{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:14:53Z","timestamp":1779344093956,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[1998,6]]},"DOI":"10.1016\/s0955-0674(98)80013-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T10:32:55Z","timestamp":1027593175000},"page":"366-372","source":"Crossref","is-referenced-by-count":116,"title":["TCF: transcriptional activator or repressor?"],"prefix":"10.1016","volume":"10","author":[{"given":"Mariann","family":"Bienz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0955-0674(98)80013-6_BIB1_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/382638a0","article-title":"Functional interaction of \u03b2-catenin with the transcription factor LEF-1","volume":"382","author":"Behrens","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB2_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80112-9","article-title":"XTcf-3 transcription factor mediates \u03b2-catenin-axis formation in Xenopus embryos","volume":"86","author":"Molenaar","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB3_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(96)00597-7","article-title":"Nuclear localization of \u03b2-catenin by interaction with transcription factor LEF-1","volume":"59","author":"Huber","year":"1996","journal-title":"Mech Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB4_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)81924-8","article-title":"LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic","volume":"88","author":"Riese","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB5_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0092-8674(00)81925-X","article-title":"Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF","volume":"88","author":"Van de Wetering","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB6_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/385829a0","article-title":"pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila","volume":"385","author":"Brunner","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/j.1460-2075.1991.tb07928.x","article-title":"Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box","volume":"10","author":"Van de Wetering","year":"1991","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1101\/gad.5.4.656","article-title":"A thymus-specific member of the HMG protein family regulates the human T cell receptor \u03b1 enhancer","volume":"5","author":"Waterman","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB9","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1101\/gad.5.5.880","article-title":"LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function","volume":"5","author":"Travis","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/367076a0","article-title":"Components of wingless signalling in Drosophila","volume":"367","author":"Siegfried","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/367080a0","article-title":"Dishevelled and armadillo act in the wingless signalling pathway in Drosophila","volume":"367","author":"Noordermeer","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1242\/dev.120.2.369","article-title":"Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo","volume":"120","author":"Peifer","year":"1994","journal-title":"Development"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB13","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1101\/gad.10.20.2527","article-title":"Signal transduction through \u03b2-catenin and specification of cell fate during embryogenesis","volume":"10","author":"Miller","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0092-8674(00)80210-X","article-title":"A versatile transcriptional effector of Wingless signaling","volume":"89","author":"Nusse","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0960-9822(06)00214-4","article-title":"A balance between \u03b2-catenin and APC","volume":"7","author":"Gumbiner","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0959-437X(97)80071-8","article-title":"Armadillo and dTCF: a marriage made in the nucleus","volume":"7","author":"Cavallo","year":"1997","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0168-9525(97)01305-X","article-title":"TCF\/LEF factors earn their wings","volume":"13","author":"Clevers","year":"1997","journal-title":"Trends Genet"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB18","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1101\/gad.11.24.3286","article-title":"Wnt signaling: a common theme in animal development","volume":"11","author":"Cadigan","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB19_1","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a \u03b2-catenin-Tcf complex in APC-\/- colon carcinoma","volume":"275","author":"Korinek","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB20_1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of \u03b2-catenin-Tcf signaling in colon cancer by mutations in \u03b2-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB21_1","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1126\/science.275.5307.1790","article-title":"Stabilization of \u03b2-catenin by genetic defects in melanoma cell lines","volume":"275","author":"Rubinfeld","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB22_1","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1038\/sj.onc.1201462","article-title":"Induction of a \u03b2-catenin-LEF-1 complex by Wnt-1 and transforming mutants of \u03b2-catenin","volume":"15","author":"Porfiri","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1083\/jcb.128.5.959","article-title":"Embryonic axis induction by the Armadillo repeat domain of \u03b2-catenin: evidence for intracellular signaling","volume":"128","author":"Funayama","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB24","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1101\/gad.10.12.1443","article-title":"The axis-inducing activity, stability, and subcellular-distribution of \u03b2-catenin is regulated in Xenopus embryos by glycogen-synthase kinase-3","volume":"10","author":"Yost","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB25","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1083\/jcb.134.5.1283","article-title":"An in vivo structure-function study of Armadillo, the \u03b2-catenin homolog, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signalling","volume":"134","author":"Orsulic","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0959-437X(97)80017-2","article-title":"Endoderm induction in Drosophila: the nuclear targets of the inducing signals","volume":"7","author":"Bienz","year":"1997","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB27_1","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1101\/gad.11.18.2359","article-title":"A \u03b2-catenin\/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus","volume":"11","author":"Brannon","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0092-8674(95)90373-9","article-title":"Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis","volume":"81","author":"Lemaire","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1006\/dbio.1997.8797","article-title":"LEF-1\/TCF proteins mediate Wnt-inducible transcription from the Xenopus nodal-related 3 promoter","volume":"192","author":"McKendry","year":"1997","journal-title":"Dev Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB30","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1128\/MCB.16.5.2128","article-title":"Wnt-1 regulates free pools of cetenins and stabilizes APC-catenin complexes","volume":"16","author":"Papkoff","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/383627a0","article-title":"Uncoupling cadherin-based adhesion from wingless signalling in Drosophila","volume":"383","author":"Sanson","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB32","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1073\/pnas.92.7.3046","article-title":"Regulation of intracellular \u03b2-catenin levels by the adenomatous polyposis coli (APC) tumor suppressor protein","volume":"92","author":"Munemitsu","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB33_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.272.5264.1023","article-title":"Binding of Gsk3\u03b2 to the APC-\u03b2-catenin complex and regulation of complex assembly","volume":"272","author":"Rubinfeld","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1073\/pnas.94.1.242","article-title":"A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates \u03b2-catenin but its zygotic expression is not essential for the regulation of Armadillo","volume":"94","author":"Hayashi","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB35_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(00)80531-0","article-title":"Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos","volume":"90","author":"Rocheleau","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1083\/jcb.136.2.411","article-title":"Adenomatous polyposis tumor suppressor protein has signaling activity in Xenopus embryos resulting in the induction of an ectopic dorsoanterior axis","volume":"136","author":"Vleminckx","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0168-9525(94)90232-1","article-title":"HMG domain proteins: architectural elements in the assembly of nucleoprotein structures","volume":"10","author":"Grosschedl","year":"1994","journal-title":"Trends Genet"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB38","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1101\/gad.7.12a.2418","article-title":"The hLEF\/TCF-1\u03b1 HMG protein contains a context-dependent transcriptional activation domain that induces the TCR\u03b1 enhancer in T cells","volume":"7","author":"Carlsson","year":"1993","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB39","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1002\/j.1460-2075.1993.tb06155.x","article-title":"LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites","volume":"12","author":"Giese","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB40","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gad.9.8.995","article-title":"Assembly and function of a TCR\u03b1 enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions","volume":"9","author":"Giese","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB41","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1101\/gad.11.7.887","article-title":"Distinct roles for P-CREB and LEF-1 in TCR\u03b1 enhancer assembly and activation on chromatin in vitro","volume":"11","author":"Mayall","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB42","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/emboj\/16.8.2014","article-title":"A CREB binding site as target for decapentaplegic signalling during Drosophila endoderm induction","volume":"16","author":"Eresh","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB43","doi-asserted-by":"crossref","DOI":"10.1101\/gad.12.13.2022","article-title":"Functional intertwining of DPP and EGFR signalling during Drosophila endoderm induction","author":"Sz\u00fcts","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/374070a0","article-title":"An HMG-box-containing T-cell factor required for thymocyte differentiation","volume":"374","author":"Verbeek","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB45_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1074-7613(00)80454-9","article-title":"Redundant regulation of T cell differentiation and TCR\u03b1 gene expression by the transcription factors LEF-1 and TCF-1","volume":"8","author":"Okamura","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB46","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1101\/gad.8.22.2691","article-title":"Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice","volume":"8","author":"van Genderen","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB47","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/MCB.16.3.745","article-title":"Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control","volume":"16","author":"van de Wetering","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB48","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1101\/gad.11.5.629","article-title":"An HMG I\/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro","volume":"11","author":"Bagga","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB49_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1101\/gad.11.5.640","article-title":"ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCR\u03b1 enhancer function","volume":"11","author":"Bruhn","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB50","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/0092-8674(90)90413-9","article-title":"The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin","volume":"63","author":"Peifer","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB51","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1083\/jcb.136.5.1123","article-title":"Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in \u03b2-catenin that are modulated by the Wnt signalling pathway","volume":"136","author":"Larabell","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/dbio.1997.8550","article-title":"Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in Xenopus","volume":"185","author":"Merriam","year":"1997","journal-title":"Dev Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1083\/jcb.139.1.229","article-title":"Analysis of the signalling activities of localization mutants of \u03b2-catenin during axis specification in Xenopus","volume":"139","author":"Miller","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB54_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0092-8674(00)80530-9","article-title":"Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm","volume":"90","author":"Thorpe","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB55","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1002\/j.1460-2075.1995.tb00184.x","article-title":"Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut","volume":"14","author":"Hoppler","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB56","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(92)90218-2","article-title":"The reprogramming of transcriptional competence","volume":"69","author":"Travers","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(98)80013-6_BIB57","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1093\/nar\/24.24.5034","article-title":"An enhancer LEF-1\/TCF-1 site is essential for insertion site-independent transgene expression in thymus","volume":"24","author":"Haynes","year":"1996","journal-title":"Nucleic Acids Res"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067498800136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067498800136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T12:38:12Z","timestamp":1620131892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955067498800136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["S0955067498800136"],"URL":"https:\/\/doi.org\/10.1016\/s0955-0674(98)80013-6","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[1998,6]]}}}