{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:54:02Z","timestamp":1760061242918,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parallel and Distributed Computing"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1016\/s0743-7315(03)00083-2","type":"journal-article","created":{"date-parts":[[2003,7,31]],"date-time":"2003-07-31T20:39:52Z","timestamp":1059683992000},"page":"683-691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Least-squares fit of genomic data by sums of epistatic effects"],"prefix":"10.1016","volume":"63","author":[{"given":"Philip","family":"Hanlon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Andrew","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Strenski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0743-7315(03)00083-2_BIB1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/genetics\/114.4.1191","article-title":"The effect of an experimental bottleneck upon quantitative genetic variation in the housefly","volume":"114","author":"Bryant","year":"1986","journal-title":"Genetics"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/hdy.1993.20","article-title":"The effect of serial founder-flush cycles on quantitative genetic variation in the housefly","volume":"70","author":"Bryant","year":"1992","journal-title":"Heredity"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.es.15.110184.000525","article-title":"Genetic revolutions in relation to speciation phenomena","volume":"15","author":"Carson","year":"1984","journal-title":"Annu. Rev. Ecol. Syst."},{"key":"10.1016\/S0743-7315(03)00083-2_BIB4","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/genetics\/139.3.1455","article-title":"Epistasis and its contribution to genetic variance components","volume":"139","author":"Cheverud","year":"1995","journal-title":"Genetics"},{"issue":"13","key":"10.1016\/S0743-7315(03)00083-2_BIB5","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1073\/pnas.95.13.7502","article-title":"Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p,3q, and 4q: evidence of epistasis between 1p and IBD1","volume":"95","author":"Cho","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"4","key":"10.1016\/S0743-7315(03)00083-2_BIB6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U","article-title":"Anxiety proneness linked to epistatic loci in genome scan of human personality traits","volume":"81","author":"Cloninger","year":"1998","journal-title":"Amer. J. Med. Genet."},{"key":"10.1016\/S0743-7315(03)00083-2_BIB7","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/genetics\/39.6.859","article-title":"An extension of the concept of partitioning hereditary variance for analysis of covariances among relatives when epistasis is present","volume":"39","author":"Cockerham","year":"1954","journal-title":"Genetics"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB8","series-title":"Statistical Genetics and Plant Breeding","first-page":"53","article-title":"Estimation of genetic variances","author":"Cockerham","year":"1963"},{"unstructured":"G. Dantzig, A. Veinott (Eds.), Mathematics of the Decision Sciences, Amer. Math. Soc., Providence, RI, 1968.","key":"10.1016\/S0743-7315(03)00083-2_BIB9"},{"year":"1989","author":"Falconer","series-title":"Introduction to Quantitative Genetics","key":"10.1016\/S0743-7315(03)00083-2_BIB10"},{"issue":"4","key":"10.1016\/S0743-7315(03)00083-2_BIB11","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1093\/genetics\/148.4.1885","article-title":"Epistatic interactions between smell-impaired loci in Drosophila melanogaster","volume":"148","author":"Fedorowicz","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1558-5646.1987.tb05772.x","article-title":"On the effect of founder events on epistatic genetic variance","volume":"41","author":"Goodnight","year":"1987","journal-title":"Evolution"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1558-5646.1988.tb04144.x","article-title":"Epistasis and the effect of founder events on the additive genetic variance","volume":"42","author":"Goodnight","year":"1988","journal-title":"Evolution"},{"issue":"1\u20132","key":"10.1016\/S0743-7315(03)00083-2_BIB14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0004-3702(95)00040-2","article-title":"PALO","volume":"84","author":"Greiner","year":"1996","journal-title":"Artif. Intell."},{"key":"10.1016\/S0743-7315(03)00083-2_BIB15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/genetics\/102.1.129","article-title":"Unexpected behavior in two-locus genetic systems","volume":"102","author":"Hastings","year":"1982","journal-title":"Genetics"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB16","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/genetics\/109.4.799","article-title":"Multilocus population genetics with weak epistasis. I. Equilibrium properties of two-locus two-allele models","volume":"109","author":"Hastings","year":"1985","journal-title":"Genetics"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2307\/3001481","article-title":"The description of genic interaction in continuous variation","volume":"10","author":"Hayman","year":"1955","journal-title":"Biometrics"},{"issue":"4","key":"10.1016\/S0743-7315(03)00083-2_BIB18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/hdy.1997.58","article-title":"Genetic basis of sperm and testis length differences and epistatic effect on hybrid inviability and sperm motility between Drosophila simulans and D. sechellia","volume":"78","author":"Joly","year":"1997","journal-title":"Heredity"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB19","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0040-5809(75)90025-8","article-title":"General two-locus selection models","volume":"7","author":"Karlin","year":"1975","journal-title":"Theor. Popul. Biol."},{"key":"10.1016\/S0743-7315(03)00083-2_BIB20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0040-5809(70)90041-9","article-title":"Linkage and selection","volume":"1","author":"Karlin","year":"1970","journal-title":"Theor. Popul. Biol."},{"key":"10.1016\/S0743-7315(03)00083-2_BIB21","first-page":"458","article-title":"The evolutionary dynamics of complex polymorphisms","volume":"14","author":"Lewontin","year":"1960","journal-title":"Evolution"},{"issue":"2","key":"10.1016\/S0743-7315(03)00083-2_BIB22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/genetics\/145.2.453","article-title":"Epistatis for three grain yield components in rice (oryza sativa L.)","volume":"145","author":"Li S.R. Pinson","year":"1997","journal-title":"Genetics"},{"issue":"1","key":"10.1016\/S0743-7315(03)00083-2_BIB23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/genetics\/147.1.315","article-title":"Dissection of a synthesized quantitative trait to characterize transgene interactions","volume":"147","author":"Nap","year":"1997","journal-title":"Genetics"},{"year":"1986","author":"Provine","series-title":"Sewall Wright and Evolutionary Biology","key":"10.1016\/S0743-7315(03)00083-2_BIB24"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB25","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/genetics\/121.4.839","article-title":"A building block model for quantitative genetics","volume":"121","author":"Tachida","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB26","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/genetics\/92.4.1265","article-title":"The unit of selection in Drosophila mercatorum II, Genetic revolution and the origin of coadapted genomes in parthenogentic strains","volume":"92","author":"Templeton","year":"1979","journal-title":"Genetics"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB27","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/genetics\/94.4.1011","article-title":"The theory of speciation via the founder principle","volume":"94","author":"Templeton","year":"1980","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/S0743-7315(03)00083-2_BIB28","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1137\/0606040","article-title":"Hill climbing with multiple local optima","volume":"6","author":"Tovey","year":"1985","journal-title":"SIAM J. Algebraic Discrete Methods"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB29","first-page":"33","article-title":"Sewall Wright","volume":"8","author":"Wade","year":"1992","journal-title":"Oxford Surv. Evol. Biol."},{"issue":"11","key":"10.1016\/S0743-7315(03)00083-2_BIB30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s003359900586","article-title":"Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat","volume":"8","author":"Wendell","year":"1997","journal-title":"Mamm. Genome"},{"unstructured":"S. Wright, The roles of mutation, inbreeding, crossbreeding and selection in evolution, Proceedings of the Sixth International Congress of Genetics, Vol. 1, Ithaca, NY, 1932, pp. 356\u2013366.","key":"10.1016\/S0743-7315(03)00083-2_BIB31"},{"key":"10.1016\/S0743-7315(03)00083-2_BIB32","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1558-5646.1980.tb04022.x","article-title":"Genic and organismic selection","volume":"34","author":"Wright","year":"1980","journal-title":"Evolution"}],"container-title":["Journal of Parallel and Distributed Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0743731503000832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0743731503000832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:52:23Z","timestamp":1760046743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0743731503000832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":32,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S0743731503000832"],"URL":"https:\/\/doi.org\/10.1016\/s0743-7315(03)00083-2","relation":{},"ISSN":["0743-7315"],"issn-type":[{"type":"print","value":"0743-7315"}],"subject":[],"published":{"date-parts":[[2003,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Least-squares fit of genomic data by sums of epistatic effects","name":"articletitle","label":"Article Title"},{"value":"Journal of Parallel and Distributed Computing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0743-7315(03)00083-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}