{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:42:36Z","timestamp":1770478956441,"version":"3.49.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics &amp; Development"],"published-print":{"date-parts":[[1992]]},"DOI":"10.1016\/s0959-437x(05)80288-6","type":"journal-article","created":{"date-parts":[[2005,6,17]],"date-time":"2005-06-17T20:04:34Z","timestamp":1119038674000},"page":"299-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Sex differentiation: The role of alternative splicing"],"prefix":"10.1016","volume":"2","author":[{"given":"Michael","family":"McKeown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0959-437X(05)80288-6_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/genetics\/107.2.231","article-title":"Autoregulatory Functioning of a Drosophila Gene Product that Establishes and Maintains the Sexually Determined State","volume":"107","author":"Cline","year":"1984","journal-title":"Genetics"},{"key":"10.1016\/S0959-437X(05)80288-6_bib2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0092-8674(88)90248-6","article-title":"Sex-lethal, a Drosophila Sex Determination Switch Gene, Exhibits Sex-specific RNA Splicing and Sequence Similarity to RNA Binding Proteins","volume":"55","author":"Bell","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(88)90384-4","article-title":"The Control of Alternative Splicing at Genes Regulating Sexual Differentiation in Drosophila melanogaster","volume":"53","author":"Nagoshi","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/344461a0","article-title":"Binding of the Drosophila Sex-lethal Gene Product to the Alternative Splice Site of Transformer Primary Transcript","volume":"344","author":"Inoue","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(05)80288-6_bib5","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0092-8674(88)90369-8","article-title":"Ectopic Expression of the Female Transformer Gene Product Leads to Female Differentiation of Chromosomally Male Drosophila","volume":"53","author":"McKeown","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib6_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1126\/science.1902987","article-title":"Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila","volume":"252","author":"Hoshijima","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0959-437X(05)80288-6_bib7_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0092-8674(91)90090-L","article-title":"Sex-specific Splicing and Polyadenylation of dsx Pre-mRNA Requires a Sequence that Binds Specifically to tra-2 Protein In Vitro","volume":"65","author":"Hedley","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib8_1","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1101\/gad.5.11.2071","article-title":"Regulation of Doublesex pre-mRNA Processing Occurs by 3\u2032-splice Site Activation","volume":"5","author":"Ryner","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(05)80288-6_bib9_1","first-page":"3584","article-title":"The Complex Set of Late Transcripts from the Drosophila Sex Determination Gene Sex-lethal Encodes Multiple Related Polypeptides","volume":"11","author":"Samuels","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(05)80288-6_bib10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/gad.5.3.403","article-title":"Developmental Distribution of Female-specific Sex-lethal Proteins in Drosophila melanogaster","volume":"5","author":"Bopp","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(05)80288-6_bib11_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(91)90157-T","article-title":"Positive Autoregulation of Sex-lethal by Alternative Splicing Maintains the Female Determined State in Drosophila","volume":"65","author":"Bell","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0092-8674(87)90332-1","article-title":"Regulation of Sexual Differentiation in D. melanogaster Via Alternative Splicing of RNA from the Transformer Gene","volume":"50","author":"Boggs","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0092-8674(89)90426-1","article-title":"Sex-specific Alternative Splicing of RNA from the transformer Gene Results from Sequence-dependent Splice Site Blockage","volume":"58","author":"Sosnowski","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib14","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/0092-8674(89)90633-8","article-title":"Drosophila doublesex Gene Controls Somatic Sexual Differentiation by Producing Alternatively Spliced mRNAs Encoding Related Sex-specific Polypeptides","volume":"56","author":"Burtis","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(05)80288-6_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1101\/gad.4.1.89","article-title":"Regulation of the Sex-specific RNA Splicing at the Drosophila doublesex Gene: cis-acting Mutations in Exon Sequences Alter Sex-specific RNA Splicing Patterns","volume":"4","author":"Nagoshi","year":"1990","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(05)80288-6_bib16_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1101\/gad.5.5.786","article-title":"Autoregulation of the Splicing of Transcripts from the transformer-2 Gene of Drosophila","volume":"5","author":"Mattox","year":"1991","journal-title":"Genes Dev"}],"container-title":["Current Opinion in Genetics &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X05802886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X05802886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:31:58Z","timestamp":1760700718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X05802886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992]]}},"alternative-id":["S0959437X05802886"],"URL":"https:\/\/doi.org\/10.1016\/s0959-437x(05)80288-6","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[1992]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differentiation: The role of alternative splicing","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0959-437X(05)80288-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1992 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}