{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:36:46Z","timestamp":1770500206032,"version":"3.49.0"},"reference-count":126,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[1997,9]]},"DOI":"10.1016\/s0959-8049(97)00251-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T16:07:59Z","timestamp":1027613279000},"page":"1611-1618","source":"Crossref","is-referenced-by-count":50,"title":["Osteosarcoma"],"prefix":"10.1016","volume":"33","author":[{"given":"J.S.","family":"Whelan","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0959-8049(97)00251-7_BIB1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/1097-0142(19950101)75:1+<203::AID-CNCR2820751308>3.0.CO;2-V","article-title":"Bone cancers","volume":"75","author":"Dorfmann","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00454247","article-title":"Osteosarcoma after the fourth decade: a clinico-pathological review","volume":"104","author":"Brooks","year":"1985","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB3","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/1097-0142(19860401)57:7<1442::AID-CNCR2820570734>3.0.CO;2-3","article-title":"Osteogenic sarcoma of bones and soft tissues in older persons","volume":"57","author":"Huvos","year":"1986","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/bjc.1986.110","article-title":"Second primary neoplasms in patients with retinoblastoma","volume":"53","author":"Draper","year":"1986","journal-title":"Br J Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB5","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJM198709033171002","article-title":"Bone sarcomas linked to radiotherapy and chemotherapy in children","volume":"317","author":"Tucker","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/jnci\/85.14.1121","article-title":"Mortality from second tumors among long-term survivors of retinoblastoma","volume":"85","author":"Eng","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB7","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/jnci\/88.5.270","article-title":"Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer","volume":"88","author":"Hawkins","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB8","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0161-6420(84)34127-6","article-title":"Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced?","volume":"91","author":"Abramson","year":"1984","journal-title":"Ophthalmology"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/13577149778425","article-title":"Should cancer survivors fear radiation-induced sarcomas?","volume":"1","author":"Feigen","year":"1997","journal-title":"Sarcoma"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB10","first-page":"5358","article-title":"A cancer family syndrome in twenty-four kindreds","volume":"48","author":"Li","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB11","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJM199205143262002","article-title":"Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms","volume":"326","author":"Malkin","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB12","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM199205143262001","article-title":"Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma","volume":"326","author":"Toguchida","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1200\/JCO.1994.12.5.925","article-title":"Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma","volume":"12","author":"McIntyre","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB14","first-page":"1334","article-title":"Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridisation","volume":"55","author":"Tarkannen","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/360741a0","article-title":"Bone and haematopoietic defects in mice lacking c-fos","volume":"360","author":"Wang","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB16","first-page":"6244","article-title":"c-fos-induced osteosarcoma formation in transgenic mice: cooperativity with c-jun and the role of endogenous c-fos","volume":"55","author":"Wang","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB17","first-page":"989","article-title":"The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas","volume":"5","author":"Wu","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB18","first-page":"6216","article-title":"Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition","volume":"82","author":"Hansen","year":"1985"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/323643a0","article-title":"A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma","volume":"323","author":"Friend","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB20","first-page":"3939","article-title":"Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma","volume":"48","author":"Toguchida","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/08880019209018328","article-title":"Studies of the RB1 gene and the p53 gene in human osteosarcomas","volume":"9","author":"Scholz","year":"1992","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB22","first-page":"3042","article-title":"Mutation spectrum of the retinoblastoma gene in osteosarcomas","volume":"54","author":"Wadayama","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB23","first-page":"5535","article-title":"Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas","volume":"53","author":"Khatib","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0165-4608(95)00216-2","article-title":"Alterations of the p 15, p 16,and p18 genes in osteosarcoma","volume":"86","author":"Miller","year":"1996","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/jor.1100140504","article-title":"SAS is amplified predominantly in surface osteosarcoma","volume":"14","author":"Noble","year":"1996","journal-title":"J Orthop Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/jnci\/82.4.301","article-title":"Insulin-like growth factor I: a potent mitogen for human osteogenic sarcoma","volume":"82","author":"Polak","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB27","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/jnci\/87.23.1787","article-title":"Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone","volume":"87","author":"Pinski","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB28","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/(SICI)1097-0215(19960315)65:6<870::AID-IJC27>3.0.CO;2-6","article-title":"Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice","volume":"65","author":"Pinski","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB29","series-title":"2nd Osteosarcoma Research Conference","first-page":"200","article-title":"The growth hormone\/IGF-1 axis as a potential target for therapy in osteosarcoma","author":"Helman","year":"1996"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB30","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/1097-0142(197503)35:3+<936::AID-CNCR2820350714>3.0.CO;2-B","article-title":"The rationale for multiple drug chemotherapy in the treatment of osteogenic sarcoma","volume":"35","author":"Rosen","year":"1975","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB31","first-page":"14","article-title":"Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy, en bloc resection, and prosthetic bone replacement","volume":"101","author":"Huvos","year":"1977","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB32","first-page":"135","article-title":"Bestimmung dess morphologischen Regressionsgrades nach Chemotherapie bei malignen Knochentumoren","volume":"4","author":"Salzer-Kuntschik","year":"1983","journal-title":"Pathologe"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB33","first-page":"342A","article-title":"A reproducible method of assessing the post-chemotherapy changes in high grade central osteosarcoma","volume":"155","author":"Malcolm","year":"1988","journal-title":"J Pathol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1200\/JCO.1994.12.2.423","article-title":"Prognostic factors in osteosarcoma: a critical review","volume":"12","author":"Davis","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00003086-199109000-00003","article-title":"Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study","volume":"270","author":"Link","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1200\/JCO.1992.10.1.5","article-title":"Chemotherapy for non-metastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience","volume":"10","author":"Meyers","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB37","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/1097-0142(19930215)71:4<1224::AID-CNCR2820710409>3.0.CO;2-M","article-title":"Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy","volume":"71","author":"Bacci","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/1120009X.1994.11741153","article-title":"Prognostic significance of serum lactate dehydrogenase in patients with osteosarcoma of the extremities","volume":"6","author":"Bacci","year":"1994","journal-title":"J Chemother"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000227573","article-title":"Bone-specific alkaline phosphatase in plasma as tumour marker for osteosarcoma","volume":"53","author":"Liu","year":"1996","journal-title":"Oncology"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB40","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1200\/JCO.1996.14.3.848","article-title":"Tumor size and prognosis in aggressively treated osteosarcoma","volume":"14","author":"Bieling","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB41","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1056\/NEJM197411072911902","article-title":"Adjuvant methotrexate citrovorum factor treatment of osteogenic sarcoma","volume":"291","author":"Jaffe","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB42","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1200\/JCO.1987.5.12.2017","article-title":"High-dose methotrexate: a critical appraisal","volume":"5","author":"Ackland","year":"1987","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB43","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/jnci\/80.9.626","article-title":"The role of methotrexate in osteosarcoma","volume":"80","author":"Grem","year":"1988","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB44","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1200\/JCO.1994.12.7.1443","article-title":"Methotrexate pharmacokinetics and prognosis in osteosarcoma","volume":"12","author":"Graf","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/1120009X.1993.11739222","article-title":"Serum methotrexate (MTX) concentrations and prognosis in patients with osteosarcoma of the extremities treated with a multidrug neoadjuvant regimen","volume":"5","author":"Ferrari","year":"1993","journal-title":"J Chemother"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB46","first-page":"489","article-title":"Dose escalation with pharmacokinetics monitoring in methotrexate chemotherapy of osteosarcoma","volume":"15","author":"Delepine","year":"1995","journal-title":"Anticancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB47","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/(SICI)1097-0142(19961115)78:10<2127::AID-CNCR13>3.0.CO;2-0","article-title":"Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic osteosarcoma. Analysis of the literature","volume":"78","author":"Delepine","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1200\/JCO.1996.14.2.467","article-title":"Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma","volume":"14","author":"Feugeas","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1097-0142(19960101)77:1<71::AID-CNCR13>3.0.CO;2-5","article-title":"ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma","volume":"77","author":"Onda","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB50","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1056\/NEJM199511233332103","article-title":"Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome","volume":"333","author":"Baldini","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB51","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/0959-8049(95)00335-5","article-title":"Analysis of P-glycoprotein expression in osteosarcoma","volume":"31A","author":"Serra","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB52","first-page":"2434","article-title":"Multidrug resistance and malignancy in human osteosarcoma","volume":"56","author":"Scotlandi","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB53","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00003086-198011000-00013","article-title":"A system for the surgical staging of musculoskeletal sarcoma","volume":"153","author":"Enneking","year":"1980","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB54","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1148\/radiology.187.2.8475300","article-title":"Pulmonary nodules: detection with thick-section spiral CT versus conventional CT","volume":"187","author":"Remy-Jardin","year":"1993","journal-title":"Radiology"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB55","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1148\/radiology.185.2.1410378","article-title":"Osteosarcoma after chemotherapy: evaluation with contrast material-enhanced subtraction MR imaging","volume":"185","author":"de Baere","year":"1992","journal-title":"Radiology"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB56","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.182.3.1535905","article-title":"Osteosarcoma: chemotherapy-induced changes at MR imaging","volume":"182","author":"Holscher","year":"1992","journal-title":"Radiology"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB57","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jmri.1880050612","article-title":"Dynamic contrast-enhanced MR imaging evaluation of osteosarcoma response to neoadjuvant chemotherapy","volume":"5","author":"Reddick","year":"1995","journal-title":"J Magn Reson Imag"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB58","first-page":"302","article-title":"Serial thallium-201 scintigraphy in osteosarcoma. Correlation with tumor necrosis after preoperative chemotherapy","volume":"293","author":"Rosen","year":"1993","journal-title":"Clin Orthop"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB59","doi-asserted-by":"crossref","first-page":"526","DOI":"10.2106\/00004623-199304000-00008","article-title":"Thallium-201 scanning for the evaluation of osteosarcoma and soft-tissue sarcoma. A study of the evaluation and predictability of the histological response to chemotherapy","volume":"75","author":"Menendez","year":"1993","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB60","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/BF00801605","article-title":"Correlation of the findings of thallium-201 chloride scans with those of other imaging modalities and histology following therapy in patients with bone and soft tissue sarcomas","volume":"22","author":"Kostakoglu","year":"1995","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB61","first-page":"1444","article-title":"Thallium-201 scintigraphy to assess effect of chemotherapy in osteosarcoma","volume":"37","author":"Ohtomo","year":"1996","journal-title":"J Nucl Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB62","first-page":"463","article-title":"Positron emission tomography scanning with 18-Fluorodeoxyglucose correlates with histologic response in children with osteosarcoma and Ewing sarcoma","volume":"15","author":"Abella","year":"1996"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB63","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1148\/radiology.191.2.8153316","article-title":"Changes in tumor perfusion induced by chemotherapy in bone sarcomas: color doppler flow imaging compared with contrast enhanced MR imaging and three-phase bone scintigraphy","volume":"191","author":"van der Woude","year":"1994","journal-title":"Radiology"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB64","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2214\/ajr.165.1.7785571","article-title":"Treatment of high grade bone sarcomas with neoadjuvant chemotherapy: the utility of sequential color doppler flow sonography in predicting histologic response","volume":"165","author":"van der Woude","year":"1995","journal-title":"Am J Roentgenol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB65","first-page":"263","article-title":"No evidence for improved event-free survival with presurgical chemotherapy for non-metastatic extremity osteosarcoma: preliminary results of a randomised non-metastatic pediatric oncology group trial 8651","volume":"27","author":"Goorin","year":"1996","journal-title":"Med Ped Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB66","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1056\/NEJM198606193142502","article-title":"The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity","volume":"314","author":"Link","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB67","series-title":"2nd Osteosarcoma Research Conference","first-page":"142","article-title":"Local relapse in primary high grade osteosarcoma of the extremities treated with neoadjuvant chemotherapy: risk factors and prognosis in the Rizzoli experience","author":"Bacci","year":"1996"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB68","series-title":"2nd Osteosarcoma Research Conference","first-page":"141","article-title":"Local recurrence in osteosarcoma: risk factors and prognosis","author":"Kempf-Bielack","year":"1996"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB69","series-title":"Bone Tumours","first-page":"156","article-title":"Osteogenic sarcoma","author":"Dahlin","year":"1970"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB70","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1200\/JCO.1987.5.1.21","article-title":"Adjuvant chemotherapy for osteosarcoma: a randomised prospective trial","volume":"5","author":"Eilber","year":"1987","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB71","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/1097-0142(19820315)49:6<1221::AID-CNCR2820490625>3.0.CO;2-E","article-title":"Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy","volume":"49","author":"Rosen","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB72","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1200\/JCO.1992.10.10.1579","article-title":"A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup","volume":"10","author":"Bramwell","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB73","first-page":"520","article-title":"A randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup","volume":"15","author":"Souhami","year":"1996"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB74","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1200\/JCO.1994.12.9.1842","article-title":"Two weekly doxorubicin and cisplatin with granulocyte colony stimulating factor as adjuvant chemotherapy for osteosarcoma: a phase II trial of the European Osteosarcoma Intergroup","volume":"12","author":"Ornadel","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB75","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1200\/JCO.1988.6.2.329","article-title":"Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response","volume":"6","author":"Winkler","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB76","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1002\/1097-0142(19900601)65:11<2539::AID-CNCR2820651125>3.0.CO;2-M","article-title":"Primary chemotherapy and elayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities","volume":"65","author":"Bacci","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1200\/JCO.1992.10.1.5","article-title":"Chemotherapy for non-metastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience","volume":"10","author":"Meyers","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB78","first-page":"412","article-title":"Osteogenic sarcoma (OS): a prospective randomised trial of intensive pre-operative (PRE-OP) chemotherapy (CHEMO) versus CHEMO guided by histologic response (HR) to PRE-OP CHEMO","volume":"12","author":"Meyers","year":"1993"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB79","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1002\/1097-0142(19931201)72:11<3227::AID-CNCR2820721116>3.0.CO;2-C","article-title":"Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities. Results in 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin","volume":"72","author":"Bacci","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB80","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1200\/JCO.1997.15.1.76","article-title":"Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group","volume":"15","author":"Provisor","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB81","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF00253234","article-title":"Ifosfamide in pediatric malignant solid tumors","volume":"24","author":"Pratt","year":"1989","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB82","first-page":"115","article-title":"High dose ifosfamide in advanced osteosarcoma","volume":"69","author":"Marti","year":"1985","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB83","first-page":"214","article-title":"Activity of ifosfamide in metastatic and unresectable osteosarcoma","volume":"6","author":"Bowman","year":"1987"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB84","first-page":"261","article-title":"The activity of ifosfamide (IFOS) in previously untreated patients with osteosarcoma (OS): preliminary results of the SJCRH OS-86 study","volume":"7","author":"Meyer","year":"1988"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB85","first-page":"1755","article-title":"Phase II study of VP-16-213 in childhood malignant disease: a Children's Cancer Study Group report","volume":"63","author":"Chard","year":"1979","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB86","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM198503143121106","article-title":"Drug therapy. Etoposide (VP-16-213). Current status of an active anticancer drug","volume":"312","author":"O'Dwyer","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB87","first-page":"473","article-title":"P-16-213 monotherapy for remission induction in small cell lung cancer: a randomised trial using 3 dosage schedules","volume":"62","author":"Cavalli","year":"1978","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB88","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1200\/JCO.1989.7.9.1333","article-title":"A randomized trial to evaluate the effect of schedule on the activity of etoposide in smallcell lung cancer","volume":"7","author":"Slevin","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB89","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/1097-0142(19900215)65:4<861::AID-CNCR2820650405>3.0.CO;2-H","article-title":"Response of osteogenic sarcoma to the combination of etoposide and cyclophosphamide as neoadjuvant chemotherapy","volume":"65","author":"Saleh","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB90","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1200\/JCO.1987.5.8.1191","article-title":"Ifosfamide with mesna uroprotection and etoposide: an effective regimen in the treatment of recurrent sarcomas and other tumors of children and young adults","volume":"5","author":"Miser","year":"1987","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB91","series-title":"EMSOS 7th Annual Meeting","article-title":"Phase II study of carboplatin (CB) and etoposide (VP16) in pretreated disseminated osteosarcoma (OS)","author":"Fuchs","year":"1994"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB92","first-page":"865","article-title":"Phase I study of carboplatin (CBDCA) in children with cancer","volume":"70","author":"Bacha","year":"1986","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB93","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/1097-0142(19940215)73:4<1297::AID-CNCR2820730427>3.0.CO;2-#","article-title":"A phase II study of carboplatin in children with recurrent or progressive solid tumors. A report from the Childrens Cancer Group","volume":"73","author":"Ettinger","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB94","first-page":"521","article-title":"Carboplatin in the treatment of newly-diagnosed metastatic or unresectable osteosarcoma: a Paediatric Oncology Group Study","volume":"15","author":"Ferguson","year":"1996"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB95","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/(SICI)1097-0142(19960815)78:4<741::AID-CNCR8>3.0.CO;2-H","article-title":"Phase II study of paclitaxel in patients with previously treated osteosarcoma and its variants","volume":"78","author":"Patel","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB96","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0889-8588(18)30079-0","article-title":"Biologic therapy for osteosarcoma using liposome-encapsulated muramyl tripeptide","volume":"9","author":"Kleinerman","year":"1995","journal-title":"Hematol Clin N Am"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB97","first-page":"239","article-title":"Phase II study of high dose thiotepa and hematopoietic stem cell transplantation support in children with metastatic osteosarcoma","volume":"27","author":"Valteau-Couanet","year":"1996","journal-title":"Med Ped Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB98","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2106\/00004623-197052030-00001","article-title":"Osteogenic sarcoma under the age of 21\u2014a review of 145 operative cases","volume":"52","author":"Marcove","year":"1970","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB99","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/bjc.1975.136","article-title":"The metastatic patterns of osteosarcoma","volume":"32","author":"Jeffree","year":"1975","journal-title":"Br J Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1302\/0301-620X.49B1.74","article-title":"Surgical treatment of pulmonary metastases from primary tumours of bone","volume":"49B","author":"Sweetnam","year":"1967","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB101","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0003-4975(10)65124-7","article-title":"Multiple pulmonary resections in the treatment of osteogenic sarcoma","volume":"12","author":"Martini","year":"1971","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB102","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2106\/00004623-197658050-00007","article-title":"Pulmonary resection for metastatic osteogenic sarcoma","volume":"58","author":"Spanos","year":"1976","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB103","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0022-3468(81)80848-2","article-title":"Aggressive thoracotomy for pulmonary metastatic osteogenic sarcoma in children and young adolescents","volume":"16","author":"Han","year":"1981","journal-title":"J Pediat Surg"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB104","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0003-4975(10)60679-0","article-title":"Survival following aggressive resection of pulmonary metastases from osteogenic sarcoma: analysis of prognostic factors","volume":"36","author":"Putnam","year":"1983","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1200\/JCO.1984.2.5.425","article-title":"Prognostic significance of complete surgical resection of pulmonary metastases in patients with osteogenic sarcoma: analysis of 32 patients","volume":"2","author":"Goorin","year":"1984","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB106","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/1097-0142(19850315)55:6<1361::AID-CNCR2820550633>3.0.CO;2-F","article-title":"Differing determinants of prognosis following resection of pulmonary metastases from osteogenic and soft tissue sarcoma patients","volume":"55","author":"Roth","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB107","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/1097-0142(19870115)59:2<374::AID-CNCR2820590235>3.0.CO;2-6","article-title":"Thoracotomy for pulmonary metastatic osteosarcoma: an analysis of prognostic indicators of survival","volume":"59","author":"Meyer","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB108","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1002\/1097-0142(19890615)63:12<2546::AID-CNCR2820631232>3.0.CO;2-X","article-title":"Resection of pulmonary metastases in osteosarcoma. A retrospective analysis of 44 patients","volume":"63","author":"Belli","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB109","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/1010-7940(90)90169-Z","article-title":"Median sternotomy and multiple lung resections for metastatic sarcomas","volume":"4","author":"Pastorino","year":"1990","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00003086-199101000-00012","article-title":"Pulmonary metastases and bone sarcomas\u2014surgical removal of lesions appearing after adjuvant chemotherapy","volume":"262","author":"Burk","year":"1991","journal-title":"Clin Orth Relat Res"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB111","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1001\/archsurg.1992.01420090073010","article-title":"Surgical treatment and chemotherapy for pulmonary metastases from osteosarcoma","volume":"127","author":"Skinner","year":"1992","journal-title":"Arch Surg"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB112","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/1097-0142(197503)35:3<618::AID-CNCR2820350312>3.0.CO;2-Z","article-title":"The management of pulmonary metastases in children with osteogenic sarcoma with surgical resection combined with chemotherapy","volume":"35","author":"Beattie","year":"1975","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB113","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/1097-0142(197803)41:3<841::AID-CNCR2820410310>3.0.CO;2-Z","article-title":"Chemotherapy and thoracotomy for metastatic osteogenic sarcoma: a model for adjuvant chemotherapy and the rationale for the timing of thoracic surgery","volume":"41","author":"Rosen","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB114","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1200\/JCO.1994.12.9.1849","article-title":"Pulmonary metastases of stage IIB extremity osteosarcoma and subsequent pulmonary metastases","volume":"12","author":"Ward","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB115","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/1097-0142(19950301)75:5<1084::AID-CNCR2820750506>3.0.CO;2-F","article-title":"Systemic relapse in osteogenic sarcoma: prognostic factors for long term survival","volume":"75","author":"Saeter","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB116","first-page":"79","article-title":"Osteogenic sarcoma: a study based on 133 patients","volume":"1","author":"Cade","year":"1955","journal-title":"J R Coll Surg Edin"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB117","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/02841869609101655","article-title":"Targeted radiotherapy of osteosarcoma using 153-Sm-EDTMP. A new promising approach","volume":"35","author":"Bruland","year":"1996","journal-title":"Acta Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB118","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1002\/1097-0142(19921201)70:11<2722::AID-CNCR2820701125>3.0.CO;2-S","article-title":"Improved prognosis of children with osteosarcoma metastatic to the lung(s) at the time of diagnosis","volume":"70","author":"Marina","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB119","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1200\/JCO.1993.11.3.449","article-title":"Osteogenic sarcoma with clinically detectable metastasis at initial presentation","volume":"11","author":"Meyers","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB120","series-title":"2nd Osteosarcoma Research Conference","first-page":"77","article-title":"Osteosarcoma of the extremities with synchronous metastases: results in 67 patients treated with chemotherapy and simultaneous resection of primary and metastatic lesions","author":"Ferrari","year":"1996"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB121","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/oxfordjournals.annonc.a010769","article-title":"Synchronous multifocal osteosarcoma: results in twelve patients treated with neoadjuvant chemotherapy and simultaneous resection of all involved bones","volume":"7","author":"Bacci","year":"1996","journal-title":"Ann Oncol"},{"issue":"Suppl. 2","key":"10.1016\/S0959-8049(97)00251-7_BIB122","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/annonc\/3.suppl_2.S19","article-title":"Treatment of pelvic osteosarcoma","volume":"3","author":"Marangolo","year":"1992","journal-title":"Ann Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB123","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2106\/00004623-199274030-00002","article-title":"Osteosarcoma of the pelvis. A clinical and histopathological study of twenty-five patients","volume":"74","author":"Fahey","year":"1992","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB124","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/cncr.2820690513","article-title":"Primary treatment of pelvic osteosarcoma. Report of five cases","volume":"69","author":"Estrada Aguilar","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/mpo.2950240103","article-title":"Osteosarcoma of the trunk treated by multimodal therapy: experience of the Cooperative Osteosarcoma Study Group","volume":"24","author":"Bielack","year":"1995","journal-title":"Med Ped Oncol"},{"key":"10.1016\/S0959-8049(97)00251-7_BIB126","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/1097-0142(19920201)69:3<698::AID-CNCR2820690317>3.0.CO;2-G","article-title":"Survival, prognosis, and therapeutic response in osteogenic sarcoma. The Memorial Hospital experience","volume":"69","author":"Glasser","year":"1992","journal-title":"Cancer"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804997002517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804997002517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:36:31Z","timestamp":1681086991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804997002517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":126,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["S0959804997002517"],"URL":"https:\/\/doi.org\/10.1016\/s0959-8049(97)00251-7","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}