{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:37:46Z","timestamp":1774867066580,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1016\/s0899-9007(00)00307-5","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T16:38:16Z","timestamp":1027615096000},"page":"675-677","source":"Crossref","is-referenced-by-count":47,"title":["Homocysteine, Alzheimer\u2019s disease, and cognitive function"],"prefix":"10.1016","volume":"16","author":[{"given":"Joshua W","family":"Miller","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0899-9007(00)00307-5_BIB1","unstructured":"United Nations General Assembly. Proclamation on Ageing. Resolution 47\/ 1998:5"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB2","unstructured":"Bush G. Presidential Proclamation 1990:6158"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB3","series-title":"World population prospects. Sex and age","year":"1998"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB4","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1001\/jama.262.18.2551","article-title":"Prevalence of Alzheimer\u2019s disease in a community population of older persons","volume":"262","author":"Evans","year":"1989","journal-title":"JAMA"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB6","unstructured":"Kandel ER, Schwartz JH, Jessell TM. Principles of Neuroscience, 3rd ed. Norwalk, CO: Appleton + Lange, 1991"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(96)09328-2","article-title":"Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer\u2019s disease in the Rotterdam Study","volume":"349","author":"Hofman","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00294173","article-title":"Pathological alterations of the cerebral microvasculature in Alzheimer\u2019s disease and related dementing disorders","volume":"87","author":"Bu\u00e9e","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB9","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1001\/jama.274.23.1846","article-title":"The association between midlife blood pressure levels and late-life cognitive function","volume":"274","author":"Launer","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.med.47.1.387","article-title":"Apolipoprotein E alleles as risk factors in Alzheimer\u2019s disease","volume":"47","author":"Roses","year":"1996","journal-title":"Annu Rev Med"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jama.282.1.40","article-title":"The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons","volume":"282","author":"Haan","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB12","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.277.10.813","article-title":"Brain infarction and the clinical expression of Alzheimer disease","volume":"277","author":"Snowden","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998","journal-title":"Annu Rev Med"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB14","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB15","first-page":"126","article-title":"Homocysteine and Alzheimer\u2019s disease","volume":"57","author":"Miller","year":"1999","journal-title":"Nutr Rev"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0447.1992.tb03285.x","article-title":"Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people","volume":"86","author":"Bell","year":"1992","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcn\/63.3.306","article-title":"Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study","volume":"63","author":"Riggs","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8","article-title":"Total serum homocysteine in senile dementia of the Alzheimer\u2019s type","volume":"13","author":"McCaddon","year":"1998","journal-title":"Int J Geriatr Psychiatry"},{"issue":"suppl","key":"10.1016\/S0899-9007(00)00307-5_BIB19","first-page":"S1","article-title":"Homocysteine metabolism 2nd international conference","volume":"52","author":"Blijhan","year":"1998","journal-title":"Neth J Med"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB20","first-page":"A374","article-title":"Homocysteine correlates with cognitive function in the Sacramento Area Latino Study of Aging (SALSA)","volume":"13","author":"Miller","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.aje.a010000","article-title":"Total homocysteine and cognitive decline in a community-based sample of elderly subjects","volume":"150","author":"Kalmijn","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB23","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1001\/jama.270.22.2693","article-title":"Vitamin status and intake as primary determinants of homocysteinemia in an elderly population","volume":"270","author":"Selhub","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB24","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0140-6736(99)03227-4","article-title":"Trends in serum folate after food fortification","volume":"354","author":"Lawrence","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB26","first-page":"47","article-title":"Folate deficiency beyond megaloblastic anemia","volume":"36","author":"Green","year":"1999","journal-title":"Semin Hematol"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB27","unstructured":"Chanarin I. The Megaloblastic Anemias, 2nd ed. Oxford: Blackwell Scientific Publications, 1979"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB28","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archinte.156.10.1097","article-title":"Prevalence of undiagnosed pernicious anemia in the elderly","volume":"156","author":"Carmel","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB29","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1001\/archinte.148.8.1715","article-title":"Food cobalamin malabsorption occurs frequently in patients with unexplained low serum cobalamin levels","volume":"148","author":"Carmel","year":"1988","journal-title":"Arch Int Med"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB30","first-page":"1155","article-title":"High prevalence of cobalamin deficiency in elderly outpatients","volume":"39","author":"Pennypacker","year":"1991","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB31","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1182\/blood.V92.4.1191","article-title":"Effective treatment of cobalamin deficiency with oral cobalamin","volume":"92","author":"Kuzminski","year":"1998","journal-title":"Blood"},{"key":"10.1016\/S0899-9007(00)00307-5_BIB32","first-page":"A936","article-title":"Oral vitamin B12 supplementation decreases homocysteine in healthy elderly people with suboptimal vitamin B12 status","volume":"13","author":"Miller","year":"1999","journal-title":"FASEB J"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900700003075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900700003075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T11:26:07Z","timestamp":1579173967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900700003075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":32,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0899900700003075"],"URL":"https:\/\/doi.org\/10.1016\/s0899-9007(00)00307-5","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}