{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:11:51Z","timestamp":1767845511899,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1016\/s0303-7207(99)00241-5","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:39:58Z","timestamp":1027607998000},"page":"61-66","source":"Crossref","is-referenced-by-count":95,"title":["Revelations of ovarian follicle biology from gene knockout mice"],"prefix":"10.1016","volume":"163","author":[{"given":"Martin M.","family":"Matzuk","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0303-7207(99)00241-5_BIB1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-8529(18)30229-9","article-title":"Intraovarian peptides. Stimulators and inhibitors of follicular growth and differentiation","volume":"21","author":"Adashi","year":"1992","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1095\/biolreprod60.2.381","article-title":"Molecular cloning of the ovine growth\/differentiation factor-9 gene and expression of growth\/differentiation factor-9 in ovine and bovine ovaries","volume":"60","author":"Bodensteiner","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB3","series-title":"The Physiology of Reproduction","first-page":"1749","article-title":"Gonadotropins: chemistry and biosynthesis","author":"Bousfield","year":"1994"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1006\/dbio.1998.9087","article-title":"Characterization of oocyte and follicle development in growth differentiation factor-9-deficient mice","volume":"203","author":"Carabatsos","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB5","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/me.10.5.534","article-title":"Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice","volume":"10","author":"Coerver","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/383531a0","article-title":"Growth differentiation factor-9 is required during early ovarian folliculogenesis","volume":"383","author":"Dong","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB7","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1210\/me.12.12.1809","article-title":"The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes","volume":"12","author":"Dube","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1210\/endo-87-2-288","article-title":"Role of the ovum in follicular luteinization","volume":"87","author":"El-Fouly","year":"1970","journal-title":"Endocrinology"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1530\/ror.0.0030183","article-title":"Mouse models of ovarian failure","volume":"3","author":"Elvin","year":"1998","journal-title":"Rev. Reprod."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1210\/me.13.6.1035","article-title":"Paracrine actions of growth differentiation factor 9 in the mammalian ovary","volume":"13","author":"Elvin","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB11","doi-asserted-by":"crossref","unstructured":"Elvin, J.A., Yan, C., Matzuk, M.M. (1999b) Oocyte-expressed TGF-\u03b2 superfamily members in female fertility. Mol. Cell. Endocrinol. 159, 1\u20135.","DOI":"10.1016\/S0303-7207(99)00185-9"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1210\/me.13.6.1018","article-title":"Molecular characterization of the follicle defects in the growth differentiation factor-9-deficient ovary","volume":"13","author":"Elvin","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB13","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1095\/biolreprod56.4.976","article-title":"Murine oocytes suppress expression of luteinizing hormone receptor messenger ribonucleic acid by granulosa cells","volume":"56","author":"Eppig","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB14","first-page":"127","article-title":"Oocyte control of granulosa cell development: how and why","volume":"12","author":"Eppig","year":"1997","journal-title":"Human Reprod."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB15","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1101\/gad.12.16.2636","article-title":"Activin is an essential early mesenchymal signal in tooth development that is required for patterning of murine dentition","volume":"12","author":"Ferguson","year":"1998","journal-title":"Gene. Dev."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB16","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1210\/en.139.5.2571","article-title":"Merchenthaler ribonucleic acid in ovarian and nonovarian rodent and human tissues","volume":"139","author":"Fitzpatrick","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB17","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1210\/en.140.3.1236","article-title":"Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles","volume":"140","author":"Hayashi","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB18","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1095\/biolreprod44.6.1157","article-title":"Theca cells may be present at the outset of follicular growth","volume":"44","author":"Hirshfield","year":"1991","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0167-4889(94)90034-5","article-title":"Structure of the mouse growth\/differentiation factor 9 gene","volume":"1222","author":"Incerti","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng0297-201","article-title":"Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility","volume":"15","author":"Kumar","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0925-4773(98)00161-0","article-title":"A novel growth differentiation factor-9 (GDF-9) related factor is co-expressed with GDF-9 in mouse oocytes during folliculogenesis","volume":"78","author":"Laitinen","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB22","first-page":"75","article-title":"Transgenic models in the study of reproduction","volume":"12","author":"Lau","year":"1999","journal-title":"Gravit. Space Biol. Bull."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB23","series-title":"Inhibin, Activin, and Follistatin: Regulatory Functions in System and Cell Biology","first-page":"220","article-title":"Transgenic approaches to study the functions of the transforming growth factor \u03b2 superfamily members","author":"Lau","year":"1997"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1210\/me.12.2.181","article-title":"Stimulation of activin receptor II signaling pathways inhibits differentiation of multiple gastric epithelial lineages","volume":"12","author":"Li","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/360313a0","article-title":"\u03b1-Inhibin is a tumor-suppressor gene with gonadal specificity in mice","volume":"360","author":"Matzuk","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB26","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1073\/pnas.91.19.8817","article-title":"Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice","volume":"91","author":"Matzuk","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/374356a0","article-title":"Different phenotypes for mice deficient in either activins or activin receptor type II","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/374354a0","article-title":"Functional analysis of activins in mammalian development","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB29","first-page":"123","article-title":"Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development","volume":"51","author":"Matzuk","year":"1996","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1210\/me.9.1.131","article-title":"Oocyte-specific expression of growth\/differentiation factor-9","volume":"9","author":"McGrath","year":"1995","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB31","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1016\/S0021-9258(18)53714-5","article-title":"GDF-3 and GDF-9: two new members of the transforming growth factor-\u03b2 superfamily containing a novel pattern of cysteines","volume":"268","author":"McPherron","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/biolreprod\/4.2.154","article-title":"Morphological changes of rat follicular cells as influenced by oocytes","volume":"4","author":"Nekola","year":"1971","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1210\/edrv-15-6-725","article-title":"Hormonal control of gene expression in the ovary","volume":"15","author":"Richards","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1095\/biolreprod33.1.229","article-title":"Granulosa cells stimulate in vitro the expansion of isolated mouse cumuli oophori: involvement of prostaglandin E2","volume":"33","author":"Salustri","year":"1985","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1017\/S0967199400003312","article-title":"Endocrine and paracrine regulation of cumulus expansion","volume":"4","author":"Salustri","year":"1996","journal-title":"Zygote"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0925-4773(94)90094-9","article-title":"Mice homozygous for a null mutation of activin \u03b2B are viable and fertile","volume":"47","author":"Schrewe","year":"1994","journal-title":"Mech. Dev."},{"key":"10.1016\/S0303-7207(99)00241-5_BIB37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1210\/en.133.1.423","article-title":"Mouse oocytes regulate granulosa cell steroidogenesis","volume":"133","author":"Vanderhyden","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/S0303-7207(99)00241-5_BIB38","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1101\/gad.8.4.414","article-title":"Activin\/inhibin \u03b2B subunit gene disruption leads to defects in eyelid development and female reproduction","volume":"8","author":"Vassalli","year":"1994","journal-title":"Gene. Dev."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720799002415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720799002415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T06:50:15Z","timestamp":1620370215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720799002415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["S0303720799002415"],"URL":"https:\/\/doi.org\/10.1016\/s0303-7207(99)00241-5","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}