{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:14:23Z","timestamp":1773922463683,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1016\/s0306-4522(02)00538-9","type":"journal-article","created":{"date-parts":[[2002,12,27]],"date-time":"2002-12-27T19:20:46Z","timestamp":1041016846000},"page":"1109-1117","source":"Crossref","is-referenced-by-count":122,"title":["High-frequency stimulation of the subthalamic nucleus silences subthalamic neurons: a possible cellular mechanism in Parkinson\u2019s disease"],"prefix":"10.1016","volume":"115","author":[{"given":"C","family":"Magari\u00f1os-Ascone","sequence":"first","affiliation":[]},{"given":"J.H","family":"Pazo","sequence":"additional","affiliation":[]},{"given":"O","family":"Macadar","sequence":"additional","affiliation":[]},{"given":"W","family":"Bu\u00f1o","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0306-4522(02)00538-9_BIB1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902360102","article-title":"Light microscopic analysis of Golgi-impregnated rat subthalamic neurons","volume":"236","author":"Afsharpour","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/bem.2250050112","article-title":"Cell membrane temperature rate sensitivity predicted from the Nernst equation","volume":"5","author":"Barnes","year":"1984","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/S0306-4522(02)00538-9_BIB3","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1523\/JNEUROSCI.22-02-00592.2002","article-title":"Effects of focal inactivation of the basal ganglia in Parkinsonian primates","volume":"22","author":"Baron","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3171\/jns.1996.84.2.0203","article-title":"Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders","volume":"84","author":"Benabid","year":"1996","journal-title":"J. Neurosurg."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1460-9568.1993.tb00505.x","article-title":"Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys","volume":"5","author":"Benazzouz","year":"1992","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB6","first-page":"S13","article-title":"Mechanism of action of deep brain stimulation","volume":"55","author":"Benazzouz","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/S0306-4522(02)00538-9_BIB7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/jn.1994.72.2.507","article-title":"The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonian","volume":"72","author":"Bergman","year":"1994","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB8","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1152\/jn.2001.85.4.1351","article-title":"High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons","volume":"85","author":"Beurrier","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB9","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1152\/jn.2000.83.4.1951","article-title":"Slowly inactivating sodium current (INaP) underlies single-spike activity in rat subthalamic neurons","volume":"83","author":"Beurrier","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1523\/JNEUROSCI.19-02-00599.1999","article-title":"Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode","volume":"19","author":"Beurrier","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB11","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1152\/jn.00582.2001","article-title":"Regulation of the timing and pattern of action potential generation in rat subthalamic neurons in vitro by GABA-A IPSPs","volume":"87","author":"Bevan","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB12","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1523\/JNEUROSCI.19-17-07617.1999","article-title":"Mechanism underlying spontaneous oscillation and rhytmic firing in rat subthalamic neurons","volume":"19","author":"Bevan","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB13","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1152\/jn.2000.83.5.3169","article-title":"Equilibrium potential of GABAA current and implications for rebound burst firing in rat subthalamic neurons in vitro","volume":"83","author":"Bevan","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/BF00968559","article-title":"Effect of short-and-long term exposure to low environmental temperature on brain regional GABA metabolism","volume":"15","author":"Biswas","year":"1990","journal-title":"Neurochem. Res."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0166-2236(90)90110-V","article-title":"Primate models of movement disorders of basal ganglia origin","volume":"13","author":"DeLong","year":"1990","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB16","first-page":"593","article-title":"Role of electrical interactions in synchronization of epileptiform bursts","volume":"44","author":"Dudek","year":"1986","journal-title":"Adv. Neurol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/(SICI)1096-9861(19991206)415:1<33::AID-CNE3>3.0.CO;2-M","article-title":"Cellular heterogeneity in cerebral cortex: a study of the morphology of pyramidal neurones in visual areas of the marmoset monkey","volume":"415","author":"Elston","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1212\/WNL.58.3.469","article-title":"Further supporting evidence of beneficial subthalamic stimulation in Parkinson\u2019s patients","volume":"58","author":"Figueiras-M\u00e9ndez","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/S0306-4522(02)00538-9_BIB19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/2882","article-title":"Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex","volume":"1","author":"Galarreta","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00228702","article-title":"Membrane potential oscillations in CA1 hippocampal pyramidal neurons in vitro: intrinsic rhythms and fluctuation entrained by sinusoidal current","volume":"97","author":"Garc\u0131\u0301a-Mu\u00f1oz","year":"1993","journal-title":"Exp. Brain Res."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0306-4522(83)90009-X","article-title":"Intracellular labeling of rat subthalamic neurones with horseradish peroxidase: computer analysis of dendrites and characterization of axon arborization","volume":"8","author":"Hammond","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(02)00538-9_BIB22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-8993(92)91108-Q","article-title":"Subthalamic nucleus cell firing in the 6-OHDA-treated rat: basal activity and response to haloperidol","volume":"590","author":"Hollerman","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/ana.410440407","article-title":"Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson\u2019s disease","volume":"44","author":"Hutchison","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cne.901820303","article-title":"A Golgy study on the subthalamic nucleus of the cat","volume":"182","author":"Iwahori","year":"1978","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/jn.1987.57.1.325","article-title":"Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition","volume":"57","author":"Korn","year":"1987","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0140-6736(95)90062-4","article-title":"Effect on Parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation","volume":"345","author":"Limousin","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/S0306-4522(02)00538-9_BIB27","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1046\/j.1460-9568.2000.00127.x","article-title":"Subthalamic neuron activity related to tremor and movement in Parkinson\u2019s disease","volume":"12","author":"Magari\u00f1os-Ascone","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0006-8993(87)91524-1","article-title":"Electrical membrane properties of rat subthalamic neurons in an in vitro slice preparation","volume":"437","author":"Nakanishi","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB29","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1046\/j.1460-9568.1999.00605.x","article-title":"In vitro electrophysiological properties of rat dorsal column nuclei neurons","volume":"11","author":"Nu\u00f1ez","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB30","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1152\/jn.2001.86.4.1816","article-title":"Excitatory postsynaptic potentials a trigger plateau potential in rat subthalamic neurons at hyperpolarized states","volume":"86","author":"Osuka","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB31","unstructured":"Paxinos, G., Watson, C., 1998. The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/cne.901680105","article-title":"The neurons in the primate subthalamic nucleus: a Golgi and electron microscopic study","volume":"168","author":"Rafols","year":"1976","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/mds.870131320","article-title":"The subthalamic nucleus and tremor in Parkinson\u2019s disease","volume":"13","author":"Rodr\u0131\u0301guez","year":"1998","journal-title":"Mov. Disord."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000099503","article-title":"Stereoencephalotomy and control of skeletal muscle tone","volume":"52","author":"Struppler","year":"1989","journal-title":"Proc. Microelectrode Meet. Stereotact. Funct. Neurosurg."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB35","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1046\/j.1460-9568.2000.00296.x","article-title":"Effect of high frequency stimulation of subthalamic nucleus on extracellular glutamate and GABA in substantia nigra and globus pallidus in the normal rat","volume":"12","author":"Windels","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0306-4522(02)00538-9_BIB36","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1113\/jphysiol.1992.sp019401","article-title":"Different firing patterns generated in dendrites and somata of CA1 pyramidal neurones in guinea-pig hippocampus","volume":"457","author":"Wong","year":"1992","journal-title":"J. Physiol."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452202005389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452202005389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T23:32:30Z","timestamp":1583969550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452202005389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["S0306452202005389"],"URL":"https:\/\/doi.org\/10.1016\/s0306-4522(02)00538-9","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}