{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:39:48Z","timestamp":1771468788020,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1016\/s0946-672x(01)80019-5","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T07:37:07Z","timestamp":1124350627000},"page":"5-10","source":"Crossref","is-referenced-by-count":33,"title":["Zinc intervention on macrophages and lymphocytes response"],"prefix":"10.1016","volume":"15","author":[{"given":"Ma D.","family":"Lastra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pastelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Monroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.E.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0946-672X(01)80019-5_bib1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/jn\/110.4.805","article-title":"Impaired immunological ontogeny in postnatal zinc deprivation","volume":"110","author":"Beach","year":"1980","journal-title":"J Nutr"},{"key":"10.1016\/S0946-672X(01)80019-5_bib2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0955-2863(93)90052-X","article-title":"Physiological roles of zinc in the plasma membrane of mammalian cells","volume":"4","author":"Bettger","year":"1993","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/S0946-672X(01)80019-5_bib3","series-title":"The cytokine Facts Book","first-page":"31","article-title":"The cytokines and their receptors","author":"Callard","year":"1994"},{"key":"10.1016\/S0946-672X(01)80019-5_bib4","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/jama.1984.03350110043027","article-title":"Excessive intake of zinc impairs immune responses","volume":"252","author":"Chandra","year":"1984","journal-title":"JAMA"},{"key":"10.1016\/S0946-672X(01)80019-5_bib5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/ajcn\/53.5.1087","article-title":"1990 McCollum award lecture. Nutrition and immunity: Lessons from the past and new insights into the future","volume":"53","author":"Chandra","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/S0946-672X(01)80019-5_bib6","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/0140-6736(92)93151-C","article-title":"Effect of vitamin and trace element supplementation on immune responses and infection in elderly subjects","volume":"340","author":"Chandra","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/S0946-672X(01)80019-5_bib7","series-title":"Therapeutic Uses of Trace Elements","first-page":"177","article-title":"Inmunostimulating effect of zinc supplements during recovery of severely malnourished children","author":"Chevalier","year":"1996"},{"key":"10.1016\/S0946-672X(01)80019-5_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1079\/BJN19860010","article-title":"T lymphocyte subsets and interleukin-2 production in zinc-deficient rats","volume":"55","author":"Dowd","year":"1986","journal-title":"Journal of Nutrition"},{"key":"10.1016\/S0946-672X(01)80019-5_bib9","first-page":"272","article-title":"Zinc regulates cytokine induction by superantigens and lipopolysaccharide","volume":"89","author":"Driessen","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/S0946-672X(01)80019-5_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0192-0561(92)90165-H","article-title":"Nutrition and cellular immunity","volume":"14","author":"Good","year":"1992","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/ajcn\/37.4.572","article-title":"Zinc supplementation during pregnancy: zinc concentration of serum and hair from low-income women of mexican descent","volume":"37","author":"Hunt","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/S0946-672X(01)80019-5_bib12","first-page":"17","volume":"34","author":"Ivanova","year":"1995","journal-title":"Akush Ginekiol (Sofia)"},{"key":"10.1016\/S0946-672X(01)80019-5_bib13","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/jn\/117.11.1982","article-title":"Macrophagemediated depression of T cell proliferation in zinc deficient mice","volume":"117","author":"James","year":"1987","journal-title":"J Nutr"},{"key":"10.1016\/S0946-672X(01)80019-5_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0022-1759(85)90233-9","article-title":"A rapid and sensitive method allowing photometric determination of erythrophagocytosis by mononuclear phagocytes","volume":"82","author":"Jungi","year":"1985","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/S0946-672X(01)80019-5_bib15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev.nu.10.070190.002215","article-title":"Zinc deficiency and immune funtion","volume":"10","author":"Keen","year":"1990","journal-title":"Ann Rev Nutr"},{"key":"10.1016\/S0946-672X(01)80019-5_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1203\/00006450-199303000-00005","article-title":"Effect of severity of maternal zinc deficiency on pregnancy outcome and infant zinc status in rheusus monkeys","volume":"33","author":"Keen","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1016\/S0946-672X(01)80019-5_bib17","first-page":"67","article-title":"Increment of immune responses in mice perinatal stages after zinc supplementation","volume":"28","author":"Lastra","year":"1997","journal-title":"Arch Med Res"},{"key":"10.1016\/S0946-672X(01)80019-5_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0041-008X(81)90241-6","article-title":"Heavy metal modulation of lymphocyte activities I. In vitro effects of heavy metals on primary humoral immune responses","volume":"57","author":"Lawrence","year":"1981","journal-title":"Tox Appl Pharmacol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0008-8749(84)90334-4","article-title":"Modulatory effects of zinc on the proliferative response of murine spleen cells to polyclonal T cell mitogens","volume":"89","author":"Malav\u00e9","year":"1984","journal-title":"Cell Immunol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0162-3109(90)90002-V","article-title":"Effect of zinc on the proliferative response of human lymphocytes: mechanism of its mitogenic action","volume":"20","author":"Malav\u00e9","year":"1990","journal-title":"Immunopharmacol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib21","first-page":"453","article-title":"Supression of antibody response by excess dietary zinc exposure during certain stages of ontogeny","volume":"180","author":"Mulhern","year":"1985"},{"issue":"13","key":"10.1016\/S0946-672X(01)80019-5_bib22","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1056\/NEJM199509283331311","article-title":"Zinc in the management of diarrhea in young children","volume":"333","author":"Penny","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/S0946-672X(01)80019-5_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000243926","article-title":"Reduced secretion of interleukin 1 and tumor necrosis factor a by neonatal monocytes","volume":"63","author":"Peter","year":"1993","journal-title":"Biol neonate"},{"key":"10.1016\/S0946-672X(01)80019-5_bib24","first-page":"117","article-title":"Effect of vitamin and trace elements supplementation on immunological indices in healthly elderly","volume":"65","author":"Pike","year":"1995","journal-title":"Int J vitamin Nutr Res"},{"key":"10.1016\/S0946-672X(01)80019-5_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/(SICI)1520-670X(1998)11:2\/3<63::AID-JTRA2>3.0.CO;2-5","article-title":"Zinc in human health: An update","volume":"65","author":"Prasad","year":"1998","journal-title":"Journal of trace elements in Experimental Medicine"},{"key":"10.1016\/S0946-672X(01)80019-5_bib26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM199509283331304","article-title":"Zinc supplementation in young children with acute diarrhea in India","volume":"333","author":"Sazawal","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/S0946-672X(01)80019-5_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jlb.50.1.35","article-title":"Developmental regulation of the cytokine repertoire in human macrophages. IL-1, IL-6, TNF\u03b1, and M-CSF","volume":"50","author":"Scheinbenbogen","year":"1991","journal-title":"Journal of Leucocyte Biology"},{"key":"10.1016\/S0946-672X(01)80019-5_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0008-8749(90)90330-T","article-title":"Differential effects of copper and zinc on human peripheral blood monocyte cytokine secretion","volume":"126","author":"Scuderi","year":"1990","journal-title":"Cell Immunol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0192-0561(95)00061-6","article-title":"Zn induces thymulin secretion from human thymic epithelial cells in vitro and augments splenocyte and thymocyte responses in vivo","volume":"17","author":"Saha","year":"1995","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib30","first-page":"389","article-title":"The molecular basis of metal recognition by T cells","volume":"102","author":"Sinagaglia","year":"1994","journal-title":"J Invest dermato"},{"key":"10.1016\/S0946-672X(01)80019-5_bib31","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0041-008X(88)90007-5","article-title":"Immunomodulation of in vitro antigen presentation by cations","volume":"96","author":"Smith","year":"1988","journal-title":"Tox Appl Phar"},{"key":"10.1016\/S0946-672X(01)80019-5_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1753-4887.1998.tb01656.x","article-title":"Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity","volume":"56","author":"Solomons","year":"1998","journal-title":"Nutr Rev"},{"key":"10.1016\/S0946-672X(01)80019-5_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-9877(97)90244-9","article-title":"Zinc-controlled Th1\/Th2 switch significantly determines development of diseases","volume":"49","author":"Sprietsma","year":"1997","journal-title":"Med Hypotheses"},{"key":"10.1016\/S0946-672X(01)80019-5_bib34","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/0306-3623(94)90364-6","article-title":"Cytotoxicity and accumulation of Hg, Ag, Cd, Cu, Pb and Zn in human peripherical T and B lymphocytes and monocytes in vitro","volume":"25","author":"Steffensen","year":"1994","journal-title":"Gen Pharmac"},{"key":"10.1016\/S0946-672X(01)80019-5_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1289\/ehp.941025","article-title":"Zinc: Health effects and research priorities for the 1990s","volume":"102","author":"Walsh","year":"1994","journal-title":"Environ Health Perspec"},{"key":"10.1016\/S0946-672X(01)80019-5_bib36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0008-8749(86)90155-3","article-title":"Stimulation of murine lymphocyte responses by cations","volume":"101","author":"Warner","year":"1986","journal-title":"Cell Immunol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0192-0561(88)90082-3","article-title":"The effect of metals on IL-2 related lymphocyte proliferation","volume":"10","author":"Warner","year":"1988","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0167-5699(97)01146-8","article-title":"The immunobiology of zinc","volume":"18","author":"Wellinghausen","year":"1997","journal-title":"Immunology Today"},{"key":"10.1016\/S0946-672X(01)80019-5_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0090-1229(88)90111-0","article-title":"Supplemental zinc restores antibody formation in cultures of aged spleen cells III. Impairment of IL-2 mediated responses","volume":"49","author":"Winchurch","year":"1988","journal-title":"Clin Immunol Immunophatol"},{"key":"10.1016\/S0946-672X(01)80019-5_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0008-8749(81)90260-4","article-title":"The differential sensitivity of cell and B cell mitogenesis to in vitro zinc deficiency","volume":"60","author":"Zanzonico","year":"1981","journal-title":"Cell Immunol"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X01800195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X01800195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,17]],"date-time":"2019-03-17T00:15:15Z","timestamp":1552781715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X01800195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0946672X01800195"],"URL":"https:\/\/doi.org\/10.1016\/s0946-672x(01)80019-5","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}