{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:20:39Z","timestamp":1777605639793,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":1645,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study examines the ability of osteoprotegerin (OPG) to prevent the local bone resorption caused by sciatic nerve damage. Sixty\u2010five 18\u2010week\u2010old male mice were assigned to one of six groups (<jats:italic>n<\/jats:italic> = 10\u201311\/group). A baseline control group was sacrificed on day zero of the 10\u2010day study. The remaining groups were placebo sham operated, placebo nerve crush (Plac NC) operated, 0.1 mg\/kg\/day OPG + nerve crush (LOW), 0.3 mg\/kg\/day OPG + nerve crush (MED), and 1.0 mg\/kg\/day OPG + nerve crush (HI). Nerve crush or sham operations were performed on the right leg. The left leg served as a contralateral control to the nerve crushed (ipsilateral) leg. The difference in mass between the right and left femur and tibia was examined. Additionally, quantitative histomorphometry was performed on the right and left femur and tibia diaphyses. Nerve crush resulted in a significant loss of bone mass in the ipsilateral side compared to the contralateral side. Bone mass for the ipsilateral bones of the Plac NC group were significantly reduced by 3.8% in the femur and 3.5% in the tibia compared to the contralateral limb. The percent diminution was reduced for OPG treated mice compared to the Plac NC group for both the femur and tibia. In the femur, the percent reduction of ipsilateral bone mass was reduced to 1.0% (LOW), 1.3% (MED) and 1.6% (HI) compared to the contralateral limb. In the tibia, loss of bone mass in the ipsilateral limb was reduced to 1.4% (LOW), 1.4% (MED), and 2.4% (HI) compared to the contralateral. OPG also decreased the amount of tibial endocortical resorption compared to the Plac NC group. In summary, OPG mitigated bone loss caused by damage to the sciatic nerve. \u00a9 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.<\/jats:p>","DOI":"10.1016\/s0736-0266(00)00057-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T18:09:00Z","timestamp":1027620540000},"page":"518-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Osteoprotegerin ameliorates sciatic nerve crush induced bone loss"],"prefix":"10.1002","volume":"19","author":[{"given":"Ted A.","family":"Bateman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin R.","family":"Dunstan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Lacey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia L.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reed A.","family":"Ayers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Simske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9294"},{"key":"e_1_2_1_3_2","first-page":"S528","article-title":"Comparison of osteoprotegerin, pamidronate and ibandronate in the treatment of suspension induced osteopenia","volume":"14","author":"Bateman TA","year":"1999","journal-title":"J Bone Miner Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00256-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.2106\/00004623-198567070-00005","article-title":"Treatment of sciatic denervation disuse osteoporosis in the rat tibia with capacitively coupled electrical stimulation","volume":"67","author":"Brighton CT","year":"1985","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.9.1260"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.3.527"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00003086-198303000-00034","article-title":"The effect of pulsing electromagnetic fields on bone metabolism in experimental disuse osteoporosis","volume":"173","author":"Cruess RL","year":"1983","journal-title":"Clin Orthop"},{"key":"e_1_2_1_9_2","first-page":"181","article-title":"Pig calcitonin in the treatment of localized osteoporosis","volume":"2","author":"De Bastinani G","year":"1976","journal-title":"Ital J Orthop Traumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(81)90147-3"},{"key":"e_1_2_1_11_2","unstructured":"FleetML.The effect of developmental stage on the mouse response to induced osteopenia. 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