{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:28:23Z","timestamp":1770902903841,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1016\/s0304-3835(03)00088-0","type":"journal-article","created":{"date-parts":[[2003,4,4]],"date-time":"2003-04-04T18:06:29Z","timestamp":1049479589000},"page":"93-98","source":"Crossref","is-referenced-by-count":135,"title":["The p53 pathway and its inactivation in neuroblastoma"],"prefix":"10.1016","volume":"197","author":[{"given":"Deborah A.","family":"Tweddle","sequence":"first","affiliation":[]},{"given":"Andrew D.J.","family":"Pearson","sequence":"additional","affiliation":[]},{"given":"Michelle","family":"Haber","sequence":"additional","affiliation":[]},{"given":"Murray D.","family":"Norris","sequence":"additional","affiliation":[]},{"given":"Chengyuan","family":"Xue","sequence":"additional","affiliation":[]},{"given":"Claudia","family":"Flemming","sequence":"additional","affiliation":[]},{"given":"John","family":"Lunec","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0304-3835(03)00088-0_BIB1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB3","first-page":"127","article-title":"Expression of p53 in neuroblastoma and neuroepithelioma-derived cell lines","volume":"7","author":"Davidoff","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB4","doi-asserted-by":"crossref","first-page":"18497","DOI":"10.1074\/jbc.M100638200","article-title":"Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma","volume":"276","author":"Isaacs","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB5","first-page":"2575","article-title":"The p53 response to ionising radiation in adult and developing murine tissues","volume":"13","author":"MacCallum","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB6","first-page":"8","article-title":"Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line","volume":"61","author":"Tweddle","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB7","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1073\/pnas.92.10.4407","article-title":"Wild-type p53 undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not differentiated tumors","volume":"92","author":"Moll","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB8","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1016\/S0002-9440(10)64678-0","article-title":"p53 cellular localisation and function in neuroblastoma: Evidence for defective G1 arrest despite WAF1 induction in MYCN amplified cells","volume":"158","author":"Tweddle","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB9","first-page":"1381","article-title":"The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic location","volume":"148","author":"Goldman","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB10","first-page":"4199","article-title":"Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated","volume":"5","author":"McKenzie","year":"1999","journal-title":"Clin. Cancer. Res."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/sj.onc.1204251","article-title":"Evidence that wild-type p53 in neuroblastoma cells is in a conformation refractory to integration into the transcriptional complex","volume":"20","author":"Wolff","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB12","first-page":"6185","article-title":"Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines","volume":"61","author":"Keshelava","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB13","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/MCB.16.3.1126","article-title":"Cytoplasmic sequestration of wild-type p53 impairs the G1 checkpoint after DNA damage","volume":"16","author":"Moll","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB14","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/sj.onc.1205180","article-title":"Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN","volume":"21","author":"Teitz","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB15","first-page":"676","article-title":"Defects in p53 apoptotic pathway associated with extensive multidrug resistance in heavy metal-selected neuroblastoma cells # 4299","volume":"41","author":"Norris","year":"2000","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/excr.2002.5493","article-title":"Expression of different mutant p53 transgenes in neuroblastoma cells leads to different cellular responses to genotoxic agents","volume":"275","author":"Gangopadhyay","year":"2002","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0304-3835(03)00088-0_BIB17","first-page":"1081","article-title":"Non-syntenic amplification of MDM2 and MYCN in neuroblastoma","volume":"10","author":"Corvi","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0304-3835(03)00088-0_BIB18","first-page":"679","article-title":"Homozygous deletion of CDKN2A (p16INK4\u03b1a\/p14ARF) but not within 1p36 or at other tumour suppressor loci in neuroblastoma","volume":"61","author":"Thompson","year":"2001","journal-title":"Cancer Res."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383503000880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383503000880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T04:59:01Z","timestamp":1553403541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383503000880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":18,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S0304383503000880"],"URL":"https:\/\/doi.org\/10.1016\/s0304-3835(03)00088-0","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}