{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:42:06Z","timestamp":1770518526465,"version":"3.49.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1016\/s0304-3835(00)00646-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T18:16:42Z","timestamp":1027621002000},"page":"181-191","source":"Crossref","is-referenced-by-count":135,"title":["Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily"],"prefix":"10.1016","volume":"162","author":[{"given":"Elizabeth","family":"Hopper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G","family":"Belinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Tosolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R","family":"Testa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D","family":"Kruh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0304-3835(00)00646-7_BIB1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.bi.62.070193.002125","article-title":"Biochemistry of multidrug resistance mediated by the multidrug transporter","volume":"62","author":"Gottesman","year":"1993","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB2","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1360704","article-title":"Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line","volume":"258","author":"Cole","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB3","first-page":"4124","article-title":"A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation","volume":"56","author":"Taniguchi","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB4","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1074\/jbc.271.25.15091","article-title":"cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats","volume":"271","author":"Buchler","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB5","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.271.5252.1126","article-title":"Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene","volume":"271","author":"Paulusma","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB6","doi-asserted-by":"crossref","first-page":"27807","DOI":"10.1016\/S0021-9258(18)46856-1","article-title":"The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates","volume":"269","author":"Leier","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB7","doi-asserted-by":"crossref","first-page":"13033","DOI":"10.1073\/pnas.91.26.13033","article-title":"Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport","volume":"91","author":"Muller","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB8","first-page":"988","article-title":"Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump","volume":"56","author":"Jedlitschky","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB9","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1074\/jbc.271.16.9683","article-title":"ATP-dependent 17 \u03b2-estradiol 17-(\u03b2-D-glucuronide) transport by multidrug resistance protein (MRP) Inhibition by cholestatic steroids","volume":"271","author":"Loe","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB10","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1074\/jbc.273.3.1684","article-title":"Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver","volume":"273","author":"Ito","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-5793(97)00245-7","article-title":"Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein","volume":"406","author":"Madon","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB12","first-page":"1062","article-title":"Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells","volume":"53","author":"van Aubel","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB13","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI119886","article-title":"Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA","volume":"101","author":"Evers","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB14","first-page":"5342","article-title":"Expression of multidrug resistance-associated protein in NIH\/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution","volume":"55","author":"Breuninger","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB15","doi-asserted-by":"crossref","first-page":"8822","DOI":"10.1073\/pnas.91.19.8822","article-title":"The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump","volume":"91","author":"Zaman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB16","first-page":"5902","article-title":"Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells","volume":"54","author":"Cole","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB17","first-page":"5475","article-title":"A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells","volume":"57","author":"Koike","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB18","first-page":"929","article-title":"Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein MRP2, permanently expressed in human and canine cells","volume":"55","author":"Cui","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0014-5793(99)00979-5","article-title":"Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT\/MRP2)","volume":"456","author":"Kawabe","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB20","first-page":"2532","article-title":"Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2","volume":"59","author":"Hooijberg","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB21","first-page":"921","article-title":"ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P","volume":"55","author":"Chen","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB22","first-page":"5351","article-title":"Double knockout of the MRP gene leads to increased drug sensitivity in vitro","volume":"56","author":"Lorico","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB23","first-page":"714","article-title":"Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells","volume":"56","author":"Van Aubel","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB24","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1093\/hmg\/5.10.1649","article-title":"Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database","volume":"5","author":"Allikmets","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB25","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/bjc.1996.545","article-title":"The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line","volume":"74","author":"Longhurst","year":"1996","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB26","first-page":"3537","article-title":"Analysis of expression of cMOAT (MRP2) MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines","volume":"57","author":"Kool","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB27","first-page":"2741","article-title":"Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein\/canalicular multispecific organic anion transporter-related transporter","volume":"58","author":"Lee","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB28","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/jnci\/90.22.1735","article-title":"Characterization of MOAT-C and MOAT-D, new members of the MRP\/cMOAT subfamily of transporter proteins","volume":"90","author":"Belinsky","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB29","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/sj.bjc.6690527","article-title":"MOAT-E (ARA) is a full-length MRP\/cMOAT subfamily transporter expressed in kidney and liver","volume":"80","author":"Belinsky","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/bbrc.1998.9546","article-title":"Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2\/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport","volume":"252","author":"Uchiumi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB31","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1006\/bbrc.1997.7346","article-title":"cDNA cloning of a short type of multidrug resistance protein homologue SMRP, from a human lung cancer cell line","volume":"238","author":"Suzuki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-5793(98)00899-0","article-title":"cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)","volume":"433","author":"Kiuchi","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB33","first-page":"175","article-title":"Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells","volume":"59","author":"Kool","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB34","first-page":"1068","article-title":"Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats","volume":"53","author":"Hirohashi","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB35","first-page":"4779","article-title":"Transport of amphipathic anions by human multidrug resistance protein 3","volume":"60","author":"Zeng","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB36","doi-asserted-by":"crossref","first-page":"15181","DOI":"10.1074\/jbc.274.21.15181","article-title":"Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3)","volume":"274","author":"Hirohashi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB37","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1074\/jbc.275.4.2905","article-title":"ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)","volume":"275","author":"Hirohashi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB38","doi-asserted-by":"crossref","first-page":"30069","DOI":"10.1074\/jbc.M005463200","article-title":"The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides","volume":"275","author":"Jedlitschky","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB39","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1124\/mol.57.3.634","article-title":"Transport function and hepatocellular localization of mrp6 in rat liver","volume":"57","author":"Madon","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB40","first-page":"5964","article-title":"Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents","volume":"59","author":"Zeng","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB41","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1073\/pnas.96.12.6914","article-title":"MRP3, an organic anion transporter able to transport anti-cancer drugs","volume":"96","author":"Kool","year":"1999","journal-title":"Proc Natl. Acad. Sci. USA"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB42","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/92.23.1934","article-title":"Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells","author":"Lee","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB43","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/12487","article-title":"MRP4: A previously unidentified factor in resistance to nucleoside- based antiviral drugs","volume":"5","author":"Schuetz","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB44","doi-asserted-by":"crossref","first-page":"23541","DOI":"10.1074\/jbc.274.33.23541","article-title":"pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells","volume":"274","author":"McAleer","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB45","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1073\/pnas.120159197","article-title":"Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs","volume":"97","author":"Wijnholds","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB46","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/jmbi.1994.1220","article-title":"Prediction of transmembrane segments in proteins utilizing multiple sequence alignments","volume":"237","author":"Persson","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000134048","article-title":"Chromosomal localization of a gene GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents","volume":"70","author":"Bell","year":"1995","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB48","doi-asserted-by":"crossref","first-page":"23623","DOI":"10.1074\/jbc.272.38.23623","article-title":"Membrane topology of the multidrug resistance protein (MRP) A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus","volume":"272","author":"Hipfner","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB49","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1073\/pnas.84.8.2377","article-title":"Isolation of a cDNA clone and localization of human glutathione S-transferase 2 genes to chromosome band 6p12","volume":"84","author":"Board","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB50","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0888-7543(05)80373-8","article-title":"Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes","volume":"18","author":"Suzuki","year":"1993","journal-title":"Genomics"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB51","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/bj3360437","article-title":"Genomic organization 5\u2032-flanking region and chromosomal localization of the human glutathione transferase A4 gene","volume":"336","author":"Desmots","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB52","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1006\/geno.1995.1293","article-title":"Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3","volume":"30","author":"Tsuchiya","year":"1995","journal-title":"Genomics"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB53","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1161\/01.CIR.99.23.3036","article-title":"Char syndrome, an inherited disorder with patent ductus arteriosus, maps to chromosome 6p12-p21","volume":"99","author":"Satoda","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB54","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0002-9394(99)80236-0","article-title":"Clinical features of autosomal dominant congenital nystagmus linked to chromosome 6p12","volume":"125","author":"Kerrison","year":"1998","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB55","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/hep.510230519","article-title":"Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome","volume":"23","author":"Kartenbeck","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB56","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/hep.510250635","article-title":"A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome","volume":"25","author":"Paulusma","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB57","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1073\/pnas.100041297","article-title":"Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter","volume":"97","author":"Ringpfeil","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0304-3835(00)00646-7_BIB58","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/76109","article-title":"Mutations in ABCC6 cause pseudoxanthoma elasticum","volume":"25","author":"Bergen","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S0304-3835(00)00646-7_BIB59","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/76102","article-title":"Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum","volume":"25","author":"Le Saux","year":"2000","journal-title":"Nat. Genet."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383500006467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383500006467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T21:51:50Z","timestamp":1733349110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383500006467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0304383500006467"],"URL":"https:\/\/doi.org\/10.1016\/s0304-3835(00)00646-7","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}