{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:23:53Z","timestamp":1765279433211},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":1706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The proto\u2010oncogene c\u2010fos has been implicated in the development of both benign and malignant lesions of bone. Although c\u2010fos expression in such lesions has been well studied in transgenic mouse models, less is known about its role in human musculoskeletal pathology. To clarify this relationship, we used in situ hybridization to localize c\u2010fos m\u2010RNA transcripts in 26 fibrous lesions (eight cases of extra\u2010abdominal fibromatosis and six cases each of fibrous dysplasia, fibrosarcoma, and malignant fibrous histiocytoma of bone) as well as six chondrosarcomas and eight conventional high grade osteosarcomas. We found detectable levels of c\u2010fos expression in tissues from each type of lesion tested. Moreover, all fibrous lesions consistently demonstrated high levels of expression in a majority of cells in each lesion. Chondrosarcomas and osteosarcomas exhibited more heterogeneity in c\u2010fos expression than fibrous tissues. Three of six chondrosarcomas showed moderate expression of c\u2010fos while only one of six was considered high. Similarly, only three of eight osteosarcomas had high expression of c\u2010fos. These findings indicate that the expression of c\u2010fos may be important in the development of a broad range of fibrous lesions as well as in bone and cartilaginous tumors. Additionally, this is the first report, to our knowledge, of detectable c\u2010fos m\u2010RNA in human chondrosarcoma. \u00a9 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.<\/jats:p>","DOI":"10.1016\/s0736-0266(00)90020-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T21:59:41Z","timestamp":1027634381000},"page":"339-345","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Detection of c\u2010fos expression in benign and malignant musculoskeletal lesions"],"prefix":"10.1002","volume":"19","author":[{"given":"Jason S.","family":"Weisstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Majeska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Einhorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"129","article-title":"The role of jun, fos, and the AP\u20101 complex in cell proliferation and transformation","volume":"1072","author":"Angel P","year":"1991","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100110410"},{"key":"e_1_2_1_4_2","first-page":"3808","article-title":"C\u2010Myc amplification and expression in newly established human osteosarcoma cell lines","volume":"47","author":"Bogenmann E","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506083322304"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199203000-00035"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.6.3272"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.6.11.1834"},{"key":"e_1_2_1_9_2","first-page":"579","article-title":"Nonradioactive in situ hybridization using digoxigeninlabeled oligonucleotides","volume":"141","author":"Crabb ID","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.151.3711.698"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000398246"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050199"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000011912"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/311433a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.3.685"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7939685"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s004280050121","article-title":"Cellular distribution of c\u2010jun and c\u2010fos in rat lung before and after bleomycin induced injury","volume":"431","author":"Haase M","year":"1997","journal-title":"Virchows Arch"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940060207"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090808"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1989.tb02236.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508033330508"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202675"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.134.1.441"},{"key":"e_1_2_1_24_2","first-page":"832","article-title":"Expression of c\u2010met proto\u2010oncogene product (c\u2010met) in benign and malignant bone tumors","volume":"10","author":"Naka T","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80757-T"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.41.25715"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199610)63:1<37::AID-JCB3>3.0.CO;2-0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/325412a0"},{"key":"e_1_2_1_29_2","first-page":"861","article-title":"c\u2010Fos expression induces bone tumors in transgenic mice","volume":"4","author":"Ruther U","year":"1989","journal-title":"Oncogene"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102.3.461"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910380112"},{"key":"e_1_2_1_32_2","first-page":"606","article-title":"Expression of c\u2010fos mRNA during fracture healing in the rat","volume":"22","author":"Silver J","year":"1997","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<386::AID-DVG8>3.0.CO;2-2"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00040-7"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100130506"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07783.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080710"},{"key":"e_1_2_1_38_2","first-page":"6244","article-title":"c\u2010Fos\u2010induced osteosarcoma formation in transgenic mice: co\u2010operativity with c\u2010jun and the role of endogenous c\u2010fos","volume":"55","author":"Wang ZQ","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_1_39_2","first-page":"3985","article-title":"Histogenesis and morphology of periosteal sarcomas induced by FBJ virus in NIH Swiss mice","volume":"36","author":"Ward JM","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_40_2","first-page":"989","article-title":"The proto\u2010oncogene c\u2010fos is over\u2010expressed in the majority of human osteosarcomas","volume":"5","author":"Wu JX","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198803000-00046"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1994.tb02368.x"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0736-0266(00)90020-2","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0736-0266%2800%2990020-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:40:20Z","timestamp":1700307620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/S0736-0266%2800%2990020-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1016\/S0736-0266(00)90020-2"],"URL":"https:\/\/doi.org\/10.1016\/s0736-0266(00)90020-2","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]},"assertion":[{"value":"2000-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}