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Bacteriol."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB70","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1038\/sj.onc.1202862","article-title":"Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death","volume":"18","author":"Robles","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0531-5565(01)00227-3_BIB71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00295598","article-title":"Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations","volume":"62","author":"Salk","year":"1982","journal-title":"Hum. Genet."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB72","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000131596","article-title":"Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism","volume":"30","author":"Salk","year":"1981","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB73","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/978-1-4684-7853-2_14","article-title":"Growth characteristics of Werner syndrome cells in vitro","volume":"190","author":"Salk","year":"1985","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB74","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/BF02346184","article-title":"Accelarated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells","volume":"97","author":"Schulz","year":"1996","journal-title":"Hum. Genet."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/hmg\/7.1.69","article-title":"Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation","volume":"7","author":"Schweitzer","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB76","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/nar\/26.12.2879","article-title":"Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A","volume":"26","author":"Shen","year":"1998","journal-title":"Nucl. Acid Res."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB77","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1093\/nar\/28.17.3260","article-title":"Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA","volume":"28","author":"Shen","year":"2000","journal-title":"Nucl. Acid Res."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB78","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1074\/jbc.270.9.4193","article-title":"Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5\u2032- to 3\u2032-exonuclease required for lagging strand DNA synthesis in reconstituted systems","volume":"270","author":"Sommers","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB79","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1101\/gad.13.11.1355","article-title":"p53-mediated apoptosis is attenuated in Werner syndrome cells","volume":"13","author":"Spillare","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB80","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1093\/nar\/25.15.2973","article-title":"DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system","volume":"25","author":"Suzuki","year":"1997","journal-title":"Nucl. Acid Res."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB81","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1093\/nar\/27.11.2361","article-title":"Werner syndrome helicase contains a 5\u2032\u21923\u2032 exonuclease activity that digests DNA and RNA strands in DNA\/DNA and RNA\/DNA duplexes dependent on unwinding","volume":"27","author":"Suzuki","year":"1999","journal-title":"Nucl. Acid Res."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB82","doi-asserted-by":"crossref","first-page":"11365","DOI":"10.1073\/pnas.97.21.11365","article-title":"Werner protein recruits DNA polymerase delta to the nucleolus","volume":"97","author":"Szekely","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/S0531-5565(01)00227-3_BIB83","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF00569220","article-title":"Altered frequency of initiation sites of DNA replication in Werner's syndrome cells","volume":"60","author":"Takeuchi","year":"1982","journal-title":"Hum. Genet."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB84","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)81846-2","article-title":"A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair","volume":"88","author":"Tishkoff","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0531-5565(01)00227-3_BIB85","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1128\/MCB.15.8.4291","article-title":"Mutations in RAD27 define a potential link between G1 cyclins and DNA replication","volume":"15","author":"Vallen","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB86","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1146\/annurev.biochem.67.1.721","article-title":"The DNA replication fork in eukaryotic cells","volume":"67","author":"Waga","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB87","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1101\/gad.8.23.2817","article-title":"Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1\/cip 1","volume":"8","author":"Wagner","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB88","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1101\/gad.10.10.1219","article-title":"The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway","volume":"10","author":"Wang","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB89","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1006\/excr.1996.0137","article-title":"DNA repair fine structure in Werner's syndrome cell lines","volume":"224","author":"Webb","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB90","unstructured":"Werner, O., 1904. Uber Katarakt in Verbindung mit Sklerodermic. Doctoral dissertation, Kiel University, Schmidt and Klauning."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB91","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.biochem.66.1.61","article-title":"Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism","volume":"66","author":"Wold","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0531-5565(01)00227-3_BIB92","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1060832","article-title":"Molecular biology. 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