{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:29:55Z","timestamp":1770503395770,"version":"3.49.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics &amp; Development"],"published-print":{"date-parts":[[1995,2]]},"DOI":"10.1016\/s0959-437x(95)90050-0","type":"journal-article","created":{"date-parts":[[2004,5,15]],"date-time":"2004-05-15T06:35:24Z","timestamp":1084602924000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Signal transduction and growth control in yeast"],"prefix":"10.1016","volume":"5","author":[{"given":"Janet","family":"Schultz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"George F.","family":"Sprague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0959-437X(95)90050-0_BIB1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0959-437X(94)90096-5","article-title":"Sex, stress and integrity: the importance of MAP kinases in yeast","volume":"4","author":"Ammerer","year":"1994","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0968-0004(94)90147-3","article-title":"Diversity in function and regulation of MAP kinase pathways","volume":"19","author":"Blumer","year":"1994","journal-title":"Trends Biochem"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0955-0674(93)90112-4","article-title":"A conserved kinase cascade for MAP kinase activation in yeast","volume":"5","author":"Errede","year":"1993","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB4","first-page":"49","article-title":"Conservation and reiteration of a kinase cascade","volume":"5","author":"Nieman","year":"1993","journal-title":"Trends Genet"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB5","series-title":"Molecular mechanisms of signal transduction in genetically tractable organisms","first-page":"187","article-title":"Signal transduction pathway for pheromone response in Saccharomyces cerevisiae","author":"Whiteway","year":"1994"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB6","series-title":"Annual review of genetics","first-page":"147","article-title":"The pheromone response pathway in Saccharomyces cerevisiae","author":"Kurjan","year":"1993"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB7","series-title":"The molecular and cellular biology of the yeast Saccharomyces: gene expression","first-page":"657","article-title":"Pheromone response and signal transduction during the mating process of Saccharomyces cervisiae","author":"Sprague","year":"1992"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB8","series-title":"Annual review of cell biology","first-page":"699","article-title":"Signal transduction during pheromone response in yeast","author":"Marsh","year":"1991"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB9","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1101\/gad.6.7.1293","article-title":"Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein","volume":"6","author":"Stevenson","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB10","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1101\/gad.6.7.1305","article-title":"Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and multiple phosphorylation of the STE7 kinase","volume":"6","author":"Cairns","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB11","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1101\/gad.6.7.1280","article-title":"Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1","volume":"6","author":"Gartner","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB12_1","first-page":"2069","article-title":"Pheromoneinduced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases","volume":"13","author":"Zhou","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB13_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/362261a0","article-title":"MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro","volume":"362","author":"Errede","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB14_1","first-page":"3398","article-title":"Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11","volume":"91","author":"Neiman","year":"1994"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB15_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(93)90254-N","article-title":"FAR1 links the signal transduction pathway to the cell cycle machinery in yeast","volume":"73","author":"Peter","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1091\/mbc.4.5.495","article-title":"FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1","volume":"4","author":"Elion","year":"1993","journal-title":"Mol Biol Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB17","first-page":"5703","article-title":"The yeast STE12 protein binds to the DNA sequence mediating pheromone response induction","volume":"86","author":"Dolan","year":"1989"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1101\/gad.3.9.1349","article-title":"STE12, a protein involved in cell type specific transcription and signal transduction in yeast is part of protein-DNA complexes","volume":"3","author":"Errede","year":"1989","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB19","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1101\/gad.5.5.741","article-title":"Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation","volume":"5","author":"Song","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB20","first-page":"2952","article-title":"Pheromone response elements are necessary and sufficient for basal and pheromone-induced transcription of the FUS1 gene of Saccharomyces cerevisiae","volume":"11","author":"Hagen","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB21_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/367040a0","article-title":"A brain serine\/threonine protein kinase activated by Cdc42 and Rac1","volume":"367","author":"Manser","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0168-9525(94)90147-3","article-title":"The 3 R's of life: Ras, Raf, and growth regulation","volume":"10","author":"Moodie","year":"1994","journal-title":"Trends Genet"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB23_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1101\/gad.8.3.313","article-title":"The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5","volume":"8","author":"Kranz","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB24_1","first-page":"7762","article-title":"Complexes between STES and components of the pheromone-responsive mitogenactivated protein kinase module","volume":"91","author":"Marcus","year":"1994"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB25_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0092-8674(94)90427-8","article-title":"Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae","volume":"78","author":"Choi","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB26_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/genetics\/138.3.609","article-title":"Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade","volume":"138","author":"Printen","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB27_1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1126\/science.8259520","article-title":"Elements of the yeast pheromone response pathway required for fiilamentous growth of diploids","volume":"262","author":"Liu","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB28","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0092-8674(92)90079-R","article-title":"Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS","volume":"68","author":"Gimeno","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB29","first-page":"1054","article-title":"Mutational activation of the STES gene product bypasses the requirement for G protein \u03b2 and \u03b3 subunits in the yeast pheromone response pathway","volume":"14","author":"Hasson","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB30_1","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.7681220","article-title":"An osmosensing signal transduction pathway in yeast","volume":"259","author":"Brewster","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB31_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/369242a0","article-title":"A two component system that regulates an osmosensing MAP kinase cascade in yeast","volume":"369","author":"Maeda","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB32","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1126\/science.8211183","article-title":"A yeast protein similar to bacterial two-component regulators","volume":"262","author":"Ota","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB33","first-page":"5408","article-title":"Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine\/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae","volume":"13","author":"Maeda","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB34_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/j.1460-2075.1994.tb06235.x","article-title":"MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae","volume":"13","author":"Doi","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB35","first-page":"3067","article-title":"A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase","volume":"13","author":"Lee","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB36_1","first-page":"5843","article-title":"A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway","volume":"13","author":"Lee","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB37","first-page":"11734","article-title":"Molecular cloning and analysis of a yeast protein phosphatase with an unusual amino-terminal region","volume":"267","author":"Posas","year":"1992","journal-title":"J Biol Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB38","doi-asserted-by":"crossref","first-page":"64b","DOI":"10.1016\/0092-8674(90)90668-5","article-title":"FUS3 encodes a cdc2\/CDC28-related kinase required for the transition from mitosis into conjugation","volume":"60","author":"Elion","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB39","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0092-8674(90)90503-7","article-title":"Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2","volume":"63","author":"Chang","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1091\/mbc.3.4.445","article-title":"Phosphorylation of FAR1 in response to \u03b1-factor: a possible requirement for cell-cycle arrest","volume":"3","author":"Chang","year":"1992","journal-title":"Mol Biol Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB41_1","first-page":"5659","article-title":"Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes","volume":"13","author":"Tyers","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB42_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1101\/gad.7.5.833","article-title":"Negative regulation of FAR1 at the Start of the yeast cell cycle","volume":"7","author":"McKinney","year":"1993","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB43_1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.8066461","article-title":"Direct inhibition of the yeast cyclin-dependent kinase Cdc28-CIn2 by Far1","volume":"265","author":"Peter","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB44","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1083\/jcb.111.4.1451","article-title":"The SPA2 gene of Saccharomyces cerevisiae is important for pheromone-induced morphogenesis and efficient mating","volume":"111","author":"Gehrung","year":"1990","journal-title":"J CCell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB45","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.349694","article-title":"A mutant of yeast defective in cellular morphogenesis","volume":"200","author":"Sloat","year":"1978","journal-title":"Science"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB46","first-page":"1295","article-title":"Use of a screen for synthetic-lethal and multicopy suppressor mutations to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae","volume":"11","author":"Bender","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/356077a0","article-title":"A yeast gene (BEM1) required for cell polarization whose product contains two SH3 domains","volume":"356","author":"Chenevert","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB48","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/genetics\/136.4.1287","article-title":"Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae","volume":"136","author":"Chenevert","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB49","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0092-8674(88)80005-9","article-title":"The C-terminus of the S. cerevisiae \u03b1-pheromone receptor mediates an adaptive response to pheromone","volume":"54","author":"Konopka","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB50","first-page":"172","article-title":"Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog","volume":"12","author":"Lee","year":"1992","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB51_1","first-page":"2041","article-title":"Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START","volume":"14","author":"Epstein","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB52","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1083\/jcb.123.6.1821","article-title":"The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae","volume":"123","author":"Mazzoni","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB53","first-page":"1162","article-title":"A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth","volume":"12","author":"Costigan","year":"1992","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(95)90050-0_BIB54_1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1083\/jcb.120.6.1305","article-title":"Morphogenesis in the yeast cell cycle: regulation by cdc28 and cyclins","volume":"120","author":"Lew","year":"1993","journal-title":"J Cell Biol"}],"container-title":["Current Opinion in Genetics &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X95900500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X95900500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:27:53Z","timestamp":1760700473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X95900500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["S0959437X95900500"],"URL":"https:\/\/doi.org\/10.1016\/s0959-437x(95)90050-0","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[1995,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signal transduction and growth control in yeast","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0959-437X(95)90050-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1995 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}