{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:46:42Z","timestamp":1761763602817,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[1998,9,2]],"date-time":"1998-09-02T00:00:00Z","timestamp":904694400000},"content-version":"vor","delay-in-days":124,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1016\/s0306-4522(97)00689-1","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T18:57:50Z","timestamp":1027623470000},"page":"39-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Presynaptic injection of syntaxin-specific antibodies blocks transmission in the squid giant synapse"],"prefix":"10.1016","volume":"86","author":[{"given":"M","family":"Sugimori","sequence":"first","affiliation":[]},{"given":"C.-K","family":"Tong","sequence":"additional","affiliation":[]},{"given":"M","family":"Fukuda","sequence":"additional","affiliation":[]},{"given":"J.E","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"T","family":"Kojima","sequence":"additional","affiliation":[]},{"given":"K","family":"Mikoshiba","sequence":"additional","affiliation":[]},{"given":"R","family":"Llin\u00e1s","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0306-4522(97)00689-1_BIB1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0165-3806(85)90116-6","article-title":"A marker of early amacrine cell development in rat retina","volume":"352","author":"Barnstable","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1321498","article-title":"Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones","volume":"257","author":"Bennett","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0092-8674(93)90466-4","article-title":"The syntaxin family of vesicular transport receptors","volume":"74","author":"Bennett","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/378623a0","article-title":"Functional impact of syntaxin on gating of N-type and Q-type calcium channels","volume":"378","author":"Bezprozvanny","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB5","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1002\/j.1460-2075.1993.tb06171.x","article-title":"Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1\/syntaxin","volume":"12","author":"Blasi","year":"1993","journal-title":"Eur. molec. Biol. Org. J."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0896-6273(95)90154-X","article-title":"Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila","volume":"15","author":"Broadie","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB7","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1126\/science.1589771","article-title":"Synaptotagmin: a calcium sensor on the synaptic vesicle surface","volume":"256","author":"Brose","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB8","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/S0021-9258(18)47003-2","article-title":"SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils","volume":"269","author":"Chapman","year":"1994","journal-title":"J. biol. Chem."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB9","doi-asserted-by":"crossref","first-page":"23667","DOI":"10.1074\/jbc.270.40.23667","article-title":"Ca2+ regulates the interaction between synaptotagmin and syntaxin I","volume":"270","author":"Chapman","year":"1995","journal-title":"J. biol. Chem."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.1965.sp007639","article-title":"A quantitative study of end-plates in isolated human muscle","volume":"178","author":"Elmqvist","year":"1965","journal-title":"J. Physiol., Lond."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB11","doi-asserted-by":"crossref","first-page":"29206","DOI":"10.1016\/S0021-9258(19)62031-4","article-title":"Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP\/Synaptotagmin II","volume":"269","author":"Fukuda","year":"1994","journal-title":"J. biol. Chem."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB12","doi-asserted-by":"crossref","first-page":"10708","DOI":"10.1073\/pnas.92.23.10708","article-title":"Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal","volume":"92","author":"Fukuda","year":"1995","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB13","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1126\/science.8438167","article-title":"A functional role for GTP-binding proteins in synaptic vesicle cycling","volume":"259","author":"Hess","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB14","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/0896-6273(94)90443-X","article-title":"A post docking role for synaptobrevin in synaptic vesicle fusion","volume":"12","author":"Hunt","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB15","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1016\/S0021-9258(19)50061-8","article-title":"Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1","volume":"267","author":"Inoue","year":"1992","journal-title":"J. biol. Chem."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB16","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0896-6273(95)90337-2","article-title":"Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation","volume":"14","author":"Kee","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB17","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1523\/JNEUROSCI.16-06-01975.1996","article-title":"Localization of synaptotagmin-binding domains on syntaxin","volume":"16","author":"Kee","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB18","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1016\/S0021-9258(17)37372-6","article-title":"Purification of the N-type calcium channel associated with syntaxin and synaptotagmin","volume":"269","author":"L\u00e9v\u00e8que","year":"1994","journal-title":"J. biol. Chem."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB19","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/375594a0","article-title":"Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins","volume":"375","author":"Li","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0006-3495(81)84898-9","article-title":"Presynaptic calcium currents in squid giant synapse","volume":"33","author":"Llin\u00e1s","year":"1981","journal-title":"Biophys. J."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB21","doi-asserted-by":"crossref","first-page":"12990","DOI":"10.1073\/pnas.91.26.12990","article-title":"The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study","volume":"91","author":"Llin\u00e1s","year":"1994","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB22","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1126\/science.1350109","article-title":"Microdomains of high calcium concentration in a presynaptic terminal","volume":"256","author":"Llin\u00e1s","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB23","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1074\/jbc.271.12.6567","article-title":"Interaction of snare complexes with P\/Q-type calcium channels in rat cerebellar synaptosomes","volume":"271","author":"Martin-Moutot","year":"1996","journal-title":"J. biol. Chem."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB24","doi-asserted-by":"crossref","unstructured":"Marsal J., Ruiz-Montasell B., Blasi J., Moreira J. E., Contreras D., Sugimori M. and Llin\u00e1s R. (1997) Block of transmitter release by botulinum C1 action on syntaxin at the squid giant synapse. Proc. natn. Acad. Sci. U.S.A. (in press).","DOI":"10.1073\/pnas.94.26.14871"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB25","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1073\/pnas.92.23.10703","article-title":"Role of the c2a domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal","volume":"92","author":"Mikoshiba","year":"1995","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB26","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0306-4522(94)00508-3","article-title":"Impairment of syntaxin by botulinum neurotoxin C1 or antibodies inhibits acetylcholine release but not Ca2+ channel activity","volume":"65","author":"Mochida","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0896-6273(00)80209-3","article-title":"Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type Ca2+ channels","volume":"17","author":"Mochida","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/345260a0","article-title":"Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C","volume":"345","author":"Perin","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0896-6273(94)90352-2","article-title":"Specificity and regulation of a synaptic vesicle docking complex","volume":"13","author":"Pevsner","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB30","doi-asserted-by":"crossref","first-page":"7363","DOI":"10.1073\/pnas.93.14.7363","article-title":"Isoform-specific interaction of the a1A subunits of brain Ca2+ channels with the presynaptic protein syntaxin and SNAP-25","volume":"93","author":"Rettig","year":"1996","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/384170a0","article-title":"Timing of neurotransmission at fast synapses in the mammalian brain","volume":"384","author":"Sabatini","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB32","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0896-6273(95)90328-3","article-title":"Membrane trafficking in the presynaptic nerve terminal","volume":"14","author":"Scheller","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB33","doi-asserted-by":"crossref","first-page":"10566","DOI":"10.1074\/jbc.270.18.10566","article-title":"Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins","volume":"270","author":"Schiavo","year":"1995","journal-title":"J. biol. Chem."},{"key":"10.1016\/S0306-4522(97)00689-1_BIB34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0092-8674(95)90414-X","article-title":"Genetic and electrophysiological studies of Drosophila syntaxin-1A and demonstrates its role in non-neuronal secretion and neurotransmission","volume":"80","author":"Schulze","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0896-6273(95)90213-9","article-title":"From vesicle docking to endocytosis: intermediate reactions of exocytosis","volume":"14","author":"Schweizer","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0896-6273(01)80052-0","article-title":"Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch","volume":"118","author":"Shao","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/379451a0","article-title":"Calcium-dependent interaction of N-type calcium channels with the synaptic core complex","volume":"379","author":"Sheng","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB38","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0896-6273(94)90417-0","article-title":"Identification of a syntaxin-binding site on N-type calcium channels","volume":"13","author":"Sheng","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-1119(88)90005-4","article-title":"Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase","volume":"67","author":"Smith","year":"1986","journal-title":"Gene"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/362318a0","article-title":"SNAP receptors implicated in vesicle targeting and fusion","volume":"362","author":"S\u00f6llner","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB41","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/375645a0","article-title":"The synaptic vesicle cycle: a cascade of protein-protein interactions","volume":"375","author":"S\u00fcdhof","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0306-4522(97)00689-1_BIB42","doi-asserted-by":"crossref","first-page":"24925","DOI":"10.1016\/S0021-9258(19)73984-2","article-title":"HPC-1 is associated with synaptotagmin and \u03c9-conotoxin receptor","volume":"267","author":"Yoshida","year":"1994","journal-title":"J. biol. Chem."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452297006891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452297006891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:15:39Z","timestamp":1759677339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452297006891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0306452297006891"],"URL":"https:\/\/doi.org\/10.1016\/s0306-4522(97)00689-1","relation":{},"ISSN":["0306-4522"],"issn-type":[{"type":"print","value":"0306-4522"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presynaptic injection of syntaxin-specific antibodies blocks transmission in the squid giant synapse","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0306-4522(97)00689-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}