{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:01:25Z","timestamp":1779346885818,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics & Development"],"published-print":{"date-parts":[[1999,2]]},"DOI":"10.1016\/s0959-437x(99)80003-3","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T13:27:54Z","timestamp":1027603674000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":546,"title":["The oncogenic activation of \u03b2-catenin"],"prefix":"10.1016","volume":"9","author":[{"given":"Paul","family":"Polakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0959-437X(99)80003-3_BIB1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0962-8924(00)89015-7","article-title":"Cell adhesion and signal transduction: the armadillo connection","volume":"5","author":"Peifer","year":"1995","journal-title":"Trends Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/bies.950160607","article-title":"Drosophila wingless: a paradigm for the function, mechanism of Wnt signaling","volume":"16","author":"Siegfried","year":"1994","journal-title":"Bioessays"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB3","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0955-0674(95)80104-9","article-title":"Signal transduction of \u03b2-catenin","volume":"7","author":"Gumbiner","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB4","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1083\/jcb.132.6.1105","article-title":"Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus","volume":"132","author":"Fagotto","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/383627a0","article-title":"Uncoupling cadherin-based adhesion from wingless signalling in Drosophila","volume":"383","author":"Sanson","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB6","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1083\/jcb.134.5.1283","article-title":"An in vivo structure-function study of armadillo, the \u03b2-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling","volume":"134","author":"Orsulic","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0092-8674(82)90409-3","article-title":"Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome","volume":"31","author":"Nusse","year":"1982","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB8","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.8259518","article-title":"Association of the APC gene product with \u03b2-catenin","volume":"262","author":"Rubinfeld","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB9","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.8259519","article-title":"Association of the APC tumor suppressor protein with catenins","volume":"262","author":"Su","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB10","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1073\/pnas.92.7.3046","article-title":"Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein","volume":"92","author":"Munemitsu","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB11","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1083\/jcb.124.5.729","article-title":"Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing \u03b2-catenin binding to the cell adhesion protein cadherin","volume":"124","author":"Hinck","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB12","first-page":"2213","article-title":"Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients","volume":"56","author":"Inomata","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB13","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1126\/science.275.5307.1790","article-title":"Stabilization of beta-catenin by genetic defects in melanoma cell lines","volume":"275","author":"Rubinfeld","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB14","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/hmg\/1.4.229","article-title":"Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene","volume":"1","author":"Miyoshi","year":"1992","journal-title":"Hum Mol Genet"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB16","first-page":"4624","article-title":"Loss of beta catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene","volume":"57","author":"Rubinfeld","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB17","first-page":"F127","article-title":"The adenomatous polyposis coli (APC) tumor suppressor","volume":"1332","author":"Polakis","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB18","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.280.5363.596","article-title":"Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3\u03b2","volume":"280","author":"Behrens","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02281864","article-title":"Attenuated familial adenomatous polyposis due to a mutation in the 3\u2032 part of the APC gene. A clue for understanding the function of the APC protein","volume":"97","author":"Friedl","year":"1996","journal-title":"Hum Genet"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB20","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/hmg\/5.12.1921","article-title":"Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3\u2032 APC gene mutation","volume":"5","author":"Scott","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1073\/pnas.94.1.242","article-title":"A Drosophila homolog of the tumor suppressor adenomatous polyposis coli down-regulates \u03b2-catenin but its zygotic expression is not essential for the regulation of armadillo","volume":"94","author":"Hayashi","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1083\/jcb.136.2.411","article-title":"Adenomatous polyposis coli tumor suppressor protein has signaling acitivity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis","volume":"136","author":"Vleminckx","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB23","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0092-8674(00)81461-0","article-title":"Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development","volume":"93","author":"Ahmed","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1083\/jcb.136.3.693","article-title":"NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein, altered MDCK cell adhesion","volume":"136","author":"Barth","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB25","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1128\/MCB.16.8.4088","article-title":"Deletion of amino-terminal sequence stabilizes \u03b2-catenin in vivo and promotes the hyperphosphorylation of the adenomatous polyposis coli tumor suppressor protein","volume":"16","author":"Munemitsu","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB26","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1242\/dev.124.11.2255","article-title":"Negative regulation of Armadillo, a Wingless effector in Drosophila","volume":"124","author":"Pai","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB27","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1084\/jem.183.3.1185","article-title":"A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes","volume":"183","author":"Robbins","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB28","first-page":"1130","article-title":"Mutational analysis of the APC\/beta-catenin\/Tcf pathway in colorectal cancer","volume":"58","author":"Sparks","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB29","first-page":"1021","article-title":"Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations","volume":"58","author":"Iwao","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB30","first-page":"1127","article-title":"High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat","volume":"58","author":"Dashwood","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB31","first-page":"42","article-title":"Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors","volume":"58","author":"Takahashi","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB32","first-page":"2524","article-title":"Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3","volume":"58","author":"Miyoshi","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB33","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1073\/pnas.95.15.8847","article-title":"Somatic mutations of the beta-catenin gene are frequent in mouse, human hepatocellular carcinomas","volume":"95","author":"de La Coste","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB34","first-page":"3526","article-title":"Beta-catenin mutation in carcinoma of the uterine endometrium","volume":"58","author":"Fukuchi","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB35","first-page":"1344","article-title":"Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas","volume":"58","author":"Palacios","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB36","first-page":"2520","article-title":"Beta-catenin mutations in human prostate cancer","volume":"58","author":"Voeller","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB37","first-page":"896","article-title":"Sporadic medulloblastomas contain oncogenic beta-catenin mutations","volume":"58","author":"Zurawel","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB38","first-page":"1349","article-title":"Transformation by Wnt family proteins correlates with regulation of beta-catenin","volume":"8","author":"Shimizu","year":"1997","journal-title":"Cell Growth Differ"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB39","first-page":"3495","article-title":"Aberrant expression of the growth factor Wnt-5A in human malignancy","volume":"55","author":"Iozzo","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB40","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/bjc.1997.195","article-title":"Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma","volume":"75","author":"Bui","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB41","first-page":"153","article-title":"Evidence for the involvement of the Wnt 2 gene in human colorectal cancer","volume":"12","author":"Vider","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB42","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1038\/sj.onc.1201593","article-title":"Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice","volume":"15","author":"Lane","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB43","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/sj.onc.1200936","article-title":"A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas","volume":"14","author":"Bui","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB44","doi-asserted-by":"crossref","first-page":"10164","DOI":"10.1073\/pnas.95.17.10164","article-title":"A novel frizzled gene identified in human esophageal carcinoma mediates APC\/beta-catenin signals","volume":"95","author":"Tanaka","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB45","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)81921-2","article-title":"Frz\u03b2-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer","volume":"88","author":"Leyns","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB46","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0092-8674(00)81922-4","article-title":"Frzb, a secreted protein expressed in the Spemann organizer binds, inhibits Wnt-8","volume":"88","author":"Wang","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB47","doi-asserted-by":"crossref","first-page":"11196","DOI":"10.1073\/pnas.94.21.11196","article-title":"The cysteine-rich frizzled domain of Frz\u03b2-1 is required and sufficient for modulation of Wnt signaling","volume":"94","author":"Lin","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB48","doi-asserted-by":"crossref","first-page":"13636","DOI":"10.1073\/pnas.94.25.13636","article-title":"SARPs: a family of secreted apoptosis-related proteins","volume":"94","author":"Melkonyan","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB49","first-page":"1798","article-title":"Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system","volume":"58","author":"Reifenberger","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/34201","article-title":"Activating Smoothened mutations in sporadic basal-cell carcinoma","volume":"391","author":"Xie","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0925-4773(97)00150-0","article-title":"Hedgehog signaling regulates transcription through Gli\/Ci binding sites in the wingless enhancer","volume":"68","author":"Von Ohlen","year":"1997","journal-title":"Mech Dev"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB52","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1101\/gad.10.12.1443","article-title":"The axis-inducing activity, stability, and subcellular distribution of \u03b2-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3","volume":"10","author":"Yost","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB53","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.272.5264.1023","article-title":"Binding of GSK3\u03b2 to the APC-\u03b2-catenin complex and regulation of complex assembly","volume":"272","author":"Rubinfeld","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB54","doi-asserted-by":"crossref","first-page":"10823","DOI":"10.1074\/jbc.273.18.10823","article-title":"Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of \u03b2-catenin","volume":"273","author":"Kishida","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB55","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0960-9822(98)70226-X","article-title":"Downregulation of \u03b2-catenin by human axin, its association with the APC tumor suppressor, \u03b2-catenin, GSK3\u03b2","volume":"8","author":"Hart","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB56","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0960-9822(98)70229-5","article-title":"Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and \u03b2-catenin","volume":"8","author":"Itoh","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB57","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1073\/pnas.95.6.3020","article-title":"Bridging of \u03b2-catenin and glycogen synthase kinase-3\u03b2 by axin and inhibition of beta-catenin-mediated transcription","volume":"95","author":"Sakanaka","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB58","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/emboj\/17.5.1371","article-title":"Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3\u03b2, \u03b2-catenin, promotes GSK-3 \u03b2-dependent phosphorylation of \u03b2-catenin","volume":"17","author":"Ikeda","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB59","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0168-9525(98)01473-5","article-title":"Combinatorial control in ubiquitin-dependent proteolysis: don\u2019t Skp the F-box hypothesis","volume":"14","author":"Patton","year":"1998","journal-title":"Trends Genet"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB60","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/35154","article-title":"Regulation of the Hedgehog and Wingless signalling pathways by the F-box\/WD40-repeat protein Slimb","volume":"391","author":"Jiang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0168-9525(93)90250-L","article-title":"From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion","volume":"9","author":"Kemler","year":"1993","journal-title":"Trends Genet"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB62","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1242\/jcs.107.12.3655","article-title":"Assembly of the cadherin-catenin complex in vitro with recombinant proteins","volume":"107","author":"Aberle","year":"1994","journal-title":"J Cell Sci"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB63","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1083\/jcb.127.5.1375","article-title":"\u03b2-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor","volume":"127","author":"Hoschuetzky","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB64","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1083\/jcb.134.5.1271","article-title":"\u03b2-catenin associates with the actin-bundling protein fascin in a noncadherin complex","volume":"134","author":"Tao","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB65","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80112-9","article-title":"Xtcf-3 transcription factor mediates \u03b2-catenin-induced axis formation in Xenopus embryos","volume":"86","author":"Molenaar","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB66","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/382638a0","article-title":"Functional interaction of \u03b2-catenin with the transcription factor LEF-1","volume":"382","author":"Behrens","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB67","doi-asserted-by":"crossref","first-page":"12492","DOI":"10.1074\/jbc.272.19.12492","article-title":"Interaction of the DF3\/MUC1 breast carcinoma-associated antigen and \u03b2-catenin in cell adhesion","volume":"272","author":"Yamamoto","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB68","doi-asserted-by":"crossref","first-page":"16470","DOI":"10.1074\/jbc.273.26.16470","article-title":"The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains \u03b2-catenin","volume":"273","author":"Yu","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB69","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1083\/jcb.138.3.681","article-title":"Cellular redistribution of protein tyrosine phosphatases LAR and PTP\u03c3 by inducible proteolytic processing","volume":"138","author":"Aicher","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB70","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1126\/science.281.5378.832","article-title":"Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell\u2013cell adhesion","volume":"281","author":"Kuroda","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0959-437X(99)80003-3_BIB71","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","article-title":"Identification of c-MYC as a target of the APC pathway","volume":"281","author":"He","year":"1998","journal-title":"Science"}],"container-title":["Current Opinion in Genetics & Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X99800033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X99800033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:22:50Z","timestamp":1760700170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X99800033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["S0959437X99800033"],"URL":"https:\/\/doi.org\/10.1016\/s0959-437x(99)80003-3","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[1999,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The oncogenic activation of \u03b2-catenin","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0959-437X(99)80003-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}