{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:22:42Z","timestamp":1778588562504,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2002,4,11]],"date-time":"2002-04-11T00:00:00Z","timestamp":1018483200000},"content-version":"vor","delay-in-days":740,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1016\/s0896-6273(00)81152-6","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T14:52:12Z","timestamp":1088779932000},"page":"219-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory\u2013Motor Synapses in Aplysia"],"prefix":"10.1016","volume":"26","author":[{"given":"Michael A","family":"Sutton","sequence":"first","affiliation":[]},{"given":"Thomas J","family":"Carew","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0896-6273(00)81152-6_BIB1","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1523\/JNEUROSCI.11-09-02655.1991","article-title":"Biochemical studies of stimulus convergence during classical conditioning in Aplysia","volume":"11","author":"Abrams","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1523\/JNEUROSCI.18-01-00458.1998","article-title":"Involvement of presynaptic and postsynaptic mechanisms in a cellular analog of classical conditioning at Aplysia sensory-motor neuron synapses in isolated cell culture","volume":"18","author":"Bao","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB3","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/0092-8674(95)90213-9","article-title":"Aplysia CREB2 represses long-term facilitation","volume":"83","author":"Bartsch","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB4","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1073\/pnas.87.5.2040","article-title":"Second messengers involved in the the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons","volume":"87","author":"Braha","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1126\/science.2165631","article-title":"Long-term synaptic changes produced by a cellular analog of classical conditioning in Aplysia","volume":"249","author":"Buonomono","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1523\/JNEUROSCI.16-02-00425.1996","article-title":"Presynaptic facilitation revisited","volume":"16","author":"Byrne","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)81653-0","article-title":"A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis","volume":"99","author":"Casadio","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB8","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1073\/pnas.77.12.7492","article-title":"Intracellular injection of the catalytic subunit of cyclic AMP\u2013dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia","volume":"77","author":"Castellucci","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB9","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1523\/JNEUROSCI.02-12-01673.1982","article-title":"Inhibitor of cAMP-dependent protein kinase blocks presynaptic facilitation in Aplysia","volume":"2","author":"Castellucci","year":"1982","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB10","doi-asserted-by":"crossref","first-page":"11411","DOI":"10.1073\/pnas.90.23.11411","article-title":"Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses","volume":"90","author":"Clark","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB11","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.1523\/JNEUROSCI.18-15-05988.1998","article-title":"Cellular correlates of long-term sensitization in Aplysia","volume":"18","author":"Cleary","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1523\/JNEUROSCI.09-02-00473.1989","article-title":"Protein kinase inhibitors selectively block phorbol ester\u2013 or forskolin-induced changes in excitability of Aplysia neurons","volume":"9","author":"Conn","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/nlme.1997.3779","article-title":"Long-term enhancement but not short-term in Hermissenda is dependent upon mRNA synthesis","volume":"68","author":"Crow","year":"1997","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/jn.1999.82.1.495","article-title":"Protein synthesis\u2013dependent and mRNA synthesis\u2013independent intermediate phase of memory in Hermissenda","volume":"82","author":"Crow","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB15","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/345718a0","article-title":"Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation","volume":"345","author":"Dash","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB16","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1037\/0033-2909.96.3.518","article-title":"Protein synthesis and memory","volume":"96","author":"Davis","year":"1984","journal-title":"Psychol. Bull."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0166-2236(95)93905-D","article-title":"Dissection of memory formation","volume":"18","author":"DeZazzo","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1126\/science.8211146","article-title":"Long-term synaptic facilitation in the absence of short-term facilitation in Aplysia neurons","volume":"262","author":"Emptage","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0006-8993(88)90008-X","article-title":"Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro","volume":"452","author":"Frey","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB20","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1126\/science.8389057","article-title":"Effect of cAMP simulates a late stage of LTP in hippocampal CA1 neurons","volume":"260","author":"Frey","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB21","doi-asserted-by":"crossref","first-page":"8266","DOI":"10.1073\/pnas.82.23.8266","article-title":"Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization","volume":"82","author":"Frost","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0896-6273(92)90185-G","article-title":"Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release of depressed and non-depressed synapses in Aplysia sensory neurons","volume":"9","author":"Ghirardi","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0896-6273(95)90297-X","article-title":"A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor synapse of Aplysia","volume":"14","author":"Ghirardi","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB24","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1523\/JNEUROSCI.15-03-01617.1995","article-title":"Learning and memory in the honeybee","volume":"15","author":"Hammer","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB25","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.6294833","article-title":"A cellular mechanism of classical conditioning in Aplysia","volume":"219","author":"Hawkins","year":"1983","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB26","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1523\/JNEUROSCI.09-12-04227.1989","article-title":"Identified serotonergic neurons LCB1 and RCB1 in the cerebral ganglia of Aplysia produce presynaptic facilitation of siphon sensory neurons","volume":"9","author":"Mackey","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB27","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1152\/jn.1998.79.3.1210","article-title":"Long-term changes in excitability induced by protein kinase C activation in Aplysia sensory neurons","volume":"79","author":"Manseau","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB28","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0092-8674(00)80484-5","article-title":"Synapse-specific, long-term facilitation of Aplysia sensory neurons","volume":"91","author":"Martin","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB29","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1523\/JNEUROSCI.16-22-07099.1996","article-title":"Dynamics of induction and expression of long-term synaptic facilitation in Aplysia","volume":"16","author":"Mauelshagen","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB30","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1101\/lm.5.3.246","article-title":"Differential induction of long-term synaptic facilitation by massed and spaced applications of serotonin at sensory neuron synapses of Aplysia californica","volume":"5","author":"Mauelshagen","year":"1998","journal-title":"Learn. Mem."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB31","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.153.3742.1351","article-title":"Time-dependent processes in memory storage","volume":"153","author":"McGaugh","year":"1966","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB32","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.1662413","article-title":"Pharmacological dissociation of modulatory effects of serotonin in Aplysia sensory neurons","volume":"254","author":"Mercer","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB33","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1126\/science.3775383","article-title":"A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia","volume":"234","author":"Montarolo","year":"1986","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB34","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0896-6273(00)80660-1","article-title":"Serotonin induces temporally and mechanistically distinct phases of persistent PKA activitiy in Aplysia sensory neurons","volume":"21","author":"M\u00fcller","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.278.5337.467","article-title":"Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses","volume":"278","author":"Murphy","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB36","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1126\/science.8066450","article-title":"Requirement of a critical period of transcription for induction of a late phase of LTP","volume":"265","author":"Nguyen","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB37","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1523\/JNEUROSCI.15-05-03519.1995","article-title":"Long-term structural remodeling in Aplysia sensory neurons requires de novo protein synthesis during a critical time period","volume":"15","author":"O'Leary","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB38","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.182.4116.1039","article-title":"Long-term sensitization of a defensive withdrawal reflex in Aplysia californica","volume":"182","author":"Pinsker","year":"1973","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB39","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1126\/science.2454509","article-title":"cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis","volume":"240","author":"Schacher","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB40","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1523\/JNEUROSCI.17-02-00597.1997","article-title":"Pathway-specific synaptic plasticity","volume":"17","author":"Schacher","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB41","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.285.5435.1911","article-title":"Coincident induction of long-term synaptic facilitation in Aplysia","volume":"285","author":"Sherff","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB42","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1101\/lm.3.5.389","article-title":"An autonomous kinase generated during long-term facilitation in Aplysia is related to the Ca2+-independent protein kinase C Apl II","volume":"3","author":"Sossin","year":"1997","journal-title":"Learn. Mem."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB43","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1523\/JNEUROSCI.12-04-01160.1992","article-title":"Selective activation of Ca++-activated PKCs in Aplysia sensory neurons by 5-HT","volume":"12","author":"Sossin","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB44","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1101\/lm.1.3.189","article-title":"Persistent activation of PKC during the development of long-term facilitation in Aplysia","volume":"1","author":"Sossin","year":"1994","journal-title":"Learn. Mem."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1152\/jn.1992.68.2.643","article-title":"Involvement of protein kinase C in serotonin-induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia","volume":"68","author":"Sugita","year":"1992","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.6294834","article-title":"Associative conditioning of single sensory neurons suggests a cellular mehcanism for learning","volume":"219","author":"Walters","year":"1983","journal-title":"Science"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB47","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1152\/jn.1983.50.6.1543","article-title":"Mechanoafferent neurons innervating tail of Aplysia. II. Modulation by sensitizing stimulation","volume":"50","author":"Walters","year":"1983","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB48","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8674(00)80896-X","article-title":"Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin","volume":"92","author":"Winder","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0896-6273(00)81152-6_BIB49","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1471-4159.1998.70020572.x","article-title":"Biochemical pathways by which serotonin regulates translation in the nervous system of Aplysia","volume":"70","author":"Yanow","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/S0896-6273(00)81152-6_BIB50","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.275.5304.1318","article-title":"Role of transforming growth factor-\u03b2 in long-term synaptic facilitation in Aplysia","volume":"275","author":"Zhang","year":"1997","journal-title":"Science"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300811526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627300811526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:30:37Z","timestamp":1760250637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627300811526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S0896627300811526"],"URL":"https:\/\/doi.org\/10.1016\/s0896-6273(00)81152-6","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory\u2013Motor Synapses in Aplysia","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0896-6273(00)81152-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}