{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:14:19Z","timestamp":1770473659719,"version":"3.49.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Genetics &amp; Development"],"published-print":{"date-parts":[[1997,2]]},"DOI":"10.1016\/s0959-437x(97)80116-5","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T10:21:15Z","timestamp":1027592475000},"page":"99-104","source":"Crossref","is-referenced-by-count":96,"title":["Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks"],"prefix":"10.1016","volume":"7","author":[{"given":"Michael R","family":"Lieber","sequence":"first","affiliation":[]},{"given":"Ulf","family":"Grawunder","sequence":"additional","affiliation":[]},{"given":"Xiantuo","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Mariana","family":"Yaneva","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0959-437X(97)80116-5_BIB1_1","author":"Friedberg","year":"1995"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB2","first-page":"621","article-title":"Illegitimate recombination in mammalian cells","author":"Roth","year":"1998"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0092-8674(90)90340-K","article-title":"A novel pathway of DNA end-to-end joining","volume":"60","author":"Thode","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB4_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0092-8674(95)90116-7","article-title":"Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps","volume":"83","author":"McBlane","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0092-8674(00)81086-7","article-title":"The RAG1 and RAG2 proteins establish the 12\/23 rule in V(D)J recombination","volume":"85","author":"Van Gent","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB6","first-page":"127","article-title":"The mechanism of V(D)J joining: lessons from molecular, immunological, comparative analyses","volume":"56","author":"Lewis","year":"1994","journal-title":"Adv Immunol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/363625a0","article-title":"Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination","volume":"363","author":"Gerstein","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB8","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/j.1460-2075.1990.tb07382.x","article-title":"Sequence homologies, N sequence insertion and JH gene utilization in VHDHJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation","volume":"9","author":"Gu","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/301527a0","article-title":"A severe combined immunodeficiency mutation in the mouse","volume":"301","author":"Bosma","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB10","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0092-8674(86)90695-1","article-title":"Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency","volume":"46","author":"Schuler","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0092-8674(88)90004-9","article-title":"The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination","volume":"55","author":"Lieber","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0092-8674(88)90066-9","article-title":"The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism","volume":"54","author":"Malynn","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB13","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/0092-8674(92)90248-B","article-title":"V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in SCID mouse thymocytes","volume":"70","author":"Roth","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/347479a0","article-title":"The scid mutation in mice causes a general defect in DNA repair","volume":"347","author":"Fulop","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB15","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1073\/pnas.88.10.4061","article-title":"A link between double-strand break-related repair and V(D)J recombination: the scid mutation","volume":"88","author":"Hendrickson","year":"1991","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB16","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1073\/pnas.88.4.1394","article-title":"scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair","volume":"88","author":"Biedermann","year":"1991","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB17_1","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.1073\/pnas.92.16.7515","article-title":"Gene for the catalytic subunit of the human DNA-a ctivated protein kinase maps to the site of the XRCC 7 gene on chromosome 8","volume":"92","author":"Sipley","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB18_1","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1073\/pnas.92.23.10792","article-title":"Gene for the catalytic subunit of mouse DNA-PK maps to the scid locus","volume":"92","author":"Miller","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB19","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0092-8674(95)90360-7","article-title":"Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation","volume":"80","author":"Blunt","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB20","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1073\/pnas.92.8.3171","article-title":"Loss of the catalytic subunit of DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells","volume":"92","author":"Peterson","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB21","doi-asserted-by":"crossref","first-page":"10285","DOI":"10.1073\/pnas.93.19.10285","article-title":"Identification of a nonsense mutation in the carboxy-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse","volume":"93","author":"Blunt","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB22","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1128\/MCB.16.10.5507","article-title":"Biochemical and genetic defects in DNA-dependent protein kinase in murine scid lymphocytes","volume":"16","author":"Danska","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB23","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.4049\/jimmunol.155.10.4529","article-title":"Human DNA-PK is homologous to PI kinases","volume":"155","author":"Poltoratsky","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB24_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0092-8674(95)90482-4","article-title":"DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product","volume":"82","author":"Hartley","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(95)90225-2","article-title":"When is a lipid kinase not a lipid kinase? When it is a protein kinase","volume":"83","author":"Hunter","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0092-8674(95)90463-8","article-title":"ATM-related genes: what do they tell us about functions of the human gene?","volume":"82","author":"Zakian","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB27","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1128\/MCB.10.12.6460","article-title":"A DNA-activated protein kinase from HeLa cell nuclei","volume":"10","author":"Carter","year":"1990","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB28","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1128\/MCB.10.12.6472","article-title":"Human cells contain a DNA-activated protein kinase that phosphorylates SV40 T antigen, mouse p53, and the human Ku autoantigen","volume":"10","author":"Lees-Miller","year":"1990","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB29_1","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1128\/MCB.15.10.5700","article-title":"scid cells are deficient in Ku and replication protein A phosphorylation by DNA-PK","volume":"15","author":"Boubnov","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB30_1","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1074\/jbc.271.15.8936","article-title":"The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit","volume":"271","author":"Chan","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-1110(90)90028-A","article-title":"Studies on mammalian mutants defective in rejoining double-strand breaks in DNA","volume":"239","author":"Jeggo","year":"1990","journal-title":"Mutat Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB32","doi-asserted-by":"crossref","first-page":"10375","DOI":"10.1016\/S0021-9258(18)67534-9","article-title":"Mechanism of interaction between Ku protein and DNA","volume":"261","author":"Mimori","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB33_1","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1128\/MCB.16.8.4189","article-title":"Mutations in two Ku homologs define a DNA end-joining repair pathway in S. cerevisiae","volume":"16","author":"Milne","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0022-2836(89)90088-0","article-title":"HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex","volume":"208","author":"DeVries","year":"1989","journal-title":"J Mol Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB35","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1093\/nar\/19.20.5619","article-title":"Analysis of the mechanism of interaction of simian Ku with DNA","volume":"19","author":"Paillard","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0092-8674(93)90057-W","article-title":"The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen","volume":"72","author":"Gottlieb","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB37","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1073\/pnas.92.1.320","article-title":"DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair","volume":"92","author":"Finnie","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.8469973","article-title":"Impairment of V(D)J recombination in double-strand break repair mutants","volume":"260","author":"Taccioli","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB39_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(00)80111-7","article-title":"Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates","volume":"86","author":"Zhu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB40","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1126\/science.7939667","article-title":"Restoration of X-ray resistance and V(D)J recombination in mutant mammalian cells by Ku","volume":"266","author":"Smider","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB41","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1126\/science.8073286","article-title":"Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination","volume":"265","author":"Taccioli","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB42_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/382551a0","article-title":"Requirement for Ku80 in growth and immunoglobulin V(D)J recombination","volume":"382","author":"Nussenzweig","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB43","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1128\/MCB.16.9.5186","article-title":"Protein\u2014protein and protein\u2014DNA interaction regions within the DNA end binding protein Ku70\u2013Ku86","volume":"16","author":"Wu","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB44","doi-asserted-by":"crossref","first-page":"10440","DOI":"10.1016\/S0021-9258(18)82219-0","article-title":"Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II","volume":"268","author":"Dvir","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB45","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1073\/pnas.91.26.12520","article-title":"The DNA-activated protein kinase is required for the phosphorylation of replication protein A during SV40 DNA replication","volume":"91","author":"Brush","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB46","first-page":"113","article-title":"Role of the Ku autoantigen in V(D)J recombination and double-strand break repair","author":"Chu","year":"1996"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB47","first-page":"1774","article-title":"The scid factor on human chromosome 8 restores both V(D)J recombination and double-strand break repair","volume":"55","author":"Komatsu","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB48","first-page":"189","article-title":"X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand rejoining","volume":"132","author":"Kemp","year":"1984","journal-title":"Mutat Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB49","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1101\/gad.9.19.2409","article-title":"Formation and resolution of double-strand break intermediates in V(D)J rearrangement","volume":"9","author":"Ramsden","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB50","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1002\/j.1460-2075.1994.tb06826.x","article-title":"Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen","volume":"13","author":"Tuteja","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB51","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1021\/bi00194a021","article-title":"DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen","volume":"33","author":"Cao","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB52_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/380265a0","article-title":"Sequence-specific DNA binding by Ku autoantigen and its effects on transcription","volume":"380","author":"Giffin","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB53","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.6648528","article-title":"X-ray induced breakage and rejoining of human interphase chromosomes","volume":"222","author":"Cornforth","year":"1983","journal-title":"Science"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB54_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2307\/3579193","article-title":"Induction of repair of chromosome aberrations in scid cells measured by premature chromosome condensation","volume":"145","author":"Evans","year":"1996","journal-title":"Radiat Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB55","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2307\/3578485","article-title":"Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells","volume":"130","author":"Pandita","year":"1992","journal-title":"Radiat Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB56","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0959-437X(96)90005-2","article-title":"The recognition of DNA damage","volume":"6","author":"Jackson","year":"1996","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB58","doi-asserted-by":"crossref","first-page":"20105","DOI":"10.1016\/S0021-9258(20)80700-5","article-title":"V(D)J recombination in ataxiatelangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder","volume":"268","author":"Hsieh","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB59","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4049\/jimmunol.152.1.176","article-title":"Normal V(D)J coding junction formation in DNA ligase I deficiency syndromes","volume":"152","author":"Petrini","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB60","article-title":"The identification and characterization of mammalian proteins involved in the rejoining of DNA double\u2014strand breaks in vitro","author":"Johnson","year":"1997","journal-title":"Mutat Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB61","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/nar\/23.6.1036","article-title":"A modified single-strand annealing model best explains the joining of DNA double-strand breaks in mammalian cells and cell extracts","volume":"23","author":"Nicolas","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01543175","article-title":"Isolation of cell-cycle dependent \u03b3-ray sensitive Chinese hamster ovary cells","volume":"9","author":"Stamato","year":"1983","journal-title":"Somat Cell Mol Genet"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB63_1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0092-8674(95)90135-3","article-title":"The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination","volume":"83","author":"Li","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB64","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01534671","article-title":"Genetic analysis of the XR-1 mutation in hamster and human hybrids","volume":"15","author":"Giaccia","year":"1989","journal-title":"Somat Cell Mol Genet"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB65","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/j.1460-2075.1990.tb08158.x","article-title":"Intermediates of recombination during mating type switching in S. cerevisiae","volume":"9","author":"White","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB66_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/bies.950170707","article-title":"In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases","volume":"17","author":"Haber","year":"1995","journal-title":"Bioessays"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB67","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1128\/MCB.13.3.1363","article-title":"V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites","volume":"13","author":"Sheehan","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(97)80116-5_BIB68","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/1074-7613(95)90082-9","article-title":"Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination","volume":"2","author":"Zhu","year":"1995","journal-title":"Immunity"}],"container-title":["Current Opinion in Genetics &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X97801165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X97801165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T12:51:37Z","timestamp":1680785497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X97801165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0959437X97801165"],"URL":"https:\/\/doi.org\/10.1016\/s0959-437x(97)80116-5","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}