{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:00:15Z","timestamp":1773288015006,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI38166"],"award-info":[{"award-number":["AI38166"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK48029"],"award-info":[{"award-number":["DK48029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HG00313"],"award-info":[{"award-number":["HG00313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HG00820"],"award-info":[{"award-number":["HG00820"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["VM-121"],"award-info":[{"award-number":["VM-121"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005714","name":"Office of Experimental Program to Stimulate Competitive Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[1998,11]]},"DOI":"10.1016\/s0378-1119(98)00164-4","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:20:46Z","timestamp":1027610446000},"page":"175-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Novel sequence organization and insertion specificity of IS605 and IS606: chimaeric transposable elements of Helicobacter pylori"],"prefix":"10.1016","volume":"223","author":[{"given":"Dangeruta","family":"Kersulyte","sequence":"first","affiliation":[]},{"given":"Natalia S","family":"Akopyants","sequence":"additional","affiliation":[]},{"given":"Sandra W","family":"Clifton","sequence":"additional","affiliation":[]},{"given":"Bruce A","family":"Roe","sequence":"additional","affiliation":[]},{"given":"Douglas E","family":"Berg","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0378-1119(98)00164-4_BIB1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2958.1998.00770.x","article-title":"Analyses of the cag pathogenicity island of Helicobacter pylori","volume":"28","author":"Akopyants","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB2","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1093\/nar\/20.19.5137","article-title":"DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting","volume":"20","author":"Akopyanz","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB3","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1093\/nar\/20.23.6221","article-title":"PCR-based RFLP analysis of DNA sequence diversity in the gastric pathogen Helicobacter pylori","volume":"20","author":"Akopyanz","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB4","unstructured":"Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., Struhl, K.A., 1994. Current Protocols in Molecular Biology; Supplement 27 CPMB. Greene Publishing and Wiley Interscience, New York, p. 2.4.1."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB5","unstructured":"Berg, C.M., Berg, D.E., 1996. Transposable element tools for microbial genetics. In: Neidhardt, F.C. et al. (Eds.), Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology II. American Society for Microbiology, Washington, DC, pp. 2588\u20132612."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB6","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1073\/pnas.80.3.792","article-title":"Structural requirement for IS50-mediated gene transposition","volume":"80","author":"Berg","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB7","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1073\/pnas.72.9.3628","article-title":"Transposition of R factor genes to bacteriophage \u03bb","volume":"72","author":"Berg","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB8","unstructured":"Berg, D.E., Howe, M.M. (Eds.), 1989. Mobile DNA. American Society for Microbiology, Washington, DC."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB9","first-page":"411","article-title":"Bacterial transposon Tn5: evolutionary inferences","volume":"1","author":"Berg","year":"1984","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0966-842X(97)01164-5","article-title":"The Helicobacter pylori genome sequence: genetic factors for long life in the gastric mucosa","volume":"5","author":"Berg","year":"1997","journal-title":"Trends Microbiol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB11","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/nar\/25.7.1355","article-title":"Conserved structure of IS200 elements in Salmonella","volume":"25","author":"Beuzon","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0378-1119(96)00032-7","article-title":"Identification of a native Dichelobacter nodosus plasmid and implications for the evolution of the vap regions","volume":"172","author":"Billington","year":"1996","journal-title":"Gene"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/genetics\/133.3.449","article-title":"Natural populations of Escherichia coli and Salmonella typhimurium harbor the same classes of insertion sequences","volume":"133","author":"Bisercic","year":"1993","journal-title":"Genetics"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB14","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1126\/science.277.5331.1453","article-title":"The complete genome sequence of Escherichia coli K-12","volume":"277","author":"Blattner","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2958.1994.tb00332.x","article-title":"Ordered cosmid library and high-resolution physical\u2013genetic map of Helicobacter pylori strain NCTC11638","volume":"11","author":"Bukanov","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0378-1119(79)90078-7","article-title":"Nomenclature of transposable elements in prokaryotes","volume":"5","author":"Campbell","year":"1979","journal-title":"Gene"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB17","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1073\/pnas.93.25.14648","article-title":"cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors","volume":"93","author":"Censini","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB18","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.90.12.5791","article-title":"Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer","volume":"90","author":"Covacci","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.biochem.66.1.437","article-title":"Target site selection in transposition","volume":"66","author":"Craig","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB20","unstructured":"Deonier, R.C., 1996. Native insertion sequence elements: locations, distributions and sequence relationships. In: Neidhardt, F.C. et al. (Eds.), Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology II. American Society for Microbiology, Washington, DC, pp. 2000\u20132011."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00333860","article-title":"Polar mutations in lac, gal and phage lambda consist of a few IS-DNA sequences inserted with either orientation","volume":"119","author":"Fiandt","year":"1972","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0378-1119(77)90021-X","article-title":"Identification of the gal3 insertion in Escherichia coli as IS2","volume":"2","author":"Fiandt","year":"1977","journal-title":"Gene"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB23","unstructured":"Galas, D.J., Chandler, M., 1989. Bacterial insertion sequences. In: Berg, D.E., Howe, M.M. (Eds.), Mobile DNA. American Society for Microbiology, Washington, DC, pp. 109\u2013162."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1101\/SQB.1981.045.01.022","article-title":"Identification of a sex-factor-affinity site in E. coli as gamma delta","volume":"45","author":"Guyer","year":"1981","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB25","doi-asserted-by":"crossref","unstructured":"H\u00f6\u00f6k-Nikanne, J., Berg, D.E., Peek, R.R., Kersulyte, D., Tummuru, M.K.R., Blaser, M.J., 1998. DNA sequence conservation and diversity in transposable element IS605 of Helicobacter pylori. Helicobacter 3, in press.","DOI":"10.1111\/j.1523-5378.1998.08011.x"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB26","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1365-2958.1996.tb02521.x","article-title":"Variability of gene order in different Helicobacter pylori strains contributes to genome diversity","volume":"20","author":"Jiang","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB27","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1128\/jb.172.10.5956-5960.1990","article-title":"Mutations that affect Tn5 insertion into pBR322: importance of local DNA supercoiling","volume":"172","author":"Lodge","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00333859","article-title":"Electron microscopy of polar insertions in the lac operon of Escherichia coli","volume":"119","author":"Malamy","year":"1972","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB29","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/nar\/19.5.1154","article-title":"Construction of T vectors, a rapid system for cloning unmodified PCR products","volume":"19","author":"Marchuk","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00337943","article-title":"Insertion sequence IS2 near the gene for prophage lambda excision","volume":"147","author":"Mosharrafa","year":"1976","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-1119(95)00384-I","article-title":"A novel insertion sequence (IS)-like element of the thermophilic bacterium PS3 promotes expression of the alanine carrier protein-encoding gene","volume":"163","author":"Murai","year":"1995","journal-title":"Gene"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-1119(77)90073-7","article-title":"Insertion sequence IS2 associated with int-constitutive mutants of bacteriophage lambda","volume":"2","author":"Pilacinski","year":"1977","journal-title":"Gene"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB33","unstructured":"Sambrook, J., Fritsch, E.F., Maniatis, T., 1989. Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/genetics\/115.1.51","article-title":"Distribution and abundance of insertion sequences among natural isolates of Escherichia coli","volume":"115","author":"Sawyer","year":"1987","journal-title":"Genetics"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB35","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1073\/pnas.76.4.1933","article-title":"Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements","volume":"76","author":"Shapiro","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB36","unstructured":"Szybalski, W., 1977. IS elements in Escherichia coli, plasmids, and bacteriophages. In: Bukhari, A.I., Shapiro, J.A., Adhya, S. (Eds.), DNA Insertion Elements, Plasmids and Episomes. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 583\u2013590."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB37","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/jcm.33.4.918-923.1995","article-title":"Long-term colonization with single and multiple strains of Helicobacter pylori assessed by DNA fingerprinting","volume":"33","author":"Taylor","year":"1995","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/41483","article-title":"The complete genome sequence of the gastric pathogen Helicobacter pylori","volume":"388","author":"Tomb","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0378-1119(98)00164-4_BIB39","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1365-2958.1995.18050867.x","article-title":"Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of Il-8 in gastric epithelial cells","volume":"18","author":"Tummuru","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S0378-1119(98)00164-4_BIB40","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1099\/00221287-139-10-2485","article-title":"Transformation of Helicobacter pylori by chromosomal metronidazole resistance and by a plasmid with a selectable chloramphenicol resistance marker","volume":"139","author":"Wang","year":"1993","journal-title":"J. Gen. Microbiol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111998001644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111998001644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:58:39Z","timestamp":1759852719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111998001644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11]]},"references-count":40,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1998,11]]}},"alternative-id":["S0378111998001644"],"URL":"https:\/\/doi.org\/10.1016\/s0378-1119(98)00164-4","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[1998,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel sequence organization and insertion specificity of IS605 and IS606: chimaeric transposable elements of Helicobacter pylori","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0378-1119(98)00164-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Elsevier Science B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}