{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:58:52Z","timestamp":1770721132003,"version":"3.49.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1994,6,1]],"date-time":"1994-06-01T00:00:00Z","timestamp":770428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[1994,6]]},"DOI":"10.1016\/s0960-9822(00)00111-1","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T18:22:43Z","timestamp":1090434163000},"page":"506-517","source":"Crossref","is-referenced-by-count":316,"title":["The dynamic regulation of integrin adhesiveness"],"prefix":"10.1016","volume":"4","author":[{"given":"Michael S.","family":"Diamond","sequence":"first","affiliation":[]},{"given":"Timothy A.","family":"Springer","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0960-9822(00)00111-1_BIB1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI114957","article-title":"Integrins","volume":"87","author":"Ruoslahti","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(92)90115-S","article-title":"Integrins: versatility, modulation, and signaling in cell adhesion","volume":"69","author":"Hynes","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.iy.08.040190.002053","article-title":"VLA proteins in the integrin family: Structures, functions, and their role on leukocytes","volume":"8","author":"Hemler","year":"1990","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0092-8674(93)90575-B","article-title":"A novel divalent cation-binding site in the A domain of the \u03b22 integrin CR3 (CD11b\/CD18) is essential for ligand binding","volume":"72","author":"Michishita","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.120.4.1031","article-title":"The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b\/CD18) for four distinct adhesion ligands","volume":"120","author":"Diamond","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB6","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.4049\/jimmunol.152.9.4582","article-title":"The leukocyte integrin p150,95 (CD11c\/CD18) as a receptor for iC3b: Activation by a heterologous \u03b2 subunit and localization of a ligand recognition site to the I domain","volume":"152","author":"Bilsland","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB7","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/j.1460-2075.1989.tb03516.x","article-title":"The primary structure of \u03b1-4 subunit of VLA-4: Homology to other integrins and possible cell-cell adhesion function","volume":"8","author":"Takada","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB8","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0955-0674(93)90031-K","article-title":"Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra-\u00a0 and intracellular initiated transmembrane signaling","volume":"5","author":"Sastry","year":"1993","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1083\/jcb.124.6.1047","article-title":"Integrin cytoplasmic domains mediate inside-out signal transduction","volume":"124","author":"O'Toole","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB10","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1084\/jem.174.5.1227","article-title":"The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 \u03b2 subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site","volume":"174","author":"Hibbs","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/bj2740457","article-title":"Further studies on the topography of the N-terminal region of human platelet glycoprotein IIIa: Localization of monoclonal antibody epitopes and the putative fibrinogen-binding sites","volume":"274","author":"Calvete","year":"1991","journal-title":"Biochem J"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB12","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0092-8674(87)90246-7","article-title":"Cloning of the beta subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family","volume":"48","author":"Kishimoto","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0065-2776(08)60653-7","article-title":"The leukocyte integrins: LFA-1, Mac-1, and p150,95","volume":"46","author":"Kishimoto","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(93)90305-A","article-title":"\u03b14 \u03b27 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1","volume":"74","author":"Berlin","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/346425a0","article-title":"Adhesion receptors of the immune system","volume":"346","author":"Springer","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: the multi-step paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB17","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/341619a0","article-title":"T cell receptor cross-linking transiently stimulates adhesiveness through LFA-1","volume":"341","author":"Dustin","year":"1989","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB18","doi-asserted-by":"crossref","first-page":"21693","DOI":"10.1016\/S0021-9258(20)80597-3","article-title":"Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells","volume":"268","author":"Lollo","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB19","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/342811a0","article-title":"Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes","volume":"342","author":"van Kooyk","year":"1989","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.175.2.577","article-title":"Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion","volume":"175","author":"Shimizu","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0092-8674(91)90548-D","article-title":"Binding of the integrin Mac-1 (CD11b\/CD18) to the third Ig-like domain of ICAM-1 (CD54) and its regulation by glycosylation","volume":"65","author":"Diamond","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB22","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.4049\/jimmunol.146.10.3273","article-title":"Stimulation of B lymphocytes through surface Ig receptors induces LFA-1 and ICAM-1-dependent adhesion","volume":"146","author":"Dang","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB23","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1084\/jem.172.5.1513","article-title":"Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion","volume":"172","author":"Mourad","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB24","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1084\/jem.163.5.1132","article-title":"The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester","volume":"163","author":"Rothlein","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB25","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.4049\/jimmunol.137.4.1270","article-title":"A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1","volume":"137","author":"Rothlein","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB26","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1084\/jem.156.4.1000","article-title":"Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor","volume":"156","author":"Beller","year":"1982","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB27","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.4049\/jimmunol.136.5.1759","article-title":"Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes","volume":"136","author":"Wright","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB28","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1084\/jem.171.4.1155","article-title":"Neutrophil-activating protein 1\/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b\/CD18 on human neutrophils","volume":"171","author":"Detmers","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.137.1.15","article-title":"Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: Structure-function assessments employing subunit-specific monoclonal antibodies","volume":"137","author":"Anderson","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB30","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.4049\/jimmunol.137.10.3259","article-title":"Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies","volume":"137","author":"Dana","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB31","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1084\/jem.158.6.2016","article-title":"Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes","volume":"158","author":"Wright","year":"1983","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB32","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.4049\/jimmunol.147.12.4211","article-title":"Differential effects of neutrophil-activating peptide 1\/IL-8 and its homologues on leukocyte adhesion and phagocytosis","volume":"147","author":"Detmers","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB33","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1073\/pnas.85.20.7734","article-title":"Complement receptor type three (CD11b\/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen","volume":"85","author":"Wright","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB34","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1172\/JCI114111","article-title":"Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.","volume":"83","author":"Smith","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB35","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1083\/jcb.111.6.3129","article-title":"ICAM-1 (CD54): A counter-receptor for Mac-1 (CD11b\/CD18)","volume":"111","author":"Diamond","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB36","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1084\/jem.169.5.1779","article-title":"Transient adhesion of neutrophils to endothelium","volume":"169","author":"Lo","year":"1989","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB37","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.4049\/jimmunol.140.9.3156","article-title":"Dissociation between increased surface expression of Gp165\/95 and homotypic neutrophil aggregation","volume":"140","author":"Buyon","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB38","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI111572","article-title":"Human neutrophils increase expression of C3bi as well as C3b receptors upon activation","volume":"74","author":"Berger","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB39","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1172\/JCI111538","article-title":"Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion","volume":"74","author":"Todd","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB40","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1172\/JCI113102","article-title":"Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface","volume":"80","author":"Miller","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB41","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1126\/science.3629236","article-title":"Chemoattractant-regulated fusion of a novel,mobilizable intracellular compartment with the plasma membrane in human neutrophils","volume":"237","author":"Borregaard","year":"1987","journal-title":"Science"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB42","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.166.6.1641","article-title":"Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils","volume":"166","author":"Bainton","year":"1987","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB43","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1172\/JCI113372","article-title":"Increased surface expression of CD11b\/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium","volume":"81","author":"Vedder","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB44","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.4049\/jimmunol.142.10.3537","article-title":"The cell surface glycoprotein Mac-1 (CD11b\/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression","volume":"142","author":"Schleiffenbaum","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB45","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1083\/jcb.120.2.545","article-title":"A sub-population of Mac-1 (CD11b\/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen","volume":"120","author":"Diamond","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB46","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1172\/JCI113623","article-title":"Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation","volume":"82","author":"Philips","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB47","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1182\/blood.V81.11.2827.2827","article-title":"Regulation of vascular integrins","volume":"81","author":"Smyth","year":"1993","journal-title":"Blood"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB48","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1091\/mbc.1.12.883","article-title":"Affinity modulation of the alpha llb beta 3 integrin (platelet GPIIb IIIa) is an intrinsic property of the receptor","volume":"1","author":"O'Toole","year":"1990","journal-title":"Cell Regul"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB49","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/345250a0","article-title":"Regulated expression and function of three VLA (beta 1) integrin receptors on T cells","volume":"345","author":"Shimizu","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB50","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4049\/jimmunol.147.2.398","article-title":"T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix","volume":"147","author":"Chan","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB51","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/eji.1830211021","article-title":"Differential expression of VLA-4 integrin by resident and peripheral blood B lymphocytes. Acquisition of functionally active \u03b14\u03b21-fibronectin receptors upon B cell activation","volume":"21","author":"Postigo","year":"1991","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB52","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1083\/jcb.110.6.2167","article-title":"The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the \u03b16\u03b21 integrin","volume":"110","author":"Shaw","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB53","doi-asserted-by":"crossref","first-page":"11401","DOI":"10.1016\/S0021-9258(18)82138-X","article-title":"Inside-out integrin signaling in macrophages. Analysis of the role of the \u03b16A\u03b21 and \u03b16B\u03b21 integrin variants in laminin adhesion by cDNA expression in an \u03b16 integrin-deficient macrophage cell line","volume":"268","author":"Shaw","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/361079a0","article-title":"T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1\u03b2","volume":"361","author":"Tanaka","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/15419069309095679","article-title":"Role of intracellular Ca2+ levels in the regulation of CD11a\/CD18 mediated cell adhesion","volume":"1","author":"Van Kooyk","year":"1993","journal-title":"Cell Adhesion Commun"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB56","series-title":"Leukocyte Typing II: Human Myeloid and Hematopoietic Cells Vol. 3","first-page":"77","article-title":"Phosphorylation of alpha, beta subunits of 180\/100-Kd polypeptides (LFA-1) and related antigens","author":"Hara","year":"1986"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB57","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1083\/jcb.109.6.3435","article-title":"Constitutive and stimulus induced phosphorylation of CD11\/CD18 leukocyte adhesion molecules","volume":"109","author":"Chatila","year":"1989","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB58","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0167-5699(90)90112-M","article-title":"On the mode of action of LFA-1","volume":"11","author":"Figdor","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB59","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4049\/jimmunol.144.1.191","article-title":"Constitutive and induced phosphorylation of the alpha-\u00a0 and beta-chains of the CD11\/CD18 leukocyte integrin family","volume":"144","author":"Buyon","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB60","doi-asserted-by":"crossref","first-page":"990","DOI":"10.4049\/jimmunol.151.2.990","article-title":"Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b\/CD18) regulate ligand avidity and the internalization of occupied receptors","volume":"151","author":"Rabb","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB61","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.4049\/jimmunol.149.7.2295","article-title":"Regulation of LFA-1 avidity in human B cells: requirements for dephosphorylation events for high avidity ICAM-1 binding","volume":"149","author":"Hedman","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB62","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1016\/S0021-9258(17)39154-8","article-title":"Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation","volume":"260","author":"Shattil","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB63","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1091\/mbc.1.4.359","article-title":"The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated","volume":"1","author":"Larson","year":"1990","journal-title":"Cell Regul"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB64","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1083\/jcb.112.2.345","article-title":"Activation of LFA-1 through a Ca2+-dependent epitope stimulates lymphocyte adhesion","volume":"112","author":"Van Kooyk","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB65","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.148.4.1080","article-title":"Antibody against the Leu-cam \u03b2-chain (CD18) promotes both LFA-1-and CR3-dependent adhesion events","volume":"148","author":"Robinson","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB66","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.4049\/jimmunol.140.5.1393","article-title":"A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions","volume":"140","author":"Keizer","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB67","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1126\/science.1672776","article-title":"Regulation of adhesion to ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit","volume":"251","author":"Hibbs","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB68","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1083\/jcb.120.6.1519","article-title":"A novel LFA-1 activation epitope maps to the I domain","volume":"120","author":"Landis","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB69","first-page":"537","article-title":"Multiple functional forms of the integrin VLA-2 can be derived from a single \u03b12 cDNA clone: interconversion of forms induced by an anti-\u03b21 antibody","volume":"150","author":"Chan","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB70","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1083\/jcb.117.3.659","article-title":"Regulation of the VLA Integrin-Ligand Interactions through the \u03b21 Subunit","volume":"117","author":"Arroyo","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB71","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.117.2.461","article-title":"Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the beta subunit of VLA","volume":"117","author":"Van De Wiel-Van Kemenade","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB72","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0021-9258(18)54139-9","article-title":"Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1\/fibronectin and to vascular cell adhesion molecule-1","volume":"268","author":"Masumoto","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB73","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1083\/jcb.116.2.499","article-title":"A monoclonal antibody to \u03b21 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components","volume":"116","author":"Kovach","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB74","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.121.1.155","article-title":"Affinity modulation of integrin \u03b15\u03b21: Regulation of the functional response by soluble fibronectin","volume":"121","author":"Faull","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB75","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1016\/S0021-9258(18)98425-5","article-title":"A high affinity conformational state on VLA integrin heterodimers induced by an anti-\u03b21 chain monoclonal antibody","volume":"268","author":"Arroyo","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB76","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4049\/jimmunol.144.3.777","article-title":"A monoclonal antibody to VLA-4 alpha chain (CD49d) induces homotypic lymphocyte aggregation","volume":"144","author":"Bednarczyk","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB77","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1083\/jcb.110.6.2157","article-title":"An alternative leukocyte homotypic adhesion mechanism, LFA-1\/ICAM-1 independent, triggered through the human VLA-4 integrin","volume":"110","author":"Campanero","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB78","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1016\/S0021-9258(18)99215-X","article-title":"Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct \u03b14 epitopes","volume":"266","author":"Pulido","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB79","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1002\/j.1460-2075.1989.tb08552.x","article-title":"Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits","volume":"8","author":"Dransfield","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB80","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.4049\/jimmunol.147.6.1891","article-title":"Occupancy of CD11b\/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion","volume":"147","author":"Altieri","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB81","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1016\/S0021-9258(20)64346-0","article-title":"Calcium as a potential physiological regulator of integrin-mediated cell adhesion","volume":"266","author":"Kirchhofer","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB82","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1002\/j.1460-2075.1987.tb02746.x","article-title":"cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95","volume":"6","author":"Corbi","year":"1987","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB83","doi-asserted-by":"crossref","first-page":"12922","DOI":"10.1016\/S0021-9258(18)69249-X","article-title":"cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide","volume":"261","author":"Argraves","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB84","doi-asserted-by":"crossref","first-page":"8476","DOI":"10.1016\/S0021-9258(18)47438-8","article-title":"Structure of the platelet membrane glycoprotein IIb: Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors","volume":"262","author":"Poncz","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB85","doi-asserted-by":"crossref","first-page":"14080","DOI":"10.1016\/S0021-9258(18)47907-0","article-title":"Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs","volume":"262","author":"Suzuki","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB86","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1083\/jcb.116.1.219","article-title":"Divalent cation regulation of the function of the leukocyte integrin LFA-1","volume":"116","author":"Dransfield","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB87","doi-asserted-by":"crossref","first-page":"12927","DOI":"10.1016\/S0021-9258(18)37650-6","article-title":"Regulation of the fibronectin receptor affinity by divalent cations","volume":"263","author":"Gailit","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB88","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.112.1.169","article-title":"Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by ARG-GLY-ASP peptide and by divalent cations","volume":"112","author":"Elices","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB89","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/336487a0","article-title":"Laminin receptor on platelets is the integrin VLA-6","volume":"336","author":"Sonnenberg","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB90","doi-asserted-by":"crossref","first-page":"18525","DOI":"10.1016\/S0021-9258(17)44783-1","article-title":"Cation-dependent changes in the binding specificity of the platelet receptor GPIIb\/IIIa","volume":"265","author":"Kirchhofer","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB91","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1083\/jcb.123.1.245","article-title":"Mutation of putative divalent cation sites in the \u03b14 subunit of the integrin VLA-4: distinct effects on adhesion to CS1\/fibronectin, VCAM-1, and invasin","volume":"123","author":"Masumoto","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB92","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1126\/science.2392682","article-title":"A \u03b23 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation","volume":"249","author":"Loftus","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB93","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.1016\/S0021-9258(19)39332-9","article-title":"Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers","volume":"265","author":"Frelinger","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB94","doi-asserted-by":"crossref","first-page":"17106","DOI":"10.1016\/S0021-9258(19)47346-8","article-title":"Monoclonal antibodies to ligand-occupied conformers of integrin \u03b1IIb\u03b23 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function","volume":"266","author":"Frelinger","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB95","doi-asserted-by":"crossref","first-page":"12397","DOI":"10.1016\/S0021-9258(18)37769-X","article-title":"Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion","volume":"263","author":"Frelinger","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB96","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1073\/pnas.90.12.5838","article-title":"Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1","volume":"90","author":"Caba\u00f1as","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB97","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.1016\/S0021-9258(18)68596-5","article-title":"The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor","volume":"263","author":"Altieri","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB98","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1083\/jcb.107.5.1893","article-title":"Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen","volume":"107","author":"Altieri","year":"1988","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB99","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1083\/jcb.105.3.1137","article-title":"Aggregation of complement receptors on human neutrophils in the absence of ligand","volume":"105","author":"Detmers","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB100","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1172\/JCI109731","article-title":"Motility and adhesiveness in human neutrophils: redistribution of chemotactic factor-induced adhesion sites","volume":"65","author":"Smith","year":"1980","journal-title":"J Clin Invest"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB101","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1126\/science.1948065","article-title":"Modulation of the affinity of integrin \u03b1IIb\u03b23 (GPIIb-IIIa) by the cytoplasmic domain of \u03b1IIb","volume":"254","author":"O'Toole","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB102","doi-asserted-by":"crossref","first-page":"10169","DOI":"10.1073\/pnas.89.21.10169","article-title":"Ser-752\u2192Pro mutation in the cytoplasmic domain of integrin \u03b23 subunit and defective activation of platelet integrin \u03b1IIb\u03b23 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia","volume":"89","author":"Chen","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB103","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1083\/jcb.109.2.853","article-title":"Expression of normal and mutant avian integrin subunits in rodent cells","volume":"109","author":"Solowska","year":"1989","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB104","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1083\/jcb.110.1.175","article-title":"Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells","volume":"110","author":"Hayashi","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB105","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1091\/mbc.1.8.597","article-title":"Mapping of the functional determinants of the integrin beta-1 cytoplasmic domain by site-directed mutagenesis","volume":"1","author":"Marcantonio","year":"1990","journal-title":"Cell Regul"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB106","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1091\/mbc.4.6.593","article-title":"Ligand-dependent and \u00a0-independent integrin focal contact localization: the role of the \u03b1 chain cytoplasmic domain","volume":"4","author":"Briesewitz","year":"1993","journal-title":"Mol Biol Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB107","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.122.1.209","article-title":"Functional role of the cytoplasmic domain of the integrin \u03b15 subunit","volume":"122","author":"Bauer","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB108","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1084\/jem.178.2.649","article-title":"Interchangeable \u03b1 chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a \u03b21 integrin","volume":"178","author":"Kassner","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB109","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1073\/pnas.85.2.497","article-title":"Dynamic membrane-cytoskeleton interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes","volume":"85","author":"Burn","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.iy.07.040189.001521","article-title":"Cell biology of cytotoxic and helper T cell functions. Immunofluorescence microscopic studies of single cells and cell couples","volume":"7","author":"Kupfer","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB111","first-page":"572","article-title":"LFA-1 and actin filaments co-distribute at the contact area in lytic NK-cell conjugates","volume":"315","author":"Carpen","year":"1986","journal-title":"Sixth Int Congr Immunol (abstracts)"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB112","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/320531a0","article-title":"Interaction of plasma membrane fibronectin receptor with talin \u2014 a transmembrane linkage","volume":"320","author":"Horwitz","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB113","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1083\/jcb.111.2.721","article-title":"An interaction between alpha-actinin and the \u03b21 integrin subunit in vitro.","volume":"111","author":"Otey","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0092-8674(92)90475-R","article-title":"Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins","volume":"68","author":"Hermanowski-Vosatka","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB115","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.4049\/jimmunol.151.6.3324","article-title":"Ligand specificity of purified complement receptor type three (CD11b\/CD18, amb2, Mac-1): Indirect effects of an ARG-GLY-ASP (RGD) sequence","volume":"151","author":"Van Strijp","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB116","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/S0021-9258(19)39695-4","article-title":"Modulation of vitronectin receptor binding by membrane lipid composition","volume":"265","author":"Conforti","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB117","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1083\/jcb.105.3.1163","article-title":"An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in a divalent cation-dependent functional complex with the disialoganglioside GD2","volume":"105","author":"Cheresh","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(00)00111-1_BIB118","doi-asserted-by":"crossref","first-page":"15568","DOI":"10.1016\/S0021-9258(19)49574-4","article-title":"Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin \u03b1IIb\u03b23) is modulated by lipids","volume":"267","author":"Smyth","year":"1992","journal-title":"J Biol Chem"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982200001111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982200001111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T01:40:34Z","timestamp":1682732434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982200001111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":118,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["S0960982200001111"],"URL":"https:\/\/doi.org\/10.1016\/s0960-9822(00)00111-1","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}