{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:41:45Z","timestamp":1770698505336,"version":"3.49.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Immunology"],"published-print":{"date-parts":[[1996,12]]},"DOI":"10.1016\/s0952-7915(96)80011-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T10:33:24Z","timestamp":1027593204000},"page":"822-830","source":"Crossref","is-referenced-by-count":73,"title":["Costimulation and autoimmunity"],"prefix":"10.1016","volume":"8","author":[{"given":"Elizabeth A","family":"Tivol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Nicola","family":"Schweitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlene H","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0952-7915(96)80011-2_BIB1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0167-5699(94)90080-9","article-title":"The B7 and CD28 receptor families","volume":"15","author":"June","year":"1994","journal-title":"Immunol Today"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0952-7915(94)90087-6","article-title":"Blockade of the CD28 costimulatory pathway: a means to induce tolerance","volume":"6","author":"Boussiotis","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/367425a0","article-title":"How B and T cells talk to each other","volume":"367","author":"Clark","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB4_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.immunol.14.1.233","article-title":"CD28\/B7 system of T cell costimulation","volume":"14","author":"Lenschow","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/1074-7613(94)90071-X","article-title":"CTLA-4 can function as a negative regulator of T cell activation","volume":"1","author":"Walunas","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB6","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1073\/pnas.92.3.811","article-title":"CTLA-4 mediated costimulation induces apoptosis of activated human T lymphocytes","volume":"92","author":"Gribben","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB7_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.182.2.459","article-title":"CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation","volume":"182","author":"Krummel","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB8_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/1074-7613(95)90125-6","article-title":"Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4","volume":"3","author":"Tivol","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB9_1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.270.5238.985","article-title":"Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4","volume":"270","author":"Waterhouse","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB10_1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0960-9822(02)00506-7","article-title":"Lymphocyte activation: T cell regulation by CTLA-4","volume":"4","author":"Linsley","year":"1996","journal-title":"Curr Biol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1074-7613(00)80480-X","article-title":"Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement","volume":"4","author":"Linsley","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1074-7613(94)80021-9","article-title":"Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA4 receptors","volume":"1","author":"Linsley","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB13","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.4049\/jimmunol.153.5.1990","article-title":"Differential up-regulation of the B7-1 and B7-2 costimulatory molecules following immunoglobulin receptor engagement by antigen","volume":"153","author":"Lenschow","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB14_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/1074-7613(95)90032-2","article-title":"B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4","volume":"2","author":"Freeman","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4049\/jimmunol.156.2.465","article-title":"B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro","volume":"156","author":"Gajewski","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.154.1.97","article-title":"CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL","volume":"154","author":"Lanier","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB17","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1084\/jem.176.6.1595","article-title":"Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes","volume":"176","author":"Linsley","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB18_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4049\/jimmunol.155.3.1032","article-title":"Antigen-dependent clonal expansion of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4","volume":"155","author":"Kearney","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/intimm\/8.4.519","article-title":"Superantigen responses and costimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo","volume":"8","author":"Krummel","year":"1995","journal-title":"Int Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB20_1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/eji.1830260420","article-title":"Evidence that induction of tolerance in vivo involves active signaling via a B7 ligand-dependent mechanism: CTLA4-Ig protects V\u03b28+ T cells from tolerance induction by the superantigen staphylococcal enterotoxin B","volume":"26","author":"Lane","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0952-7915(94)90013-2","article-title":"Apoptosis, Fas, and systemic autoimmunity: the MRL-lpr\/lpr model","volume":"6","author":"Singer","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB22_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0952-7915(96)80125-7","article-title":"Role of Fas-mediated cell death in the regulation of immune responses","volume":"8","author":"Van Parijs","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB23_1","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.271.5256.1734","article-title":"Enhancement of antitumor immunity by CTLA-4 blockade","volume":"271","author":"Leach","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB24_1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1084\/jem.184.2.783","article-title":"CTLA-4: a negative regulator of autoimmune disease","volume":"184","author":"Karandikar","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB25_1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4049\/jimmunol.157.4.1333","article-title":"CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis","volume":"157","author":"Perrin","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB26_1","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1084\/jem.183.6.2533","article-title":"CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells","volume":"183","author":"Krummel","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB27_1","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1084\/jem.183.6.2541","article-title":"CTLA-4 ligation blocks CD28-dependent T cell activation","volume":"183","author":"Walunas","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB28_1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1126\/science.272.5265.1170","article-title":"Regulation of T cell receptor signaling by tyrosine phosphatase syp association with CTLA-4","volume":"272","author":"Marengere","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.7618087","article-title":"A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP","volume":"269","author":"Doody","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1084\/jem.183.2.547","article-title":"CD22 associates with protein tyrosine phosphatase 1C, syk, and phospholipase C-gamma upon B cell activation","volume":"183","author":"Law","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB31","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1084\/jem.181.6.1953","article-title":"Of ITAMS and ITIMS: turning on and off the B cell antigen receptor","volume":"181","author":"Thomas","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1074-7613(00)80300-3","article-title":"Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor","volume":"4","author":"Burshtyn","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB33_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/clin.1995.1058","article-title":"Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion","volume":"75","author":"Harlan","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB34_1","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1172\/JCI117982","article-title":"Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA4-Fc supports a key role for CD28 costimulation","volume":"95","author":"Cross","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB35_1","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1172\/JCI118274","article-title":"Distinct roles for B7-1 (CD80) and B7-2 (CD86) in the initiation of experimental allergic encephalomyelitis","volume":"96","author":"Racke","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB36_1","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.4049\/jimmunol.154.3.1481","article-title":"Role of B7\/CD28 CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis","volume":"154","author":"Perrin","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB37_1","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.4049\/jimmunol.155.10.4521","article-title":"CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spare Th2 cytokines in the central nervous system","volume":"155","author":"Khoury","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB38_1","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.4049\/jimmunol.156.12.4916","article-title":"Inhibition by CTLA-4-Ig of experimental allergic encephalomyelitis","volume":"156","author":"Arima","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB39_1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1084\/jem.181.3.1145","article-title":"Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse","volume":"181","author":"Lenschow","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB40","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1126\/science.7520604","article-title":"Treatment of murine lupus with CTLA4Ig","volume":"265","author":"Finck","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB41_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0092-8674(95)90349-6","article-title":"B7-1 and B7-2 costimulatory molecules differentially activate the Th1\/Th2 developmental pathways: application to autoimmune disease therapy","volume":"80","author":"Kuchroo","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB42_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/1074-7613(95)90063-2","article-title":"Blockade of CD28\/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE","volume":"3","author":"Miller","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB43_1","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1002\/eji.1830251112","article-title":"Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule","volume":"25","author":"Nakajima","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB44","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1093\/intimm\/7.12.1885","article-title":"Pancreatic expression of B7 costimulatory molecules in the non-obese diabetic mouse","volume":"7","author":"Stephens","year":"1995","journal-title":"Int Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB45","first-page":"155","article-title":"Signal transduction by B7\/BB1 expressed on activated T lymphocytes-crosslinking of B7\/BB1 induces protein tyrosine phosphorylation and synergizes with signaling through T-cell receptor\/CD3","volume":"86","author":"Hirokawa","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB46_1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1084\/jem.182.6.1985","article-title":"Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86) and Interleukin 12 cytokine in multiple sclerosis lesions","volume":"182","author":"Windhagen","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB47","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00005072-199503000-00004","article-title":"The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions","volume":"54","author":"De Simone","year":"1995","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB48","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1002\/eji.1830241217","article-title":"B7\/BB1 antigen expression on adult human microglia studied in vitro and in situ","volume":"24","author":"Williams","year":"1994","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB49","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/art.1780371113","article-title":"Elevated expression of CD80 (B&\/BB1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis","volume":"37","author":"Ranheim","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB50","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.4049\/jimmunol.153.3.1378","article-title":"Expression of functional B7 and CTLA4 on rheumatoid synovial T cells","volume":"153","author":"Verwilghen","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB51","first-page":"231","article-title":"Expression of the costimulatory molecule B7\/BB1 antigen in autoimmune thyroid disease","volume":"87","author":"Tandon","year":"1994","journal-title":"Quart J Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB52","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/1523-1747.ep12395743","article-title":"Expression of the B7\/BB1 antigen and its ligand CD28 in T-cell-mediated skin diseases","volume":"103","author":"Simon","year":"1994","journal-title":"J Invest Derm"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB53","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1182\/blood.V83.9.2580.2580","article-title":"T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: a ligand for CD28","volume":"83","author":"Nickoloff","year":"1994","journal-title":"Blood"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB54_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0952-7915(95)80115-4","article-title":"Analysis of lymphocyte costimulation in vivo using transgenic and \u2018knockout\u2019 mice","volume":"7","author":"Sharpe","year":"1995","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB55","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1073\/pnas.91.11.5138","article-title":"Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor \u03b1 leads to autoimmunity in transgenic mice","volume":"91","author":"Guerder","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB56","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.4049\/jimmunol.153.11.5038","article-title":"Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location to chromosome 16, band 5","volume":"153","author":"Borriello","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB57","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.V79.2.489.489","article-title":"The gene for B7, a costimulatory signal for T cell activation, maps to chromosomal region 3q13.3-3q21","volume":"79","author":"Freeman","year":"1992","journal-title":"Blood"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB58","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/eji.1830250548","article-title":"CD28\/CTLA-4 ligands: the gene encoding CD86 (B70.B7.2) maps to the same region as CD80 (B7.B7.1) gene in human chromosome 3q13-q23","volume":"25","author":"Fernandez-Ruiz","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB59","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/371130a0","article-title":"A genome-wide search for human type 1 diabetes susceptibility genes","volume":"371","author":"Davies","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB60","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.4049\/jimmunol.157.5.2186","article-title":"Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL\/J and B10.S mice","volume":"157","author":"Encinas","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB61","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1073\/pnas.92.11.4758","article-title":"Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16","volume":"92","author":"Wardell","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB62","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.272.5269.1811","article-title":"Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus","volume":"272","author":"Morahan","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB63_1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/hmg\/5.7.1075","article-title":"The CTLA-4 gene region of chromosome 2q33 is linked to and associated with type 1 diabetes","volume":"7","author":"Nistico","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB64","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1210\/jc.80.1.41","article-title":"CTLA-4 gene polymorphism associated with Grave's disease in a Caucasian population","volume":"80","author":"Yanagawa","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB65","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.183.3.777","article-title":"A cell type-specific enhancer in the human B7-1 gene regulated by NF-kappa-B","volume":"183","author":"Zhao","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0952-7915(96)80011-2_BIB66","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.4049\/jimmunol.156.11.4154","article-title":"Regulation of CTLA-4 expression during T cell activation","volume":"156","author":"Perkins","year":"1996","journal-title":"J Immunol"}],"container-title":["Current Opinion in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791596800112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952791596800112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T15:37:18Z","timestamp":1680795438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952791596800112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["S0952791596800112"],"URL":"https:\/\/doi.org\/10.1016\/s0952-7915(96)80011-2","relation":{},"ISSN":["0952-7915"],"issn-type":[{"value":"0952-7915","type":"print"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}