"Cloning of P13 kinase-associated p85 utilizing a novel method for expression\/cloning of target proteins for receptor tyrosine kinases","volume":"65","author":"Skolnik","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB201","doi-asserted-by":"crossref","first-page":"14661","DOI":"10.1016\/S0021-9258(17)36676-0","article-title":"Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin","volume":"269","author":"Sliwkowski","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB202","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01869927","article-title":"Biosynthesis and metabolic degradation of receptors for epidermal growth factor","volume":"90","author":"Soderquist","year":"1986","journal-title":"J. Membr. Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB203","doi-asserted-by":"crossref","first-page":"17472","DOI":"10.1016\/S0021-9258(18)41950-3","article-title":"Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase","volume":"267","author":"Soltoff","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB204","first-page":"3550","article-title":"ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor","volume":"14","author":"Soltoff","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB205","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1074\/jbc.271.1.563","article-title":"p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells","volume":"271","author":"Soltoff","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB206","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1074\/jbc.270.2.619","article-title":"Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2","volume":"270","author":"Sorkin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB207","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.8342026","article-title":"Interaction of activated EGF receptors with coated pit adaptins","volume":"261","author":"Sorkin","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB208","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/bies.950150603","article-title":"Endocytosis of growth factor receptors","volume":"15","author":"Sorkin","year":"1993","journal-title":"Bioessays"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB209","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0968-0004(94)90134-1","article-title":"The coordinated action of protein tyrosine phosphatases and kinases in cell signaling","volume":"19","author":"Sun","year":"1994","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB210","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1016\/S0021-9258(19)44847-3","article-title":"Epidermal growth factor. Physical and chemical properties","volume":"247","author":"Taylor","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB211","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0006-8993(89)90380-6","article-title":"Influence of epidermal growth factor on long-term potentiation in the hippocampal slice","volume":"484","author":"Terlau","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB212","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/264026a0","article-title":"Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells","volume":"264","author":"Todaro","year":"1976","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB213","doi-asserted-by":"crossref","first-page":"32358","DOI":"10.1016\/S0021-9258(18)31643-0","article-title":"Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3","volume":"269","author":"Toker","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB214","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1126\/science.3201259","article-title":"Molecular cloning of two types of GAP complementary DNA from human placenta","volume":"242","author":"Trahey","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB215","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj2880351","article-title":"Sustained activation of the mitogen-activated protein (MAP)_kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor","volume":"288","author":"Traverse","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB216","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0960-9822(00)00154-8","article-title":"EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptro","volume":"4","author":"Traverse","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB217","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0959-437X(94)90097-3","article-title":"Ternary complex factors: growth factor regulated transcriptional activators","volume":"4","author":"Treisman","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB218","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0006-8993(93)91187-W","article-title":"Localization of immunoreactive epidermal growth factor receptor in neonatal and adult rat hippocampus","volume":"631","author":"Tucker","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB219","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.cb.10.110194.001343","article-title":"Receptor protein-tyrosine kinases and their signal transduction pathways","volume":"10","author":"van der Geer","year":"1994","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB220","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/335090a0","article-title":"Cloning of bovine GAP and its interaction with oncogenic ras p21","volume":"335","author":"Vogel","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB221","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0165-3806(88)90009-0","article-title":"Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells","volume":"468","author":"Walicke","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB222","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0092-8674(92)90456-M","article-title":"Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit","volume":"69","author":"Wen","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB223","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/36.1.3275713","article-title":"Localization of immunoreactive epidermal growth factor receptors in human nervous system","volume":"36","author":"Werner","year":"1988","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB224","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0006-291X(76)90522-2","article-title":"Density dependent proliferation of human glia cells stimulated by epidermal growth factor","volume":"69","author":"Westermark","year":"1976","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB225","first-page":"6899","article-title":"Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification","volume":"84","author":"Wong","year":"1987"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB226","first-page":"5016","article-title":"The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction","volume":"90","author":"Wood","year":"1993"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB227","doi-asserted-by":"crossref","first-page":"21244","DOI":"10.1016\/S0021-9258(17)31955-5","article-title":"Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction","volume":"269","author":"Xiao","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB228","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0006-8993(94)91190-8","article-title":"Sustained tyrosine phosphorylation of p140trkA in PC12h-R cells responding rapidly to NGF","volume":"661","author":"Yamada","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB229","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1111\/j.1460-9568.1995.tb00635.x","article-title":"Epidermal growth factor prevents oxygen-triggered apoptosis and induces sustained signalling in cultured rat cerebral cortical neurons","volume":"7","author":"Yamada","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB230","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1097-4547(19960201)43:3<355::AID-JNR10>3.0.CO;2-4","article-title":"PC12h-R cell, a subclone of PC12 cells, shows EGF-induced neuronal differentiation and sustained signalling","volume":"43","author":"Yamada","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB231","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/BF02532305","article-title":"EGF-induced sustained tyrosine phosphorylation and decreased rate of down-regulation of EGF receptor in PC12h-R cells which show neuronal differentiation in response to EGF","volume":"21","author":"Yamada","year":"1996","journal-title":"Neurochem. Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB232","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1126\/science.7701324","article-title":"Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor","volume":"267","author":"Yao","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB233","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0165-3806(94)90027-2","article-title":"Septal neuron cholinergic and GABAergic functions: differential regulation by basic fibroblast growth factor and epidermal growth factor","volume":"78","author":"Yokoyama","year":"1994","journal-title":"Dev. Brain Res."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB234","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/346754a0","article-title":"Suppression of c-ras transformation by GTPase-activating protein","volume":"346","author":"Zhang","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0301-0082(96)00046-9_BIB235","doi-asserted-by":"crossref","first-page":"16116","DOI":"10.1016\/S0021-9258(19)85396-6","article-title":"Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr\/Tyr protein phosphatase","volume":"268","author":"Zheng","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0301-0082(96)00046-9_BIB236","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.8140422","article-title":"Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6","volume":"264","author":"Zhong","year":"1994","journal-title":"Science"}],"container-title":["Progress in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301008296000469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301008296000469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:51:30Z","timestamp":1759549890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301008296000469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":236,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["S0301008296000469"],"URL":"https:\/\/doi.org\/10.1016\/s0301-0082(96)00046-9","relation":{},"ISSN":["0301-0082"],"issn-type":[{"value":"0301-0082","type":"print"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The neurotrophic action and signalling of epidermal growth factor","name":"articletitle","label":"Article Title"},{"value":"Progress in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0301-0082(96)00046-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}