{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:15:35Z","timestamp":1780362935951,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1016\/s0952-7915(00)00116-3","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T20:35:07Z","timestamp":1027629307000},"page":"432-436","source":"Crossref","is-referenced-by-count":81,"title":["Immune responses in tuberculosis"],"prefix":"10.1016","volume":"12","author":[{"given":"JoAnne L","family":"Flynn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0952-7915(00)00116-3_BIB1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1126\/science.285.5428.732","article-title":"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors","volume":"285","author":"Brightbill","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB2","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.163.7.3920","article-title":"Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis","volume":"163","author":"Means","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB3","doi-asserted-by":"crossref","first-page":"14459","DOI":"10.1073\/pnas.96.25.14459","article-title":"Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages","volume":"96","author":"Underhill","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/360593a0","article-title":"CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen","volume":"360","author":"Porcelli","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB5","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.4049\/jimmunol.157.7.2795","article-title":"CD1c restricts responses of mycobacteria-specific T cells","volume":"157","author":"Beckman","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/372691a0","article-title":"Recognition of a lipid antigen by CD1-restricted \u03b1\u03b2+ T cells","volume":"372","author":"Beckman","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.4049\/jimmunol.162.1.366","article-title":"CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ \u03b1\u03b2 T cell pool","volume":"162","author":"Rosat","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB8","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.276.5319.1684","article-title":"Differential effects of cytolytic T cell subsets on intracellular infection","volume":"276","author":"Stenger","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB9","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.89.24.12013","article-title":"Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection","volume":"89","author":"Flynn","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB10","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0092-8674(05)80068-6","article-title":"TAP1 mutant mice are deficient in antigen presentation, surface Class I molecules, and CD4-8+ T cells","volume":"71","author":"Van Kaer","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB11","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1084\/jem.188.8.1529","article-title":"CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells","volume":"188","author":"Spada","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB12","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1084\/jem.189.12.1973","article-title":"Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis","volume":"189","author":"Behar","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB13","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.4049\/jimmunol.163.10.5478","article-title":"Conservation of a CD1 multigene family in the guinea pig","volume":"163","author":"Dascher","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB14","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.4049\/jimmunol.161.5.2400","article-title":"CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19kDa lipoprotein","volume":"161","author":"Mohagheghpour","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB15","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/intimm\/9.11.1669","article-title":"Specificity of CD8+ T cells from subunit vaccinated or infected H-2b mice recognizing the 38 kDa antigen of Mycobacterium tuberculosis","volume":"9","author":"Zhu","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB16","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1073\/pnas.95.1.270","article-title":"Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis","volume":"95","author":"Lalvani","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB17","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1128\/IAI.67.8.3980-3988.1999","article-title":"Early emergence of CD8+ T cells primed for production of Type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice","volume":"67","author":"Serbina","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB18","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1128\/IAI.67.7.3242-3247.1999","article-title":"Increase in gamma interferon-secreting CD8+, as well as CD4+ T cells in lungs following aerosol infection with Mycobacterium tuberculosis","volume":"67","author":"Feng","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB19","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.165.1.353","article-title":"CD8+ cytotoxic T lymphocytes from lungs of M. tuberculosis infected mice express perforin in vivo and lyse infected macrophages","author":"Serbina","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB20","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1128\/IAI.67.10.5223-5230.1999","article-title":"Characterization of human Mycobacterium bovis bacille Calmette-Guerin-reactive CD8+ T cells","volume":"67","author":"Smith","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4049\/jimmunol.162.1.372","article-title":"Activation of human CD8+ \u03b1\u03b2 TCR+ cells by Mycobacterium tuberculosis via an alternate Class I MHC antigen processing pathway","volume":"162","author":"Canaday","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB22","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1084\/jem.187.10.1633","article-title":"Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen presenting cells","volume":"187","author":"Lewinsohn","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1146\/annurev.immunol.15.1.851","article-title":"H2-M3, a full service Class IB histocompatibilitiy antigen","volume":"15","author":"Lindahl","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0092-8674(92)90097-V","article-title":"H2-M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes","volume":"70","author":"Pamer","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB25","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1084\/jem.187.10.1711","article-title":"H2-M3 restricted presentation of a Listeria-derived leader peptide","volume":"187","author":"Princiotta","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.190.2.195","article-title":"H2-M3 restricted T cells in bacterial infection: rapid primary but diminished memory responses","volume":"190","author":"Kerksiek","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB27","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.4049\/jimmunol.162.9.5407","article-title":"Mice deficient in CD4 T cells have only transiently diminished levels of IFN-\u03b3, yet succumb to tuberculosis","volume":"162","author":"Caruso","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB28","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/IAI.66.2.830-834.1998","article-title":"Protection against Mycobacterium tuberculosis infection by CD8 T cells requires production of gamma interferon","volume":"66","author":"Tascon","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB29","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.4049\/jimmunol.163.7.3898","article-title":"Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1","volume":"163","author":"Ting","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB30","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1164\/ajrccm.158.2.9707102","article-title":"CD4(+) T cell and natural killer cell-dependent killing of Mycobacterium tuberculosis by human monocytes","volume":"158","author":"Yoneda","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB31","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.4049\/jimmunol.160.5.2408","article-title":"Lymphocyte-dependent inhibition of growth of virulent Mycobacterium tuberculosis H37Rv within human monocytes: requirement for CD4+ T cells in purified protein derivative-positive, but not in purified protein derivative-negative subjects","volume":"160","author":"Silver","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.282.5386.121","article-title":"An antimicrobial activity of cytotoxic T cells mediated by granulysin","volume":"282","author":"Stenger","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB33","doi-asserted-by":"crossref","first-page":"15190","DOI":"10.1073\/pnas.96.26.15190","article-title":"Mycobacterial infection of macrophages results in membrane-permeable phagosomes","volume":"96","author":"Teitelbaum","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB34","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/IAI.65.4.1317-1320.1997","article-title":"The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms","volume":"65","author":"Cooper","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/IAI.65.1.127-132.1997","article-title":"Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice","volume":"65","author":"Laochumroonvorapong","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB36","first-page":"4202","article-title":"Relative contributions of distinct MHC Class I-dependent cell populations in protection to tuberculosis infection in mice","volume":"97","author":"Sousa","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(00)00116-3_BIB37","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1128\/JVI.73.3.2527-2536.1999","article-title":"A role for perforin in downregulating T-cell responses during chronic viral infection","volume":"73","author":"Matloubian","year":"1999","journal-title":"J Virol"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791500001163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791500001163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T05:02:00Z","timestamp":1681362120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791500001163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S0952791500001163"],"URL":"https:\/\/doi.org\/10.1016\/s0952-7915(00)00116-3","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}