{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:32:10Z","timestamp":1770777130866,"version":"3.50.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[1998,12]]},"DOI":"10.1016\/s0959-8049(98)00282-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T17:45:37Z","timestamp":1027619137000},"page":"2041-2045","source":"Crossref","is-referenced-by-count":131,"title":["Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer"],"prefix":"10.1016","volume":"34","author":[{"given":"I","family":"Hyodo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tanimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Jinno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0959-8049(98)00282-2_BIB1","first-page":"1029","article-title":"Vascular permeability factor\/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis","volume":"146","author":"Dvorak","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB2","doi-asserted-by":"crossref","unstructured":"Senger D, Van De Water L, Brown L, et al. Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev 1993, 12, 303\u2013324.","DOI":"10.1007\/BF00665960"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB3","doi-asserted-by":"crossref","unstructured":"Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983, 219, 983\u2013985.","DOI":"10.1126\/science.6823562"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB4","doi-asserted-by":"crossref","unstructured":"Leung DW, Cachianes G, Kuang W-J, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246, 1306\u20131309.","DOI":"10.1126\/science.2479986"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jcp.1041530317","article-title":"Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells","volume":"153","author":"Unemori","year":"1992","journal-title":"J Cell Physiol"},{"issue":"14","key":"10.1016\/S0959-8049(98)00282-2_BIB6","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/S0959-8049(96)00387-5","article-title":"Vascular endothelial growth factor","volume":"32A","author":"Ferrara","year":"1996","journal-title":"Eur J Cancer"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB7","doi-asserted-by":"crossref","unstructured":"Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature (Lond) 1993, 362, 841\u2013844.","DOI":"10.1038\/362841a0"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nature Med"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1476-5381.1995.tb13221.x","article-title":"Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A","volume":"114","author":"Hu","year":"1995","journal-title":"Br J Pharmacol"},{"issue":"14","key":"10.1016\/S0959-8049(98)00282-2_BIB10","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/S0959-8049(96)00388-7","article-title":"TNP-470 (AGM-1470): mechanisms of action and early clinical development","volume":"32A","author":"Castronovo","year":"1996","journal-title":"Eur J Cancer"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB11","first-page":"1054","article-title":"Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers","volume":"57","author":"Joseph","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB12","doi-asserted-by":"crossref","unstructured":"Vermeulen PB, Verhoeven D, Hubens G, et al. Microvessel density, endothelial cell proliferation and tumour cell proliferation in human colorectal adenocarcinomas. Ann Oncol 1995, 6, 59\u201364.","DOI":"10.1093\/oxfordjournals.annonc.a059043"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB13","unstructured":"Weidner N, Folkman J. Tumoral vascularity as a prognostic factor in cancer. In DeVita VT, Hellman S, Rosenberg SA, eds. Important Advances in Oncology. Philadelphia, Lippincott-Raven, 1996, 167\u2013190."},{"key":"10.1016\/S0959-8049(98)00282-2_BIB14","doi-asserted-by":"crossref","unstructured":"Tanigawa N, Amaya H, Matsumura M, et al. Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma. J Clin Oncol 1997, 15, 826\u2013832.","DOI":"10.1200\/JCO.1997.15.2.826"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB15","doi-asserted-by":"crossref","unstructured":"Kondo S, Asano M, Matsuo K, et al. Vascular endothelial growth factor\/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients. Biochim Biophys Acta 1994, 1221, 211\u2013214.","DOI":"10.1016\/0167-4889(94)90016-7"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB16","unstructured":"Yamamoto Y, Toi M, Kondo S, et al. Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clin Cancer Res 1996, 2, 821\u2013826."},{"key":"10.1016\/S0959-8049(98)00282-2_BIB17","doi-asserted-by":"crossref","unstructured":"Dirix LY, Vermeulen PB, Pawinski A, et al. Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br J Cancer 1997, 76, 238\u2013243.","DOI":"10.1038\/bjc.1997.368"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB18","doi-asserted-by":"crossref","unstructured":"M\u00f6hle R, Green D, Moore MAS, et al. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci 1997, 94, 663\u2013668.","DOI":"10.1073\/pnas.94.2.663"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB19","unstructured":"Verheul HMW, Hoekman K, Luykx-de Bakker S, et al. Platelet: transporter of vascular endothelial growth factor. Clin Cancer Res 1997, 3, 2187\u20132190."},{"key":"10.1016\/S0959-8049(98)00282-2_BIB20","doi-asserted-by":"crossref","unstructured":"Hyodo I, Doi T, Endo H, et al. Detection of circulating vascular endothelial growth factor (VEGF), matrix metalloproteinase-3 (MMP-3) and -9 (MMP-9) in gastrointestinal cancer. Eur J Cancer 1997, 33(Suppl. 8), A195.","DOI":"10.1016\/S0959-8049(97)84583-2"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6","article-title":"Reporting results of cancer treatment","volume":"47","author":"Miller","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","article-title":"What is the evidence that tumors are angiogenesis dependent?","volume":"82","author":"Folkman","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0092-8674(91)90642-C","article-title":"Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation","volume":"64","author":"Liotta","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00047657","article-title":"Role of plasma, platelets, and endothelial cells in tumor metastasis","volume":"3","author":"Gasic","year":"1984","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB25","first-page":"1460","article-title":"Functional role of platelets in experimental metastasis studied with cloned murine fibrosarcoma cell variants","volume":"48","author":"Mahalingam","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB26","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1349-7006.1994.tb02904.x","article-title":"Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer","volume":"85","author":"Toi","year":"1994","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/S0959-8049(98)00282-2_BIB27","unstructured":"Takahashi Y, Kitadai Y, Bucana CD, et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995, 55, 3964\u20133968."}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804998002822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804998002822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T14:24:10Z","timestamp":1556115850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804998002822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":27,"journal-issue":{"issue":"13","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S0959804998002822"],"URL":"https:\/\/doi.org\/10.1016\/s0959-8049(98)00282-2","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}