{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:07:37Z","timestamp":1759342057414},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1016\/s0920-9964(01)00243-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T16:37:03Z","timestamp":1027615023000},"page":"77-86","source":"Crossref","is-referenced-by-count":25,"title":["Ethical issues in early-intervention clinical trials involving minors at risk for schizophrenia"],"prefix":"10.1016","volume":"51","author":[{"given":"David","family":"DeGrazia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0920-9964(01)00243-2_BIB1","unstructured":"Advisory Committee on Human Radiation Experiments, 1995. Final Report, Government Printing Office, Washington, DC."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1001\/archpsyc.1997.01830140025004","article-title":"Rethinking the conduct of psychiatric research","volume":"54","author":"Appelbaum","year":"1997","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2307\/3562038","article-title":"False hopes and best data: consent to research and the therapeutic misconception","volume":"17","author":"Appelbaum","year":"1987","journal-title":"Hastings Center Report"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB4","series-title":"Principles of Biomedical Ethics","author":"Beauchamp","year":"1994"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB5","series-title":"Children as Research Subjects: Science, Ethics, and Law","first-page":"81","article-title":"Ethical issues in exposing children to risks in research","author":"Brock","year":"1994"},{"issue":"1","key":"10.1016\/S0920-9964(01)00243-2_BIB6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0920-9964(01)00236-5","article-title":"Treatment of the schizophrenia prodrome: progress and problems","volume":"51","author":"Cornblatt","year":"2001","journal-title":"Schizophrenia Research"},{"issue":"6","key":"10.1016\/S0920-9964(01)00243-2_BIB7","doi-asserted-by":"crossref","DOI":"10.2307\/3563879","article-title":"The ethics of involving psychiatrically impaired persons in research","volume":"16","author":"DeRenzo","year":"1994","journal-title":"IRB"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB8","series-title":"Taking Rights Seriously","author":"Dworkin","year":"1977"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00137935","article-title":"The nature and value of rights","volume":"4","author":"Feinberg","year":"1970","journal-title":"Journal of Value Inquiry"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1056\/NEJM198707163170304","article-title":"Equipoise and the ethics of clinical research","volume":"317","author":"Freedman","year":"1987","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB11","series-title":"Interests and Rights","author":"Frey","year":"1980"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB12","first-page":"1017","article-title":"Medication discontinuation and symptom provocation in research: a consumer and family perspective","volume":"46","author":"Hall","year":"1999","journal-title":"Biological Psychiatry"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB13","series-title":"Grounding for the Metaphysics of Morals","author":"Kant","year":"1981"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1532-5415.1997.tb05174.x","article-title":"Research on the cognitively impaired: lessons and warnings from the emergency research debate","volume":"45","author":"Karlawish","year":"1997","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB15","unstructured":"Kong, D., 1998a. Debatable forms of consent. The Boston Globe (11\/16\/98)."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB16","unstructured":"Kong, D., 1998b. Consent forms fall short of full disclosure. The Boston Globe (11\/16\/98)."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB17","unstructured":"Kong, D., 1998c. Drug studies are questioned. The Boston Globe (12\/31\/98)."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB18","unstructured":"Kong, D., 1999. Study harmed mentally ill, agency reports. The Boston Globe (2\/9\/99)."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB19","unstructured":"Kong, D., 1999. U.S. orders halt to studies at Los Angeles VA center. The Boston Globe (3\/25\/99)."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/schbul\/22.2.327","article-title":"Early detection and intervention in schizophrenia: research","volume":"22","author":"McGlashan","year":"1996","journal-title":"Schizophrenia Bulletin"},{"issue":"1","key":"10.1016\/S0920-9964(01)00243-2_BIB21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0920-9964(01)00235-3","article-title":"Ethics and early intervention in psychosis: keeping up the pace and staying in step","volume":"51","author":"McGorry","year":"2001","journal-title":"Schizophrenia Research"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB22","unstructured":"National Bioethics Advisory Commission (NBAC), 1998. Research Involving Persons with Mental Disorders That May Affect Decision-making Capacity, vol. 1. NBAC, Rockville, MD."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB23","unstructured":"Office for Protection from Research Risks (OPRR), 1994. Evaluation of human subjects protections in schizophrenia research, The University of California, Los Angeles, OPRR, Bethesda, MD."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB24","unstructured":"President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, 1983. Deciding to Forgo Life-sustaining Treatment, Government Printing Office, Washington, DC."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB25","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1056\/NEJM199408113310611","article-title":"The continuing unethical use of placebo controls","volume":"331","author":"Rothman","year":"1994","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"10.1016\/S0920-9964(01)00243-2_BIB26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0920-9964(01)00234-1","article-title":"Preventing severe mental illnesses: new prospects and ethical challenges","volume":"51","author":"Schaffner","year":"2001","journal-title":"Schizophrenia Research"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB27","first-page":"S23","article-title":"Unethical use of persons with mental illnesses in high risk research experiments","volume":"2","author":"Shamoo","year":"1997","journal-title":"BioLaw"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB28","first-page":"1013","article-title":"An NIMH commentary on the NBAC report (Appendix 1. Interim \u2014 research involving individuals with questionable capacity to consent: points to consider)","volume":"46","author":"Shore","year":"1999","journal-title":"Biological Psychiatry"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB29","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S0006-3223(99)00162-6","article-title":"Integrating science and ethics in child and adolescent psychiatry research","volume":"46","author":"Vitiello","year":"1999","journal-title":"Biological Psychiatry"},{"key":"10.1016\/S0920-9964(01)00243-2_BIB30","unstructured":"Weiss, R., 2000. FDA seeks to penalize genes scientist. The Washington Post (12\/12\/00), A14."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB31","unstructured":"Weiss, R., Nelson, D., 2000. FDA halts experiments on genes at university. The Washington Post (1\/22\/00), A12."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB32","unstructured":"Wilwerth, J., 1993. Tinkering with madness. Time (8\/30\/93), pp. 40\u201342."},{"key":"10.1016\/S0920-9964(01)00243-2_BIB33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0022-3956(97)00014-9","article-title":"The effects of early and sustained invervention on the long-term morbidity of schizophrenia","volume":"32","author":"Wyatt","year":"1998","journal-title":"Journal of Psychiatric Research"},{"issue":"suppl. 33","key":"10.1016\/S0920-9964(01)00243-2_BIB34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1192\/S0007125000297602","article-title":"Prediction of psychosis: a step towards indicated prevention of schizophrenia","volume":"172","author":"Yung","year":"1998","journal-title":"British Journal of Psychiatry"}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996401002432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996401002432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T20:31:37Z","timestamp":1578774697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996401002432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["S0920996401002432"],"URL":"https:\/\/doi.org\/10.1016\/s0920-9964(01)00243-2","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}