{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:20:21Z","timestamp":1778800821659,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5768,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuron"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1016\/s0896-6273(00)80970-8","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T09:31:41Z","timestamp":1081848701000},"page":"893-901","source":"Crossref","is-referenced-by-count":272,"title":["Kainate Receptors Presynaptically Downregulate GABAergic Inhibition in the Rat Hippocampus"],"prefix":"10.1016","volume":"19","author":[{"given":"Antonio","family":"Rodr\u00edguez-Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Herreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Lerma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0896-6273(00)80970-8_BIB1","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1523\/JNEUROSCI.14-09-05525.1994","article-title":"Kainate receptor gene expression in the developing rat brain","volume":"14","author":"Bahn","year":"1994","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB2","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/346724a0","article-title":"Presynaptic mechanism for long-term potentiation in the hippocampus","volume":"346","author":"Bekkers","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB3","doi-asserted-by":"crossref","first-page":"7834","DOI":"10.1073\/pnas.88.17.7834","article-title":"Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture","volume":"88","author":"Bekkers","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB4","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1471-4159.1984.tb05396.x","article-title":"Elevation of extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis","volume":"43","author":"Benveniste","year":"1984","journal-title":"J. Neurochem"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/40645","article-title":"Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons","volume":"388","author":"Castillo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0920-1211(90)90062-Z","article-title":"Effects of kainate on excitability of rat hippocampal neurones","volume":"5","author":"Cherubini","year":"1990","journal-title":"Epilepsy Res"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/379078a0","article-title":"Regulation of glutamate release by presynaptic kainate receptors in the hippocampus","volume":"379","author":"Chittajalu","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0165-0270(90)90012-5","article-title":"A statistical test for demonstrating a presynaptic site of action for a modulator of synaptic amplitude","volume":"31","author":"Clements","year":"1990","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/353396a0","article-title":"Quantal synaptic transmission?","volume":"353","author":"Clements","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB10","first-page":"1","article-title":"Neurotoxic actions of kainic acid","volume":"41","author":"Coyle","year":"1983","journal-title":"J. Neurochem"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB001","series-title":"The Biochemical Basis of Neuropharmacology","author":"Cooper","year":"1986"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0896-6273(93)90054-U","article-title":"The distribution of glutamate receptors in cultured rat hippocampal neurons","volume":"10","author":"Craig","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0301-0082(92)90015-7","article-title":"The pyramidal neuron of the cerebral cortex","volume":"39","author":"DeFelipe","year":"1992","journal-title":"Prog. Neurobiol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB13","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1523\/JNEUROSCI.04-05-01312.1984","article-title":"Electrophysiological mechanisms of kainic acid-induced epileptiform activity in the rat hippocampal slice","volume":"4","author":"Fisher","year":"1984","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1990.sp018240","article-title":"Glutamate autoreceptors depress excitatory monosynaptic transmission between mouse hippocampal neurones","volume":"429","author":"Forsythe","year":"1990","journal-title":"J. Physiol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1152\/jn.1994.71.1.204","article-title":"Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat CA3 pyramidal neurons","volume":"71","author":"Gaiarsa","year":"1994","journal-title":"J. Neurophysiol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/BF01181528","article-title":"Synaptic organization of immunocytochemically identified GABA neurons in the monkey sensory-motor cortex","volume":"12","author":"Hendry","year":"1983","journal-title":"J. Neurocytol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB18","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1523\/JNEUROSCI.14-11-07087.1994","article-title":"Role of neuronal synchronizing mechanisms in the propagation of spreading depression in the in vivo hippocampus","volume":"14","author":"Herreras","year":"1994","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.2899909","article-title":"Quinoxalinediones","volume":"241","author":"Honore","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB20","doi-asserted-by":"crossref","unstructured":"Houser, C.R., Vaughn, J.E., Hendry, S.H.C., Jones, E.D., and Peters, A. (1984). GABA neurons in the cerebral cortex. In Cerebral Cortex, Volume Two: Functional Properties of Cortical Cells, E.D. Jones and A. Peters, eds. (New York: Plenum Press), pp. 63\u201389.","DOI":"10.1007\/978-1-4615-6610-6_3"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB21","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1523\/JNEUROSCI.13-07-02965.1993","article-title":"Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recognizes glutamate receptor subunits GluR5\/6\/7","volume":"13","author":"Huntley","year":"1993","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB22","first-page":"309","article-title":"A pharmacological characterization of chloride- and potassium-dependent inhibition in the CA3 region of the rat hippocampus in vitro","volume":"60","author":"Kehl","year":"1985","journal-title":"Exp. Brain Res"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0166-2236(91)90042-S","article-title":"Quantal analysis and synaptic efficacy in the CNS","volume":"14","author":"Korn","year":"1991","journal-title":"Trends Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0896-6273(00)80178-6","article-title":"LTP of AMPA and NMDA receptor-mediated signals","volume":"17","author":"Kullmann","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB25","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1523\/JNEUROSCI.16-03-01219.1996","article-title":"The effect of depressing glial function on rat brain in situ on ion homeostasis, synaptic transmission and neuronal survival","volume":"16","author":"Largo","year":"1996","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0896-6273(92)90300-3","article-title":"Spermine regulates N-methyl-D-aspartate receptor desensitization","volume":"8","author":"Lerma","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB27","doi-asserted-by":"crossref","first-page":"11688","DOI":"10.1073\/pnas.90.24.11688","article-title":"Functional kainate-selective glutamate receptors in cultured hippocampal neurons","volume":"90","author":"Lerma","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-2236(96)20055-4","article-title":"Glutamate receptors of the kainate type and synaptic transmission","volume":"20","author":"Lerma","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB29","unstructured":"Lerma, J., Morales, M., and Vicente, M.A. (1997b). Single CNS Neurons in Culture. In Cellular Techniques in Developmental Biology, F. de Pablo, A. Ferr\u00fas, and C.D. Stern, eds. (London: Academic Press), in press."},{"key":"10.1016\/S0896-6273(00)80970-8_BIB30","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/j.1460-9568.1996.tb01611.x","article-title":"Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus","volume":"8","author":"Luj\u00e1n","year":"1996","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/346177a0","article-title":"Presynaptic enhancement shown by whole-cell recordings of long-term potentiation","volume":"346","author":"Malinow","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB002","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0959-4388(96)80118-8","article-title":"Presynaptic ionotropic receptors","volume":"6","author":"McGehee","year":"1996","journal-title":"Curr. Opin. Neurobiol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0896-6273(95)90253-8","article-title":"Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons","volume":"14","author":"Paternain","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB33","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1111\/j.1460-9568.1996.tb00734.x","article-title":"Comparative antagonism of kainate-activated AMPA and kainate receptors in hippocampal neurons","volume":"8","author":"Paternain","year":"1996","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/cne.903490107","article-title":"Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6\/7, in the rat nervous system using selective antipeptide antibodies","volume":"349","author":"Petralia","year":"1994","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB35","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1471-4159.1988.tb02977.x","article-title":"Kainic acid inhibits the synaptosomal plasma membrane glutamate carrier and allows glutamate leakage from cytoplasm but does not affect glutamate exocytosis","volume":"50","author":"Pocock","year":"1988","journal-title":"J. Neurochem"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB36","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(87)90237-5","article-title":"Kainate binding sites in the hippocampal mossy fibers","volume":"20","author":"Represa","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF01173991","article-title":"Aspinous and sparsely spinous stellate neurons in the visual cortex of rate contain glutamic acid decarboxylase","volume":"7","author":"Ribak","year":"1978","journal-title":"J. Neurocytol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB38","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF00373625","article-title":"Block of GABAB-activated K+ conductance by kainate and quisqualate in rat hippocampal pyamidal neurons","volume":"415","author":"Rovira","year":"1990","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB39","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0896-6273(95)90339-9","article-title":"Kainate receptor subunits expressed in single cultured hippocampal neurons","volume":"14","author":"Ruano","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80333-5","article-title":"Glutamate receptors are selectively targeted to postsynaptic sites in neurons","volume":"18","author":"Rubio","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB41","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/381523a0","article-title":"Target-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone","volume":"381","author":"Shigemoto","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB42","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1523\/JNEUROSCI.15-04-02707.1995","article-title":"Distribution of the excitatory amino acid receptor subunits GluR2(4) in monkey hippocampus and colocalization with subunits GluR5\u20137 and NMDAR1","volume":"15","author":"Siegel","year":"1995","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0959-4388(91)90018-3","article-title":"Learning-related synaptic plasticity","volume":"1","author":"Siegelbaum","year":"1991","journal-title":"Curr. Opin. Neurobiol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB44","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0028-3908(81)90088-5","article-title":"On the relationship between kainic acid-induced epileptiform activity and hippocampal neuronal damage","volume":"20","author":"Sloviter","year":"1981","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB45","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/BF00374949","article-title":"Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy","volume":"423","author":"Stuart","year":"1993","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB46","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","article-title":"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1","volume":"276","author":"Tanaka","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB47","unstructured":"Thomson, A.M., and Deuchars, J. (1995). Diverse pre- and post-synaptic properties of fast excitatory synapses. In Excitatory Amino Acids and Synaptic Transmission, H. Wheal and A. Thomson, eds. (London: Academic Press), pp. 145\u2013172."},{"key":"10.1016\/S0896-6273(00)80970-8_BIB48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/40639","article-title":"The synaptic activation of kainate receptors","volume":"388","author":"Vignes","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB49","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1527-3458.1996.tb00292.x","article-title":"2,3-Benzodiazepines (GYKI 52466 and analogs)","volume":"2","author":"Vizi","year":"1996","journal-title":"CNS Drug Rev"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB50","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0006-8993(83)91098-3","article-title":"Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity","volume":"273","author":"Westbrook","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB51","first-page":"582","article-title":"Differential antagonism of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines","volume":"47","author":"Wilding","year":"1995","journal-title":"Mol. Pharmacol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB52","first-page":"540","article-title":"Antagonism pharmacology of kainate- and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring receptors","volume":"49","author":"Wilding","year":"1996","journal-title":"Mol. Pharmacol"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB53","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1523\/JNEUROSCI.17-08-02713.1997","article-title":"Activation and desensitization of hippocampal kainate receptors","volume":"17","author":"Wilding","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/S0896-6273(00)80970-8_BIB54","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1073\/pnas.89.9.4134","article-title":"Coupling of a purified goldfish brain kainate receptor with a pertussis toxin-sensitive G protein","volume":"1","author":"Ziegra","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300809708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300809708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T04:26:16Z","timestamp":1550118376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627300809708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0896627300809708"],"URL":"https:\/\/doi.org\/10.1016\/s0896-6273(00)80970-8","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}