{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:44:13Z","timestamp":1761630253335,"version":"build-2065373602"},"reference-count":73,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":8559,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[1999,1]]},"DOI":"10.1016\/s0301-472x(98)00015-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T13:52:27Z","timestamp":1027605147000},"page":"75-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Retroviral transduction of enriched hematopoietic stem cells allows lifelong Bcl-2 expression in multiple lineages but does not perturb hematopoiesis"],"prefix":"10.1016","volume":"27","author":[{"given":"Karin M","family":"Innes","sequence":"first","affiliation":[]},{"given":"Stephen J","family":"Szilvassy","sequence":"additional","affiliation":[]},{"given":"Heather E","family":"Davidson","sequence":"additional","affiliation":[]},{"given":"Leonie","family":"Gibson","sequence":"additional","affiliation":[]},{"given":"Jerry M","family":"Adams","sequence":"additional","affiliation":[]},{"given":"Suzanne","family":"Cory","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0301-472X(98)00015-0_BIB1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/stem.5530120604","article-title":"Gene transfer into hematopoietic progenitor and stem cells","volume":"12","author":"Dunbar","year":"1994","journal-title":"Stem Cells"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB2","first-page":"141","article-title":"Gene transfer into hematopoietic stem cells","volume":"20","author":"Nienhuis","year":"1994","journal-title":"Blood Cells"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/stem.150162","article-title":"Retroviral stem cell gene therapy","volume":"15","author":"Havenga","year":"1997","journal-title":"Stem Cells"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB4","first-page":"S53","article-title":"Construction of retroviral vectors for targeted delivery and expression of therapeutic genes","volume":"9","author":"Salmons","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB5","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.1073\/pnas.87.19.7433","article-title":"Resting and activated subsets of mouse multipotent hematopoietic stem cells","volume":"87","author":"Spangrude","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB6","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1182\/blood.V78.5.1237.1237","article-title":"Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil","volume":"78","author":"Harrison","year":"1991","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB7","first-page":"4239","article-title":"Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection","volume":"10","author":"Miller","year":"1990","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB8","doi-asserted-by":"crossref","first-page":"8736","DOI":"10.1073\/pnas.87.22.8736","article-title":"Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy","volume":"87","author":"Szilvassy","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB9","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1182\/blood.V81.9.2310.2310","article-title":"Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow","volume":"81","author":"Szilvassy","year":"1993","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1182\/blood.V84.1.74.74","article-title":"Efficient retroviral gene transfer to purified long-term repopulating hematopoietic stem cells","volume":"84","author":"Szilvassy","year":"1994","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB11","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1182\/blood.V71.6.1738.1738","article-title":"Restriction of expression of an integrated recombinant retrovirus in primary but not immortalized murine hematopoietic stem cells","volume":"71","author":"Williams","year":"1988","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB12","first-page":"229","article-title":"Expression of genes transferred to haemopoietic stem cells by recombinant retroviruses","volume":"4","author":"Bowtell","year":"1987","journal-title":"Mol Biol Med"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB13","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.6610211","article-title":"Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation","volume":"224","author":"Tsujimoto","year":"1984","journal-title":"Science"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.iy.13.040195.002501","article-title":"Regulation of lymphocyte survival by the BCL-2 gene family","volume":"13","author":"Cory","year":"1995","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1097-4644(19960101)60:1<12::AID-JCB3>3.0.CO;2-6","article-title":"BCL-2, a novel regulator of apoptosis","volume":"60","author":"Park","year":"1996","journal-title":"J Cell Biochem"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB16","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm0697-614","article-title":"The proto-oncogene Bcl-2 and its role in regulating apoptosis","volume":"3","author":"Kroemer","year":"1997","journal-title":"Nature Med"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB17","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/335440a0","article-title":"Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells","volume":"335","author":"Vaux","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1097-4644(19960101)60:1<23::AID-JCB5>3.0.CO;2-5","article-title":"BCL-2 family proteins","volume":"60","author":"Reed","year":"1996","journal-title":"J Cell Biochem"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB19","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1073\/pnas.88.16.6961","article-title":"BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death","volume":"88","author":"Hockenbery","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB20","first-page":"225","article-title":"Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation","volume":"137","author":"Pezzella","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB21","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.4049\/jimmunol.151.5.2546","article-title":"Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes","volume":"151","author":"Veis","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB22","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/j.1460-2075.1994.tb06307.x","article-title":"Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes","volume":"13","author":"Merino","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB23","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1182\/blood.V79.5.1291.1291","article-title":"bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells","volume":"79","author":"Delia","year":"1992","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB24","first-page":"1191","article-title":"Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia","volume":"9","author":"Porwit-MacDonald","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(89)90174-8","article-title":"bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation","volume":"57","author":"McDonnell","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB26","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1073\/pnas.88.19.8661","article-title":"Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease","volume":"88","author":"Strasser","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB27","doi-asserted-by":"crossref","first-page":"11376","DOI":"10.1073\/pnas.89.23.11376","article-title":"Differential effects of Bcl-2 on T and B cells in transgenic mice","volume":"89","author":"Katsumata","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/349254a0","article-title":"Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)","volume":"349","author":"McDonnell","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB29","first-page":"1","article-title":"E\u03bc-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells","volume":"8","author":"Strasser","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(91)90361-2","article-title":"bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes","volume":"67","author":"Sentman","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0092-8674(91)90362-3","article-title":"Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship","volume":"67","author":"Strasser","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB32","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1182\/blood.V84.2.440.440","article-title":"Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes","volume":"84","author":"Park","year":"1994","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB33","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1182\/blood.V83.8.2261.2261","article-title":"Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells","volume":"83","author":"Naumovski","year":"1994","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB34","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.179.3.1047","article-title":"bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages","volume":"179","author":"Lagasse","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB35","first-page":"175","article-title":"Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice","volume":"166","author":"Strasser","year":"1990","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB36","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1073\/pnas.87.23.9202","article-title":"Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells","volume":"87","author":"Grez","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB37","first-page":"980","article-title":"Improved retroviral vectors for gene transfer and expression","volume":"7","author":"Miller","year":"1989","journal-title":"Biotechniques"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB38","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1128\/jvi.61.5.1647-1650.1987","article-title":"Effect of internal viral sequences on the utility of retroviral vectors","volume":"61","author":"Armentano","year":"1987","journal-title":"J Virol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB39","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0092-8674(84)90440-9","article-title":"Construction and application of a highly transmissible murine retrovirus shuttle vector","volume":"37","author":"Cepko","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB40","first-page":"286","article-title":"Viral transfer, transcription, and rescue of a selectable myeloproliferative sarcoma virus in embryonal cell lines","volume":"6","author":"Seliger","year":"1986","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB41","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1093\/nar\/18.12.3587","article-title":"Advanced mammalian gene transfer","volume":"18","author":"Morgenstern","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB42","first-page":"466","article-title":"SR\u03b1 promoter","volume":"8","author":"Takebe","year":"1988","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0092-8674(86)90362-4","article-title":"Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2\/immunoglobulin transcript resulting from the t(14;18) translocation","volume":"47","author":"Cleary","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB44","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0076-6879(92)16035-I","article-title":"pac genes as efficient dominant marker and reporter gene in mammalian cells","volume":"216","author":"De La Luna","year":"1992","journal-title":"Methods Enzymol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB45","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1128\/jvi.65.7.3887-3890.1991","article-title":"Production of high-titer helper virus-free retroviral vectors by cocultivation of packaging cells with different host ranges","volume":"65","author":"Lynch","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB46","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1084\/jem.150.3.580","article-title":"Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors","volume":"150","author":"Unkeless","year":"1979","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB47","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.1002\/j.1460-2075.1995.tb00304.x","article-title":"Bcl-2 and Fas\/APO-1 regulate distinct pathways to lymphocyte apoptosis","volume":"14","author":"Strasser","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB48","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0092-8674(90)90262-D","article-title":"A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells","volume":"62","author":"Ikuta","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.1041000102","article-title":"Isolation and surface labeling of murine polymorphonuclear neutrophils","volume":"100","author":"Watt","year":"1979","journal-title":"J Cell Physiol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/eji.1830020410","article-title":"Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides","volume":"2","author":"Andersson","year":"1972","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB51","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/08977198909000253","article-title":"GM-CSF expression is preferential to multi-CSF (IL-3) expression in murine T lymphocyte clones","volume":"1","author":"Gough","year":"1989","journal-title":"Growth Factors"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB52","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1093\/nar\/19.14.4008","article-title":"\u201cTouchdown\u201d PCR to circumvent spurious priming during gene amplification","volume":"19","author":"Don","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB53","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1126\/science.2360047","article-title":"RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination","volume":"248","author":"Oettinger","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB54","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1182\/blood.V90.4.1435","article-title":"Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells","volume":"90","author":"Elefanty","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB55","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1128\/jvi.65.9.4691-4698.1991","article-title":"A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells","volume":"65","author":"Grez","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB56","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1128\/jvi.62.7.2464-2473.1988","article-title":"Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes","volume":"62","author":"Bowtell","year":"1988","journal-title":"J Virol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB57","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1073\/pnas.92.15.6733","article-title":"Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells","volume":"92","author":"Rivi\u00e8re","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB58","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.176.4.1149","article-title":"Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus","volume":"176","author":"Hawley","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB59","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1182\/blood.V78.2.310.310","article-title":"Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells","volume":"78","author":"Apperley","year":"1991","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0378-1119(91)90134-W","article-title":"The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells","volume":"99","author":"Artlet","year":"1992","journal-title":"Gene"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB61","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1002\/j.1460-2075.1993.tb06062.x","article-title":"Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene","volume":"12","author":"Perkins","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB62","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1182\/blood.V80.2.396.396","article-title":"Stem cell factor, interleukin-3, and interleukin-6 promote retroviral-mediated gene transfer into murine hematopoietic stem cells","volume":"80","author":"Luskey","year":"1992","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB63","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1084\/jem.147.5.1526","article-title":"Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging","volume":"147","author":"Harrison","year":"1978","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB64","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/jtbi.1995.0237","article-title":"Lymphocyte development in irradiated thymuses","volume":"177","author":"Mehr","year":"1995","journal-title":"J Theor Biol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB65","first-page":"185","article-title":"A quantitative dose-response study of lymphoid-tumor development in irradiated C57 black mice","volume":"13","author":"Kaplan","year":"1952","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB66","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1128\/jvi.69.12.7541-7547.1995","article-title":"Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells","volume":"69","author":"Baum","year":"1995","journal-title":"J Virol"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB67","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.onc.1200848","article-title":"Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death","volume":"14","author":"Huang","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB68","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1002\/j.1460-2075.1996.tb01090.x","article-title":"The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry","volume":"15","author":"O\u2019Reilly","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB69","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1084\/jem.183.5.2219","article-title":"Regulation of cell division cycle progression by bcl-2 expression","volume":"183","author":"Mazel","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB70","first-page":"1511","article-title":"Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival","volume":"13","author":"Vairo","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB71","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1182\/blood.V89.3.853","article-title":"Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell","volume":"89","author":"Matsuzaki","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB72","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0092-8674(00)80290-1","article-title":"Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteoperosis in op\/op mice","volume":"89","author":"Lagasse","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0301-472X(98)00015-0_BIB73","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1182\/blood.V91.2.419","article-title":"Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment","volume":"91","author":"Ogilvy","year":"1998","journal-title":"Blood"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X98000150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X98000150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:10:17Z","timestamp":1759565417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X98000150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["S0301472X98000150"],"URL":"https:\/\/doi.org\/10.1016\/s0301-472x(98)00015-0","relation":{},"ISSN":["0301-472X"],"issn-type":[{"type":"print","value":"0301-472X"}],"subject":[],"published":{"date-parts":[[1999,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retroviral transduction of enriched hematopoietic stem cells allows lifelong Bcl-2 expression in multiple lineages but does not perturb hematopoiesis","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0301-472X(98)00015-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}