{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:48:59Z","timestamp":1773290939703,"version":"3.50.1"},"reference-count":83,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1016\/s0955-0674(99)00071-x","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T01:52:44Z","timestamp":1027648364000},"page":"157-165","source":"Crossref","is-referenced-by-count":324,"title":["The Ras branch of small Gtpases: Ras family members don\u2019t fall far from the tree"],"prefix":"10.1016","volume":"12","author":[{"given":"Gary W","family":"Reuther","sequence":"first","affiliation":[]},{"given":"Channing J","family":"Der","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0955-0674(99)00071-X_BIB1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0955-0674(96)80066-4","article-title":"Ras effectors","volume":"8","author":"Marshall","year":"1996","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/sj.onc.1202174","article-title":"Increasing complexity of Ras signaling","volume":"17","author":"Campbell","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB3","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1101\/gad.11.18.2295","article-title":"Rho GTPases and signaling networks","volume":"11","author":"Van Aelst","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB4","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/sj.onc.1202181","article-title":"Rho family proteins and Ras transformation: the RHOad less traveled gets congested","volume":"17","author":"Zohn","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB5","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1073\/pnas.92.5.1709","article-title":"The murine N-ras gene is not essential for growth and development","volume":"92","author":"Umanoff","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB6","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1101\/gad.11.19.2468","article-title":"K-ras is an essential gene in the mouse with partial functional overlap with N-ras","volume":"11","author":"Johnson","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB7","first-page":"51","article-title":"Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?","volume":"1333","author":"Cox","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB8","first-page":"19","article-title":"Farnesyltransferase inhibitors: targeting the molecular basis of cancer","volume":"1423","author":"Oliff","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB9","doi-asserted-by":"crossref","first-page":"15030","DOI":"10.1074\/jbc.273.24.15030","article-title":"Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum","volume":"273","author":"Dai","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB10","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1091\/mbc.9.8.2231","article-title":"The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane","volume":"9","author":"Romano","year":"1998","journal-title":"Mol Biol Cell"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB11","doi-asserted-by":"crossref","first-page":"11175","DOI":"10.1073\/pnas.95.19.11175","article-title":"Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage","volume":"95","author":"Schmidt","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0092-8674(90)90294-O","article-title":"A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane","volume":"63","author":"Hancock","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0092-8674(00)80607-8","article-title":"Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi","volume":"98","author":"Choy","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/15687","article-title":"Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains","volume":"1","author":"Roy","year":"1999","journal-title":"Nat Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.biochem.67.1.199","article-title":"The caveolae membrane system","volume":"67","author":"Anderson","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/10100","article-title":"Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans","volume":"1","author":"Scheel","year":"1999","journal-title":"Nat Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB18","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/dev.121.8.2525","article-title":"Three genes of the MAP kinase cascade, mek-2, mpk-1\/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans","volume":"121","author":"Church","year":"1995","journal-title":"Development"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB19","doi-asserted-by":"crossref","first-page":"24052","DOI":"10.1074\/jbc.273.37.24052","article-title":"Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase","volume":"273","author":"Yan","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB20","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/385544a0","article-title":"Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB","volume":"385","author":"Kauffmann-Zeh","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB21","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1126\/science.278.5344.1812","article-title":"Requirement, of NF-\u03baB activation to suppress p53-independent apoptosis induced by oncogenic Ras","volume":"278","author":"Mayo","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/10018","article-title":"Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases","volume":"1","author":"Feig","year":"1999","journal-title":"Nat Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB23","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1128\/MCB.14.6.4108","article-title":"Aberrant function of the Ras-related TC21\/R-Ras2 protein triggers malignant transformation","volume":"14","author":"Graham","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB24","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1128\/MCB.16.11.6132","article-title":"TC21 causes transformation by Raf-independent signaling pathways","volume":"16","author":"Graham","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB25","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/emboj\/18.5.1270","article-title":"Activation of the Raf\/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells","volume":"18","author":"Rosario","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB26","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1101\/gad.12.19.2997","article-title":"Senescence of human fibroblasts induced by oncogenic Raf","volume":"12","author":"Zhu","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB27","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1101\/gad.12.19.3008","article-title":"Premature senescence involving p53 and p16 is activated in response to constitutive MEK\/MAPK mitogenic signaling","volume":"12","author":"Lin","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB28","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1073\/pnas.91.16.7558","article-title":"A human oncogene of the ras superfamily unmasked by expression cDNA cloning","volume":"91","author":"Chan","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB29","first-page":"1255","article-title":"A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line","volume":"11","author":"Huang","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/bjc.1998.490","article-title":"Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in breast carcinomas in vivo","volume":"78","author":"Barker","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB31","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1083\/jcb.129.4.1103","article-title":"R-Ras accelerates apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism","volume":"129","author":"Wang","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0092-8674(00)81082-X","article-title":"Integrin activation by R-Ras","volume":"85","author":"Zhang","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)81892-9","article-title":"Suppression of integrin activation: a novel function of a Ras\/Raf-initiated MAP kinase pathway","volume":"88","author":"Hughes","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0960-9822(06)00028-5","article-title":"R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways","volume":"7","author":"Marte","year":"1996","journal-title":"Curr Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB35","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/j.1460-2075.1996.tb00416.x","article-title":"Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation","volume":"15","author":"Urano","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB36","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1038\/sj.onc.1201416","article-title":"Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton","volume":"15","author":"Matsumoto","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB37","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1038\/sj.onc.1201674","article-title":"Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution","volume":"15","author":"Kimmelman","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB38","doi-asserted-by":"crossref","first-page":"23850","DOI":"10.1074\/jbc.274.34.23850","article-title":"M-Ras\/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6","volume":"274","author":"Quilliam","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB39","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1182\/blood.V94.7.2433.419k31_2433_2444","article-title":"M-Ras, a widely expressed 29-kD homologue of p21 ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line","volume":"94","author":"Ehrhardt","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB40","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1182\/blood.V94.5.1701","article-title":"Interleukin-9-induced expression of M-Ras\/R-Ras3 oncogene in T-helper clones","volume":"94","author":"Louahed","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0092-8674(89)90985-9","article-title":"A ras-related gene with transformation suppressor activity","volume":"56","author":"Kitayama","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB42","first-page":"820","article-title":"Signal transduction","volume":"400","author":"Zwartkruis","year":"1999","journal-title":"Rhapsody in G proteins. Nature"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB43","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.278.5335.124","article-title":"Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1","volume":"278","author":"Boussiotis","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB44","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1093\/emboj\/17.9.2554","article-title":"Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes","volume":"17","author":"Okada","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB45","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1073\/pnas.88.5.1606","article-title":"Association of the Ras-antagonistic Rap1\/Krev-1 proteins with the Golgi complex","volume":"88","author":"Beranger","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB46","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.1093\/emboj\/17.20.5905","article-title":"Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling","volume":"17","author":"Zwartkruis","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB47","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.onc.1201268","article-title":"Association of Krev-1\/rap1a with Krit1, a novel ankyrin repeat- containing protein encoded by a gene mapping to 7q21-22","volume":"15","author":"Serebriiskii","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1074\/jbc.274.1.48","article-title":"Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation","volume":"274","author":"Hu","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB49","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/emboj\/16.2.252","article-title":"Rapid Ca+-mediated activation of Rap1 in human platelets","volume":"16","author":"Franke","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB50","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1182\/blood.V92.6.2133","article-title":"Activation of the small GTPase rap1 in human neutrophils","volume":"92","author":"M\u2019Rabet","year":"1998","journal-title":"Blood"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB51","doi-asserted-by":"crossref","first-page":"29218","DOI":"10.1074\/jbc.273.44.29218","article-title":"Activation of the Rap1 GTPase by the B cell antigen receptor","volume":"273","author":"Mcleod","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB52","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1074\/jbc.273.9.4944","article-title":"Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes","volume":"273","author":"Reedquist","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB53","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/24884","article-title":"Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP","volume":"396","author":"De Rooij","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB54","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.282.5397.2275","article-title":"A family of cAMP-binding proteins that directly activate Rap1","volume":"282","author":"Kawasaki","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB55","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1073\/pnas.95.22.13278","article-title":"A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia","volume":"95","author":"Kawasaki","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB56","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1126\/science.280.5366.1082","article-title":"RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs","volume":"280","author":"Ebinu","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB57","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1128\/MCB.18.12.6995","article-title":"Regulation of RasGRP via a phorbol ester-responsive C1 domain","volume":"18","author":"Tognon","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB58","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-5793(99)01012-1","article-title":"Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1","volume":"457","author":"Ichiba","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/bbrc.1999.1619","article-title":"nRap GEP: a novel neural GDP\/GTP exchange protein for Rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)","volume":"265","author":"Ohtsuka","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB60","doi-asserted-by":"crossref","first-page":"14376","DOI":"10.1074\/jbc.274.20.14376","article-title":"Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504","volume":"274","author":"Ichiba","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB61","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0959-437X(99)80016-1","article-title":"Ras caught in another affair: the exchange factors for Ral","volume":"9","author":"Wolthuis","year":"1999","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB62","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1038\/sj.onc.1202850","article-title":"RalA requirement for v-src- and v-ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases","volume":"18","author":"Aguirre-Ghiso","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB63","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1128\/MCB.19.3.1731","article-title":"Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth","volume":"19","author":"Goi","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB64","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0960-9822(98)70327-6","article-title":"Ras-independent activation of Ral by a Ca+-dependent pathway","volume":"8","author":"Hofer","year":"0042","journal-title":"Curr Biol 1998"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB65","first-page":"14525","article-title":"Ca+\/calmodulin stimulates GTP binding to the ras-related protein ral-A","volume":"274","author":"Wang","year":"0042","journal-title":"J Biol Chem 1999"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB66","doi-asserted-by":"crossref","first-page":"16439","DOI":"10.1074\/jbc.271.28.16439","article-title":"A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation","volume":"271","author":"White","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(00)80226-3","article-title":"Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras","volume":"89","author":"Rodriguez-Viciana","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB68","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1128\/MCB.16.7.3923","article-title":"Oncogenic Ras activation of Raf\/MAP kinase-independent pathways is sufficient to cause tumorigenic transformation","volume":"16","author":"Khosravi-Far","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB69","doi-asserted-by":"crossref","first-page":"8773","DOI":"10.1073\/pnas.95.15.8773","article-title":"Signaling pathways in Ras-mediated tumorigenicity and metastasis","volume":"95","author":"Webb","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB70","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/sj.onc.1200860","article-title":"Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator","volume":"14","author":"Okazaki","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB71","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1074\/jbc.272.16.10483","article-title":"Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP\/GTP exchange of Ral","volume":"272","author":"Murai","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB72","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1093\/emboj\/16.22.6748","article-title":"Stimulation of gene induction and cell growth by the Ras effector Rlf","volume":"16","author":"Wolthuis","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB73","doi-asserted-by":"crossref","first-page":"22033","DOI":"10.1074\/jbc.274.31.22033","article-title":"Multiple ras effector pathways contribute to G(1) cell cycle progression","volume":"274","author":"Gille","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB74","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/19328","article-title":"Direct control of the Forkhead transcription factor AFX by protein kinase B","volume":"398","author":"Kops","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB75","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1093\/emboj\/18.13.3629","article-title":"Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors","volume":"18","author":"Nakashima","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB76","doi-asserted-by":"crossref","first-page":"16333","DOI":"10.1016\/S0021-9258(17)34012-7","article-title":"rheb, a growth factor-and synaptic activity-regulated gene, encodes a novel Ras-related protein","volume":"269","author":"Yamagata","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB77","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/00001756-199904060-00029","article-title":"Induction of Rheb mRNA following middle cerebral artery occlusion in the rat","volume":"10","author":"Kinouchi","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB78","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1074\/jbc.272.16.10608","article-title":"The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation","volume":"272","author":"Clark","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB79","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1128\/MCB.17.2.921","article-title":"Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals","volume":"17","author":"Yee","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB80","article-title":"The S. cerevisiae Rheb G-protein, ScRheb, is involved in regulating canavanine resistance and arginine uptake","author":"Urano","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB81","doi-asserted-by":"crossref","first-page":"6784","DOI":"10.1523\/JNEUROSCI.16-21-06784.1996","article-title":"Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins","volume":"16","author":"Lee","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB82","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1002\/j.1460-2075.1996.tb00971.x","article-title":"RIC, a calmodulin-binding Ras-like GTPase","volume":"15","author":"Wes","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S0955-0674(99)00071-X_BIB83","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/abbi.1999.1448","article-title":"Biochemical characterization of the Ras-related GTPases Rit and Rin","volume":"371","author":"Shao","year":"1999","journal-title":"Arch Biochem Biophys"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095506749900071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095506749900071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T04:38:06Z","timestamp":1620967086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095506749900071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":83,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S095506749900071X"],"URL":"https:\/\/doi.org\/10.1016\/s0955-0674(99)00071-x","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}