{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:24:34Z","timestamp":1696976674444},"reference-count":16,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4702,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1016\/s0960-9822(00)00665-5","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:19:09Z","timestamp":1027606749000},"page":"R642-R645","source":"Crossref","is-referenced-by-count":14,"title":["T-cell lineage fate: Instructed by receptor signals?"],"prefix":"10.1016","volume":"10","author":[{"given":"Harald","family":"von Boehmer","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0960-9822(00)00665-5_BIB1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80184-3","article-title":"Lck activity controls CD4\/CD8 T cell lineage commitment","volume":"12","author":"Hern\u00e1ndez-Hoyos","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1074-7613(00)80205-8","article-title":"Inducible expression of a p56lck transgene reveals a central role for lck in the differentiation of CD4 SP thymocytes","volume":"12","author":"Legname","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/35006664","article-title":"The duration of antigen receptor signaling determines CD4+ versus CD8+ T cell lineage fate","volume":"404","author":"Yasutomo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(00)00008-X","article-title":"Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells","volume":"13","author":"Brugnera","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/335229a0","article-title":"Thymic major histocompatibility complex antigens and the \u03b1\u03b2 T cell receptor determine the CD4\/CD8 phenotype of T cells","volume":"335","author":"Teh","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(89)90502-3","article-title":"Fazekas dS, Mathis D, Benoist C, Davis M","volume":"58","author":"Berg","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0167-5699(86)90139-8","article-title":"The selection of the \u03b1,\u03b2 heterodimeric T cell receptor for antigen","volume":"7","author":"von Boehmer","year":"1986","journal-title":"Immunol Today"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(93)90225-F","article-title":"Another view of the selective model of thymocyte selection","volume":"74","author":"Chan","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev.immunol.17.1.523","article-title":"The regulation of CD4 and CD8 coreceptor gene expression during T cell development","volume":"17","author":"Ellmeier","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0092-8674(00)81368-9","article-title":"An activated form of Notch influences the choice between CD4 and CD8 T cell lineages","volume":"87","author":"Robey","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1074-7613(00)00009-1","article-title":"Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes","volume":"13","author":"Deftos","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.183.3.731","article-title":"The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells","volume":"183","author":"Itano","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB13","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1084\/jem.179.6.1997","article-title":"Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II MHC mutant mice","volume":"179","author":"Robey","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB14","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/eji.1830260918","article-title":"Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture","volume":"26","author":"Iwata","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1084\/jem.180.1.25","article-title":"Thymic selection of CD8+ single positive-cells with a class II MHC-restricted receptor","volume":"180","author":"Kirberg","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(00)00665-5_BIB16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1074-7613(00)80190-9","article-title":"Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment","volume":"12","author":"Itano","year":"2000","journal-title":"Immunity"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982200006655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982200006655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T11:57:38Z","timestamp":1556452658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982200006655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":16,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0960982200006655"],"URL":"https:\/\/doi.org\/10.1016\/s0960-9822(00)00665-5","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}