{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:17:34Z","timestamp":1772792254541,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5221,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuron"],"published-print":{"date-parts":[[1999,4]]},"DOI":"10.1016\/s0896-6273(00)80737-0","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T18:52:12Z","timestamp":1088794332000},"page":"789-798","source":"Crossref","is-referenced-by-count":235,"title":["Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels"],"prefix":"10.1016","volume":"22","author":[{"given":"Giles E.","family":"Hardingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco H.","family":"Cruzalegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilmar","family":"Bading","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0896-6273(00)80737-0_BIB1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1210\/mend.11.6.0011","article-title":"Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+\/calmodulin-dependent protein kinase IV","volume":"11","author":"Anderson","year":"1997","journal-title":"Mol. Endocrinol"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/374081a0","article-title":"A family of transcriptional adapter proteins targeted by the E1A oncoprotein","volume":"374","author":"Arany","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB3","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.1715095","article-title":"Stimulation of protein tyrosine phosphorylation by NMDA receptor activation","volume":"253","author":"Bading","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.8097060","article-title":"Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways","volume":"260","author":"Bading","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0306-4522(94)00462-E","article-title":"N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons","volume":"64","author":"Bading","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1006\/bbrc.1997.7037","article-title":"Gene regulation by nuclear and cytoplasmic calcium signals","volume":"236","author":"Bading","year":"1997","journal-title":"Biochem. Biophys. Res. Com"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB7","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1002\/j.1460-2075.1995.tb00157.x","article-title":"CBP-induced stimulation of c-Fos activity is abrogated by E1A","volume":"14","author":"Bannister","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB9","first-page":"2509","article-title":"Stimulation of c-Jun activity by CBP","volume":"11","author":"Bannister","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB10","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/j.1460-9568.1993.tb00917.x","article-title":"Increased expression of GAP-43, somatostatin and neuropeptide Y mRNA in the hippocampus during development of hippocampal kindling in rats","volume":"5","author":"Bendotti","year":"1993","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0306-4522(93)90207-V","article-title":"Regulation of neurotrophin and trkA, trkB and trkC tyrosine kinase receptor mRNA expression in kindling","volume":"53","author":"Bengzon","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB12","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0092-8674(00)81816-4","article-title":"CREB phosphorylation and dephosphorylation","volume":"87","author":"Bito","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/386284a0","article-title":"Homer","volume":"386","author":"Brakeman","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/18044","article-title":"DREAM is a Ca2+-regulated transcriptional repressor","volume":"398","author":"Carri\u00f3n","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB15","series-title":"Integrative Aspects of Calcium Signaling","article-title":"Function of nuclear and cytoplasmic calcium in the control of gene expression","author":"Chawla","year":"1998"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB16","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1126\/science.281.5382.1505","article-title":"CBP","volume":"281","author":"Chawla","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/365855a0","article-title":"Phosphorylated CREB binds specifically to the nuclear protein CBP","volume":"365","author":"Chrivia","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB18","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/emboj\/18.5.1335","article-title":"c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK\/SAPK1 activation","volume":"18","author":"Cruzalegui","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0896-6273(00)80026-4","article-title":"Signaling from synapse to nucleus","volume":"16","author":"Deisseroth","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB20","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0092-8674(94)90380-8","article-title":"JNK1","volume":"76","author":"D\u00e9rijard","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB21","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1101\/gad.8.8.869","article-title":"Molecular cloning and functional analysis of the adenovirus E1A-associated 300-KD protein (p300) reveals a protein with properties of a transcriptional adapter","volume":"8","author":"Eckner","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0896-6273(91)90084-D","article-title":"Increased levels of mRNAs for neurotrophic factors in the brain during kindling epileptogenesis","volume":"7","author":"Ernfors","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.7716515","article-title":"Calcium signaling in neurons","volume":"268","author":"Ghosh","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1126\/science.8097062","article-title":"Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock","volume":"268","author":"Ginty","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB25","first-page":"103","article-title":"The multifunctional role of the co-activator CBP in transcriptional regulation","volume":"52","author":"Goldman","year":"1997","journal-title":"Recent Prog. Horm. Res"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1023\/A:1009257909785","article-title":"Nuclear calcium","volume":"11","author":"Hardingham","year":"1998","journal-title":"Biometals"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/385260a0","article-title":"Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression","volume":"385","author":"Hardingham","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0143-4160(98)90111-7","article-title":"Mechanisms controlling gene expression by nuclear calcium signals","volume":"23","author":"Hardingham","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB29","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0960-9822(02)00636-X","article-title":"Transcriptional control","volume":"6","author":"Janknecht","year":"1996","journal-title":"Curr. Biol"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB30","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1073\/pnas.88.7.2850","article-title":"Nuclear and axonal localization of Ca2+\/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex","volume":"88","author":"Jensen","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB31","doi-asserted-by":"crossref","first-page":"6189","DOI":"10.1523\/JNEUROSCI.17-16-06189.1997","article-title":"Calcium controls gene expression via three distinct pathways that can function independently of the Ras\/Mitogen-activated protein kinases (ERKs) signaling cascade","volume":"17","author":"Johnson","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB32","doi-asserted-by":"crossref","first-page":"18518","DOI":"10.1074\/jbc.272.30.18518","article-title":"Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells","volume":"272","author":"Kawasaki","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/369156a0","article-title":"The stress-activated protein kinase subfamily of c-Jun kinases","volume":"369","author":"Kyriakis","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB34","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1523\/JNEUROSCI.12-08-02973.1992","article-title":"NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involved calcium influx via different routes","volume":"12","author":"Lerea","year":"1992","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB35","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0896-6273(00)80245-7","article-title":"Spatiotemporal dynamics of CREB phosphorylation","volume":"17","author":"Liu","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0896-6273(95)90299-6","article-title":"ARC, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites","volume":"14","author":"Lyford","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(94)90197-X","article-title":"Increase in synaptic vesicle proteins accompanies long-term potentiation in the dentate gyrus","volume":"60","author":"Lynch","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.ne.14.030191.002225","article-title":"Stimulus-transcription coupling in the nervous system","volume":"14","author":"Morgan","year":"1991","journal-title":"Annu. Rev. Neurosci"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB39","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/363718a0","article-title":"Numerous candidate plasticity-related genes revealed by differential cDNA cloning","volume":"363","author":"Nedivi","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB41","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1128\/MCB.16.2.694","article-title":"Phosphorylation of CREB at Ser-133 induces complex formation with the CREB-binding protein via a direct mechanism","volume":"16","author":"Parker","year":"1996","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0306-4522(93)90064-M","article-title":"Differential regulation of N-methyl-D-aspartate receptor subunit mRNAs in kindling-induced epileptogenesis","volume":"57","author":"Pratt","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB43","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1002\/j.1460-2075.1996.tb01046.x","article-title":"The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light","volume":"15","author":"Price","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB44","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/361453a0","article-title":"Tissue-plasminogen activator is induced as an immediate early gene during seizure, kindling and long-term potentiation","volume":"361","author":"Qian","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB45","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/j.1460-2075.1993.tb05741.x","article-title":"UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase","volume":"12","author":"Radler-Pohl","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB46","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0896-6273(94)90438-3","article-title":"Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras","volume":"12","author":"Rosen","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB47","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1523\/JNEUROSCI.17-10-03455.1997","article-title":"Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neuron","volume":"17","author":"Schwarzschild","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB48","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/MCB.8.7.2787","article-title":"Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences","volume":"8","author":"Sheng","year":"1988","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB49","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.1646483","article-title":"CREB","volume":"252","author":"Sheng","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB50","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0896-6273(00)81011-9","article-title":"Identification of a signaling pathway involved in calcium regulation of BDNF expression","volume":"20","author":"Shieh","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB51","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1101\/gad.8.21.2527","article-title":"Differential activation of CREB by Ca2+\/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity","volume":"8","author":"Sun","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB52","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Calcium influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism","volume":"20","author":"Tao","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0896-6273(94)90040-X","article-title":"Spatial and temporal changes in signal transduction pathways during LTP","volume":"13","author":"Thomas","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB54","doi-asserted-by":"crossref","first-page":"19067","DOI":"10.1016\/S0021-9258(17)32275-5","article-title":"Identification of two serine residues of MEK 1 that are differentially phosphorylated during activation by raf and MEK kinase","volume":"269","author":"Yan","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0896-6273(00)80737-0_BIB55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/382319a0","article-title":"p300\/CBP associated factor that competes with the adenoviral oncoprotein E1A","volume":"382","author":"Yang","year":"1996","journal-title":"Nature"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300807370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300807370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T01:04:17Z","timestamp":1624496657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627300807370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["S0896627300807370"],"URL":"https:\/\/doi.org\/10.1016\/s0896-6273(00)80737-0","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}