{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:44:56Z","timestamp":1761947096908},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1016\/s0959-8049(00)00360-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T16:01:38Z","timestamp":1027612898000},"page":"23-31","source":"Crossref","is-referenced-by-count":100,"title":["The effect of an adjuvant mistletoe treatment programme in resected head and neck cancer patients"],"prefix":"10.1016","volume":"37","author":[{"given":"M.K","family":"Steuer-Vogt","sequence":"first","affiliation":[]},{"given":"V","family":"Bonkowsky","sequence":"additional","affiliation":[]},{"given":"P","family":"Ambrosch","sequence":"additional","affiliation":[]},{"given":"M","family":"Scholz","sequence":"additional","affiliation":[]},{"given":"A","family":"Nei\u03b2","sequence":"additional","affiliation":[]},{"given":"J","family":"Strutz","sequence":"additional","affiliation":[]},{"given":"M","family":"Hennig","sequence":"additional","affiliation":[]},{"given":"T","family":"Lenarz","sequence":"additional","affiliation":[]},{"given":"W","family":"Arnold","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0959-8049(00)00360-9_BIB1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1001\/jama.280.18.1569","article-title":"Trends in alternative medicine use in the United States, 1990\u20131997","volume":"280","author":"Eisenberg","year":"1998","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<777::AID-CNCR22>3.0.CO;2-O","article-title":"The prevalence of complementary\/alternative medicine in cancer","volume":"83","author":"Ernst","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s004310051000","article-title":"Prevalence of complementary\/alternative medicine for children","volume":"158","author":"Ernst","year":"1999","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/jnci\/92.1.42","article-title":"Alternative therapies used by women with breast cancer in four ethnic populations","volume":"92","author":"Lee","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s005200050175","article-title":"The use of unproven methods of treatment by cancer patients. Frequency, expectations and cost","volume":"6","author":"Miller","year":"1998","journal-title":"Support Care Cancer"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1055\/s-2007-1024099","article-title":"Use of alternative medicine in oncology patients","volume":"123","author":"Grothey","year":"1998","journal-title":"Dtsch Med. Wochenschr."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB7","series-title":"Immuntherapeutika und Zytostatika","author":"Haustein","year":"1998"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0944-7113(11)80073-5","article-title":"Mistletoe treatment for cancer","volume":"1","author":"Kleijnen","year":"1994","journal-title":"Phytomedicine"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB9","series-title":"Krebszusatztherapie beim fortgeschrittenen nicht-kleinzelligen Bronchialkarzinom","author":"Dold","year":"1991"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB10","first-page":"915","article-title":"Treatment of advanced pancreatic cancer with mistletoe","volume":"16","author":"Friess","year":"1996","journal-title":"Anticancer Res."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3109\/08923979809034819","article-title":"Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity","volume":"20","author":"Baxevanis","year":"1998","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB12","first-page":"29","article-title":"Influence of treatment with the immunomodulatory effective dose of the beta-galactoside-specific lectin from mistletoe on tumor colonization in BALB\/c-mice for two experimental model systems","volume":"5","author":"Beuth","year":"1991","journal-title":"In Vivo"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB13","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/BF00180280","article-title":"Behavior of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in breast cancer patients","volume":"70","author":"Beuth","year":"1992","journal-title":"Clin. Invest."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB14","first-page":"3322","article-title":"Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract","volume":"50","author":"Hajto","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0192-0561(97)00063-5","article-title":"The immunopharmacology of head and neck cancer","volume":"19","author":"Hadden","year":"1997","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4615-5357-1_27","article-title":"Immune cells in the tumor microenvironment. Mechanisms responsible for functional and signaling defects","volume":"451","author":"Whiteside","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0192-0561(99)00008-9","article-title":"Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers","volume":"21","author":"Young","year":"1999","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB18","first-page":"725","article-title":"Sensitive detection of squamous cells in bone marrow and blood of head and neck cancer patients by E48 reverse transcriptase-polymerase chain reaction","volume":"5","author":"Brakenhoff","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB19","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF02630722","article-title":"In vitro T-lymphocyte function in head and neck cancer patients","volume":"254","author":"Heimdal","year":"1997","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/00016489950181828","article-title":"Peripheral blood mononuclear cell (PBMC) responsiveness in patients with head and neck cancer in relation to tumour stage and prognosis","volume":"119","author":"Heimdal","year":"1999","journal-title":"Acta Otolaryngol. (Stockh.)"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB21","first-page":"4803","article-title":"Modulatory potency of the beta-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients","volume":"49","author":"Hajto","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB22","first-page":"583","article-title":"Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract","volume":"18","author":"Heiny","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB23","series-title":"TNM Classification of Malignant Tumours","author":"Sobin","year":"1992"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/sim.4780110205","article-title":"A comparison of sample size methods for the logrank statistic","volume":"11","author":"Lakatos","year":"1992","journal-title":"Stat. Med."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2307\/2986225","article-title":"Graphical comparison of nonparametric curves","volume":"45","author":"Bowman","year":"1996","journal-title":"Appl. Statist."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2307\/2530245","article-title":"A multiple testing procedure for clinical trials","volume":"35","author":"O\u2018Brien","year":"1979","journal-title":"Biometrics"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB27","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM199809173391210","article-title":"Alternative medicine\u00a0\u2014 the risks of untested and unregulated remedies","volume":"339","author":"Angell","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0025-7125(05)70099-7","article-title":"Current options in management of head and neck cancer patients","volume":"83","author":"Correa","year":"1999","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1001\/archotol.1997.01900020023003","article-title":"Prognostic value of histologic findings in neck dissections for squamous cell carcinoma","volume":"123","author":"Pinsolle","year":"1997","journal-title":"Arch. Otolaryngol. Head. Neck Surg."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB30","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1288\/00005537-199410000-00003","article-title":"Distant metastases from head and neck squamous cell carcinomas","volume":"104","author":"Calhoun","year":"1994","journal-title":"Laryngoscope"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB31","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/1097-0142(19941001)74:7<1933::AID-CNCR2820740718>3.0.CO;2-X","article-title":"Synchronous and metachronous head and neck carcinomas","volume":"74","author":"Schwartz","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB32","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/S0959-8049(98)00328-1","article-title":"Variation in survival of patients with head and neck cancer in Europe by the site of origin of the tumours. EUROCARE Working Group","volume":"34","author":"Berrino","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/S0959-8049(00)00360-9_BIB33","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/archotol.124.9.951","article-title":"The National Cancer Data Base report on cancer of the head and neck","volume":"124","author":"Hoffman","year":"1998","journal-title":"Arch. Otolaryngol. Head. Neck. Surg."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bmj.282.6259.186","article-title":"Mistletoe hepatitis","volume":"282","author":"Harvey","year":"1981","journal-title":"Br. Med. J."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB35","first-page":"1240","article-title":"Immunomodulating ability of galactoside-specific lectin standardized and depleted mistletoe extract","volume":"45","author":"Beuth","year":"1995","journal-title":"Drug Res."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB36","first-page":"166","article-title":"Comparative studies on the immunoactive action of galactoside-specific mistletoe lectin. Pure substance compared to the standardized extract","volume":"43","author":"Beuth","year":"1993","journal-title":"Drug Res."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s004320050138","article-title":"Inability of galactoside-specific mistletoe lectin to inhibit N-methyl-N-nitrosourea-induced tumor development in the urinary bladder of rats and to mediate a local cellular immune response after long-term administration","volume":"124","author":"Kunze","year":"1998","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s004320050022","article-title":"Long-term administration of galactoside-specific mistletoe lectin in an animal model","volume":"126","author":"Kunze","year":"2000","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000021253","article-title":"Lymphocyte subsets in tumour patients during subcutaneous mistletoe therapy","volume":"6","author":"B\u00fcssing","year":"1999","journal-title":"Forsch. Komplementarmed."},{"key":"10.1016\/S0959-8049(00)00360-9_BIB40","first-page":"1339","article-title":"Mistletoe extract standardized for the galactoside-specific lectin (ML-1) induces beta-endorphin release and immunopotentiation in breast cancer patients","volume":"14","author":"Heiny","year":"1994","journal-title":"Anticancer Res."}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804900003609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804900003609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T21:24:33Z","timestamp":1555881873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804900003609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0959804900003609"],"URL":"https:\/\/doi.org\/10.1016\/s0959-8049(00)00360-9","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}