{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:45:16Z","timestamp":1760424316146},"reference-count":97,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[1999,10]]},"DOI":"10.1016\/s0306-4522(99)00295-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T13:01:24Z","timestamp":1027602084000},"page":"685-696","source":"Crossref","is-referenced-by-count":41,"title":["Autoradiographic comparison of [3H](\u2212)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease"],"prefix":"10.1016","volume":"94","author":[{"given":"W.","family":"Sihver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.-G.","family":"Gillberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-L.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nordberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0306-4522(99)00295-X_BIB1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00688184","article-title":"Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariant data analysis","volume":"74","author":"Alafuzoff","year":"1987","journal-title":"Acta neuropath."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/syn.890020504","article-title":"[3H]vesamicol binding in brain: autoradiographic distribution, pharmacology, and effects of cholinergic lesions","volume":"2","author":"Altar","year":"1988","journal-title":"Synapse"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00697388","article-title":"Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease","volume":"61","author":"Arendt","year":"1983","journal-title":"Acta neuropath."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1523\/JNEUROSCI.17-02-00516.1997","article-title":"Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele","volume":"17","author":"Arendt","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease","volume":"1","author":"Arnold","year":"1991","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB7","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1523\/JNEUROSCI.14-05-02476.1994","article-title":"Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions","volume":"14","author":"Aubert","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-9861(19960520)369:1<31::AID-CNE3>3.0.CO;2-L","article-title":"Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors, in the rat brain","volume":"369","author":"Aubert","year":"1996","journal-title":"J. comp. Neurol."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB9","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0306-4522(97)00026-2","article-title":"Nicotinic receptor mediates spontaneous GABA release in the rat dorsal motor nucleus of the vagus","volume":"79","author":"Bertolino","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB10","unstructured":"Bogdanovic N. and Morris J. H. (1995) Diagnostic criteria for Alzheimer's disease in multi-centre brain banking. In Neuropathological Diagnostic Criteria for Brain Banking (eds Cruz-Sanchez et al.), pp. 20\u201329. IOS, Amsterdam."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB11","unstructured":"Brodmann K. (1909) Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues. Barth, Leipzig."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/cercor\/7.1.86","article-title":"The autonomic-related cortex: pathology in Alzheimer's disease","volume":"7","author":"Chu","year":"1997","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB14","first-page":"125","article-title":"Age-associated decline in high affinity nicotine binding in human brain frontal cortex does not correlate with the changes in choline acetyltransferase activity","volume":"10","author":"Court","year":"1992","journal-title":"Neurosci. Res. Commun."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB15","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1126\/science.6338589","article-title":"Alzheimer's disease: a disorder of cortical cholinergic innervation","volume":"219","author":"Coyle","year":"1983","journal-title":"Science"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(97)81946-2","article-title":"Vesamicol and some of its derivatives: questionable ligands for selectively labeling acetylcholine transporters in rat brain","volume":"338","author":"Custers","year":"1997","journal-title":"Eur. J. Pharmac."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0006-2952(94)00541-S","article-title":"Vesamicol analogues as sigma ligands","volume":"49","author":"Efange","year":"1995","journal-title":"Biochem. Pharmac."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0197-4580(97)00038-9","article-title":"Vesicular acetylcholine transporter density and Alzheimer's disease","volume":"18","author":"Efange","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB19","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0306-4522(86)90142-9","article-title":"Nucleus basalis neuronal loss. Neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease","volume":"19","author":"Etienne","year":"1986","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB20","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1111\/j.1471-4159.1986.tb13113.x","article-title":"Characterization of l-[3H]nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal","volume":"47","author":"Flynn","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB21","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1471-4159.1975.tb11895.x","article-title":"A rapid radiochemical method of the determination of choline acetyltransferase","volume":"24","author":"Fonnum","year":"1975","journal-title":"J. Neurochem."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-3223(94)00123-K","article-title":"Decreased phospholipase A2 activity in Alzheimer brains","volume":"37","author":"Gattaz","year":"1995","journal-title":"Biol. Psychiat."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB23","first-page":"774","article-title":"Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors","volume":"48","author":"Gerzanich","year":"1995","journal-title":"Molec. Pharmac."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0306-4522(89)90399-0","article-title":"Cortical cholinergic fibers in aging and Alzheimer's disease: a morphometric study","volume":"33","author":"Geula","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/cercor\/6.2.165","article-title":"Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease","volume":"6","author":"Geula","year":"1996","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00005072-199801000-00008","article-title":"Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease","volume":"57","author":"Geula","year":"1998","journal-title":"J. Neuropath. exp. Neurol."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease","volume":"41","author":"Gomez-Isla","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0301-0082(97)00034-8","article-title":"Human neuronal nicotinic receptors","volume":"53","author":"Gotti","year":"1997","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB29","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/00001756-199403000-00009","article-title":"Acetylcholine active transport by rat brain synaptic vesicles","volume":"5","author":"Haigh","year":"1994","journal-title":"NeuroReport"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB30","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0306-4522(94)90484-7","article-title":"Localization of nicotinic cholinergic receptors in rat brain: autoradiographic studies with [3H]cytisine","volume":"62","author":"Happe","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0169-328X(99)00030-3","article-title":"Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain","volume":"66","author":"Hellstr\u00f6m-Lindahl","year":"1999","journal-title":"Molec. Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0006-8993(83)90880-6","article-title":"Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients","volume":"267","author":"Henke","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1471-4159.1991.tb03780.x","article-title":"Purification and characterization of a non-vesicular vesamicol-binding-protein from electric organ and demonstration of a protein in mammalian brain","volume":"57","author":"Hicks","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(91)90191-U","article-title":"Object recognition deficit in Alzheimer' disease: possible disconnection of the occipito-temporal component of the visual system","volume":"122","author":"Hof","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB35","first-page":"280","article-title":"Characterization of (\u00b1)-[3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain","volume":"48","author":"Houghtling","year":"1995","journal-title":"Molec. Pharmac."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0197-4580(94)90031-0","article-title":"Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease","volume":"15","author":"Hyman","year":"1994","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB37","unstructured":"Kandel E. (1991) Perception of motion, depth, and form. In Principles of Neuronal Science (eds Kandel E. R. et al.), pp. 440\u2013466. Prentice Hall International, London."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0304-3940(90)90689-7","article-title":"[3H]Vesamicol binding in human brain cholinergic deficiency disorders","volume":"177","author":"Kish","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ana.410400309","article-title":"In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease","volume":"40","author":"Kuhl","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB40","unstructured":"Kupfermann I. (1991) Learning and memory. In Principles of Neuronal Science (eds Kandel E. R. et al.), pp. 997\u20131009. Prentice Hall International, London."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB41","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/BF00964952","article-title":"Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia","volume":"14","author":"London","year":"1989","journal-title":"Neurochem. Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB42","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0166-2236(87)90044-0","article-title":"The vesicular acetylcholine transport system","volume":"10","author":"Marshall","year":"1987","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0006-8993(98)00558-7","article-title":"Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (\u00b1)[3H]epibatidine","volume":"801","author":"Marutle","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB44","doi-asserted-by":"crossref","unstructured":"Marutle A., Warpman U., Bogdanovic N., Lannfelt L. and Nordberg A. (1999) Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish APP 670\/671 mutation. J. Neurochem. 72, 1161\u20131169.","DOI":"10.1046\/j.1471-4159.2000.0721161.x"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB45","first-page":"528","article-title":"Determination of nicotinic receptor subtypes in chick retina using monoclonal antibodies and [3H]epibatidine","volume":"4","author":"McKay","year":"1994","journal-title":"Med. chem. Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB46","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB47","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0079-6123(08)60908-5","article-title":"Human brain cholinergic pathways","volume":"84","author":"Mesulam","year":"1990","journal-title":"Prog. Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB48","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0006-8993(92)90543-I","article-title":"Overlap between acetycholinesterase-rich and choline acetytransferase-positive (cholinergic) axons in human cerebral cortex","volume":"577","author":"Mesulam","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF01245165","article-title":"Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis","volume":"82","author":"Miyai","year":"1990","journal-title":"J. neural Transm."},{"issue":"Suppl.","key":"10.1016\/S0306-4522(99)00295-X_BIB50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-3-7091-6892-9_14","article-title":"Molecular biology of Apo E alleles in Alzheimer's and non-Alzheimer's dementias","volume":"47","author":"Morris","year":"1996","journal-title":"J. neural Transm."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB51","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00174504","article-title":"Intravenous nicotine in Alzheimer's disease: a pilot study","volume":"95","author":"Newhouse","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF01243353","article-title":"Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level","volume":"67","author":"Nilsson","year":"1986","journal-title":"J. neural Transm."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0304-3940(86)90629-4","article-title":"Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains","volume":"72","author":"Nordberg","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB54","first-page":"331","article-title":"Heterogeneous cholinergic nicotinic receptors in the CNS","volume":"H25","author":"Nordberg","year":"1988","journal-title":"NATO ASI Series"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB55","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0304-3940(88)90503-4","article-title":"Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains","volume":"86","author":"Nordberg","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB56","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0079-6123(08)62495-4","article-title":"The role of nicotinic receptors in the pathophysiology of Alzheimer's disease","volume":"79","author":"Nordberg","year":"1989","journal-title":"Prog. Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02257652","article-title":"Decreased uptake and binding of 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography","volume":"2","author":"Nordberg","year":"1990","journal-title":"J. neural Transm."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jnr.490310115","article-title":"Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia","volume":"31","author":"Nordberg","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB59","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00002093-199505000-00006","article-title":"Kinetic analysis of regional (S)(\u2212)[11C]nicotine in normal and Alzheimer brains\u2014in vivo assessment using positron emission tomography","volume":"9","author":"Nordberg","year":"1995","journal-title":"Alzheimer Dis. assoc. Disord."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB60","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0006-8993(91)90676-M","article-title":"High-affinity choline uptake carrier in Alzheimer's disease: implications for the cholinergic hypothesis of dementia","volume":"552","author":"Pascual","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB61","first-page":"1030","article-title":"[3H]Epibatidine labels nicotinic receptors in rat brain: an autoradiographic study","volume":"275","author":"Perry","year":"1995","journal-title":"J. Pharmac. exp. Ther."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB62","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02257646","article-title":"Cholinergic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types","volume":"2","author":"Perry","year":"1990","journal-title":"J. neural Transm."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB63","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0891-0618(92)90056-V","article-title":"Autoradiographic distribution of [3H]nicotine binding in human cortex: relative abundance in subicular complex","volume":"5","author":"Perry","year":"1992","journal-title":"J. chem. Neuroanat."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB64","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0306-4522(94)00410-7","article-title":"Alteration in nicotinic binding sites in Parkinson's disease, Lewy body disease and Alzheimer's disease: possible index of early neuropathology","volume":"64","author":"Perry","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB65","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1749-6632.1996.tb34450.x","article-title":"\u03b2-Amyloidosis in normal aging and transmitter signaling in human temporal lobe","volume":"777","author":"Perry","year":"1996","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB66","doi-asserted-by":"crossref","first-page":"12,260","DOI":"10.1073\/pnas.92.26.12260","article-title":"Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease","volume":"92","author":"Poirier","year":"1995","journal-title":"Proc. natn. Acad. Sci. USA"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB67","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02260937","article-title":"Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer's disease: an autoradiographic study using [3H]hemicholinium-3","volume":"8","author":"Rodriguez-Puertas","year":"1994","journal-title":"J. neural Transm."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB68","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1523\/JNEUROSCI.05-10-02801.1985","article-title":"Quantitative morphology and regional and laminar distribution of senile plaques in Alzheimer's disease","volume":"5","author":"Rogers","year":"1985","journal-title":"J. Neurosci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB69","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0306-4522(97)00291-1","article-title":"Distribution of the vesicular transporter for acetylcholine in the rat central nervous system","volume":"82","author":"Roghani","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jnr.490400105","article-title":"Differential changes in cholinergic markers from selected brain regions after specific immunolesion of the rat cholinergic basal forebrain system","volume":"40","author":"Rossner","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB71","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/j.1460-9568.1994.tb00550.x","article-title":"Distribution of nicotinic receptors in the human hippocampus and thalamus","volume":"6","author":"Rubboli","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB72","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0306-4522(90)90086-J","article-title":"Choline acetyltransferase activity and [3H]vesamicol binding in the temporal cortex of patients with Alzheimer's disease, and rats with basal forebrain lesions","volume":"35","author":"Ruberg","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB73","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1192\/bjp.154.6.797","article-title":"The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type","volume":"154","author":"Sahakian","year":"1989","journal-title":"Br. J. Psychiat."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB74","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.ne.16.030193.002155","article-title":"The diversity of neuronal nicotinic acetylcholine receptors","volume":"16","author":"Sargent","year":"1993","journal-title":"A. Rev. Neurosci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB75","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB76","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(89)90624-0","article-title":"Immunohisto- and cytochemical localization of cortical nicotinic cholinoceptors in rat and man","volume":"502","author":"Schr\u00f6der","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB77","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0197-4580(91)90107-U","article-title":"Nicotinic cholinoceptive neurones of the frontal cortex are reduced in Alzheimer's disease","volume":"12","author":"Schr\u00f6der","year":"1991","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/bbrc.1997.6940","article-title":"Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease","volume":"236","author":"Shimohama","year":"1997","journal-title":"Biochem. biophys. Res. Commun."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB79","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0306-4522(97)00652-0","article-title":"Laminar distribution of nicotinic receptor subtypes in human cerebral cortex as determined by [3H](\u2212)nicotine, [3H]cytisine and [3H]epibatidine in vitro autoradiography","volume":"85","author":"Sihver","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB80","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(98)00794-0","article-title":"Immunohistochemical localization of nicotinic beta2 and alpha4 receptor subunits in normal human brain and individuals with Lewy body and Alzheimer's disease: preliminary observations","volume":"256","author":"Sparks","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB81","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(97)00573-9","article-title":"Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes","volume":"232","author":"Svensson","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB82","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/00002093-199404000-00002","article-title":"Alzheimer's disease: an overview","volume":"8","author":"Tariot","year":"1994","journal-title":"Alzheimer Dis. assoc. Disord."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB83","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ana.410210603","article-title":"Neocortical cell counts in normal human adult aging","volume":"21","author":"Terry","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB84","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0169-328X(98)00260-5","article-title":"Expression of the alpha3 nicotinic receptor subunit mRNA in aging and Alzheimer's disease","volume":"63","author":"Terzano","year":"1998","journal-title":"Molec. Brain Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0361-9230(95)00076-Q","article-title":"Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function","volume":"38","author":"Thorne","year":"1995","journal-title":"Brain Res. Bull."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB86","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-3940(98)00205-5","article-title":"Age-related changes in nicotinic acetylcholine receptor subunits alpha4 and beta2 messenger RNA expression in postmortem human frontal cortex and hippocampus","volume":"245","author":"Tohgi","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB87","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/cercor\/3.5.465","article-title":"Some modular features of temporal cortex in humans as revealed by pathologic changes in Alzheimer's disease","volume":"3","author":"Van Hoesen","year":"1993","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB88","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ddr.430310206","article-title":"Nicotinic potentiation of glutamatergic synapses in the prefrontal cortex: new insight into the analysis of the role of nicotinic receptors in cognitive function","volume":"31","author":"Vidal","year":"1994","journal-title":"Drug Dev. Res."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-2999(91)90318-K","article-title":"\u03b1-Adrenoceptor blocking properties of vesamicol","volume":"102","author":"Wannan","year":"1991","journal-title":"Eur. J. Pharmac."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB90","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0278-5846(92)90069-Q","article-title":"Nicotine as a cognitive enhancer","volume":"16","author":"Warburton","year":"1992","journal-title":"Prog. Neuropsychopharmac. biol. Psychiat."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB91","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1097\/00001756-199511270-00033","article-title":"Epibatidine and ABT-418 reveal selective losses of \u03b14\u03b22 nicotinic receptors in Alzheimer brains","volume":"6","author":"Warpman","year":"1995","journal-title":"NeuroReport"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB92","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1046\/j.1471-4159.1998.70052028.x","article-title":"Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells","volume":"70","author":"Warpman","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB93","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0306-4522(96)00019-X","article-title":"Choline acetyltransferase activity and vesamicol binding in Rett syndrome and in rats with nucleus basalis lesions","volume":"73","author":"Wenk","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB94","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1212\/WNL.38.5.720","article-title":"Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study","volume":"38","author":"Whitehouse","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/S0306-4522(99)00295-X_BIB95","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0166-2236(96)10073-4","article-title":"Presynaptic nicotinic ACh receptors","volume":"20","author":"Wonnacott","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB96","first-page":"482","article-title":"Nicotine-induced inhibition in medial septum involves activation of presynaptic nicotinic cholinergic receptors on \u03b3-aminobutyric acid-containing neurons","volume":"276","author":"Yang","year":"1996","journal-title":"J. Pharmac. exp. Ther."},{"key":"10.1016\/S0306-4522(99)00295-X_BIB97","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(92)91295-P","article-title":"Basal forebrain cholinergic neurons in aged rat brain are more susceptible to ibotenate-induced degeneration than neurons in young adult brain","volume":"589","author":"Zawia","year":"1992","journal-title":"Brain Res."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645229900295X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645229900295X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T14:17:51Z","timestamp":1578493071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645229900295X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":97,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["S030645229900295X"],"URL":"https:\/\/doi.org\/10.1016\/s0306-4522(99)00295-x","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[1999,10]]}}}