{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:41:05Z","timestamp":1771512065547,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1016\/s0959-8049(02)00838-9","type":"journal-article","created":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T18:20:01Z","timestamp":1047666001000},"page":"560-571","source":"Crossref","is-referenced-by-count":81,"title":["Altered fractionation and combined radio-chemotherapy approaches"],"prefix":"10.1016","volume":"39","author":[{"given":"J.","family":"Bernier","sequence":"first","affiliation":[]},{"given":"S.M.","family":"Bentzen","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0959-8049(02)00838-9_BIB1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0167-8140(92)90242-M","article-title":"Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma","volume":"25","author":"Horiot","year":"1992","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0167-8140(97)00079-0","article-title":"Accelerated fractionation (AF) compared with conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers","volume":"44","author":"Horiot","year":"1997","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/02841869309093594","article-title":"Quantitative clinical radiobiology","volume":"32","author":"Bentzen","year":"1993","journal-title":"Acta Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB4","series-title":"Basic Clinical Radiobiology","first-page":"94","article-title":"The linear-quadratic model in clinical practice","author":"Bentzen","year":"2002"},{"issue":"Suppl. 1","key":"10.1016\/S0959-8049(02)00838-9_BIB5","first-page":"S4","article-title":"The DAHANCA 6 & 7 trial. A randomized multicenter study of 5 versus 6 fractions per week of conventional radiotherapy of squamous cell carcinoma of the head and neck","volume":"56","author":"Overgaard","year":"2000","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-8140(00)00139-0","article-title":"Randomized clinical trial on 7-day-continuous accelerated irradiation (CAIR) of head and neck cancer\u2014report on 3-year tumour control and normal tissue toxicity","volume":"55","author":"Skladowski","year":"2000","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0360-3016(99)00532-5","article-title":"A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma","volume":"46","author":"Bourhis","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0360-3016(97)00509-9","article-title":"Predictive assays of radiation response in patients with head and neck squamous cell carcinoma","volume":"39","author":"Eschwege","year":"1997","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0167-8140(99)00012-2","article-title":"Altered fractionation","volume":"50","author":"Kaanders","year":"1999","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0167-8140(95)01545-R","article-title":"Acute reaction parameters for human oropharyngeal mucosa","volume":"35","author":"Denham","year":"1995","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-8140(01)00358-9","article-title":"Radiotherapy-related early morbidity in head and neck cancer","volume":"60","author":"Bentzen","year":"2001","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/02841868809090339","article-title":"Accelerated fractionation in the radiation treatment of head and neck cancer. A critical comparison of different strategies","volume":"27","author":"Peters","year":"1988","journal-title":"Acta Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0167-8140(96)01776-8","article-title":"Randomized clinical trial on accelerated 7 days per week fractionation in radiotherapy for head and neck cancer. Preliminary report on acute toxicity","volume":"40","author":"Maciejewski","year":"1996","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0167-8140(01)00429-7","article-title":"Consequential late effects in normal tissues","volume":"61","author":"Dorr","year":"2001","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-8140(97)00094-7","article-title":"A randomized multicentre trial of CHART versus conventional radiotherapy in head and neck cancer","volume":"44","author":"Dische","year":"1997","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-8140(01)00347-4","article-title":"A randomised trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck","volume":"60","author":"Poulsen","year":"2001","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0167-8140(99)00151-6","article-title":"Repair halftimes estimated from observations of treatment-related morbidity after CHART or conventional radiotherapy in head and neck cancer","volume":"53","author":"Bentzen","year":"1999","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1053\/srao.2001.23484","article-title":"Partial irradiation of the parotid gland","volume":"11","author":"Eisbruch","year":"2001","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB19","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0360-3016(00)01441-3","article-title":"A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy","volume":"49","author":"Chao","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0360-3016(99)00101-7","article-title":"Smart (simultaneous modulated accelerated radiation therapy) boost","volume":"45","author":"Butler","year":"1999","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0360-3016(79)90044-0","article-title":"Exploitable mechanisms in combined radiotherapy-chemotherapy","volume":"5","author":"Steel","year":"1979","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB22","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1200\/JCO.1996.14.3.838","article-title":"Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region. A meta-analysis of prospective and randomized trials","volume":"14","author":"El Sayed","year":"1996","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1053-4296(98)80021-0","article-title":"Radiotherapy and concurrent chemotherapy for the treatment of locally advanced head and neck squamous cell carcinoma","volume":"8","author":"Brizel","year":"1998","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/hed.1081","article-title":"Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer","volume":"23","author":"Browman","year":"2001","journal-title":"Head Neck"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/bjc.1995.17","article-title":"An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer","volume":"71","author":"Munro","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB26","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB27","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/bjc.1990.175","article-title":"Adjuvant chemotherapy in head and neck cancer","volume":"61","author":"Stell","year":"1990","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB28","first-page":"1720","article-title":"Interaction of ionizing radiation with the topoisomerase I poison camptothecin in growing V-79 and HeLa cells","volume":"54","author":"Hennequin","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1200\/JCO.20.1.110","article-title":"Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients","volume":"20","author":"Albanell","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1667\/0033-7587(2001)156[0503:ITRBCR]2.0.CO;2","article-title":"Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid","volume":"156,5 Pt1","author":"Murata","year":"2001","journal-title":"Radiat. Res."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2613.2002.00211.x","article-title":"The biology of the combretastatins as tumour vascular targeting agents","volume":"83","author":"Tozer","year":"2002","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0959-8049(01)00360-4","article-title":"Biological basis for chemo-radiotherapy interactions","volume":"38","author":"Hennequin","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-8140(00)00235-8","article-title":"Has the outlook improved for amifostine as a clinical radioprotector?","volume":"57","author":"Lindegaard","year":"2000","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB34","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0360-3016(01)01544-9","article-title":"Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy\u2014results of a multicentric randomized German trial in advanced head-and-neck cancer","volume":"50","author":"Staar","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB35","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0360-3016(01)02774-2","article-title":"Chemotherapy and altered fractionation in head-and-neck cancer","volume":"52","author":"Bentzen","year":"2002","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB36","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1200\/JCO.1994.12.8.1592","article-title":"Tumor response, toxicity, and survival after neoadjuvant organ-preserving chemotherapy for advanced laryngeal carcinoma. The Department of Veterans Affairs Cooperative Laryngeal Cancer Study Group","volume":"12","author":"Spaulding","year":"1994","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB37","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/jnci\/88.13.890","article-title":"Larynx preservation in pyriform sinus cancer","volume":"88","author":"Lefebvre","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB38","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/jnci\/92.12.977","article-title":"EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups","volume":"92","author":"van Zandwijk","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0360-3016(01)01690-X","article-title":"Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer","volume":"51","author":"Ang","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB40","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/sj.bjc.6600119","article-title":"Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer","volume":"86","author":"Awwad","year":"2002","journal-title":"Br. J. Cancer"},{"issue":"Suppl. 1","key":"10.1016\/S0959-8049(02)00838-9_BIB41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0360-3016(01)01825-9","article-title":"Chemo-radiotherapy, as compared to radiotherapy alone, significantly increases disease-free and overall survival in head and neck cancer patients after surgery","volume":"51","author":"Bernier","year":"2001","journal-title":"International Journal of Radiation Oncology Biology Physics."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB42","first-page":"226a","article-title":"Postoperative concurrent radiochemotherapy in high-risk SCCA of the head and neck","volume":"21","author":"Cooper","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB43","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/BF02573877","article-title":"The First International Conference on Sentinel Node Biopsy in Mucosal Head and Neck Cancer and adoption of a multicenter trial protocol","volume":"9","author":"Ross","year":"2002","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB44","first-page":"319","article-title":"Staging of the neck in patients with oral cavity squamous cell carcinomas","volume":"28","author":"Stuckensen","year":"2000","journal-title":"J. Maxillofac. Surg."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.2000.tb06600.x","article-title":"RT-PCR-based detection of occult disseminated tumor cells in peripheral blood and bone marrow of patients with solid tumors. An overview","volume":"906","author":"Zippelius","year":"2000","journal-title":"Ann. New York and Acad. Sci."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB46","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1749-6632.2001.tb03865.x","article-title":"Quantitative analysis of Epstein-Barr virus DNA in plasma and serum","volume":"945","author":"Lo","year":"2001","journal-title":"Ann. New York Acad. Sci."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB47","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1054\/bjoc.2001.2049","article-title":"Failure-specific prognostic factors after continuous hyperfractionated accelerated radiotherapy (CHART) or conventional radiotherapy in locally advanced non-small-cell lung cancer","volume":"85","author":"Ataman","year":"2001","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0360-3016(00)01498-X","article-title":"bcl-2 expression in head and neck cancer","volume":"49","author":"Wilson","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0360-3016(99)00558-1","article-title":"Toxicity in head and neck cancer","volume":"47","author":"Trotti","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB50","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0167-8140(01)00485-6","article-title":"Late morbidity","volume":"61","author":"Bentzen","year":"2001","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/095530099140447","article-title":"Variability in the radiosensitivity of normal cells and tissues. Report from a workshop organised by the European Society for Therapeutic Radiology and Oncology in Edinburgh, UK, 19 September 1998","volume":"75","author":"Bentzen","year":"1999","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB52","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0360-3016(01)02690-6","article-title":"Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy","volume":"52","author":"Safwat","year":"2002","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1667\/0033-7587(2002)157[0204:MNTDP]2.0.CO;2","article-title":"Modifying normal tissue damage postirradiation. Report of a workshop sponsored by the Radiation Research Program, National Cancer Institute, Bethesda, Maryland, September 6\u20138, 2000","volume":"157","author":"Stone","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0167-8140(97)00226-0","article-title":"Towards evidence based radiation oncology","volume":"46","author":"Bentzen","year":"1998","journal-title":"Radiother. Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB55","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<595::AID-HED3>3.0.CO;2-K","article-title":"Neo-adjuvant chemotherapy and supracricoid partial laryngectomy with cricohyoidopexy for advanced endolaryngeal carcinoma classified as T3-T4","volume":"20","author":"Laccourreye","year":"1998","journal-title":"Head Neck"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB56","first-page":"3564","article-title":"Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel","volume":"55","author":"Milas","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB57","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1445-2197.1995.tb00540.x","article-title":"Induction (neo-adjuvant) chemotherapy","volume":"65","author":"Stephens","year":"1995","journal-title":"Aust. N. Z. J. Surg."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB58","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1080\/028418601750444105","article-title":"Neoadjuvant chemotherapy plus conventional radiotherapy or accelerated hyperfractionation in stage III and IV nasopharyngeal carcinoma\u2014a phase II study","volume":"40","author":"El Weshi","year":"2001","journal-title":"Acta Oncol."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB59","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0360-3016(95)00202-A","article-title":"Irradiation enhances cellular uptake of carboplatin","volume":"33","author":"Yang","year":"1995","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB60","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000225540","article-title":"5-fluorouracil uptake by irradiation perturbed tumor","volume":"38","author":"Young","year":"1981","journal-title":"Oncology"},{"key":"10.1016\/S0959-8049(02)00838-9_BIB61","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0360-3016(91)90670-Y","article-title":"Prospective randomized trial comparing hyperfractionated vs. conventional radiotherapy in stages III and IV oropharyngeal carcinoma","volume":"21","author":"Pinto","year":"1991","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0360-3016(00)00663-5","article-title":"A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas","volume":"48","author":"Fu","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/S0959-8049(02)00838-9_BIB63","unstructured":"Bentzen SM. Design of clinical trials in radiation oncolgy: saving lives, not Grays. In: R. Dale, B. Jones (eds), Modelling in Radiation Oncology. British Institute of Radiology, London, in press."}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804902008389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804902008389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T06:57:48Z","timestamp":1553929068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804902008389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["S0959804902008389"],"URL":"https:\/\/doi.org\/10.1016\/s0959-8049(02)00838-9","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}