{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:40:31Z","timestamp":1726245631615},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,11,6]],"date-time":"2001-11-06T00:00:00Z","timestamp":1005004800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["RO1AG10565"],"award-info":[{"award-number":["RO1AG10565"]}]},{"name":"Merit Review Grant from the Veterans Administration"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The gene encoding zebrafish brain\u2010derived neurotrophic factor (BDNF) was cloned from a PAC genomic DNA library. The entire transcription unit was contained in two independently isolated clones that together encompass 120 kb of genomic DNA. The intron\/exon organization of the zebrafish gene was found to be identical to that of the mammalian gene but only one promoter has so far been identified. The associated 5\u2032 exon is 67% identical to exon 1c of the rat BDNF gene. A search of the 5\u2032 flank of the cloned promoter for sequence similarities with known transcription factor binding sites revealed potential AP\u20101, CREB, and SP1 binding sites. Fusion constructs containing the cloned promoter and 1.7 kb of 5\u2032 flank and an enhanced green fluorescent protein reporter that becomes membrane\u2010anchored were injected into 1\u20138 cell stage embryos. Expression was seen in notochord, muscle, epithelial and endothelial cells of the 1\u2010day\u2010old embryo in consonance with the endogenous gene. These results demonstrate that the cloned promoter mediates cell\u2010specific expression.<\/jats:p>","DOI":"10.1016\/s0736-5748(01)00046-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T09:44:56Z","timestamp":1027590296000},"page":"663-673","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Brain\u2010derived neurotrophic factor gene organization and transcription in the zebrafish embryo"],"prefix":"10.1002","volume":"19","author":[{"given":"Gigi","family":"Huynh","sequence":"first","affiliation":[{"name":"Department of Medicine Northern California Health Care System Martinez CA USA"},{"name":"East Bay Institute for Research and Education 150 Muir Road Martinez CA 94553 USA"}]},{"given":"Gerhard","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Department of Medicine Northern California Health Care System Martinez CA USA"},{"name":"Department of Medicine University of California at Davis Davis CA USA"},{"name":"East Bay Institute for Research and Education 150 Muir Road Martinez CA 94553 USA"}]}],"member":"311","published-online":{"date-parts":[[2001,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90166-D"},{"key":"e_1_2_6_3_1","first-page":"39","article-title":"Molecular control of neuronal survival in the chick embryo","volume":"71","author":"Biffo S.","year":"1994","journal-title":"EXS Med"},{"issue":"1","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0169-328X(97)00180-0","article-title":"Localization of putative calcium\u2010responsive regions in the rat BDNF gene","volume":"50","author":"Bishop J.F.","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"1","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0169-328X(94)90094-9","article-title":"Alternate 5\u2032 exons in the rat brain\u2010derived neurotrophic factor gene: differential patterns of expression across brain regions","volume":"26","author":"Bishop J.F.","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-07-01897.1986"},{"issue":"3","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/PL00000701","article-title":"Calcium regulation of the brain\u2010derived neurotrophic factor gene","volume":"57","author":"Finkbeiner S.","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1242\/dev.124.17.3313","article-title":"Control of early cell death by BDNF in the chick retina","volume":"124","author":"Frade J.M.","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/372266a0"},{"issue":"4","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/sj.ejhg.5200321","article-title":"Detailed transcript map of a 810\u2010kb region at 11p14 involving identification of 10 novel human 3\u2032 exons","volume":"7","author":"Guillemot F.","year":"1999","journal-title":"Eur. J. Hum. Genet."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0320(20010401)43:4<273::AID-CYTO1059>3.0.CO;2-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(97)00017-8"},{"issue":"2","key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0169-328X(96)00254-9","article-title":"Organization, sequence and functional analysis of a mouse BDNF promoter","volume":"45","author":"Hayes V.Y.","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1242\/dev.120.6.1643","article-title":"Expression of the BDNF gene in the developing visual system of the chick","volume":"120","author":"Herzog K.H.","year":"1994","journal-title":"Development"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/350230a0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001990102"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.3060"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-10-03031.1986"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00007-O"},{"key":"e_1_2_6_20_1","first-page":"R71","article-title":"The saga of the nerve growth factor","volume":"9","author":"Levi\u2010Montalcini R.","year":"1998","journal-title":"Neuroreport"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0736-5748(01)00041-7","article-title":"Brai\u2010derived neurotrophic factor and TrkB tyrosine receptor gene expression in zebrafish embryo and larva","volume":"19","author":"Lum de la Monte S.M.T.","year":"2001","journal-title":"Int. J. Dev. Neurosci."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2321006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90436-I"},{"issue":"6","key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1097\/00001756-199804200-00037","article-title":"Expression of mRNAs encoding BDNF and its receptor in adult rat hypothalamus","volume":"9","author":"Marmigere F.","year":"1998","journal-title":"Neuroreport"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8839"},{"issue":"19","key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1073\/pnas.90.19.8802","article-title":"Differential usage of multiple brain\u2010derived neurotrophic factor promoters in the rat brain following neuronal activation","volume":"90","author":"Metsis M.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0169-328X(98)00242-3","article-title":"Multiple promoters direct stimulus and temporal specific expression of brain\u2010derived neurotrophic factor in the somatosensory cortex","volume":"62","author":"Nanda S.","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00192-6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-09-03337.1988"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(89)90256-X"},{"issue":"3","key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1006\/bbrc.1996.1881","article-title":"BDNF gene can Be activated by Ca2+ signals without involvement of de novo AP\u20101 synthesis","volume":"229","author":"Sano K.","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_2_6_32_1","unstructured":"J.Schug G.C.Overton 1997.\u2018tess : Transcription Element Search Software on the WWW\u2019 Technical Report CBIL\u2010TR\u20101997\u20101001\u2010v0.0 of the Computational Biology and Informatics Laboratory School of Medicine University of Pennsylvania URL:http:\/\/www.cbil.upenn.edu\/tess\/index.html."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/360757a0"},{"issue":"1","key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/(SICI)1097-4695(199910)41:1<127::AID-NEU16>3.0.CO;2-J","article-title":"Molecular mechanisms underlying activity\u2010dependent regulation of BDNF expression","volume":"41","author":"Shieh P.B.","year":"1999","journal-title":"J. Neurobiol."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81011-9"},{"issue":"1","key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0006-291X(05)80148-2","article-title":"Characterization of the 5\u2032\u2010flanking region of the human brain\u2010derived neurotrophic factor gene","volume":"182","author":"Shintani A.","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Ca2+ influx regulates BDNF transcription by a CREB family transcription factor\u2010dependent mechanism","volume":"20","author":"Tao X.","year":"1998","journal-title":"Neuron"},{"issue":"2","key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0306-4522(94)90242-9","article-title":"Developmental regulation of brain\u2010derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain","volume":"60","author":"Timmusk T.","year":"1994","journal-title":"Neuroscience"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.1.185"},{"issue":"3","key":"e_1_2_6_40_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0896-6273(93)90335-O","article-title":"Multiple promoters direct tissue\u2010specific expression of the rat BDNF gene","volume":"10","author":"Timmusk T.","year":"1993","journal-title":"Neuron"},{"issue":"1","key":"e_1_2_6_41_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3940(94)90036-1","article-title":"Analysis of transcriptional initiation and translatability of brain\u2010derived neurotrophic factor mRNAs in the rat brain","volume":"177","author":"Timmusk T.","year":"1994","journal-title":"Neurosci. Lett."},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/8734"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/367489a0"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574801000466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574801000466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0736-5748%2801%2900046-6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0736-5748%2801%2900046-6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/S0736-5748%2801%2900046-6","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0736-5748%2801%2900046-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:21:09Z","timestamp":1694031669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/S0736-5748%2801%2900046-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1016\/S0736-5748(01)00046-6"],"URL":"https:\/\/doi.org\/10.1016\/s0736-5748(01)00046-6","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"2001-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}