{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:11:22Z","timestamp":1776489082984,"version":"3.51.2"},"reference-count":21,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4855,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1016\/s0960-9822(00)00449-8","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T02:22:27Z","timestamp":1027650147000},"page":"483-486","source":"Crossref","is-referenced-by-count":95,"title":["Stimulation of V(D)J recombination by histone acetylation"],"prefix":"10.1016","volume":"10","author":[{"given":"Fraser","family":"McBlane","sequence":"first","affiliation":[]},{"given":"Joan","family":"Boyes","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0960-9822(00)00449-8_BIB1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-2776(08)60450-2","article-title":"The mechanism of V(D)J joining","volume":"56","author":"Lewis","year":"1994","journal-title":"Adv Immunol"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB2","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1126\/science.2360047","article-title":"RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination","volume":"248","author":"Oettinger","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0092-8674(95)90116-7","article-title":"Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps","volume":"83","author":"McBlane","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0092-8674(86)90759-2","article-title":"Introduced T cell receptor variable region gene segments recombine in pre-B cells","volume":"44","author":"Yancopoulos","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S1097-2765(00)80297-X","article-title":"Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1","volume":"2","author":"Kwon","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB6","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1093\/emboj\/18.13.3712","article-title":"Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase","volume":"18","author":"Golding","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0092-8674(81)90401-3","article-title":"Transcription of the unrearranged mouse C kappa locus","volume":"27","author":"Van Ness","year":"1981","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB8","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1101\/gad.12.12.1801","article-title":"Kappa chain monoallelic demethylation and the establishment of allelic exclusion","volume":"12","author":"Mostoslavsky","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB9","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0092-8674(89)90951-3","article-title":"Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription","volume":"58","author":"Schlissel","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB10","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1073\/pnas.95.4.1540","article-title":"Reconstitution of hyperacetylated, DNase I sensitive chromatin characterised by high conformational flexibility of nucleosomal DNA","volume":"95","author":"Krajewski","year":"1998","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB11","doi-asserted-by":"crossref","first-page":"17923","DOI":"10.1074\/jbc.270.30.17923","article-title":"Modulation of chromatin folding by histone acetylation","volume":"270","author":"Garcia-Ramirez","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1101\/gad.8.6.688","article-title":"An active v-Abl protein kinase blocks immunoglobulin light chain rearrangement","volume":"8","author":"Chen","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0092-8674(92)90117-U","article-title":"V(D)J recombination in mouse thymocytes","volume":"69","author":"Roth","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0092-8674(00)81859-0","article-title":"A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage","volume":"88","author":"Hiom","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0092-8674(89)90431-5","article-title":"Specific protection of methylated CpGs in mammalian nuclei","volume":"58","author":"Antequera","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB18","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.93.15.7877","article-title":"Deletion of the mouse T-cell receptor \u03b2 gene enhancer blocks \u03b1\u03b2 T-cell development","volume":"93","author":"Bouvier","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB19","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1128\/MCB.18.9.5355","article-title":"A human RNA polymerase II complex containing factors that modify chromatin structure","volume":"18","author":"Cho","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1074-7613(00)80420-3","article-title":"In vivo occupancy of the \u03ba light chain enhancers in primary pro- and pre-B cells: a model for \u03ba locus activation","volume":"6","author":"Schaffer","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(00)00449-8_BIB21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0092-8674(94)90365-4","article-title":"B cell-specific demethylation","volume":"76","author":"Lichtenstein","year":"1994","journal-title":"Cell"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982200004498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982200004498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T17:55:03Z","timestamp":1555264503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982200004498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S0960982200004498"],"URL":"https:\/\/doi.org\/10.1016\/s0960-9822(00)00449-8","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}