{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:59:05Z","timestamp":1776423545955,"version":"3.51.2"},"reference-count":49,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Free Radical Biology and Medicine"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1016\/s0891-5849(03)00152-7","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T22:24:07Z","timestamp":1051741447000},"page":"1531-1543","source":"Crossref","is-referenced-by-count":64,"title":["Oxidant-mediated AA release from astrocytes involves cPLA2 and iPLA2"],"prefix":"10.1016","volume":"34","author":[{"given":"Jianfeng","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert Y","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Y","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0891-5849(03)00152-7_BIB1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/j.1471-4159.1992.tb10990.x","article-title":"Reactive oxygen species and the central nervous system","volume":"59","author":"Halliwell","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF02255928","article-title":"Oxidative stress and neurodegenerative disorders","volume":"5","author":"Sun","year":"1998","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB3","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.STR.27.6.1124","article-title":"Role of oxidants in ishemic brain damage","volume":"27","author":"Chan","year":"1996","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/S0891-5849(03)00152-7_BIB4","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/neu.2000.17.871","article-title":"Free radical pathways in CNS injury","volume":"17","author":"Lewen","year":"2000","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/S0891-5849(03)00152-7_BIB5","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1046\/j.1471-4159.2000.0752178.x","article-title":"Oxidative stress following traumatic brain injury in rats","volume":"75","author":"Tyurin","year":"2000","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/S0891-5849(03)00152-7_BIB6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0006-2952(97)00062-2","article-title":"Reactive oxygen species and Alzheimer\u2019s disease","volume":"54","author":"Multhaup","year":"1997","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/S0891-5849(03)00152-7_BIB7","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1046\/j.1471-4159.1997.68052092.x","article-title":"4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer\u2019s disease","volume":"68","author":"Sayre","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB8","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative stress, glutamate, and neurodegenerative disorders","volume":"262","author":"Coyle","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02255969","article-title":"Ethanol and oxidative mechanisms in the brain","volume":"8","author":"Sun","year":"2001","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0891-5849(97)00159-7","article-title":"Alterations of antioxidant enzyme expression in response to hydrogen peroxide","volume":"24","author":"Rohrdanz","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1006\/jmcc.1997.0623","article-title":"Stable overexpression of the constitutive form of heat shock protein 70 confers oxidative protection","volume":"30","author":"Chong","year":"1998","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0891-5849(96)00275-4","article-title":"Sevanian, A. Oxidants as stimulators of signal transduction","volume":"22","author":"Suzuki","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/(SICI)1097-4547(19990315)55:6<674::AID-JNR3>3.0.CO;2-J","article-title":"Influence of calcium and iron on cell death and mitochondrial function in oxidatively stressed astrocytes","volume":"55","author":"Robb","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB14","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0891-5849(00)00221-5","article-title":"Protein kinase C signaling and oxidative stress","volume":"28","author":"Gopalakrishna","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB15","first-page":"5627","article-title":"Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants","volume":"49","author":"Larsson","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1471-4159.2001.00520.x","article-title":"Oxidative stress induces proorphanin FQ and proenkephalin gene expression in astrocytes through p38- and ERK-MAP kinases and NF-\u03baB","volume":"79","author":"Rosenberger","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB17","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0021-9258(18)54023-0","article-title":"Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide","volume":"268","author":"Natajaran","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB18","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1006\/abbi.1994.1258","article-title":"Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts","volume":"311","author":"Kiss","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1046\/j.1471-4159.1997.69020729.x","article-title":"Hydrogen peroxide-induced phospholipase D activation in rat pheochromocytoma PC12 cells","volume":"69","author":"Ito","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB20","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1046\/j.1471-4159.2000.0752445.x","article-title":"Regulation of phospholipase D2 by H2O2 in PC12 cells","volume":"75","author":"Oh","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB21","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1046\/j.1471-4159.2000.0750788.x","article-title":"Effects of oxidative stress on phospholipid signaling in rat cultured astrocytes and brain slices","volume":"75","author":"Servitja","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB22","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1097\/00001756-200107200-00045","article-title":"Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells","volume":"12","author":"Banno","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1182\/blood.V72.2.491.491","article-title":"Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids","volume":"72","author":"Shasby","year":"1988","journal-title":"Blood"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB24","first-page":"L430","article-title":"H2O2 injury causes Ca2+-dependent and -independent hydrolysis of phosphatidylcholine in alveolar epithelial cells","volume":"263","author":"Rice","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1432-1033.1997.00587.x","article-title":"Mediation by arachidonic acid metabolites of the H2O2-induced stimulation of mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun NH2-terminal kinase)","volume":"244","author":"Tournier","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB26","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1046\/j.1471-4159.1998.70052082.x","article-title":"Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons","volume":"70","author":"Samanta","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0898-6568(94)00061-F","article-title":"Downregulation of protein kinase C attenuates the oxidant hydrogen peroxide-mediated activation of phospholipase A2 in pulmonary vascular smooth muscle cells","volume":"7","author":"Chakraborti","year":"1995","journal-title":"Cell Signal"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1006\/bbrc.2000.3479","article-title":"Hydrogen peroxide activation of Ca2+-independent phospholipase A2 in uterine stromal cells","volume":"276","author":"Birbes","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0167-4889(95)91997-Z","article-title":"Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells","volume":"1265","author":"Rao","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0006-2952(95)00195-6","article-title":"Evidence for the activation of the signal-responsive phospholipase A2 by exogenous hydrogen peroxide","volume":"50","author":"Boyer","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1165\/ajrcmb\/7.3.307","article-title":"Hydrogen peroxide increases the availability of arachidonic acid for oxidative metabolism by inhibiting acylation into phospholipids in the alveolar macrophage","volume":"7","author":"Sporn","year":"1992","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB32","doi-asserted-by":"crossref","first-page":"21505","DOI":"10.1074\/jbc.271.35.21505","article-title":"Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells","volume":"271","author":"Sapirstein","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1471-4159.2002.01145.x","article-title":"Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachidonic acid release in primary murine astrocytes","volume":"83","author":"Xu","year":"2002","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/S0891-5849(03)00152-7_BIB34","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1083\/jcb.85.3.890","article-title":"Preparation of separate astro glial and oligodendro glial cell cultures from rat cerebral tissue","volume":"85","author":"McCarthy","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB35","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1023\/A:1020981224876","article-title":"Studies on the cytosolic phospholipase A2 in immortalized astrocytes (DITNC) revealed new properties of the calcium ionophore, A23187","volume":"24","author":"Xue","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB36","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1074\/jbc.271.12.6758","article-title":"Distinct roles in signal transduction for each of the phopholipase A2 enzymes present in P388D1 macrophages","volume":"271","author":"Balsinde","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0005-2760(96)00002-1","article-title":"Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate","volume":"1302","author":"Lio","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1074\/jbc.270.1.445","article-title":"Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones","volume":"270","author":"Ackerman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB39","doi-asserted-by":"crossref","first-page":"9060","DOI":"10.1523\/JNEUROSCI.17-23-09060.1997","article-title":"Pyruvate protects neurons against hydrogen peroxide-induced toxicity","volume":"17","author":"Desagher","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0065-2571(99)00031-X","article-title":"Recent advances in the regulation of cytololic phospholipase A2","volume":"40","author":"Gij\u00f3n","year":"2000","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/abbi.1993.1123","article-title":"Establishment of a hydrogen peroxide resistant variant of renal tubular epithelial cells","volume":"301","author":"Goligorsky","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB42","doi-asserted-by":"crossref","first-page":"12710","DOI":"10.1074\/jbc.273.21.12710","article-title":"Phosphatidic acid-induced elevation of intracellular Ca2+ is mediated by RhoA and H2O2 in Rat-2 fibroblast","volume":"273","author":"Lee","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/abbi.2001.2439","article-title":"Role of Ca2+-independent phospholipase A2 on arachidonic acid release induced by reactive oxygen species","volume":"392","author":"Martinez","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.1411571","article-title":"Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C","volume":"258","author":"Nishizuka","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0891-5849(03)00152-7_BIB45","doi-asserted-by":"crossref","first-page":"35344","DOI":"10.1074\/jbc.M105264200","article-title":"Atypical \u03bb\/\u03b9 PKC conveys 5-lipoxygenase\/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-\u03baB activation in response to tumor necrosis factor-\u03b1 and interleukin-1\u03b2","volume":"276","author":"Anthonsen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB46","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1016\/S0021-9258(18)38102-X","article-title":"Inhibition of cell proliferation by \u03b1-tocopherol. Role of protein kinase C","volume":"266","author":"Boscoboinik","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/abbi.1997.0334","article-title":"Cancer preventive selenocompounds induce a specific redox modification of cysteine-rich regions in calcium-dependent isoenzymes of protein kinase C","volume":"348","author":"Gopalakrishna","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB48","first-page":"A1922","article-title":"Curcumin irreversibly inactivates protein kinase C activity and phorbol ester binding","volume":"37","author":"Chen","year":"1996","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"10.1016\/S0891-5849(03)00152-7_BIB49","doi-asserted-by":"crossref","first-page":"11233","DOI":"10.1073\/pnas.94.21.11233","article-title":"Activation of protein kinase C by tyrosine phosphorylation in response to H2O2","volume":"94","author":"Konishi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Free Radical Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891584903001527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891584903001527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T23:01:15Z","timestamp":1623020475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0891584903001527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["S0891584903001527"],"URL":"https:\/\/doi.org\/10.1016\/s0891-5849(03)00152-7","relation":{},"ISSN":["0891-5849"],"issn-type":[{"value":"0891-5849","type":"print"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}