{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:25:29Z","timestamp":1779344729071,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":6163,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuron"],"published-print":{"date-parts":[[1996,9]]},"DOI":"10.1016\/s0896-6273(00)80175-0","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T09:31:41Z","timestamp":1081848701000},"page":"423-434","source":"Crossref","is-referenced-by-count":349,"title":["A Model for Central Synaptic Junctional Complex Formation Based on the Differential Adhesive Specificities of the Cadherins"],"prefix":"10.1016","volume":"17","author":[{"given":"Allison M","family":"Fannon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R","family":"Colman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0896-6273(00)80175-0_BIB1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.6828885","article-title":"Morphological basis of long-term habituation and sensitization in Aplysia","volume":"220","author":"Bailey","year":"1983","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB2","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1073\/pnas.85.7.2373","article-title":"Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons","volume":"85","author":"Bailey","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1083\/jcb.100.1.327","article-title":"Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells","volume":"100","author":"Boller","year":"1985","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB4","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1083\/jcb.130.4.977","article-title":"Receptor protein tyrosine phosphatase PTP\u03bc associates with cadherins and catenins in vivo","volume":"130","author":"Brady-Kalnay","year":"1995","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF00519303","article-title":"The synapse en marron between golgi II neurons and mossy fibers in the rat's cerebellar cortex","volume":"133","author":"Chan-Palay","year":"1971","journal-title":"Z. Anat. Entwickl.-Gesch"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1083\/jcb.78.1.36","article-title":"Form of the postsynaptic density","volume":"78","author":"Cohen","year":"1978","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.63.2.441","article-title":"Isolation of postsynaptic densities from rat brain","volume":"63","author":"Cotman","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/368737a0","article-title":"Axonal sprouting accompanies functional reorganization in adult cat striate cortex","volume":"368","author":"Darian-Smith","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0092-8674(00)81251-9","article-title":"The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo","volume":"85","author":"DeChiara","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/jcs.1991.Supplement_15.11","article-title":"Intracellular organization of hippocampal neurons during the development of neuronal polarity","volume":"15","author":"Dotti","year":"1991","journal-title":"J. Cell Sci. (Suppl.)"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0092-8674(90)90240-F","article-title":"Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture","volume":"62","author":"Dotti","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/349158a0","article-title":"Polarized sorting of glypiated proteins in hippocampal neurons","volume":"349","author":"Dotti","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0092-8674(00)81278-7","article-title":"Origins of cell polarity","volume":"84","author":"Drubin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1096-9861(19960617)370:1<105::AID-CNE10>3.0.CO;2-R","article-title":"Regional and ultrastructural distribution of the a8 integrin subunit in developing and adult rat brain suggests a role in synaptic function","volume":"370","author":"Einheber","year":"1996","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0079-6123(08)63285-9","article-title":"Synaptic vesicle proteins and regulated exocytosis","volume":"105","author":"Elferink","year":"1995","journal-title":"Prog. Brain Res"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB16","unstructured":"Ellisman, M.H. (1987). Transcellular filament system. In Encyclopedia Neuroscience, Volume 2, G. Adelman, ed. (Boston: Birkauser), pp. 1232\u20131233."},{"key":"10.1016\/S0896-6273(00)80175-0_BIB17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.129.1.189","article-title":"Novel E-cadherin mediated adhesion in peripheral nerve","volume":"129","author":"Fannon","year":"1995","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)81253-2","article-title":"Defective neuromuscular synaptogenesis in agrin-deficient mutant mice","volume":"85","author":"Gautam","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB19","series-title":"The Formation of Nerve Connections","author":"Gaze","year":"1970"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.cb.08.110192.001515","volume":"8","author":"Geiger","year":"1992","journal-title":"Cadherins. Annu. Rev. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/356150a0","article-title":"Receptive field dynamics in adult primary visual cortex","volume":"356","author":"Gilbert","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(00)81252-0","article-title":"Agrin acts via MuSK receptor complex","volume":"85","author":"Glass","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB23","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0006-291X(05)80917-9","article-title":"Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules","volume":"173","author":"Goodwin","year":"1990","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0896-6273(00)80074-4","article-title":"Selective adhesion of cells from different telencephalic regions","volume":"16","author":"G\u00f6tz","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0955-0674(93)90028-O","article-title":"The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules","volume":"5","author":"Grunwald","year":"1993","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0896-6273(93)90068-3","article-title":"Proteins associated with the cytoplasmic surface of adhesion molecules","volume":"11","author":"Gumbiner","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)81279-9","article-title":"Cell adhesion","volume":"84","author":"Gumbiner","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB28","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1471-4159.1982.tb11504.x","article-title":"Biochemical and morphological comparison of postsynaptic densities prepared from rat, hamster, and monkey brains by phase partitioning","volume":"39","author":"Gurd","year":"1982","journal-title":"J. Neurochem"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF01735373","article-title":"Structural components in the synaptic cleft captured by freeze-substitution and deep etching of directly frozen cerebellar cortex","volume":"17","author":"Ichimura","year":"1988","journal-title":"J. Neurocytol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0896-6273(91)90075-B","article-title":"R-cadherin","volume":"7","author":"Inuzuka","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/BF01181321","article-title":"Morphological characteristics of perforated synapses in the latter stages of synaptogenesis in rat neocortex","volume":"22","author":"Itarat","year":"1993","journal-title":"J. Neurocytol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB32","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1111\/j.1471-4159.1987.tb02456.x","article-title":"Developmental changes in calmodulin-kinase II activity at brain synaptic junctions","volume":"49","author":"Kelly","year":"1987","journal-title":"J. Neurochem"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0896-6273(88)90174-2","article-title":"The cell biology of the nerve terminal","volume":"1","author":"Kelly","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(92)90404-Z","article-title":"Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain","volume":"69","author":"Kintner","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB35","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/359647a0","article-title":"A functional barrier to movement of lipids in polarized neurons","volume":"359","author":"Kobayashi","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/jnr.490320209","article-title":"Immunohistochemical and biochemical analysis of N-cadherin expression during CNS development","volume":"32","author":"Lagunowich","year":"1992","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB37","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/0955-0674(91)90060-C","article-title":"Transmembrane molecular assemblies regulated by the greater cadherin family","volume":"3","author":"Magee","year":"1991","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1126\/science.2762814","article-title":"Neural cadherin","volume":"245","author":"Miyatani","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/380360a0","article-title":"Structural basis of calcium-induced rigidification and dimerization","volume":"380","author":"Nagar","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB40","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1083\/jcb.125.6.1341","article-title":"Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells","volume":"125","author":"N\u00e4thke","year":"1994","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0092-8674(90)90222-Z","article-title":"Localization of specificity determining sites in cadherin cell adhesion molecules","volume":"61","author":"Nose","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB42","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.7824937","article-title":"Solution structure of the epithelial cadherin domain responsible for selective cell adhesion","volume":"267","author":"Overduin","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB43","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/j.1460-2075.1989.tb03563.x","article-title":"The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species","volume":"8","author":"Ozawa","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB44","series-title":"The Fine Structure of the Nervous System","author":"Peters","year":"1991"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1177\/40.7.1376741","article-title":"Techniques to optimize post-embedding single and double staining for amino acid neurotransmitters","volume":"40","author":"Phend","year":"1992","journal-title":"J. Histochem. Cytochem"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/43.3.7532656","article-title":"An osmium-free method of epon embedment that preserves both ultrastructure and antigenicity for post-embedding immunocytochemistry","volume":"43","author":"Phend","year":"1995","journal-title":"J. Histochem. Cytochem"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB47","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/cne.903330307","article-title":"Differential expression of N- and R-cadherin in functional neuronal systems and other structures of the developing chicken brain","volume":"333","author":"Redies","year":"1993","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB48","first-page":"99","article-title":"NCAM and its polysialic acid moiety","volume":"16","author":"Rutishauser","year":"1992","journal-title":"Development (Suppl.)"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB49","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1002\/j.1460-2075.1993.tb05878.x","article-title":"Protocadherins","volume":"12","author":"Sano","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/374327a0","article-title":"Structural basis of cell\u2013cell adhesion by cadherins","volume":"374","author":"Shapiro","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB51","doi-asserted-by":"crossref","first-page":"6793","DOI":"10.1073\/pnas.92.15.6793","article-title":"Considerations on the folding topology and evolutionary origin of cadherin domains","volume":"92","author":"Shapiro","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cne.900790104","article-title":"Visuomotor coordination in the newt (Triturus viridescens) after regeneration of the optic nerve","volume":"79","author":"Sperry","year":"1943","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1152\/jn.1944.7.1.57","article-title":"Optic nerve regeneration with return of vision in anurans","volume":"7","author":"Sperry","year":"1944","journal-title":"J. Neurophysiol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/jn.1945.8.1.15","article-title":"Restoration of vision after crossing of optic nerves and after contralateral transplantation of eye","volume":"8","author":"Sperry","year":"1945","journal-title":"J. Neurophysiol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB55","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1073\/pnas.50.4.703","article-title":"Chemoaffinity in the orderly growth of nerve fiber patterns and connections","volume":"50","author":"Sperry","year":"1963","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/375645a0","article-title":"The synaptic vesicle cycle","volume":"375","author":"S\u00fcdhof","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1091\/mbc.2.4.261","article-title":"Diversity of the cadherin family","volume":"2","author":"Suzuki","year":"1991","journal-title":"Cell Reg"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB58","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.2006419","article-title":"Cadherin cell adhesion receptors as a morphogenetic regulator","volume":"251","author":"Takeichi","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB59","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1083\/jcb.113.4.867","article-title":"Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated","volume":"113","author":"Tsukita","year":"1991","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB60","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0896-6273(00)80045-8","article-title":"The (Greek) key to structures of neural adhesion molecules","volume":"16","author":"Vaughn","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB61","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1083\/jcb.103.4.1441","article-title":"A-CAM","volume":"103","author":"Volk","year":"1986","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB62","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1083\/jcb.103.4.1451","article-title":"A-CAM","volume":"103","author":"Volk","year":"1986","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB63","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(87)90525-3","article-title":"Formation of heterotypic adherens-type junctions between LCAM containing liver cells and ACAM containing lens cells","volume":"50","author":"Volk","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB64","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1126\/science.7824932","article-title":"E-cadherin","volume":"267","author":"Wagner","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80175-0_BIB65","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1523\/JNEUROSCI.15-06-04556.1995","article-title":"Lamina-specific expression of adhesion molecules in developing chick optic tectum","volume":"15","author":"Yamagata","year":"1995","journal-title":"J. Neurosci"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300801750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300801750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T23:42:03Z","timestamp":1585698123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627300801750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["S0896627300801750"],"URL":"https:\/\/doi.org\/10.1016\/s0896-6273(00)80175-0","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}