{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:38:34Z","timestamp":1768563514206,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Structural Biology"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1016\/s0959-440x(00)00256-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T16:03:16Z","timestamp":1027612996000},"page":"617-622","source":"Crossref","is-referenced-by-count":119,"title":["Hyaluronan: polysaccharide chaos to protein organisation"],"prefix":"10.1016","volume":"11","author":[{"given":"Anthony J","family":"Day","sequence":"first","affiliation":[]},{"given":"John K","family":"Sheehan","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0959-440X(00)00256-6_BIB1","doi-asserted-by":"crossref","unstructured":"Day AJ, Prestwich GD: Hyaluronan-binding proteins: tying up the giant. J Biol Chem 2001, 276:in press. This article is the second in a series of four reviews on hyaluronan published in the Journal of Biological Chemistry. It describes the domain organisation of hyaladherins and covers our current understanding of the molecular basis of hyaluronan\u2013protein interactions and their regulation.","DOI":"10.1074\/jbc.R100036200"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB2","unstructured":"Day AJ: Understanding hyaluronan-protein interactions. On the World Wide Web http:\/\/www.glycoforum.gr.jp\/science\/hyaluronan\/HA16\/HA16E.html This review is part of an on-going series of web articles on diverse aspects of hyaluronan biology, written by many of the leading researchers in the field. The author suggests that the link module and hyaluronan may have appeared at about the same time during chordate evolution, with the former having evolved from the C-type lectin domain."},{"key":"10.1016\/S0959-440X(00)00256-6_BIB3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI10272","article-title":"Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme","volume":"106","author":"Camenisch","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jlb.66.2.315","article-title":"Activation and interaction of CD44 and hyaluronan in immunological systems","volume":"66","author":"Siegelman","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1172\/JCI10706","article-title":"Hyaluronan is not just a goo!","volume":"106","author":"Toole","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0955-0674(00)00135-6","article-title":"Hyaluronan: a multifunctional, mega Dalton, stealth molecule","volume":"12","author":"Lee","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB7","doi-asserted-by":"crossref","unstructured":"Tammi M, Day AJ, Turley EA: Hyaluronan and homeostasis: a balancing act. J Biol Chem 2001, in press.","DOI":"10.1074\/jbc.R100037200"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB8","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1021\/jp000402t","article-title":"Oligosaccharides as model systems for understanding water-biopolymer interaction: hydrated dynamics of a hyaluronan decamer","volume":"104","author":"Almond","year":"2000","journal-title":"J Phys Chem B"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1042\/bj2740699","article-title":"Secondary and tertiary structures of hyaluronan in aqueous solution, investigated by rotary shadowing-electron microscopy and computer simulation. Hyaluronan is a very efficient network-forming polymer","volume":"274","author":"Scott","year":"1991","journal-title":"Biochem J"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00731145","article-title":"Molecular modelling of secondary and tertiary structures of hyaluronan, compared with electron microscopy and NMR data. Possible sheets and tubular structures in aqueous solution","volume":"11","author":"Mikelsaar","year":"1994","journal-title":"Glycoconj J"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB11","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1073\/pnas.96.9.4850","article-title":"Hyaluronan forms specific stable tertiary structures in aqueous solution: a 13C NMR study","volume":"96","author":"Scott","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB12","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/S0006-3495(99)77061-X","article-title":"The molecular basis of the solution properties of hyaluronan investigated by confocal fluorescence recovery after photobleaching","volume":"77","author":"Gribbon","year":"1999","journal-title":"Biophys J"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/0264-6021:3500329","article-title":"The analysis of intermolecular interactions in concentrated hyaluronan solutions suggest no evidence for chain-chain association","volume":"350","author":"Gribbon","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0008-6215(93)80020-F","article-title":"A detailed 1H and 13C NMR study of a repeating disaccharide of hyaluronan: the effect of temperature and counterion type","volume":"242","author":"Sicinska","year":"1993","journal-title":"Carbohydr Res"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/glycob\/7.5.597","article-title":"Molecular dynamics simulations of the two disaccharides of hyaluronan in aqueous solution","volume":"7","author":"Almond","year":"1997","journal-title":"Glycobiology"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/glycob\/8.10.973","article-title":"Dynamic exchange between stabilised conformations predicted for hyaluronan tetrasaccharides: comparison of molecular dynamics simulations with available NMR data","volume":"8","author":"Almond","year":"1998","journal-title":"Glycobiology"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1021\/ma001082e","article-title":"13C NMR studies of hyaluronan. 2. Dependence of conformational dynamics on chain length and solvent","volume":"34","author":"Cowman","year":"2001","journal-title":"Macromolecules"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1006\/jmbi.1998.2245","article-title":"Deducing polymeric structure from aqueous molecular dynamics simulations of oligosaccharides: predictions from simulations of hyaluronan tetrasaccharides compared with hydrodynamic and X-ray fibre diffraction data","volume":"284","author":"Almond","year":"1998","journal-title":"J Mol Biol"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1469-7793.1999.265af.x","article-title":"Characterization of the effect of high molecular weight hyaluronan on trans-synovial flow in rabbit knees","volume":"514","author":"Coleman","year":"1999","journal-title":"J Physiol"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1006\/jmbi.2000.3817","article-title":"Mechanism of hyaluronan binding and degradation: structure of Streptococcus pneumoniae hyaluronate lyase in complex with hyaluronic acid disaccharide at 1.7 \u00c5 resolution","volume":"299","author":"Ponnuraj","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0969-2126(00)00511-6","article-title":"Crystal structure of hyaluronidase, a major allergen of bee venom","volume":"8","author":"Markovic-Housley","year":"2000","journal-title":"Structure"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB22","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1021\/bi0024254","article-title":"Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis","volume":"40","author":"Huang","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB23","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0092-8674(00)80151-8","article-title":"Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration","volume":"86","author":"Kohda","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1091\/mbc.12.4.891","article-title":"Layilin, a novel integral membrane protein, is a hyaluronan receptor","volume":"12","author":"Bono","year":"2001","journal-title":"Mol Biol Cell"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0969-2126(00)00163-5","article-title":"Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6","volume":"8","author":"Kahmann","year":"2000","journal-title":"Structure"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/prep.1998.0971","article-title":"Characterization of a functional hyaluronan-binding domain from the human CD44 molecule expressed in Escherichia coli","volume":"14","author":"Banerji","year":"1998","journal-title":"Protein Expr Purif"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1083\/jcb.144.4.789","article-title":"LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan","volume":"144","author":"Banerji","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB28","doi-asserted-by":"crossref","first-page":"19420","DOI":"10.1074\/jbc.M011004200","article-title":"Mouse LYVE-1 Is an endocytic receptor for hyaluronan in lymphatic endothelium","volume":"276","author":"Prevo","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB29","doi-asserted-by":"crossref","first-page":"28057","DOI":"10.1074\/jbc.272.44.28057","article-title":"Identification of hyaluronan-binding domains of aggrecan","volume":"272","author":"Watanabe","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB30","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1074\/jbc.273.1.338","article-title":"Identification of CD44 residues important for hyaluronan binding and delineation of the binding site","volume":"273","author":"Bajorath","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB31","doi-asserted-by":"crossref","first-page":"22764","DOI":"10.1074\/jbc.M100666200","article-title":"Mapping the hyaluronan-binding site on the link module from human TSG-6 by site-directed mutagenesis","volume":"276","author":"Mahoney","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB32","doi-asserted-by":"crossref","first-page":"26967","DOI":"10.1016\/S0021-9258(19)61467-5","article-title":"Hyaluronan binding by cell surface CD44","volume":"275","author":"Lesley","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-440X(00)00256-6_BIB33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/bj3070595","article-title":"Evidence of a defined spatial arrangement of hyaluronate in the central filament of cartilage proteoglycan aggregates","volume":"307","author":"M\u00f6rgelin","year":"1995","journal-title":"Biochem J"}],"container-title":["Current Opinion in Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X00002566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X00002566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T08:56:19Z","timestamp":1620464179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959440X00002566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S0959440X00002566"],"URL":"https:\/\/doi.org\/10.1016\/s0959-440x(00)00256-6","relation":{},"ISSN":["0959-440X"],"issn-type":[{"value":"0959-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}