{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:46:20Z","timestamp":1762159580523,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":7859,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1016\/s0301-472x(00)00543-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:16:42Z","timestamp":1027606602000},"page":"1451-1459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Autonomous behavior of hematopoietic stem cells"],"prefix":"10.1016","volume":"28","author":[{"given":"Leonie M","family":"Kamminga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Akkerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Weersing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albertina","family":"Ausema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Dontje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Van Zant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"de Haan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0301-472X(00)00543-9_BIB1","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","article-title":"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization","volume":"84","author":"Lieschke","year":"1994","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB2","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1126\/science.8073287","article-title":"Thrombocytopenia in c-mpl-deficient mice","volume":"265","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB3","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.1073\/pnas.93.17.9126","article-title":"Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor","volume":"93","author":"Kieran","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB4","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1182\/blood.V89.5.1543","article-title":"Mouse strain\u2013dependent changes in frequency and proliferation of hematopoietic stem cells during aging","volume":"89","author":"de Haan","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB5","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1182\/blood.V89.8.2736","article-title":"Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor","volume":"89","author":"Roberts","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1084\/jem.186.4.529","article-title":"Intrinsic and extrinsic control of hemopoietic stem cell numbers","volume":"186","author":"de Haan","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB7","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/stem.5530130508","article-title":"Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy","volume":"13","author":"Roberts","year":"1995","journal-title":"Stem Cells (Dayt)"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB8","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nm0296-198","article-title":"Presence of hematopoietic stem cells in the adult liver (see comments)","volume":"2","author":"Taniguchi","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB9","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1126\/science.283.5401.534","article-title":"Turning brain into blood","volume":"283","author":"Bjornson","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB10","doi-asserted-by":"crossref","first-page":"14482","DOI":"10.1073\/pnas.96.25.14482","article-title":"Hematopoietic potential of stem cells isolated from murine skeletal muscle (see comments)","volume":"96","author":"Jackson","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB11","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1182\/blood.V85.10.2654.bloodjournal85102654","article-title":"Development of human T and natural killer cells","volume":"85","author":"Spits","year":"1995","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0092-8674(83)90096-X","article-title":"Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide","volume":"35","author":"Van Zant","year":"1983","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1096\/fasebj.13.6.707","article-title":"Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span","volume":"13","author":"De Haan","year":"1999","journal-title":"Faseb J"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB14","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1084\/jem.183.3.1141","article-title":"Genetic control of the frequency of hematopoietic stem cells in mice","volume":"183","author":"Muller-Sieburg","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB15","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1182\/blood.V95.5.1872.005k26_1872_1874","article-title":"Progenitor cell mobilization by granulocyte colony-stimulating factor controlled by loci on chromosomes 2 and 11","volume":"95","author":"Hasegawa","year":"2000","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB16","doi-asserted-by":"crossref","first-page":"12804","DOI":"10.1073\/pnas.96.22.12804","article-title":"Autocrine production and action of IL-3 and granulocyte colony- stimulating factor in chronic myeloid leukemia","volume":"96","author":"Jiang","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB17","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1182\/blood.V93.10.3294.410k07_3294_3301","article-title":"Dynamic changes in mouse hematopoietic stem cell numbers during aging","volume":"93","author":"de Haan","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB18","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/S0301-472X(99)00112-5","article-title":"A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans","volume":"27","author":"Molineux","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB19","first-page":"627","article-title":"Serial bone marrow sampling for long-term follow up of human hematopoiesis in NOD\/SCID mice","volume":"26","author":"Verlinden","year":"1998","journal-title":"Exp Hematol"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB20","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1182\/blood.V78.10.2527.2527","article-title":"Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse","volume":"78","author":"Ploemacher","year":"1991","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB21","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1016\/0022-1759(82)90269-1","article-title":"The evaluation of limiting dilution assays","volume":"49","author":"Fazekas de St","year":"1982","journal-title":"J Immunol Methods"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB22","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1182\/blood.V96.4.1374","article-title":"Distinct functional properties of highly purified hematopoietic stem cells from mouse strains differing in stem cell number","volume":"96","author":"de Haan","year":"2000","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB23","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.171.5.1547","article-title":"Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice","volume":"171","author":"Van Zant","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0301-472X(98)00051-4","article-title":"Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein","volume":"27","author":"Bowen","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB25","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1182\/blood.V93.10.3294.410k07_3294_3301","article-title":"Dynamic changes in mouse hematopoietic stem cell numbers during aging","volume":"93","author":"de Haan","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB26","first-page":"470","article-title":"Stem cell quiescence\/activation is reversible by serial transplantation and is independent of stromal cell genotype in mouse aggregation chimeras","volume":"20","author":"Van Zant","year":"1992","journal-title":"Exp Hematol"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB27","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1182\/blood.V95.7.2446","article-title":"Genetic control of hematopoietic stem cell frequency in mice is mostly cell autonomous","volume":"95","author":"Muller-Sieburg","year":"2000","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB28","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1101\/gad.9.14.1753","article-title":"Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo","volume":"9","author":"Sauvageau","year":"1995","journal-title":"Gene Develop"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.191.2.253","article-title":"The role of apoptosis in the regulation of hematopoietic stem cells","volume":"191","author":"Domen","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB30","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1126\/science.287.5459.1804","article-title":"Hematopoietic stem cell quiescence maintained by p21cip1\/waf1","volume":"287","author":"Cheng","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0301-472X(00)00543-9_BIB31","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.leu.2401735","article-title":"Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice","volume":"14","author":"Roberts","year":"2000","journal-title":"Leukemia"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X00005439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X00005439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:13:29Z","timestamp":1759565609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X00005439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["S0301472X00005439"],"URL":"https:\/\/doi.org\/10.1016\/s0301-472x(00)00543-9","relation":{},"ISSN":["0301-472X"],"issn-type":[{"type":"print","value":"0301-472X"}],"subject":[],"published":{"date-parts":[[2000,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autonomous behavior of hematopoietic stem cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0301-472X(00)00543-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}